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Protein

Spliceosome RNA helicase DDX39B

Gene

DDX39B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.
Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect.

Catalytic activityi

ATP + H2O = ADP + phosphate.1 Publication

Kineticsi

  1. KM=3.3 µM for ATP1 Publication
  1. Vmax=0.126 µM/min/mg enzyme with ATP as substrate1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 96ATP8

GO - Molecular functioni

  • ATPase activity Source: Reactome
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent protein binding Source: BHF-UCL
  • ATP-dependent RNA helicase activity Source: UniProtKB
  • identical protein binding Source: IntAct
  • poly(A) RNA binding Source: UniProtKB
  • RNA-dependent ATPase activity Source: UniProtKB
  • U4 snRNA binding Source: BHF-UCL
  • U6 snRNA binding Source: BHF-UCL

GO - Biological processi

  • liver development Source: Ensembl
  • mRNA 3'-end processing Source: Reactome
  • mRNA export from nucleus Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of DNA damage checkpoint Source: UniProtKB
  • positive regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
  • positive regulation of DNA biosynthetic process Source: Ensembl
  • positive regulation of DNA-templated transcription, elongation Source: UniProtKB
  • positive regulation of translation Source: Ensembl
  • positive regulation of vascular smooth muscle cell proliferation Source: Ensembl
  • RNA export from nucleus Source: Reactome
  • RNA secondary structure unwinding Source: BHF-UCL
  • RNA splicing Source: BHF-UCL
  • spliceosomal complex assembly Source: BHF-UCL
  • termination of RNA polymerase II transcription Source: Reactome
  • viral mRNA export from host cell nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72187. mRNA 3'-end processing.

Protein family/group databases

TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Spliceosome RNA helicase DDX39B (EC:3.6.4.13)
Alternative name(s):
56 kDa U2AF65-associated protein
ATP-dependent RNA helicase p47
DEAD box protein UAP56
HLA-B-associated transcript 1 protein
Gene namesi
Name:DDX39B
Synonyms:BAT1, UAP56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13917. DDX39B.

Subcellular locationi

  • Nucleus
  • Nucleus speckle
  • Cytoplasm

  • Note: Can translocate to the cytoplasm in the presence of MX1. TREX complex assembly seems to occur in regions surrounding nuclear speckles known as perispeckles.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear matrix Source: Ensembl
  • nuclear speck Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • spliceosomal complex Source: BHF-UCL
  • transcription export complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi94 – 96GKT → AAA: Loss of ATPase and helicase activity. 1 Publication3
Mutagenesisi95K → A: Loss of ATPase and helicase activity. 2 Publications1
Mutagenesisi197E → A: Loss of ATPase and helicase activity. 1 Publication1
Mutagenesisi198C → A: No effect on ATPase activity. 1 Publication1
Mutagenesisi199D → A: Increased ATPase activity and loss of helicase activity. 1 Publication1
Mutagenesisi228 – 230SAT → AAA: Decreased ATPase activity and loss of helicase activity. 1 Publication3

Organism-specific databases

DisGeNETi7919.
OpenTargetsiENSG00000198563.
ENSG00000215425.
ENSG00000225073.
ENSG00000225859.
ENSG00000229496.
ENSG00000230624.
ENSG00000235439.
PharmGKBiPA25262.

Chemistry databases

DrugBankiDB02325. Isopropyl Alcohol.

Polymorphism and mutation databases

BioMutaiDDX39B.
DMDMi2500529.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000550712 – 428Spliceosome RNA helicase DDX39BAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei36N6-acetyllysine; alternateCombined sources1
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei38PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei172PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13838.
MaxQBiQ13838.
PaxDbiQ13838.
PeptideAtlasiQ13838.
PRIDEiQ13838.

PTM databases

iPTMnetiQ13838.
PhosphoSitePlusiQ13838.
SwissPalmiQ13838.

Expressioni

Gene expression databases

BgeeiENSG00000198563.
CleanExiHS_BAT1.
ExpressionAtlasiQ13838. baseline and differential.
GenevisibleiQ13838. HS.

Organism-specific databases

HPAiCAB034012.
HPA055334.
HPA058450.

Interactioni

Subunit structurei

Homodimer, and heterodimer with DDX39A. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex bridges ALYREF/THOC4 and the THO complex, and, in a ATP-dependent manner, ALYREF/THOC4 and SARNP/CIP29. Component of the spliceosome. Interacts directly with U2AF2. Interacts with RBM8A, RNPS1 and SRRM1, FYTTD1/UIF, THOC1, MX1 and POLDIP3. Interacts with human cytomegalovirus/HHV-5 protein UL69. Interacts with LUZP4.16 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself9EBI-348622,EBI-348622
ALYREFQ86V814EBI-348622,EBI-347640
CHTOPQ9Y3Y26EBI-348622,EBI-347794
DDX39AO001489EBI-348622,EBI-348253
SARNPP829795EBI-348622,EBI-347495
SDCBPO005604EBI-348622,EBI-727004
U2AF2P26368-24EBI-348622,EBI-11097439

GO - Molecular functioni

  • ATP-dependent protein binding Source: BHF-UCL
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi113649. 84 interactors.
IntActiQ13838. 53 interactors.
MINTiMINT-1032422.
STRINGi9606.ENSP00000379475.

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 50Combined sources4
Helixi54 – 62Combined sources9
Helixi70 – 80Combined sources11
Beta strandi85 – 88Combined sources4
Helixi95 – 106Combined sources12
Beta strandi116 – 119Combined sources4
Helixi123 – 136Combined sources14
Turni137 – 139Combined sources3
Beta strandi145 – 149Combined sources5
Helixi154 – 163Combined sources10
Beta strandi167 – 171Combined sources5
Helixi173 – 181Combined sources9
Beta strandi183 – 185Combined sources3
Beta strandi192 – 197Combined sources6
Helixi198 – 202Combined sources5
Helixi205 – 216Combined sources12
Beta strandi220 – 229Combined sources10
Turni233 – 235Combined sources3
Helixi236 – 240Combined sources5
Beta strandi247 – 250Combined sources4
Beta strandi263 – 268Combined sources6
Helixi271 – 273Combined sources3
Helixi274 – 284Combined sources11
Beta strandi288 – 293Combined sources6
Helixi297 – 309Combined sources13
Beta strandi314 – 317Combined sources4
Beta strandi319 – 321Combined sources3
Helixi323 – 334Combined sources12
Beta strandi335 – 337Combined sources3
Beta strandi339 – 345Combined sources7
Helixi353 – 355Combined sources3
Beta strandi357 – 363Combined sources7
Helixi368 – 378Combined sources11
Helixi380 – 382Combined sources3
Beta strandi386 – 391Combined sources6
Helixi394 – 407Combined sources14
Beta strandi411 – 413Combined sources3
Beta strandi417 – 419Combined sources3
Helixi420 – 422Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T5IX-ray1.90A259-428[»]
1T6NX-ray1.94A/B34-251[»]
1XTIX-ray1.95A46-428[»]
1XTJX-ray2.70A44-423[»]
1XTKX-ray2.40A45-428[»]
ProteinModelPortaliQ13838.
SMRiQ13838.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13838.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 249Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST174
Domaini261 – 422Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 73Q motifAdd BLAST29
Motifi196 – 199DECD box4

Domaini

The helicase C-terminal domain mediates interaction with ALYREF/THOC4.1 Publication

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0329. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00830000128348.
HOVERGENiHBG107334.
InParanoidiQ13838.
KOiK12812.
OMAiLLTECNF.
OrthoDBiEOG091G0H5W.
PhylomeDBiQ13838.
TreeFamiTF300442.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13838-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAENDVDNEL LDYEDDEVET AAGGDGAEAP AKKDVKGSYV SIHSSGFRDF
60 70 80 90 100
LLKPELLRAI VDCGFEHPSE VQHECIPQAI LGMDVLCQAK SGMGKTAVFV
110 120 130 140 150
LATLQQLEPV TGQVSVLVMC HTRELAFQIS KEYERFSKYM PNVKVAVFFG
160 170 180 190 200
GLSIKKDEEV LKKNCPHIVV GTPGRILALA RNKSLNLKHI KHFILDECDK
210 220 230 240 250
MLEQLDMRRD VQEIFRMTPH EKQVMMFSAT LSKEIRPVCR KFMQDPMEIF
260 270 280 290 300
VDDETKLTLH GLQQYYVKLK DNEKNRKLFD LLDVLEFNQV VIFVKSVQRC
310 320 330 340 350
IALAQLLVEQ NFPAIAIHRG MPQEERLSRY QQFKDFQRRI LVATNLFGRG
360 370 380 390 400
MDIERVNIAF NYDMPEDSDT YLHRVARAGR FGTKGLAITF VSDENDAKIL
410 420
NDVQDRFEVN ISELPDEIDI SSYIEQTR
Length:428
Mass (Da):48,991
Last modified:November 1, 1996 - v1
Checksum:i7A55167BF576FB6F
GO
Isoform 2 (identifier: Q13838-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-114: V → VYLGRVLGRGFWLGLV

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):50,679
Checksum:i5B25C9C18CA433A4
GO

Sequence cautioni

The sequence CAI17665 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289Q → R in BAD96632 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026347114V → VYLGRVLGRGFWLGLV in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37166 mRNA. Translation: CAA85523.1.
BT009909 mRNA. Translation: AAP88911.1.
AK222912 mRNA. Translation: BAD96632.1.
AB088115 Genomic DNA. Translation: BAC54953.1.
AB103621 Genomic DNA. Translation: BAF31287.1.
AB202112 Genomic DNA. Translation: BAE78637.1.
BA000025 Genomic DNA. Translation: BAB63306.1.
AL662847 Genomic DNA. Translation: CAI17664.2.
AL662847 Genomic DNA. Translation: CAI17665.2. Sequence problems.
AL662801 Genomic DNA. Translation: CAI18279.2.
AL662801 Genomic DNA. Translation: CAI18280.1.
AL662801 Genomic DNA. Translation: CAI18281.2.
AL662801 Genomic DNA. Translation: CAI18282.2.
AL662801 Genomic DNA. Translation: CAI18283.2.
BX001040 Genomic DNA. Translation: CAI18634.1.
BX248516 Genomic DNA. Translation: CAI41922.1.
BX927320 Genomic DNA. Translation: CAQ09974.1.
CR753820 Genomic DNA. Translation: CAQ07176.1.
CR753864 Genomic DNA. Translation: CAQ10634.1.
CH471081 Genomic DNA. Translation: EAX03404.1.
BC000361 mRNA. Translation: AAH00361.1.
BC013006 mRNA. Translation: AAH13006.1.
AF029061 Genomic DNA. Translation: AAB94615.1.
AF029062 Genomic DNA. Translation: AAC63046.1.
CCDSiCCDS4697.1. [Q13838-1]
PIRiI37201.
RefSeqiNP_004631.1. NM_004640.6. [Q13838-1]
NP_542165.1. NM_080598.5. [Q13838-1]
UniGeneiHs.254042.
Hs.730849.

Genome annotation databases

EnsembliENST00000383508; ENSP00000373000; ENSG00000215425. [Q13838-1]
ENST00000396172; ENSP00000379475; ENSG00000198563. [Q13838-1]
ENST00000400295; ENSP00000383151; ENSG00000215425. [Q13838-1]
ENST00000400296; ENSP00000383152; ENSG00000215425. [Q13838-1]
ENST00000412106; ENSP00000393712; ENSG00000225073. [Q13838-1]
ENST00000412330; ENSP00000398775; ENSG00000225859. [Q13838-1]
ENST00000413678; ENSP00000391463; ENSG00000229496. [Q13838-1]
ENST00000414440; ENSP00000411853; ENSG00000229496. [Q13838-1]
ENST00000415689; ENSP00000390999; ENSG00000225073. [Q13838-1]
ENST00000416863; ENSP00000407419; ENSG00000229496. [Q13838-1]
ENST00000430784; ENSP00000399030; ENSG00000235439. [Q13838-1]
ENST00000431360; ENSP00000404695; ENSG00000235439. [Q13838-1]
ENST00000441425; ENSP00000388880; ENSG00000230624. [Q13838-1]
ENST00000445218; ENSP00000411136; ENSG00000225859. [Q13838-1]
ENST00000448296; ENSP00000405560; ENSG00000225859. [Q13838-1]
ENST00000453138; ENSP00000387994; ENSG00000230624. [Q13838-1]
ENST00000456476; ENSP00000400326; ENSG00000225073. [Q13838-1]
ENST00000456666; ENSP00000394160; ENSG00000230624. [Q13838-1]
ENST00000458640; ENSP00000416269; ENSG00000198563. [Q13838-1]
GeneIDi7919.
KEGGihsa:7919.
UCSCiuc003ntt.4. human. [Q13838-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37166 mRNA. Translation: CAA85523.1.
BT009909 mRNA. Translation: AAP88911.1.
AK222912 mRNA. Translation: BAD96632.1.
AB088115 Genomic DNA. Translation: BAC54953.1.
AB103621 Genomic DNA. Translation: BAF31287.1.
AB202112 Genomic DNA. Translation: BAE78637.1.
BA000025 Genomic DNA. Translation: BAB63306.1.
AL662847 Genomic DNA. Translation: CAI17664.2.
AL662847 Genomic DNA. Translation: CAI17665.2. Sequence problems.
AL662801 Genomic DNA. Translation: CAI18279.2.
AL662801 Genomic DNA. Translation: CAI18280.1.
AL662801 Genomic DNA. Translation: CAI18281.2.
AL662801 Genomic DNA. Translation: CAI18282.2.
AL662801 Genomic DNA. Translation: CAI18283.2.
BX001040 Genomic DNA. Translation: CAI18634.1.
BX248516 Genomic DNA. Translation: CAI41922.1.
BX927320 Genomic DNA. Translation: CAQ09974.1.
CR753820 Genomic DNA. Translation: CAQ07176.1.
CR753864 Genomic DNA. Translation: CAQ10634.1.
CH471081 Genomic DNA. Translation: EAX03404.1.
BC000361 mRNA. Translation: AAH00361.1.
BC013006 mRNA. Translation: AAH13006.1.
AF029061 Genomic DNA. Translation: AAB94615.1.
AF029062 Genomic DNA. Translation: AAC63046.1.
CCDSiCCDS4697.1. [Q13838-1]
PIRiI37201.
RefSeqiNP_004631.1. NM_004640.6. [Q13838-1]
NP_542165.1. NM_080598.5. [Q13838-1]
UniGeneiHs.254042.
Hs.730849.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T5IX-ray1.90A259-428[»]
1T6NX-ray1.94A/B34-251[»]
1XTIX-ray1.95A46-428[»]
1XTJX-ray2.70A44-423[»]
1XTKX-ray2.40A45-428[»]
ProteinModelPortaliQ13838.
SMRiQ13838.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113649. 84 interactors.
IntActiQ13838. 53 interactors.
MINTiMINT-1032422.
STRINGi9606.ENSP00000379475.

Chemistry databases

DrugBankiDB02325. Isopropyl Alcohol.

Protein family/group databases

TCDBi3.A.18.1.1. the nuclear mrna exporter (mrna-e) family.

PTM databases

iPTMnetiQ13838.
PhosphoSitePlusiQ13838.
SwissPalmiQ13838.

Polymorphism and mutation databases

BioMutaiDDX39B.
DMDMi2500529.

Proteomic databases

EPDiQ13838.
MaxQBiQ13838.
PaxDbiQ13838.
PeptideAtlasiQ13838.
PRIDEiQ13838.

Protocols and materials databases

DNASUi7919.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383508; ENSP00000373000; ENSG00000215425. [Q13838-1]
ENST00000396172; ENSP00000379475; ENSG00000198563. [Q13838-1]
ENST00000400295; ENSP00000383151; ENSG00000215425. [Q13838-1]
ENST00000400296; ENSP00000383152; ENSG00000215425. [Q13838-1]
ENST00000412106; ENSP00000393712; ENSG00000225073. [Q13838-1]
ENST00000412330; ENSP00000398775; ENSG00000225859. [Q13838-1]
ENST00000413678; ENSP00000391463; ENSG00000229496. [Q13838-1]
ENST00000414440; ENSP00000411853; ENSG00000229496. [Q13838-1]
ENST00000415689; ENSP00000390999; ENSG00000225073. [Q13838-1]
ENST00000416863; ENSP00000407419; ENSG00000229496. [Q13838-1]
ENST00000430784; ENSP00000399030; ENSG00000235439. [Q13838-1]
ENST00000431360; ENSP00000404695; ENSG00000235439. [Q13838-1]
ENST00000441425; ENSP00000388880; ENSG00000230624. [Q13838-1]
ENST00000445218; ENSP00000411136; ENSG00000225859. [Q13838-1]
ENST00000448296; ENSP00000405560; ENSG00000225859. [Q13838-1]
ENST00000453138; ENSP00000387994; ENSG00000230624. [Q13838-1]
ENST00000456476; ENSP00000400326; ENSG00000225073. [Q13838-1]
ENST00000456666; ENSP00000394160; ENSG00000230624. [Q13838-1]
ENST00000458640; ENSP00000416269; ENSG00000198563. [Q13838-1]
GeneIDi7919.
KEGGihsa:7919.
UCSCiuc003ntt.4. human. [Q13838-1]

Organism-specific databases

CTDi7919.
DisGeNETi7919.
GeneCardsiDDX39B.
HGNCiHGNC:13917. DDX39B.
HPAiCAB034012.
HPA055334.
HPA058450.
MIMi142560. gene.
neXtProtiNX_Q13838.
OpenTargetsiENSG00000198563.
ENSG00000215425.
ENSG00000225073.
ENSG00000225859.
ENSG00000229496.
ENSG00000230624.
ENSG00000235439.
PharmGKBiPA25262.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0329. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00830000128348.
HOVERGENiHBG107334.
InParanoidiQ13838.
KOiK12812.
OMAiLLTECNF.
OrthoDBiEOG091G0H5W.
PhylomeDBiQ13838.
TreeFamiTF300442.

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiDDX39B. human.
EvolutionaryTraceiQ13838.
GeneWikiiBAT1.
GenomeRNAii7919.
PROiQ13838.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198563.
CleanExiHS_BAT1.
ExpressionAtlasiQ13838. baseline and differential.
GenevisibleiQ13838. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDX39B_HUMAN
AccessioniPrimary (citable) accession number: Q13838
Secondary accession number(s): B0S8C0
, O43496, Q0EFA1, Q2L6F9, Q53GL9, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STB8, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 175 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.