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Protein

Nucleolar GTP-binding protein 2

Gene

GNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi317 – 3248GTPSequence analysis
Nucleotide bindingi361 – 3655GTPSequence analysis

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 2
Alternative name(s):
Autoantigen NGP-1
Gene namesi
Name:GNL2
Synonyms:NGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29925. GNL2.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944852.

Polymorphism and mutation databases

BioMutaiGNL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Nucleolar GTP-binding protein 2PRO_0000215806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei504 – 5041PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13823.
PaxDbiQ13823.
PeptideAtlasiQ13823.
PRIDEiQ13823.

2D gel databases

SWISS-2DPAGEQ13823.

PTM databases

iPTMnetiQ13823.
PhosphoSiteiQ13823.

Expressioni

Tissue specificityi

Ubiquitously expressed at relatively low levels in all human tissues tested, with the highest level of expression in the testes.

Gene expression databases

BgeeiQ13823.
CleanExiHS_GNL2.
ExpressionAtlasiQ13823. baseline and differential.
GenevisibleiQ13823. HS.

Organism-specific databases

HPAiHPA027163.
HPA060026.

Interactioni

Protein-protein interaction databases

BioGridi118942. 63 interactions.
IntActiQ13823. 14 interactions.
MINTiMINT-3028640.
STRINGi9606.ENSP00000362153.

Structurei

3D structure databases

ProteinModelPortaliQ13823.
SMRiQ13823. Positions 218-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 368162CP-type GPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi565 – 5717Poly-Glu

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2423. Eukaryota.
COG1161. LUCA.
HOGENOMiHOG000189714.
HOVERGENiHBG052643.
InParanoidiQ13823.
KOiK14537.
OMAiNSKVHIL.
OrthoDBiEOG7HXCQ7.
PhylomeDBiQ13823.
TreeFamiTF105668.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR024929. NOG2.
IPR012971. NOG2_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11089:SF9. PTHR11089:SF9. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
PF08153. NGP1NT. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKPKYKGRS TINPSKASTN PDRVQGAGGQ NMRDRATIRR LNMYRQKERR
60 70 80 90 100
NSRGKIIKPL QYQSTVASGT VARVEPNIKW FGNTRVIKQS SLQKFQEEMD
110 120 130 140 150
TVMKDPYKVV MKQSKLPMSL LHDRIRPHNL KVHILDTESF ETTFGPKSQR
160 170 180 190 200
KRPNLFASDM QSLIENAEMS TESYDQGKDR DLVTEDTGVR NEAQEEIYKK
210 220 230 240 250
GQSKRIWGEL YKVIDSSDVV VQVLDARDPM GTRSPHIETY LKKEKPWKHL
260 270 280 290 300
IFVLNKCDLV PTWATKRWVA VLSQDYPTLA FHASLTNPFG KGAFIQLLRQ
310 320 330 340 350
FGKLHTDKKQ ISVGFIGYPN VGKSSVINTL RSKKVCNVAP IAGETKVWQY
360 370 380 390 400
ITLMRRIFLI DCPGVVYPSE DSETDIVLKG VVQVEKIKSP EDHIGAVLER
410 420 430 440 450
AKPEYISKTY KIDSWENAED FLEKLAFRTG KLLKGGEPDL QTVGKMVLND
460 470 480 490 500
WQRGRIPFFV KPPNAEPLVA PQLLPSSSLE VVPEAAQNNP GEEVTETAGE
510 520 530 540 550
GSESIIKEET EENSHCDANT EMQQILTRVR QNFGKINVVP QFSGDDLVPV
560 570 580 590 600
EVSDLEEELE SFSDEEEEEQ EQQRDDAEES SSEPEEENVG NDTKAVIKAL
610 620 630 640 650
DEKIAKYQKF LDKAKAKKFS AVRISKGLSE KIFAKPEEQR KTLEEDVDDR
660 670 680 690 700
APSKKGKKRK AQREEEQEHS NKAPRALTSK ERRRAVRQQR PKKVGVRYYE
710 720 730
THNVKNRNRN KKKTNDSEGQ KHKRKKFRQK Q
Length:731
Mass (Da):83,655
Last modified:November 1, 1996 - v1
Checksum:iE90C638B58C0886E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841S → I in AAH00107 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti452 – 4521Q → H.
Corresponds to variant rs12025870 [ dbSNP | Ensembl ].
VAR_050291

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05425 mRNA. Translation: AAC37588.1.
BC000107 mRNA. Translation: AAH00107.1.
BC009250 mRNA. Translation: AAH09250.1.
CCDSiCCDS421.1.
RefSeqiNP_037417.1. NM_013285.2.
UniGeneiHs.75528.

Genome annotation databases

EnsembliENST00000373062; ENSP00000362153; ENSG00000134697.
GeneIDi29889.
KEGGihsa:29889.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05425 mRNA. Translation: AAC37588.1.
BC000107 mRNA. Translation: AAH00107.1.
BC009250 mRNA. Translation: AAH09250.1.
CCDSiCCDS421.1.
RefSeqiNP_037417.1. NM_013285.2.
UniGeneiHs.75528.

3D structure databases

ProteinModelPortaliQ13823.
SMRiQ13823. Positions 218-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118942. 63 interactions.
IntActiQ13823. 14 interactions.
MINTiMINT-3028640.
STRINGi9606.ENSP00000362153.

PTM databases

iPTMnetiQ13823.
PhosphoSiteiQ13823.

Polymorphism and mutation databases

BioMutaiGNL2.

2D gel databases

SWISS-2DPAGEQ13823.

Proteomic databases

EPDiQ13823.
PaxDbiQ13823.
PeptideAtlasiQ13823.
PRIDEiQ13823.

Protocols and materials databases

DNASUi29889.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373062; ENSP00000362153; ENSG00000134697.
GeneIDi29889.
KEGGihsa:29889.

Organism-specific databases

CTDi29889.
GeneCardsiGNL2.
HGNCiHGNC:29925. GNL2.
HPAiHPA027163.
HPA060026.
MIMi609365. gene.
neXtProtiNX_Q13823.
PharmGKBiPA134944852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2423. Eukaryota.
COG1161. LUCA.
HOGENOMiHOG000189714.
HOVERGENiHBG052643.
InParanoidiQ13823.
KOiK14537.
OMAiNSKVHIL.
OrthoDBiEOG7HXCQ7.
PhylomeDBiQ13823.
TreeFamiTF105668.

Miscellaneous databases

ChiTaRSiGNL2. human.
GeneWikiiGNL2.
GenomeRNAii29889.
NextBioi52437.
PROiQ13823.
SOURCEiSearch...

Gene expression databases

BgeeiQ13823.
CleanExiHS_GNL2.
ExpressionAtlasiQ13823. baseline and differential.
GenevisibleiQ13823. HS.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR024929. NOG2.
IPR012971. NOG2_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11089:SF9. PTHR11089:SF9. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
PF08153. NGP1NT. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor."
    Racevskis J., Dill A., Stockert R., Fineberg S.A.
    Cell Growth Differ. 7:271-280(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary carcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Muscle.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNOG2_HUMAN
AccessioniPrimary (citable) accession number: Q13823
Secondary accession number(s): Q9BWN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.