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Q13797

- ITA9_HUMAN

UniProt

Q13797 - ITA9_HUMAN

Protein

Integrin alpha-9

Gene

ITGA9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei565 – 5662CleavageSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi312 – 3209Sequence Analysis
    Calcium bindingi373 – 3819Sequence Analysis
    Calcium bindingi435 – 4439Sequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. cell adhesion Source: MGI
    3. extracellular matrix organization Source: Reactome
    4. integrin-mediated signaling pathway Source: UniProtKB-KW
    5. neutrophil chemotaxis Source: Ensembl
    6. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13552. Integrin cell surface interactions.
    REACT_163906. ECM proteoglycans.
    REACT_22272. Signal transduction by L1.
    SignaLinkiQ13797.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-9
    Alternative name(s):
    Integrin alpha-RLC
    Gene namesi
    Name:ITGA9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:6145. ITGA9.

    Subcellular locationi

    GO - Cellular componenti

    1. basal plasma membrane Source: Ensembl
    2. integrin alpha9-beta1 complex Source: Ensembl
    3. integrin complex Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti371007. Congenital muscular dystrophy with hyperlaxity.
    PharmGKBiPA29945.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 10351006Integrin alpha-9PRO_0000016316Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi87 ↔ 97By similarity
    Disulfide bondi142 ↔ 162By similarity
    Disulfide bondi179 ↔ 194By similarity
    Glycosylationi225 – 2251N-linked (GlcNAc...)1 Publication
    Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi482 ↔ 491By similarity
    Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi497 ↔ 555By similarity
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi620 ↔ 625By similarity
    Glycosylationi654 – 6541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi672 – 6721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi676 – 6761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi696 ↔ 706By similarity
    Glycosylationi807 – 8071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi854 – 8541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi855 ↔ 891By similarity
    Disulfide bondi898 ↔ 903By similarity
    Glycosylationi904 – 9041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ13797.
    PRIDEiQ13797.

    PTM databases

    PhosphoSiteiQ13797.

    Expressioni

    Tissue specificityi

    In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.

    Inductioni

    Up-regulated in small cell lung cancers (SCLC).

    Gene expression databases

    ArrayExpressiQ13797.
    BgeeiQ13797.
    CleanExiHS_ITGA9.
    GenevestigatoriQ13797.

    Organism-specific databases

    HPAiHPA030609.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1.

    Protein-protein interaction databases

    BioGridi109886. 2 interactions.
    MINTiMINT-1534610.
    STRINGi9606.ENSP00000264741.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13797.
    SMRiQ13797. Positions 30-867, 978-1018.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 981952ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1003 – 103533CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei982 – 100221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati35 – 9662FG-GAP 1Add
    BLAST
    Repeati111 – 17464FG-GAP 2Add
    BLAST
    Repeati182 – 23352FG-GAP 3Add
    BLAST
    Repeati234 – 28956FG-GAP 4Add
    BLAST
    Repeati290 – 34960FG-GAP 5Add
    BLAST
    Repeati351 – 40858FG-GAP 6Add
    BLAST
    Repeati411 – 47464FG-GAP 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1005 – 10095GFFKR motif

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240832.
    HOGENOMiHOG000088626.
    HOVERGENiHBG004538.
    InParanoidiQ13797.
    KOiK06585.
    OMAiNTRWVLV.
    PhylomeDBiQ13797.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF01839. FG-GAP. 2 hits.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13797-1 [UniParc]FASTAAdd to Basket

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    MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY     50
    AVLEHFHDNT RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL 100
    DMARGKNRGT SCGKTCREDR DDEWMGVSLA RQPKADGRVL ACAHRWKNIY 150
    YEADHILPHG FCYIIPSNLQ AKGRTLIPCY EEYKKKYGEE HGSCQAGIAG 200
    FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM NRRYTYLGYA 250
    VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM 300
    GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE 350
    QLALTGDGAY NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH 400
    GDAGGIVPQY SMKLSGQKIN PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM 450
    SDSVVLLRAR PVITVDVSIF LPGSINITAP QCHDGQQPVN CLNVTTCFSF 500
    HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG QVTEKLQLTY 550
    MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL 600
    RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGKLLLSSM DEKTLYLALG 650
    AVKNISLNIS ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE 700
    SDFLKCSVGF PFMRSKSKYE FSVIFDTSHL SGEEEVLSFI VTAQSGNTER 750
    SESLHDNTLV LMVPLMHEVD TSITGIMSPT SFVYGESVDA ANFIQLDDLE 800
    CHFQPINITL QVYNTGPSTL PGSSVSISFP NRLSSGGAEM FHVQEMVVGQ 850
    EKGNCSFQKN PTPCIIPQEQ ENIFHTIFAF FTKSGRKVLD CEKPGISCLT 900
    AHCNFSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMSR AKVKVDPALR 950
    VVEIAHGNPE EVTVVFEALH NLEPRGYVVG WIIAISLLVG ILIFLLLAVL 1000
    LWKMGFFRRR YKEIIEAEKN RKENEDSWDW VQKNQ 1035
    Length:1,035
    Mass (Da):114,489
    Last modified:May 5, 2009 - v2
    Checksum:iB812EDA867A3E836
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti507 – 5071G → E.2 Publications
    Corresponds to variant rs267561 [ dbSNP | Ensembl ].
    VAR_055091
    Natural varianti750 – 7501R → C in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036073

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D25303 mRNA. Translation: BAA04984.1.
    AC092055 Genomic DNA. No translation available.
    AC093415 Genomic DNA. No translation available.
    AP006240 Genomic DNA. No translation available.
    L24158 mRNA. Translation: AAA16099.1.
    CCDSiCCDS2669.1.
    PIRiI58409.
    RefSeqiNP_002198.2. NM_002207.2.
    UniGeneiHs.113157.

    Genome annotation databases

    EnsembliENST00000264741; ENSP00000264741; ENSG00000144668.
    GeneIDi3680.
    KEGGihsa:3680.
    UCSCiuc003chd.3. human.

    Polymorphism databases

    DMDMi229462922.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D25303 mRNA. Translation: BAA04984.1 .
    AC092055 Genomic DNA. No translation available.
    AC093415 Genomic DNA. No translation available.
    AP006240 Genomic DNA. No translation available.
    L24158 mRNA. Translation: AAA16099.1 .
    CCDSi CCDS2669.1.
    PIRi I58409.
    RefSeqi NP_002198.2. NM_002207.2.
    UniGenei Hs.113157.

    3D structure databases

    ProteinModelPortali Q13797.
    SMRi Q13797. Positions 30-867, 978-1018.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109886. 2 interactions.
    MINTi MINT-1534610.
    STRINGi 9606.ENSP00000264741.

    Chemistry

    BindingDBi Q13797.
    ChEMBLi CHEMBL3170.

    PTM databases

    PhosphoSitei Q13797.

    Polymorphism databases

    DMDMi 229462922.

    Proteomic databases

    PaxDbi Q13797.
    PRIDEi Q13797.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264741 ; ENSP00000264741 ; ENSG00000144668 .
    GeneIDi 3680.
    KEGGi hsa:3680.
    UCSCi uc003chd.3. human.

    Organism-specific databases

    CTDi 3680.
    GeneCardsi GC03P037468.
    H-InvDB HIX0003172.
    HGNCi HGNC:6145. ITGA9.
    HPAi HPA030609.
    MIMi 603963. gene.
    neXtProti NX_Q13797.
    Orphaneti 371007. Congenital muscular dystrophy with hyperlaxity.
    PharmGKBi PA29945.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240832.
    HOGENOMi HOG000088626.
    HOVERGENi HBG004538.
    InParanoidi Q13797.
    KOi K06585.
    OMAi NTRWVLV.
    PhylomeDBi Q13797.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_13552. Integrin cell surface interactions.
    REACT_163906. ECM proteoglycans.
    REACT_22272. Signal transduction by L1.
    SignaLinki Q13797.

    Miscellaneous databases

    GeneWikii ITGA9.
    GenomeRNAii 3680.
    NextBioi 14403.
    PROi Q13797.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13797.
    Bgeei Q13797.
    CleanExi HS_ITGA9.
    Genevestigatori Q13797.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 2 hits.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer."
      Hibi K., Yamakawa K., Ueda R., Horio Y., Murata Y., Tamari M., Uchida K., Takahashi T., Nakamura Y., Takahashi T.
      Oncogene 9:611-619(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-507.
      Tissue: Lung.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle."
      Palmer E.L., Rueegg C., Ferrando R., Pytela R., Sheppard D.
      J. Cell Biol. 123:1289-1297(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-1035, PROTEIN SEQUENCE OF 30-35, VARIANT GLU-507.
      Tissue: Intestine and Lung.
    4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-225.
      Tissue: Liver.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-750.

    Entry informationi

    Entry nameiITA9_HUMAN
    AccessioniPrimary (citable) accession number: Q13797
    Secondary accession number(s): Q14638
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3