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Q13797

- ITA9_HUMAN

UniProt

Q13797 - ITA9_HUMAN

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Protein

Integrin alpha-9

Gene

ITGA9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei565 – 5662CleavageSequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi312 – 3209Sequence Analysis
Calcium bindingi373 – 3819Sequence Analysis
Calcium bindingi435 – 4439Sequence Analysis

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. axon guidance Source: Reactome
  2. cell adhesion Source: MGI
  3. extracellular matrix organization Source: Reactome
  4. integrin-mediated signaling pathway Source: UniProtKB-KW
  5. neutrophil chemotaxis Source: Ensembl
  6. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13552. Integrin cell surface interactions.
REACT_163906. ECM proteoglycans.
REACT_22272. Signal transduction by L1.
SignaLinkiQ13797.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-9
Alternative name(s):
Integrin alpha-RLC
Gene namesi
Name:ITGA9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:6145. ITGA9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 981952ExtracellularSequence AnalysisAdd
BLAST
Transmembranei982 – 100221HelicalSequence AnalysisAdd
BLAST
Topological domaini1003 – 103533CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basal plasma membrane Source: Ensembl
  2. integrin alpha9-beta1 complex Source: Ensembl
  3. integrin complex Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti371007. Congenital muscular dystrophy with hyperlaxity.
PharmGKBiPA29945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 10351006Integrin alpha-9PRO_0000016316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi87 ↔ 97By similarity
Disulfide bondi142 ↔ 162By similarity
Disulfide bondi179 ↔ 194By similarity
Glycosylationi225 – 2251N-linked (GlcNAc...)1 Publication
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi482 ↔ 491By similarity
Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi497 ↔ 555By similarity
Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi620 ↔ 625By similarity
Glycosylationi654 – 6541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi672 – 6721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi676 – 6761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi696 ↔ 706By similarity
Glycosylationi807 – 8071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi854 – 8541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi855 ↔ 891By similarity
Disulfide bondi898 ↔ 903By similarity
Glycosylationi904 – 9041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13797.
PRIDEiQ13797.

PTM databases

PhosphoSiteiQ13797.

Expressioni

Tissue specificityi

In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.

Inductioni

Up-regulated in small cell lung cancers (SCLC).

Gene expression databases

BgeeiQ13797.
CleanExiHS_ITGA9.
ExpressionAtlasiQ13797. baseline and differential.
GenevestigatoriQ13797.

Organism-specific databases

HPAiHPA030609.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1.

Protein-protein interaction databases

BioGridi109886. 2 interactions.
MINTiMINT-1534610.
STRINGi9606.ENSP00000264741.

Structurei

3D structure databases

ProteinModelPortaliQ13797.
SMRiQ13797. Positions 30-867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 9662FG-GAP 1Add
BLAST
Repeati111 – 17464FG-GAP 2Add
BLAST
Repeati182 – 23352FG-GAP 3Add
BLAST
Repeati234 – 28956FG-GAP 4Add
BLAST
Repeati290 – 34960FG-GAP 5Add
BLAST
Repeati351 – 40858FG-GAP 6Add
BLAST
Repeati411 – 47464FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1005 – 10095GFFKR motif

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240832.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000088626.
HOVERGENiHBG004538.
InParanoidiQ13797.
KOiK06585.
OMAiNTRWVLV.
PhylomeDBiQ13797.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13797-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY
60 70 80 90 100
AVLEHFHDNT RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL
110 120 130 140 150
DMARGKNRGT SCGKTCREDR DDEWMGVSLA RQPKADGRVL ACAHRWKNIY
160 170 180 190 200
YEADHILPHG FCYIIPSNLQ AKGRTLIPCY EEYKKKYGEE HGSCQAGIAG
210 220 230 240 250
FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM NRRYTYLGYA
260 270 280 290 300
VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM
310 320 330 340 350
GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE
360 370 380 390 400
QLALTGDGAY NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH
410 420 430 440 450
GDAGGIVPQY SMKLSGQKIN PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM
460 470 480 490 500
SDSVVLLRAR PVITVDVSIF LPGSINITAP QCHDGQQPVN CLNVTTCFSF
510 520 530 540 550
HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG QVTEKLQLTY
560 570 580 590 600
MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL
610 620 630 640 650
RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGKLLLSSM DEKTLYLALG
660 670 680 690 700
AVKNISLNIS ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE
710 720 730 740 750
SDFLKCSVGF PFMRSKSKYE FSVIFDTSHL SGEEEVLSFI VTAQSGNTER
760 770 780 790 800
SESLHDNTLV LMVPLMHEVD TSITGIMSPT SFVYGESVDA ANFIQLDDLE
810 820 830 840 850
CHFQPINITL QVYNTGPSTL PGSSVSISFP NRLSSGGAEM FHVQEMVVGQ
860 870 880 890 900
EKGNCSFQKN PTPCIIPQEQ ENIFHTIFAF FTKSGRKVLD CEKPGISCLT
910 920 930 940 950
AHCNFSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMSR AKVKVDPALR
960 970 980 990 1000
VVEIAHGNPE EVTVVFEALH NLEPRGYVVG WIIAISLLVG ILIFLLLAVL
1010 1020 1030
LWKMGFFRRR YKEIIEAEKN RKENEDSWDW VQKNQ
Length:1,035
Mass (Da):114,489
Last modified:May 5, 2009 - v2
Checksum:iB812EDA867A3E836
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti507 – 5071G → E.2 Publications
Corresponds to variant rs267561 [ dbSNP | Ensembl ].
VAR_055091
Natural varianti750 – 7501R → C in a breast cancer sample; somatic mutation. 1 Publication
VAR_036073

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25303 mRNA. Translation: BAA04984.1.
AC092055 Genomic DNA. No translation available.
AC093415 Genomic DNA. No translation available.
AP006240 Genomic DNA. No translation available.
L24158 mRNA. Translation: AAA16099.1.
CCDSiCCDS2669.1.
PIRiI58409.
RefSeqiNP_002198.2. NM_002207.2.
UniGeneiHs.113157.

Genome annotation databases

EnsembliENST00000264741; ENSP00000264741; ENSG00000144668.
GeneIDi3680.
KEGGihsa:3680.
UCSCiuc003chd.3. human.

Polymorphism databases

DMDMi229462922.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25303 mRNA. Translation: BAA04984.1 .
AC092055 Genomic DNA. No translation available.
AC093415 Genomic DNA. No translation available.
AP006240 Genomic DNA. No translation available.
L24158 mRNA. Translation: AAA16099.1 .
CCDSi CCDS2669.1.
PIRi I58409.
RefSeqi NP_002198.2. NM_002207.2.
UniGenei Hs.113157.

3D structure databases

ProteinModelPortali Q13797.
SMRi Q13797. Positions 30-867.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109886. 2 interactions.
MINTi MINT-1534610.
STRINGi 9606.ENSP00000264741.

Chemistry

ChEMBLi CHEMBL3170.

PTM databases

PhosphoSitei Q13797.

Polymorphism databases

DMDMi 229462922.

Proteomic databases

PaxDbi Q13797.
PRIDEi Q13797.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264741 ; ENSP00000264741 ; ENSG00000144668 .
GeneIDi 3680.
KEGGi hsa:3680.
UCSCi uc003chd.3. human.

Organism-specific databases

CTDi 3680.
GeneCardsi GC03P037468.
H-InvDB HIX0003172.
HGNCi HGNC:6145. ITGA9.
HPAi HPA030609.
MIMi 603963. gene.
neXtProti NX_Q13797.
Orphaneti 371007. Congenital muscular dystrophy with hyperlaxity.
PharmGKBi PA29945.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240832.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000088626.
HOVERGENi HBG004538.
InParanoidi Q13797.
KOi K06585.
OMAi NTRWVLV.
PhylomeDBi Q13797.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_13552. Integrin cell surface interactions.
REACT_163906. ECM proteoglycans.
REACT_22272. Signal transduction by L1.
SignaLinki Q13797.

Miscellaneous databases

ChiTaRSi ITGA9. human.
GeneWikii ITGA9.
GenomeRNAii 3680.
NextBioi 14403.
PROi Q13797.
SOURCEi Search...

Gene expression databases

Bgeei Q13797.
CleanExi HS_ITGA9.
ExpressionAtlasi Q13797. baseline and differential.
Genevestigatori Q13797.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer."
    Hibi K., Yamakawa K., Ueda R., Horio Y., Murata Y., Tamari M., Uchida K., Takahashi T., Nakamura Y., Takahashi T.
    Oncogene 9:611-619(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-507.
    Tissue: Lung.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle."
    Palmer E.L., Rueegg C., Ferrando R., Pytela R., Sheppard D.
    J. Cell Biol. 123:1289-1297(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-1035, PROTEIN SEQUENCE OF 30-35, VARIANT GLU-507.
    Tissue: Intestine and Lung.
  4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-225.
    Tissue: Liver.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-750.

Entry informationi

Entry nameiITA9_HUMAN
AccessioniPrimary (citable) accession number: Q13797
Secondary accession number(s): Q14638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3