Q13797 (ITA9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integrin alpha-9

Alternative name(s):
Integrin alpha-RLC

Gene names

Name:

ITGA9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1035 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Subunit structure	Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.
Induction	Up-regulated in small cell lung cancers (SCLC).
Sequence similarities	Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Molecular function	Integrin Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome cell adhesion Inferred from genetic interaction PubMed 21060781. Source: MGI integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW neutrophil chemotaxis Inferred from electronic annotation. Source: Compara
Cellular_component	basal plasma membrane Inferred from electronic annotation. Source: Compara integrin complex Traceable author statement Ref.3. Source: ProtInc
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 1035	1006	Integrin alpha-9		PRO_0000016316
Regions
	Topological domain	30 – 981	952	Extracellular Potential
	Transmembrane	982 – 1002	21	Helical; Potential
	Topological domain	1003 – 1035	33	Cytoplasmic Potential
	Repeat	35 – 96	62	FG-GAP 1
	Repeat	111 – 174	64	FG-GAP 2
	Repeat	182 – 233	52	FG-GAP 3
	Repeat	234 – 289	56	FG-GAP 4
	Repeat	290 – 349	60	FG-GAP 5
	Repeat	351 – 408	58	FG-GAP 6
	Repeat	411 – 474	64	FG-GAP 7
	Calcium binding	312 – 320	9	Potential
	Calcium binding	373 – 381	9	Potential
	Calcium binding	435 – 443	9	Potential
	Motif	1005 – 1009	5	GFFKR motif
Sites
	Site	565 – 566	2	Cleavage Potential
Amino acid modifications
	Glycosylation	225	1	N-linked (GlcNAc...) Ref.4
	Glycosylation	476	1	N-linked (GlcNAc...) Potential
	Glycosylation	493	1	N-linked (GlcNAc...) Potential
	Glycosylation	612	1	N-linked (GlcNAc...) Potential
	Glycosylation	654	1	N-linked (GlcNAc...) Potential
	Glycosylation	658	1	N-linked (GlcNAc...) Potential
	Glycosylation	672	1	N-linked (GlcNAc...) Potential
	Glycosylation	676	1	N-linked (GlcNAc...) Potential
	Glycosylation	807	1	N-linked (GlcNAc...) Potential
	Glycosylation	854	1	N-linked (GlcNAc...) Potential
	Glycosylation	904	1	N-linked (GlcNAc...) Potential
	Disulfide bond	87 ↔ 97		By similarity
	Disulfide bond	142 ↔ 162		By similarity
	Disulfide bond	179 ↔ 194		By similarity
	Disulfide bond	482 ↔ 491		By similarity
	Disulfide bond	497 ↔ 555		By similarity
	Disulfide bond	620 ↔ 625		By similarity
	Disulfide bond	696 ↔ 706		By similarity
	Disulfide bond	855 ↔ 891		By similarity
	Disulfide bond	898 ↔ 903		By similarity
Natural variations
	Natural variant	507	1	G → E. Ref.1 Ref.3 Corresponds to variant rs267561 [ dbSNP | Ensembl ].		VAR_055091
	Natural variant	750	1	R → C in a breast cancer sample; somatic mutation. Ref.5		VAR_036073

Sequences

	Sequence		Length	Mass (Da)
	Q13797 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: B812EDA867A3E836	FASTA	1,035	114,489
	10 20 30 40 50 60 MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY AVLEHFHDNT 70 80 90 100 110 120 RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL DMARGKNRGT SCGKTCREDR 130 140 150 160 170 180 DDEWMGVSLA RQPKADGRVL ACAHRWKNIY YEADHILPHG FCYIIPSNLQ AKGRTLIPCY 190 200 210 220 230 240 EEYKKKYGEE HGSCQAGIAG FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM 250 260 270 280 290 300 NRRYTYLGYA VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM 310 320 330 340 350 360 GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE QLALTGDGAY 370 380 390 400 410 420 NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH GDAGGIVPQY SMKLSGQKIN 430 440 450 460 470 480 PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM SDSVVLLRAR PVITVDVSIF LPGSINITAP 490 500 510 520 530 540 QCHDGQQPVN CLNVTTCFSF HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG 550 560 570 580 590 600 QVTEKLQLTY MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL 610 620 630 640 650 660 RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGKLLLSSM DEKTLYLALG AVKNISLNIS 670 680 690 700 710 720 ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE SDFLKCSVGF PFMRSKSKYE 730 740 750 760 770 780 FSVIFDTSHL SGEEEVLSFI VTAQSGNTER SESLHDNTLV LMVPLMHEVD TSITGIMSPT 790 800 810 820 830 840 SFVYGESVDA ANFIQLDDLE CHFQPINITL QVYNTGPSTL PGSSVSISFP NRLSSGGAEM 850 860 870 880 890 900 FHVQEMVVGQ EKGNCSFQKN PTPCIIPQEQ ENIFHTIFAF FTKSGRKVLD CEKPGISCLT 910 920 930 940 950 960 AHCNFSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMSR AKVKVDPALR VVEIAHGNPE 970 980 990 1000 1010 1020 EVTVVFEALH NLEPRGYVVG WIIAISLLVG ILIFLLLAVL LWKMGFFRRR YKEIIEAEKN 1030 RKENEDSWDW VQKNQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer." Hibi K., Yamakawa K., Ueda R., Horio Y., Murata Y., Tamari M., Uchida K., Takahashi T., Nakamura Y., Takahashi T. Oncogene 9:611-619(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-507. Tissue: Lung.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle." Palmer E.L., Rueegg C., Ferrando R., Pytela R., Sheppard D. J. Cell Biol. 123:1289-1297(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-1035, PROTEIN SEQUENCE OF 30-35, VARIANT GLU-507. Tissue: Intestine and Lung.
[4]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-225, MASS SPECTROMETRY. Tissue: Liver.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-750.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D25303 mRNA. Translation: BAA04984.1. AC092055 Genomic DNA. No translation available. AC093415 Genomic DNA. No translation available. AP006240 Genomic DNA. No translation available. L24158 mRNA. Translation: AAA16099.1.
IPI	IPI00015181.
PIR	I58409.
RefSeq	NP_002198.2. NM_002207.2.
UniGene	Hs.113157.
3D structure databases
ProteinModelPortal	Q13797.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000264741.
PTM databases
PhosphoSite	Q13797.
Polymorphism databases
DMDM	229462922.
Proteomic databases
PaxDb	Q13797.
PRIDE	Q13797.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264741; ENSP00000264741; ENSG00000144668.
GeneID	3680.
KEGG	hsa:3680.
UCSC	uc003chd.3. human.
Organism-specific databases
CTD	3680.
GeneCards	GC03P037468.
H-InvDB	HIX0003172.
HGNC	HGNC:6145. ITGA9.
HPA	HPA030609.
MIM	603963. gene.
neXtProt	NX_Q13797.
PharmGKB	PA29945.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240832.
HOGENOM	HOG000088626.
HOVERGEN	HBG004538.
InParanoid	Q13797.
KO	K06585.
OMA	CHFQPIN.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6_traffickingpathway. Arf6 trafficking events.
Reactome	REACT_111045. Developmental Biology. REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q13797.
Bgee	Q13797.
CleanEx	HS_ITGA9.
Genevestigator	Q13797.
GermOnline	ENSG00000144668. Homo sapiens.
Family and domain databases
InterPro	IPR013517. FG-GAP. IPR013519. Int_alpha_beta-p. IPR000413. Integrin_alpha. IPR013649. Integrin_alpha-2. IPR018184. Integrin_alpha_C_CS. [Graphical view]
Pfam	PF01839. FG-GAP. 2 hits. PF08441. Integrin_alpha2. 1 hit. [Graphical view]
PRINTS	PR01185. INTEGRINA.
SMART	SM00191. Int_alpha. 5 hits. [Graphical view]
PROSITE	PS51470. FG_GAP. 7 hits. PS00242. INTEGRIN_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q13797.
ChEMBL	CHEMBL3170.
GenomeRNAi	3680.
NextBio	14403.
SOURCE	Search...

Entry information

Entry name

ITA9_HUMAN

Accession

Primary (citable) accession number: Q13797
Secondary accession number(s): Q14638

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.