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Protein

Integrin alpha-9

Gene

ITGA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi312 – 320Sequence analysis9
Calcium bindingi373 – 381Sequence analysis9
Calcium bindingi435 – 443Sequence analysis9

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: MGI
  • extracellular matrix organization Source: Reactome
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • neutrophil chemotaxis Source: Ensembl
  • wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144668-MONOMER.
ReactomeiR-HSA-216083. Integrin cell surface interactions.
R-HSA-3000178. ECM proteoglycans.
R-HSA-445144. Signal transduction by L1.
SignaLinkiQ13797.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-9
Alternative name(s):
Integrin alpha-RLC
Gene namesi
Name:ITGA9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6145. ITGA9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 981ExtracellularSequence analysisAdd BLAST952
Transmembranei982 – 1002HelicalSequence analysisAdd BLAST21
Topological domaini1003 – 1035CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

  • basal plasma membrane Source: Ensembl
  • integrin alpha9-beta1 complex Source: Ensembl
  • integrin complex Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3680.
MalaCardsiITGA9.
OpenTargetsiENSG00000144668.
Orphaneti371007. Congenital muscular dystrophy with hyperlaxity.
PharmGKBiPA29945.

Chemistry databases

ChEMBLiCHEMBL3170.

Polymorphism and mutation databases

BioMutaiITGA9.
DMDMi229462922.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001631630 – 1035Integrin alpha-9Add BLAST1006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi87 ↔ 97By similarity
Disulfide bondi142 ↔ 162By similarity
Disulfide bondi179 ↔ 194By similarity
Glycosylationi225N-linked (GlcNAc...)1 Publication1
Glycosylationi476N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi482 ↔ 491By similarity
Glycosylationi493N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi497 ↔ 555By similarity
Glycosylationi612N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi620 ↔ 625By similarity
Glycosylationi654N-linked (GlcNAc...)Sequence analysis1
Glycosylationi658N-linked (GlcNAc...)Sequence analysis1
Glycosylationi672N-linked (GlcNAc...)Sequence analysis1
Glycosylationi676N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi696 ↔ 706By similarity
Glycosylationi807N-linked (GlcNAc...)Sequence analysis1
Glycosylationi854N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi855 ↔ 891By similarity
Disulfide bondi898 ↔ 903By similarity
Glycosylationi904N-linked (GlcNAc...)Sequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei565 – 566CleavageSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13797.
PeptideAtlasiQ13797.
PRIDEiQ13797.

PTM databases

iPTMnetiQ13797.
PhosphoSitePlusiQ13797.

Expressioni

Tissue specificityi

In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.2 Publications

Inductioni

Up-regulated in small cell lung cancers (SCLC).1 Publication

Gene expression databases

BgeeiENSG00000144668.
CleanExiHS_ITGA9.
ExpressionAtlasiQ13797. baseline and differential.
GenevisibleiQ13797. HS.

Organism-specific databases

HPAiHPA030609.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-9 (ITGA9) associates with beta-1 (ITGB1). Integrin ITGA9:ITGB1 interacts with FBLN5 (via N-terminus).By similarity

Protein-protein interaction databases

BioGridi109886. 16 interactors.
MINTiMINT-1534610.
STRINGi9606.ENSP00000264741.

Structurei

3D structure databases

ProteinModelPortaliQ13797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 96FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati111 – 174FG-GAP 2PROSITE-ProRule annotationAdd BLAST64
Repeati182 – 232FG-GAP 3PROSITE-ProRule annotationAdd BLAST51
Repeati233 – 289FG-GAP 4PROSITE-ProRule annotationAdd BLAST57
Repeati290 – 349FG-GAP 5PROSITE-ProRule annotationAdd BLAST60
Repeati351 – 408FG-GAP 6PROSITE-ProRule annotationAdd BLAST58
Repeati411 – 474FG-GAP 7PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1005 – 1009GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000088626.
HOVERGENiHBG004538.
InParanoidiQ13797.
KOiK06585.
OMAiHFSQPTT.
OrthoDBiEOG091G011V.
PhylomeDBiQ13797.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY
60 70 80 90 100
AVLEHFHDNT RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL
110 120 130 140 150
DMARGKNRGT SCGKTCREDR DDEWMGVSLA RQPKADGRVL ACAHRWKNIY
160 170 180 190 200
YEADHILPHG FCYIIPSNLQ AKGRTLIPCY EEYKKKYGEE HGSCQAGIAG
210 220 230 240 250
FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM NRRYTYLGYA
260 270 280 290 300
VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM
310 320 330 340 350
GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE
360 370 380 390 400
QLALTGDGAY NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH
410 420 430 440 450
GDAGGIVPQY SMKLSGQKIN PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM
460 470 480 490 500
SDSVVLLRAR PVITVDVSIF LPGSINITAP QCHDGQQPVN CLNVTTCFSF
510 520 530 540 550
HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG QVTEKLQLTY
560 570 580 590 600
MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL
610 620 630 640 650
RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGKLLLSSM DEKTLYLALG
660 670 680 690 700
AVKNISLNIS ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE
710 720 730 740 750
SDFLKCSVGF PFMRSKSKYE FSVIFDTSHL SGEEEVLSFI VTAQSGNTER
760 770 780 790 800
SESLHDNTLV LMVPLMHEVD TSITGIMSPT SFVYGESVDA ANFIQLDDLE
810 820 830 840 850
CHFQPINITL QVYNTGPSTL PGSSVSISFP NRLSSGGAEM FHVQEMVVGQ
860 870 880 890 900
EKGNCSFQKN PTPCIIPQEQ ENIFHTIFAF FTKSGRKVLD CEKPGISCLT
910 920 930 940 950
AHCNFSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMSR AKVKVDPALR
960 970 980 990 1000
VVEIAHGNPE EVTVVFEALH NLEPRGYVVG WIIAISLLVG ILIFLLLAVL
1010 1020 1030
LWKMGFFRRR YKEIIEAEKN RKENEDSWDW VQKNQ
Length:1,035
Mass (Da):114,489
Last modified:May 5, 2009 - v2
Checksum:iB812EDA867A3E836
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055091507G → E.2 PublicationsCorresponds to variant rs267561dbSNPEnsembl.1
Natural variantiVAR_036073750R → C in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs781472543dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25303 mRNA. Translation: BAA04984.1.
AC092055 Genomic DNA. No translation available.
AC093415 Genomic DNA. No translation available.
AP006240 Genomic DNA. No translation available.
L24158 mRNA. Translation: AAA16099.1.
CCDSiCCDS2669.1.
PIRiI58409.
RefSeqiNP_002198.2. NM_002207.2.
UniGeneiHs.113157.

Genome annotation databases

EnsembliENST00000264741; ENSP00000264741; ENSG00000144668.
GeneIDi3680.
KEGGihsa:3680.
UCSCiuc003chd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25303 mRNA. Translation: BAA04984.1.
AC092055 Genomic DNA. No translation available.
AC093415 Genomic DNA. No translation available.
AP006240 Genomic DNA. No translation available.
L24158 mRNA. Translation: AAA16099.1.
CCDSiCCDS2669.1.
PIRiI58409.
RefSeqiNP_002198.2. NM_002207.2.
UniGeneiHs.113157.

3D structure databases

ProteinModelPortaliQ13797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109886. 16 interactors.
MINTiMINT-1534610.
STRINGi9606.ENSP00000264741.

Chemistry databases

ChEMBLiCHEMBL3170.

PTM databases

iPTMnetiQ13797.
PhosphoSitePlusiQ13797.

Polymorphism and mutation databases

BioMutaiITGA9.
DMDMi229462922.

Proteomic databases

PaxDbiQ13797.
PeptideAtlasiQ13797.
PRIDEiQ13797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264741; ENSP00000264741; ENSG00000144668.
GeneIDi3680.
KEGGihsa:3680.
UCSCiuc003chd.4. human.

Organism-specific databases

CTDi3680.
DisGeNETi3680.
GeneCardsiITGA9.
H-InvDBHIX0003172.
HGNCiHGNC:6145. ITGA9.
HPAiHPA030609.
MalaCardsiITGA9.
MIMi603963. gene.
neXtProtiNX_Q13797.
OpenTargetsiENSG00000144668.
Orphaneti371007. Congenital muscular dystrophy with hyperlaxity.
PharmGKBiPA29945.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000088626.
HOVERGENiHBG004538.
InParanoidiQ13797.
KOiK06585.
OMAiHFSQPTT.
OrthoDBiEOG091G011V.
PhylomeDBiQ13797.
TreeFamiTF105391.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144668-MONOMER.
ReactomeiR-HSA-216083. Integrin cell surface interactions.
R-HSA-3000178. ECM proteoglycans.
R-HSA-445144. Signal transduction by L1.
SignaLinkiQ13797.

Miscellaneous databases

ChiTaRSiITGA9. human.
GeneWikiiITGA9.
GenomeRNAii3680.
PROiQ13797.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144668.
CleanExiHS_ITGA9.
ExpressionAtlasiQ13797. baseline and differential.
GenevisibleiQ13797. HS.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA9_HUMAN
AccessioniPrimary (citable) accession number: Q13797
Secondary accession number(s): Q14638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.