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Q13797 (ITA9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin alpha-9
Alternative name(s):
Integrin alpha-RLC
Gene names
Name:ITGA9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1035 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.

Subunit structure

Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.

Induction

Up-regulated in small cell lung cancers (SCLC).

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 10351006Integrin alpha-9
PRO_0000016316

Regions

Topological domain30 – 981952Extracellular Potential
Transmembrane982 – 100221Helical; Potential
Topological domain1003 – 103533Cytoplasmic Potential
Repeat35 – 9662FG-GAP 1
Repeat111 – 17464FG-GAP 2
Repeat182 – 23352FG-GAP 3
Repeat234 – 28956FG-GAP 4
Repeat290 – 34960FG-GAP 5
Repeat351 – 40858FG-GAP 6
Repeat411 – 47464FG-GAP 7
Calcium binding312 – 3209 Potential
Calcium binding373 – 3819 Potential
Calcium binding435 – 4439 Potential
Motif1005 – 10095GFFKR motif

Sites

Site565 – 5662Cleavage Potential

Amino acid modifications

Glycosylation2251N-linked (GlcNAc...) Ref.4
Glycosylation4761N-linked (GlcNAc...) Potential
Glycosylation4931N-linked (GlcNAc...) Potential
Glycosylation6121N-linked (GlcNAc...) Potential
Glycosylation6541N-linked (GlcNAc...) Potential
Glycosylation6581N-linked (GlcNAc...) Potential
Glycosylation6721N-linked (GlcNAc...) Potential
Glycosylation6761N-linked (GlcNAc...) Potential
Glycosylation8071N-linked (GlcNAc...) Potential
Glycosylation8541N-linked (GlcNAc...) Potential
Glycosylation9041N-linked (GlcNAc...) Potential
Disulfide bond87 ↔ 97 By similarity
Disulfide bond142 ↔ 162 By similarity
Disulfide bond179 ↔ 194 By similarity
Disulfide bond482 ↔ 491 By similarity
Disulfide bond497 ↔ 555 By similarity
Disulfide bond620 ↔ 625 By similarity
Disulfide bond696 ↔ 706 By similarity
Disulfide bond855 ↔ 891 By similarity
Disulfide bond898 ↔ 903 By similarity

Natural variations

Natural variant5071G → E. Ref.1 Ref.3
Corresponds to variant rs267561 [ dbSNP | Ensembl ].
VAR_055091
Natural variant7501R → C in a breast cancer sample; somatic mutation. Ref.5
VAR_036073

Sequences

Sequence LengthMass (Da)Tools
Q13797 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: B812EDA867A3E836

FASTA1,035114,489
        10         20         30         40         50         60 
MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY AVLEHFHDNT 

        70         80         90        100        110        120 
RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL DMARGKNRGT SCGKTCREDR 

       130        140        150        160        170        180 
DDEWMGVSLA RQPKADGRVL ACAHRWKNIY YEADHILPHG FCYIIPSNLQ AKGRTLIPCY 

       190        200        210        220        230        240 
EEYKKKYGEE HGSCQAGIAG FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM 

       250        260        270        280        290        300 
NRRYTYLGYA VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM 

       310        320        330        340        350        360 
GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE QLALTGDGAY 

       370        380        390        400        410        420 
NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH GDAGGIVPQY SMKLSGQKIN 

       430        440        450        460        470        480 
PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM SDSVVLLRAR PVITVDVSIF LPGSINITAP 

       490        500        510        520        530        540 
QCHDGQQPVN CLNVTTCFSF HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG 

       550        560        570        580        590        600 
QVTEKLQLTY MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL 

       610        620        630        640        650        660 
RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGKLLLSSM DEKTLYLALG AVKNISLNIS 

       670        680        690        700        710        720 
ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE SDFLKCSVGF PFMRSKSKYE 

       730        740        750        760        770        780 
FSVIFDTSHL SGEEEVLSFI VTAQSGNTER SESLHDNTLV LMVPLMHEVD TSITGIMSPT 

       790        800        810        820        830        840 
SFVYGESVDA ANFIQLDDLE CHFQPINITL QVYNTGPSTL PGSSVSISFP NRLSSGGAEM 

       850        860        870        880        890        900 
FHVQEMVVGQ EKGNCSFQKN PTPCIIPQEQ ENIFHTIFAF FTKSGRKVLD CEKPGISCLT 

       910        920        930        940        950        960 
AHCNFSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMSR AKVKVDPALR VVEIAHGNPE 

       970        980        990       1000       1010       1020 
EVTVVFEALH NLEPRGYVVG WIIAISLLVG ILIFLLLAVL LWKMGFFRRR YKEIIEAEKN 

      1030 
RKENEDSWDW VQKNQ 

« Hide

References

« Hide 'large scale' references
[1]"Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer."
Hibi K., Yamakawa K., Ueda R., Horio Y., Murata Y., Tamari M., Uchida K., Takahashi T., Nakamura Y., Takahashi T.
Oncogene 9:611-619(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-507.
Tissue: Lung.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle."
Palmer E.L., Rueegg C., Ferrando R., Pytela R., Sheppard D.
J. Cell Biol. 123:1289-1297(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-1035, PROTEIN SEQUENCE OF 30-35, VARIANT GLU-507.
Tissue: Intestine and Lung.
[4]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-225.
Tissue: Liver.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-750.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D25303 mRNA. Translation: BAA04984.1.
AC092055 Genomic DNA. No translation available.
AC093415 Genomic DNA. No translation available.
AP006240 Genomic DNA. No translation available.
L24158 mRNA. Translation: AAA16099.1.
PIRI58409.
RefSeqNP_002198.2. NM_002207.2.
UniGeneHs.113157.

3D structure databases

ProteinModelPortalQ13797.
SMRQ13797. Positions 30-966, 975-1017.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109886. 2 interactions.
MINTMINT-1534610.
STRING9606.ENSP00000264741.

Chemistry

BindingDBQ13797.
ChEMBLCHEMBL3170.

PTM databases

PhosphoSiteQ13797.

Polymorphism databases

DMDM229462922.

Proteomic databases

PaxDbQ13797.
PRIDEQ13797.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264741; ENSP00000264741; ENSG00000144668.
GeneID3680.
KEGGhsa:3680.
UCSCuc003chd.3. human.

Organism-specific databases

CTD3680.
GeneCardsGC03P037468.
H-InvDBHIX0003172.
HGNCHGNC:6145. ITGA9.
HPAHPA030609.
MIM603963. gene.
neXtProtNX_Q13797.
Orphanet371007. Congenital muscular dystrophy with hyperlaxity.
PharmGKBPA29945.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240832.
HOGENOMHOG000088626.
HOVERGENHBG004538.
InParanoidQ13797.
KOK06585.
OMANTRWVLV.
PhylomeDBQ13797.
TreeFamTF105391.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_118779. Extracellular matrix organization.
SignaLinkQ13797.

Gene expression databases

ArrayExpressQ13797.
BgeeQ13797.
CleanExHS_ITGA9.
GenevestigatorQ13797.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiITGA9.
GenomeRNAi3680.
NextBio14403.
PROQ13797.
SOURCESearch...

Entry information

Entry nameITA9_HUMAN
AccessionPrimary (citable) accession number: Q13797
Secondary accession number(s): Q14638
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM