ID   ARFRP_HUMAN             Reviewed;         201 AA.
AC   Q13795; E1P5J9; Q6IBQ0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-JAN-2012, entry version 107.
DE   RecName: Full=ADP-ribosylation factor-related protein 1;
DE            Short=ARF-related protein 1;
DE            Short=ARP;
GN   Name=ARFRP1; Synonyms=ARP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=96107227; PubMed=8530503; DOI=10.1074/jbc.270.51.30657;
RA   Schuermann A., Massmann S., Joost H.-G.;
RT   "ARP is a plasma membrane-associated Ras-related GTPase with remote
RT   similarity to the family of ADP-ribosylation factors.";
RL   J. Biol. Chem. 270:30657-30663(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20122600; PubMed=10655513; DOI=10.1073/pnas.97.3.1230;
RA   Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V.,
RA   Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.;
RT   "Overexpression of M68/DcR3 in human gastrointestinal tract tumors
RT   independent of gene amplification and its location in a four-gene
RT   cluster.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH SYS1.
RX   PubMed=15077113; DOI=10.1038/ncb1120;
RA   Behnia R., Panic B., Whyte J.R.C., Munro S.;
RT   "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-
RT   terminal acetylation and the membrane protein Sys1p.";
RL   Nat. Cell Biol. 6:405-413(2004).
RN   [9]
RP   VARIANT [LARGE SCALE ANALYSIS] VAL-108.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: Possibly involved in plasma membrane-related signaling
CC       events.
CC   -!- SUBUNIT: Interacts with SYS1.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus.
CC   -!- TISSUE SPECIFICITY: Found in most tissues.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
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DR   EMBL; X91504; CAA62804.1; -; mRNA.
DR   EMBL; AF217796; AAF35246.1; -; Genomic_DNA.
DR   EMBL; CR456752; CAG33033.1; -; mRNA.
DR   EMBL; BT019624; AAV38430.1; -; mRNA.
DR   EMBL; BT019663; AAV38469.1; -; mRNA.
DR   EMBL; AL121845; CAC03669.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75231.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75232.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75235.1; -; Genomic_DNA.
DR   EMBL; BC092480; AAH92480.1; -; mRNA.
DR   EMBL; BC093967; AAH93967.1; -; mRNA.
DR   IPI; IPI00015178; -.
DR   RefSeq; NP_001128230.1; NM_001134758.1.
DR   RefSeq; NP_003215.1; NM_003224.3.
DR   UniGene; Hs.389277; -.
DR   ProteinModelPortal; Q13795; -.
DR   SMR; Q13795; 4-187.
DR   STRING; Q13795; -.
DR   DMDM; 2492927; -.
DR   PRIDE; Q13795; -.
DR   Ensembl; ENST00000324228; ENSP00000326884; ENSG00000101246.
DR   Ensembl; ENST00000359715; ENSP00000352746; ENSG00000101246.
DR   GeneID; 10139; -.
DR   KEGG; hsa:10139; -.
DR   UCSC; uc002yga.1; human.
DR   CTD; 10139; -.
DR   GeneCards; GC20M062331; -.
DR   H-InvDB; HIX0016008; -.
DR   HGNC; HGNC:662; ARFRP1.
DR   MIM; 604699; gene.
DR   neXtProt; NX_Q13795; -.
DR   eggNOG; prNOG06326; -.
DR   GeneTree; ENSGT00550000074639; -.
DR   HOGENOM; HBG745225; -.
DR   HOVERGEN; HBG002073; -.
DR   InParanoid; Q13795; -.
DR   OMA; LIGRRDC; -.
DR   OrthoDB; EOG4KWJTT; -.
DR   PhylomeDB; Q13795; -.
DR   NextBio; 38359; -.
DR   ArrayExpress; Q13795; -.
DR   Bgee; Q13795; -.
DR   CleanEx; HS_ARFRP1; -.
DR   Genevestigator; Q13795; -.
DR   GermOnline; ENSG00000101246; Homo sapiens.
DR   GO; GO:0005624; C:membrane fraction; TAS:ProtInc.
DR   GO; GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IMP:UniProtKB.
DR   GO; GO:0034067; P:protein localization in Golgi apparatus; IMP:UniProtKB.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   KO; K07952; -.
DR   PANTHER; PTHR11711; ARF/SAR; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00177; ARF; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Golgi apparatus; GTP-binding; Nucleotide-binding;
KW   Polymorphism; Reference proteome.
FT   CHAIN         1    201       ADP-ribosylation factor-related protein
FT                                1.
FT                                /FTId=PRO_0000207487.
FT   NP_BIND      24     31       GTP (By similarity).
FT   NP_BIND      75     79       GTP (By similarity).
FT   NP_BIND     134    137       GTP (By similarity).
FT   VARIANT     108    108       L -> V (in a breast cancer sample;
FT                                somatic mutation).
FT                                /FTId=VAR_036559.
SQ   SEQUENCE   201 AA;  22614 MW;  8A75CF7A3B268158 CRC64;
     MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL SKITTTVGLN
     IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI DSTDEERLAE SKQAFEKVVT
     SEALCGVPVL VLANKQDVET CLSIPDIKTA FSDCTSKIGR RDCLTQACSA LTGKGVREGI
     EWMVKCVVRN VHRPPRQRDI T
//