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Q13795 (ARFRP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP-ribosylation factor-related protein 1

Short name=ARF-related protein 1
Short name=ARP
Gene names
Name:ARFRP1
Synonyms:ARP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possibly involved in plasma membrane-related signaling events.

Subunit structure

Interacts with SYS1. Ref.8

Subcellular location

Golgi apparatus Ref.8.

Tissue specificity

Found in most tissues.

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q13795-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q13795-2)

The sequence of this isoform differs from the canonical sequence as follows:
     174-201: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201ADP-ribosylation factor-related protein 1
PRO_0000207487

Regions

Nucleotide binding24 – 318GTP By similarity
Nucleotide binding75 – 795GTP By similarity
Nucleotide binding134 – 1374GTP By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.9

Natural variations

Alternative sequence174 – 20128Missing in isoform 2.
VSP_043531
Natural variant1081L → V in a breast cancer sample; somatic mutation. Ref.10
VAR_036559

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8A75CF7A3B268158

FASTA20122,614
        10         20         30         40         50         60 
MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL SKITTTVGLN 

        70         80         90        100        110        120 
IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI DSTDEERLAE SKQAFEKVVT 

       130        140        150        160        170        180 
SEALCGVPVL VLANKQDVET CLSIPDIKTA FSDCTSKIGR RDCLTQACSA LTGKGVREGI 

       190        200 
EWMVKCVVRN VHRPPRQRDI T 

« Hide

Isoform 2 [UniParc].

Checksum: 30A53245BE1DB13B
Show »

FASTA17319,272

References

« Hide 'large scale' references
[1]"ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors."
Schuermann A., Massmann S., Joost H.-G.
J. Biol. Chem. 270:30657-30663(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster."
Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.
Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Placenta.
[8]"Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p."
Behnia R., Panic B., Whyte J.R.C., Munro S.
Nat. Cell Biol. 6:405-413(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SYS1.
[9]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-108.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91504 mRNA. Translation: CAA62804.1.
AF217796 Genomic DNA. Translation: AAF35246.1.
CR456752 mRNA. Translation: CAG33033.1.
BT019624 mRNA. Translation: AAV38430.1.
BT019663 mRNA. Translation: AAV38469.1.
AL121845 Genomic DNA. Translation: CAC03669.1.
CH471077 Genomic DNA. Translation: EAW75231.1.
CH471077 Genomic DNA. Translation: EAW75232.1.
CH471077 Genomic DNA. Translation: EAW75235.1.
BC092480 mRNA. Translation: AAH92480.1.
BC093967 mRNA. Translation: AAH93967.1.
BC143447 mRNA. Translation: AAI43448.1.
BC143448 mRNA. Translation: AAI43449.1.
CCDSCCDS13533.1. [Q13795-1]
CCDS46630.1. [Q13795-2]
RefSeqNP_001128230.1. NM_001134758.3. [Q13795-2]
NP_001254476.1. NM_001267547.2. [Q13795-1]
NP_001254477.1. NM_001267548.2. [Q13795-1]
NP_001254478.1. NM_001267549.2. [Q13795-2]
NP_003215.1. NM_003224.5. [Q13795-1]
UniGeneHs.389277.

3D structure databases

ProteinModelPortalQ13795.
SMRQ13795. Positions 4-187.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115442. 2 interactions.
STRING9606.ENSP00000326884.

PTM databases

PhosphoSiteQ13795.

Polymorphism databases

DMDM2492927.

Proteomic databases

MaxQBQ13795.
PaxDbQ13795.
PRIDEQ13795.

Protocols and materials databases

DNASU10139.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000324228; ENSP00000326884; ENSG00000101246. [Q13795-1]
ENST00000359715; ENSP00000352746; ENSG00000101246. [Q13795-1]
ENST00000440854; ENSP00000403942; ENSG00000101246. [Q13795-2]
ENST00000609142; ENSP00000476470; ENSG00000101246. [Q13795-2]
GeneID10139.
KEGGhsa:10139.
UCSCuc002yga.3. human. [Q13795-1]

Organism-specific databases

CTD10139.
GeneCardsGC20M062331.
HGNCHGNC:662. ARFRP1.
HPAHPA047028.
HPA050634.
MIM604699. gene.
neXtProtNX_Q13795.
PharmGKBPA24946.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000163691.
HOVERGENHBG002073.
InParanoidQ13795.
KOK07952.
OMASKNYKGM.
PhylomeDBQ13795.
TreeFamTF105788.

Gene expression databases

BgeeQ13795.
CleanExHS_ARFRP1.
GenevestigatorQ13795.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamPF00025. Arf. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSARFRP1. human.
GeneWikiARFRP1.
GenomeRNAi10139.
NextBio38359.
PROQ13795.
SOURCESearch...

Entry information

Entry nameARFRP_HUMAN
AccessionPrimary (citable) accession number: Q13795
Secondary accession number(s): B7ZKX7, E1P5J9, Q6IBQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM