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Q13795

- ARFRP_HUMAN

UniProt

Q13795 - ARFRP_HUMAN

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Protein

ADP-ribosylation factor-related protein 1

Gene

ARFRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Possibly involved in plasma membrane-related signaling events.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi75 – 795GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: ProtInc
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. gastrulation Source: Ensembl
  2. Golgi to plasma membrane protein transport Source: UniProtKB
  3. GTP catabolic process Source: GOC
  4. protein localization to Golgi apparatus Source: UniProtKB
  5. retrograde transport, endosome to Golgi Source: UniProtKB
  6. signal transduction Source: ProtInc
  7. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-related protein 1
Short name:
ARF-related protein 1
Short name:
ARP
Gene namesi
Name:ARFRP1
Synonyms:ARP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:662. ARFRP1.

Subcellular locationi

Golgi apparatus 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. membrane Source: ProtInc
  3. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201ADP-ribosylation factor-related protein 1PRO_0000207487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ13795.
PaxDbiQ13795.
PRIDEiQ13795.

PTM databases

PhosphoSiteiQ13795.

Expressioni

Tissue specificityi

Found in most tissues.

Gene expression databases

BgeeiQ13795.
CleanExiHS_ARFRP1.
ExpressionAtlasiQ13795. baseline and differential.
GenevestigatoriQ13795.

Organism-specific databases

HPAiHPA047028.
HPA050634.

Interactioni

Subunit structurei

Interacts with SYS1.1 Publication

Protein-protein interaction databases

BioGridi115442. 2 interactions.
STRINGi9606.ENSP00000326884.

Structurei

3D structure databases

ProteinModelPortaliQ13795.
SMRiQ13795. Positions 4-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00550000074639.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ13795.
KOiK07952.
OMAiSKNYKGM.
PhylomeDBiQ13795.
TreeFamiTF105788.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13795-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL
60 70 80 90 100
SKITTTVGLN IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI
110 120 130 140 150
DSTDEERLAE SKQAFEKVVT SEALCGVPVL VLANKQDVET CLSIPDIKTA
160 170 180 190 200
FSDCTSKIGR RDCLTQACSA LTGKGVREGI EWMVKCVVRN VHRPPRQRDI

T
Length:201
Mass (Da):22,614
Last modified:November 1, 1996 - v1
Checksum:i8A75CF7A3B268158
GO
Isoform 2 (identifier: Q13795-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-201: Missing.

Note: No experimental confirmation available.

Show »
Length:173
Mass (Da):19,272
Checksum:i30A53245BE1DB13B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036559

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei174 – 20128Missing in isoform 2. 1 PublicationVSP_043531Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91504 mRNA. Translation: CAA62804.1.
AF217796 Genomic DNA. Translation: AAF35246.1.
CR456752 mRNA. Translation: CAG33033.1.
BT019624 mRNA. Translation: AAV38430.1.
BT019663 mRNA. Translation: AAV38469.1.
AL121845 Genomic DNA. Translation: CAC03669.1.
CH471077 Genomic DNA. Translation: EAW75231.1.
CH471077 Genomic DNA. Translation: EAW75232.1.
CH471077 Genomic DNA. Translation: EAW75235.1.
BC092480 mRNA. Translation: AAH92480.1.
BC093967 mRNA. Translation: AAH93967.1.
BC143447 mRNA. Translation: AAI43448.1.
BC143448 mRNA. Translation: AAI43449.1.
CCDSiCCDS13533.1. [Q13795-1]
CCDS46630.1. [Q13795-2]
RefSeqiNP_001128230.1. NM_001134758.3. [Q13795-2]
NP_001254476.1. NM_001267547.2. [Q13795-1]
NP_001254477.1. NM_001267548.2. [Q13795-1]
NP_001254478.1. NM_001267549.2. [Q13795-2]
NP_003215.1. NM_003224.5. [Q13795-1]
UniGeneiHs.389277.

Genome annotation databases

EnsembliENST00000612157; ENSP00000479058; ENSG00000101246. [Q13795-2]
ENST00000618838; ENSP00000479616; ENSG00000101246. [Q13795-1]
ENST00000619493; ENSP00000479940; ENSG00000101246. [Q13795-1]
ENST00000622789; ENSP00000483486; ENSG00000101246. [Q13795-1]
GeneIDi10139.
KEGGihsa:10139.
UCSCiuc002yga.3. human. [Q13795-1]

Polymorphism databases

DMDMi2492927.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91504 mRNA. Translation: CAA62804.1 .
AF217796 Genomic DNA. Translation: AAF35246.1 .
CR456752 mRNA. Translation: CAG33033.1 .
BT019624 mRNA. Translation: AAV38430.1 .
BT019663 mRNA. Translation: AAV38469.1 .
AL121845 Genomic DNA. Translation: CAC03669.1 .
CH471077 Genomic DNA. Translation: EAW75231.1 .
CH471077 Genomic DNA. Translation: EAW75232.1 .
CH471077 Genomic DNA. Translation: EAW75235.1 .
BC092480 mRNA. Translation: AAH92480.1 .
BC093967 mRNA. Translation: AAH93967.1 .
BC143447 mRNA. Translation: AAI43448.1 .
BC143448 mRNA. Translation: AAI43449.1 .
CCDSi CCDS13533.1. [Q13795-1 ]
CCDS46630.1. [Q13795-2 ]
RefSeqi NP_001128230.1. NM_001134758.3. [Q13795-2 ]
NP_001254476.1. NM_001267547.2. [Q13795-1 ]
NP_001254477.1. NM_001267548.2. [Q13795-1 ]
NP_001254478.1. NM_001267549.2. [Q13795-2 ]
NP_003215.1. NM_003224.5. [Q13795-1 ]
UniGenei Hs.389277.

3D structure databases

ProteinModelPortali Q13795.
SMRi Q13795. Positions 4-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115442. 2 interactions.
STRINGi 9606.ENSP00000326884.

PTM databases

PhosphoSitei Q13795.

Polymorphism databases

DMDMi 2492927.

Proteomic databases

MaxQBi Q13795.
PaxDbi Q13795.
PRIDEi Q13795.

Protocols and materials databases

DNASUi 10139.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000612157 ; ENSP00000479058 ; ENSG00000101246 . [Q13795-2 ]
ENST00000618838 ; ENSP00000479616 ; ENSG00000101246 . [Q13795-1 ]
ENST00000619493 ; ENSP00000479940 ; ENSG00000101246 . [Q13795-1 ]
ENST00000622789 ; ENSP00000483486 ; ENSG00000101246 . [Q13795-1 ]
GeneIDi 10139.
KEGGi hsa:10139.
UCSCi uc002yga.3. human. [Q13795-1 ]

Organism-specific databases

CTDi 10139.
GeneCardsi GC20M062331.
HGNCi HGNC:662. ARFRP1.
HPAi HPA047028.
HPA050634.
MIMi 604699. gene.
neXtProti NX_Q13795.
PharmGKBi PA24946.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00550000074639.
HOGENOMi HOG000163691.
HOVERGENi HBG002073.
InParanoidi Q13795.
KOi K07952.
OMAi SKNYKGM.
PhylomeDBi Q13795.
TreeFami TF105788.

Miscellaneous databases

ChiTaRSi ARFRP1. human.
GeneWikii ARFRP1.
GenomeRNAii 10139.
NextBioi 38359.
PROi Q13795.
SOURCEi Search...

Gene expression databases

Bgeei Q13795.
CleanExi HS_ARFRP1.
ExpressionAtlasi Q13795. baseline and differential.
Genevestigatori Q13795.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view ]
Pfami PF00025. Arf. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00177. ARF. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51417. ARF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors."
    Schuermann A., Massmann S., Joost H.-G.
    J. Biol. Chem. 270:30657-30663(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster."
    Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.
    Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Placenta.
  8. "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p."
    Behnia R., Panic B., Whyte J.R.C., Munro S.
    Nat. Cell Biol. 6:405-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SYS1.
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-108.

Entry informationi

Entry nameiARFRP_HUMAN
AccessioniPrimary (citable) accession number: Q13795
Secondary accession number(s): B7ZKX7, E1P5J9, Q6IBQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3