Reviewed,
UniProtKB/Swiss-Prot Q13795 (ARFRP_HUMAN)
Last modified
February 9, 2010.
Version 91.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: ADP-ribosylation factor-related protein 1 Short name=ARF-related protein 1 Short name=ARP | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 201 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Possibly involved in plasma membrane-related signaling events. |
| Subunit structure | Interacts with SYS1. Ref.7 |
| Subcellular location | |
| Tissue specificity | Found in most tissues. |
| Sequence similarities | Belongs to the small GTPase superfamily. Arf family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus |
| Coding sequence diversity | Polymorphism |
| Ligand | GTP-binding Nucleotide-binding |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell membrane fraction Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 201 | 201 | ADP-ribosylation factor-related protein 1 | PRO_0000207487 | |||||
Regions | |||||||||
| Nucleotide binding | 24 – 31 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 75 – 79 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 134 – 137 | 4 | GTP By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 108 | 1 | L → V in a breast cancer sample; somatic mutation. Ref.8 | VAR_036559 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors." Schuermann A., Massmann S., Joost H.-G. J. Biol. Chem. 270:30657-30663(1995) [PubMed: 8530503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster." Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T. Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed: 10655513] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta. |
| [7] | "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p." Behnia R., Panic B., Whyte J.R.C., Munro S. Nat. Cell Biol. 6:405-413(2004) [PubMed: 15077113] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SYS1. |
| [8] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-108. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X91504 mRNA. Translation: CAA62804.1. AF217796 Genomic DNA. Translation: AAF35246.1. CR456752 mRNA. Translation: CAG33033.1. BT019624 mRNA. Translation: AAV38430.1. BT019663 mRNA. Translation: AAV38469.1. AL121845 Genomic DNA. Translation: CAC03669.1. BC092480 mRNA. Translation: AAH92480.1. BC093967 mRNA. Translation: AAH93967.1. |
| IPI | IPI00015178. |
| RefSeq | NP_001128230.1. NP_003215.1. |
| UniGene | Hs.389277 |
3D structure databases | |
| SMR | Q13795. Positions 8-186. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q13795. |
Proteomic databases | |
| PRIDE | Q13795. |
Genome annotation databases | |
| Ensembl | ENST00000324228; ENSP00000326884; ENSG00000101246; Homo sapiens. [Genome view] ENST00000359715; ENSP00000352746; ENSG00000101246; Homo sapiens. [Genome view] |
| GeneID | 10139. |
| KEGG | hsa:10139. |
| UCSC | uc002yga.1. human. |
Organism-specific databases | |
| CTD | 10139. |
| GeneCards | GC20M061800. |
| H-InvDB | HIX0016008. HIX0080492. |
| HGNC | HGNC:662. ARFRP1. |
| MIM | 604699. gene. |
| PharmGKB | PA24946. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG06326. |
| HOGENOM | HBG745225. |
| HOVERGEN | Q13795. |
| InParanoid | Q13795. |
| OMA | SESKRAF. |
| OrthoDB | EOG9GTNZ4. |
| PhylomeDB | Q13795. |
Gene expression databases | |
| ArrayExpress | Q13795. |
| Bgee | Q13795. |
| CleanEx | HS_ARFRP1. |
| Genevestigator | Q13795. |
| GermOnline | ENSG00000101246. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006688. ARF. IPR006689. ARF/SAR. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view] |
| PANTHER | PTHR11711. ARF/SAR. 1 hit. |
| Pfam | PF00025. Arf. 1 hit. [Graphical view] |
| PRINTS | PR00449. RASTRNSFRMNG. |
| SMART | SM00177. ARF. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. |
| PROSITE | PS51417. ARF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 38359. |
| SOURCE | Search... |
Entry information
| Entry name | ARFRP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13795 Secondary accession number(s): Q6IBQ0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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