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Q13795

- ARFRP_HUMAN

UniProt

Q13795 - ARFRP_HUMAN

Protein

ADP-ribosylation factor-related protein 1

Gene

ARFRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Possibly involved in plasma membrane-related signaling events.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPBy similarity
    Nucleotide bindingi75 – 795GTPBy similarity
    Nucleotide bindingi134 – 1374GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: ProtInc
    2. GTP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. gastrulation Source: Ensembl
    2. Golgi to plasma membrane protein transport Source: UniProtKB
    3. GTP catabolic process Source: GOC
    4. protein localization to Golgi apparatus Source: UniProtKB
    5. retrograde transport, endosome to Golgi Source: UniProtKB
    6. signal transduction Source: ProtInc
    7. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor-related protein 1
    Short name:
    ARF-related protein 1
    Short name:
    ARP
    Gene namesi
    Name:ARFRP1
    Synonyms:ARP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:662. ARFRP1.

    Subcellular locationi

    Golgi apparatus 1 Publication

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. membrane Source: ProtInc
    3. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24946.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201ADP-ribosylation factor-related protein 1PRO_0000207487Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ13795.
    PaxDbiQ13795.
    PRIDEiQ13795.

    PTM databases

    PhosphoSiteiQ13795.

    Expressioni

    Tissue specificityi

    Found in most tissues.

    Gene expression databases

    BgeeiQ13795.
    CleanExiHS_ARFRP1.
    GenevestigatoriQ13795.

    Organism-specific databases

    HPAiHPA047028.
    HPA050634.

    Interactioni

    Subunit structurei

    Interacts with SYS1.1 Publication

    Protein-protein interaction databases

    BioGridi115442. 2 interactions.
    STRINGi9606.ENSP00000326884.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13795.
    SMRiQ13795. Positions 4-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Arf family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000163691.
    HOVERGENiHBG002073.
    InParanoidiQ13795.
    KOiK07952.
    OMAiSKNYKGM.
    PhylomeDBiQ13795.
    TreeFamiTF105788.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00177. ARF. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13795-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL    50
    SKITTTVGLN IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI 100
    DSTDEERLAE SKQAFEKVVT SEALCGVPVL VLANKQDVET CLSIPDIKTA 150
    FSDCTSKIGR RDCLTQACSA LTGKGVREGI EWMVKCVVRN VHRPPRQRDI 200
    T 201
    Length:201
    Mass (Da):22,614
    Last modified:November 1, 1996 - v1
    Checksum:i8A75CF7A3B268158
    GO
    Isoform 2 (identifier: Q13795-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         174-201: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:173
    Mass (Da):19,272
    Checksum:i30A53245BE1DB13B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081L → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036559

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei174 – 20128Missing in isoform 2. 1 PublicationVSP_043531Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91504 mRNA. Translation: CAA62804.1.
    AF217796 Genomic DNA. Translation: AAF35246.1.
    CR456752 mRNA. Translation: CAG33033.1.
    BT019624 mRNA. Translation: AAV38430.1.
    BT019663 mRNA. Translation: AAV38469.1.
    AL121845 Genomic DNA. Translation: CAC03669.1.
    CH471077 Genomic DNA. Translation: EAW75231.1.
    CH471077 Genomic DNA. Translation: EAW75232.1.
    CH471077 Genomic DNA. Translation: EAW75235.1.
    BC092480 mRNA. Translation: AAH92480.1.
    BC093967 mRNA. Translation: AAH93967.1.
    BC143447 mRNA. Translation: AAI43448.1.
    BC143448 mRNA. Translation: AAI43449.1.
    CCDSiCCDS13533.1. [Q13795-1]
    CCDS46630.1. [Q13795-2]
    RefSeqiNP_001128230.1. NM_001134758.3. [Q13795-2]
    NP_001254476.1. NM_001267547.2. [Q13795-1]
    NP_001254477.1. NM_001267548.2. [Q13795-1]
    NP_001254478.1. NM_001267549.2. [Q13795-2]
    NP_003215.1. NM_003224.5. [Q13795-1]
    UniGeneiHs.389277.

    Genome annotation databases

    EnsembliENST00000324228; ENSP00000326884; ENSG00000101246. [Q13795-1]
    ENST00000359715; ENSP00000352746; ENSG00000101246. [Q13795-1]
    ENST00000440854; ENSP00000403942; ENSG00000101246. [Q13795-2]
    ENST00000609142; ENSP00000476470; ENSG00000101246. [Q13795-2]
    GeneIDi10139.
    KEGGihsa:10139.
    UCSCiuc002yga.3. human. [Q13795-1]

    Polymorphism databases

    DMDMi2492927.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91504 mRNA. Translation: CAA62804.1 .
    AF217796 Genomic DNA. Translation: AAF35246.1 .
    CR456752 mRNA. Translation: CAG33033.1 .
    BT019624 mRNA. Translation: AAV38430.1 .
    BT019663 mRNA. Translation: AAV38469.1 .
    AL121845 Genomic DNA. Translation: CAC03669.1 .
    CH471077 Genomic DNA. Translation: EAW75231.1 .
    CH471077 Genomic DNA. Translation: EAW75232.1 .
    CH471077 Genomic DNA. Translation: EAW75235.1 .
    BC092480 mRNA. Translation: AAH92480.1 .
    BC093967 mRNA. Translation: AAH93967.1 .
    BC143447 mRNA. Translation: AAI43448.1 .
    BC143448 mRNA. Translation: AAI43449.1 .
    CCDSi CCDS13533.1. [Q13795-1 ]
    CCDS46630.1. [Q13795-2 ]
    RefSeqi NP_001128230.1. NM_001134758.3. [Q13795-2 ]
    NP_001254476.1. NM_001267547.2. [Q13795-1 ]
    NP_001254477.1. NM_001267548.2. [Q13795-1 ]
    NP_001254478.1. NM_001267549.2. [Q13795-2 ]
    NP_003215.1. NM_003224.5. [Q13795-1 ]
    UniGenei Hs.389277.

    3D structure databases

    ProteinModelPortali Q13795.
    SMRi Q13795. Positions 4-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115442. 2 interactions.
    STRINGi 9606.ENSP00000326884.

    PTM databases

    PhosphoSitei Q13795.

    Polymorphism databases

    DMDMi 2492927.

    Proteomic databases

    MaxQBi Q13795.
    PaxDbi Q13795.
    PRIDEi Q13795.

    Protocols and materials databases

    DNASUi 10139.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324228 ; ENSP00000326884 ; ENSG00000101246 . [Q13795-1 ]
    ENST00000359715 ; ENSP00000352746 ; ENSG00000101246 . [Q13795-1 ]
    ENST00000440854 ; ENSP00000403942 ; ENSG00000101246 . [Q13795-2 ]
    ENST00000609142 ; ENSP00000476470 ; ENSG00000101246 . [Q13795-2 ]
    GeneIDi 10139.
    KEGGi hsa:10139.
    UCSCi uc002yga.3. human. [Q13795-1 ]

    Organism-specific databases

    CTDi 10139.
    GeneCardsi GC20M062331.
    HGNCi HGNC:662. ARFRP1.
    HPAi HPA047028.
    HPA050634.
    MIMi 604699. gene.
    neXtProti NX_Q13795.
    PharmGKBi PA24946.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000163691.
    HOVERGENi HBG002073.
    InParanoidi Q13795.
    KOi K07952.
    OMAi SKNYKGM.
    PhylomeDBi Q13795.
    TreeFami TF105788.

    Miscellaneous databases

    ChiTaRSi ARFRP1. human.
    GeneWikii ARFRP1.
    GenomeRNAii 10139.
    NextBioi 38359.
    PROi Q13795.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13795.
    CleanExi HS_ARFRP1.
    Genevestigatori Q13795.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00177. ARF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors."
      Schuermann A., Massmann S., Joost H.-G.
      J. Biol. Chem. 270:30657-30663(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster."
      Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V., Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.
      Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Placenta.
    8. "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p."
      Behnia R., Panic B., Whyte J.R.C., Munro S.
      Nat. Cell Biol. 6:405-413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SYS1.
    9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-108.

    Entry informationi

    Entry nameiARFRP_HUMAN
    AccessioniPrimary (citable) accession number: Q13795
    Secondary accession number(s): B7ZKX7, E1P5J9, Q6IBQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3