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Q13790

- APOF_HUMAN

UniProt

Q13790 - APOF_HUMAN

Protein

Apolipoprotein F

Gene

APOF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.1 Publication

    GO - Molecular functioni

    1. cholesterol binding Source: ProtInc
    2. lipid transporter activity Source: ProtInc
    3. receptor binding Source: ProtInc

    GO - Biological processi

    1. cholesterol efflux Source: Ensembl
    2. cholesterol metabolic process Source: ProtInc
    3. lipid metabolic process Source: ProtInc
    4. lipid transport Source: ProtInc
    5. triglyceride metabolic process Source: Ensembl

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

    Enzyme and pathway databases

    ReactomeiREACT_6934. LDL-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein F
    Short name:
    Apo-F
    Alternative name(s):
    Lipid transfer inhibitor protein
    Short name:
    LTIP
    Gene namesi
    Name:APOF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:615. APOF.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. high-density lipoprotein particle Source: UniProtKB-KW
    3. low-density lipoprotein particle Source: UniProtKB-KW

    Keywords - Cellular componenti

    HDL, LDL, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24902.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Propeptidei36 – 1641292 PublicationsPRO_0000002051Add
    BLAST
    Chaini165 – 326162Apolipoprotein FPRO_0000002052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741O-linked (GalNAc...)1 Publication

    Post-translational modificationi

    O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ13790.
    PRIDEiQ13790.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.1 Publication

    Gene expression databases

    ArrayExpressiQ13790.
    BgeeiQ13790.
    CleanExiHS_APOF.
    GenevestigatoriQ13790.

    Interactioni

    Protein-protein interaction databases

    BioGridi106816. 2 interactions.
    STRINGi9606.ENSP00000381250.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13790.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG68175.
    HOGENOMiHOG000034007.
    HOVERGENiHBG050551.
    InParanoidiQ13790.
    OMAiPKSLPGF.
    PhylomeDBiQ13790.
    TreeFamiTF338778.

    Family and domain databases

    InterProiIPR026114. APOF.
    [Graphical view]
    PANTHERiPTHR15011. PTHR15011. 1 hit.
    PfamiPF15148. Apolipo_F. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13790-1 [UniParc]FASTAAdd to Basket

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    MTGLCGYSAP DMRGLRLIMI PVELLLCYLL LHPVDATSYG KQTNVLMHFP    50
    LSLESQTPSS DPLSCQFLHP KSLPGFSHMA PLPKFLVSLA LRNALEEAGC 100
    QADVWALQLQ LYRQGGVNAT QVLIQHLRGL QKGRSTERNV SVEALASALQ 150
    LLAREQQSTG RVGRSLPTED CENEKEQAVH NVVQLLPGVG TFYNLGTALY 200
    YATQNCLGKA RERGRDGAID LGYDLLMTMA GMSGGPMGLA ISAALKPALR 250
    SGVQQLIQYY QDQKDANISQ PETTKEGLRA ISDVSDLEET TTLASFISEV 300
    VSSAPYWGWA IIKSYDLDPG AGSLEI 326
    Length:326
    Mass (Da):35,399
    Last modified:April 5, 2011 - v2
    Checksum:i046A1E775E7D4320
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti178 – 1781A → G.
    Corresponds to variant rs11575216 [ dbSNP | Ensembl ].
    VAR_055520

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27050 mRNA. Translation: AAA65642.1.
    AC025574 Genomic DNA. No translation available.
    BC026257 mRNA. Translation: AAH26257.1.
    CCDSiCCDS44923.1.
    PIRiJC2549.
    RefSeqiNP_001629.1. NM_001638.2.
    UniGeneiHs.534302.

    Genome annotation databases

    EnsembliENST00000398189; ENSP00000381250; ENSG00000175336.
    GeneIDi319.
    KEGGihsa:319.
    UCSCiuc001sle.1. human.

    Polymorphism databases

    DMDMi327478500.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27050 mRNA. Translation: AAA65642.1 .
    AC025574 Genomic DNA. No translation available.
    BC026257 mRNA. Translation: AAH26257.1 .
    CCDSi CCDS44923.1.
    PIRi JC2549.
    RefSeqi NP_001629.1. NM_001638.2.
    UniGenei Hs.534302.

    3D structure databases

    ProteinModelPortali Q13790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106816. 2 interactions.
    STRINGi 9606.ENSP00000381250.

    Polymorphism databases

    DMDMi 327478500.

    Proteomic databases

    PaxDbi Q13790.
    PRIDEi Q13790.

    Protocols and materials databases

    DNASUi 319.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398189 ; ENSP00000381250 ; ENSG00000175336 .
    GeneIDi 319.
    KEGGi hsa:319.
    UCSCi uc001sle.1. human.

    Organism-specific databases

    CTDi 319.
    GeneCardsi GC12M056754.
    HGNCi HGNC:615. APOF.
    MIMi 107760. gene.
    neXtProti NX_Q13790.
    PharmGKBi PA24902.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68175.
    HOGENOMi HOG000034007.
    HOVERGENi HBG050551.
    InParanoidi Q13790.
    OMAi PKSLPGF.
    PhylomeDBi Q13790.
    TreeFami TF338778.

    Enzyme and pathway databases

    Reactomei REACT_6934. LDL-mediated lipid transport.

    Miscellaneous databases

    GeneWikii APOF.
    GenomeRNAii 319.
    NextBioi 1307.
    PROi Q13790.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13790.
    Bgeei Q13790.
    CleanExi HS_APOF.
    Genevestigatori Q13790.

    Family and domain databases

    InterProi IPR026114. APOF.
    [Graphical view ]
    PANTHERi PTHR15011. PTHR15011. 1 hit.
    Pfami PF15148. Apolipo_F. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 165-194 AND 251-265, TISSUE SPECIFICITY.
      Tissue: Hepatoma.
    2. "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F."
      Wang X., Driscoll D.M., Morton R.E.
      J. Biol. Chem. 274:1814-1820(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 165-178, FUNCTION.
      Tissue: Liver and Plasma.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    5. "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma."
      Olofsson S.-O., McConathy W.J., Alaupovic P.
      Biochemistry 17:1032-1036(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
      Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT THR-274, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiAPOF_HUMAN
    AccessioniPrimary (citable) accession number: Q13790
    Secondary accession number(s): Q8TC13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-12 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3