Reviewed, UniProtKB/Swiss-Prot Q13790 (APOF_HUMAN)

Names and origin

Protein names

Recommended name:
    Apolipoprotein F
      Short name=Apo-F
Alternative name(s):
    Lipid transfer inhibitor protein
      Short name=LTIP

Gene names

Name:

APOF

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. Ref.2
Subcellular location	Secreted.
Tissue specificity	Liver. Secreted in plasma. Ref.1

Ontologies

Keywords
Biological process	Cholesterol metabolism Lipid metabolism Lipid transport Steroid metabolism Transport
Cellular component	HDL LDL Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	cholesterol metabolic process Traceable author statement. Source: ProtInc lipid transport Traceable author statement. Source: ProtInc
Cellular component	high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW low-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cholesterol binding Traceable author statement. Source: ProtInc lipid transporter activity Traceable author statement. Source: ProtInc receptor binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 146	128			PRO_0000002051
	Chain	147 – 308	162	Apolipoprotein F		PRO_0000002052
Natural variations
	Natural variant	160	1	A → G: dbSNP rs11575216.		VAR_055520

Sequences

	Sequence		Length	Mass (Da)
	Q13790-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 9FEFB456B1537CBE	FASTA	308	33,463
	10 20 30 40 50 60 MIPVELLLCY LLLHPVDATS YGKQTNVLMH FPLSLESQTP SSDPLSCQFL HPKSLPGFSH 70 80 90 100 110 120 MAPLPKFLVS LALRNALEEA GCQADVWALQ LQLYRQGGVN ATQVLIQHLR GLQKGRSTER 130 140 150 160 170 180 NVSVEALASA LQLLAREQQS TGRVGRSLPT EDCENEKEQA VHNVVQLLPG VGTFYNLGTA 190 200 210 220 230 240 LYYATQNCLG KARERGRDGA IDLGYDLLMT MAGMSGGPMG LAISAALKPA LRSGVQQLIQ 250 260 270 280 290 300 YYQDQKDANI SQPETTKEGL RAISDVSDLE ETTTLASFIS EVVSSAPYWG WAIIKSYDLD PGAGSLEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Purification and molecular cloning of human apolipoprotein F." Day J.R., Albers J.J., Gilbert T.L., Whitmore T.E., McConathy W.J., Wolfbauer G. Biochem. Biophys. Res. Commun. 203:1146-1151(1994) [PubMed: 8093033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 147-176 AND 233-247, TISSUE SPECIFICITY. Tissue: Hepatoma.
[2]	"Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F." Wang X., Driscoll D.M., Morton R.E. J. Biol. Chem. 274:1814-1820(1999) [PubMed: 9880564] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 147-160, FUNCTION. Tissue: Liver and Plasma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[4]	"Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma." Olofsson S.-O., McConathy W.J., Alaupovic P. Biochemistry 17:1032-1036(1978) [PubMed: 204339] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L27050 mRNA. Translation: AAA65642.1. Different initiation. BC026257 mRNA. Translation: AAH26257.1. Different initiation.
IPI	IPI00299435.
PIR	JC2549.
RefSeq	NP_001629.1.
UniGene	Hs.534302
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q13790.
Proteomic databases
PRIDE	Q13790.
Genome annotation databases
Ensembl	ENST00000398189; ENSP00000381250; ENSG00000175336; Homo sapiens. [Genome view]
GeneID	319.
KEGG	hsa:319.
UCSC	uc001sle.1. human.
Organism-specific databases
CTD	319.
GeneCards	GC12M055040.
H-InvDB	HIX0022950.
HGNC	HGNC:615. APOF.
MIM	107760. gene.
PharmGKB	PA24902.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q13790.
HOVERGEN	Q13790.
Gene expression databases
ArrayExpress	Q13790.
Bgee	Q13790.
CleanEx	HS_APOF.
Genevestigator	Q13790.
GermOnline	ENSG00000175336. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	1307.
SOURCE	Search...

Entry information

Entry name

APOF_HUMAN

Accession

Primary (citable) accession number: Q13790
Secondary accession number(s): Q8TC13

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	October 13, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.