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Reviewed, UniProtKB/Swiss-Prot Q13790 (APOF_HUMAN)

Last modified October 13, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Apolipoprotein F
      Short name=Apo-F
Alternative name(s):
    Lipid transfer inhibitor protein
      Short name=LTIP
Gene names
Name: APOF
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. Ref.2

Subcellular location

Secreted.

Tissue specificity

Liver. Secreted in plasma. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 146128
PRO_0000002051
Chain147 – 308162Apolipoprotein F
PRO_0000002052

Natural variations

Natural variant1601A → G: dbSNP rs11575216.
VAR_055520

Sequences

Sequence LengthMass (Da)Tools
Q13790-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 9FEFB456B1537CBE

FASTA30833,463
        10         20         30         40         50         60 
MIPVELLLCY LLLHPVDATS YGKQTNVLMH FPLSLESQTP SSDPLSCQFL HPKSLPGFSH 

        70         80         90        100        110        120 
MAPLPKFLVS LALRNALEEA GCQADVWALQ LQLYRQGGVN ATQVLIQHLR GLQKGRSTER 

       130        140        150        160        170        180 
NVSVEALASA LQLLAREQQS TGRVGRSLPT EDCENEKEQA VHNVVQLLPG VGTFYNLGTA 

       190        200        210        220        230        240 
LYYATQNCLG KARERGRDGA IDLGYDLLMT MAGMSGGPMG LAISAALKPA LRSGVQQLIQ 

       250        260        270        280        290        300 
YYQDQKDANI SQPETTKEGL RAISDVSDLE ETTTLASFIS EVVSSAPYWG WAIIKSYDLD 


PGAGSLEI 

« Hide

References

« Hide 'large scale' references
[1]"Purification and molecular cloning of human apolipoprotein F."
Day J.R., Albers J.J., Gilbert T.L., Whitmore T.E., McConathy W.J., Wolfbauer G.
Biochem. Biophys. Res. Commun. 203:1146-1151(1994) [PubMed: 8093033] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 147-176 AND 233-247, TISSUE SPECIFICITY.
Tissue: Hepatoma.
[2]"Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F."
Wang X., Driscoll D.M., Morton R.E.
J. Biol. Chem. 274:1814-1820(1999) [PubMed: 9880564] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 147-160, FUNCTION.
Tissue: Liver and Plasma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[4]"Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma."
Olofsson S.-O., McConathy W.J., Alaupovic P.
Biochemistry 17:1032-1036(1978) [PubMed: 204339] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

L27050 mRNA. Translation: AAA65642.1. Different initiation.
BC026257 mRNA. Translation: AAH26257.1. Different initiation.
IPIIPI00299435.
PIRJC2549.
RefSeqNP_001629.1.
UniGeneHs.534302

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ13790.

Proteomic databases

PRIDEQ13790.

Genome annotation databases

EnsemblENST00000398189; ENSP00000381250; ENSG00000175336; Homo sapiens. [Genome view]
GeneID319.
KEGGhsa:319.
UCSCuc001sle.1. human.

Organism-specific databases

CTD319.
GeneCardsGC12M055040.
H-InvDBHIX0022950.
HGNCHGNC:615. APOF.
MIM107760. gene.
PharmGKBPA24902.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ13790.
HOVERGENQ13790.

Gene expression databases

ArrayExpressQ13790.
BgeeQ13790.
CleanExHS_APOF.
GenevestigatorQ13790.
GermOnlineENSG00000175336. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio1307.
SOURCESearch...

Entry information

Entry nameAPOF_HUMAN
AccessionPrimary (citable) accession number: Q13790
Secondary accession number(s): Q8TC13
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 13, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents