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Q13790

- APOF_HUMAN

UniProt

Q13790 - APOF_HUMAN

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Protein

Apolipoprotein F

Gene
APOF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.1 Publication

GO - Molecular functioni

  1. cholesterol binding Source: ProtInc
  2. lipid transporter activity Source: ProtInc
  3. receptor binding Source: ProtInc

GO - Biological processi

  1. cholesterol efflux Source: Ensembl
  2. cholesterol metabolic process Source: ProtInc
  3. lipid metabolic process Source: ProtInc
  4. lipid transport Source: ProtInc
  5. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiREACT_6934. LDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein F
Short name:
Apo-F
Alternative name(s):
Lipid transfer inhibitor protein
Short name:
LTIP
Gene namesi
Name:APOF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:615. APOF.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. high-density lipoprotein particle Source: UniProtKB-KW
  3. low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

HDL, LDL, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed predictionAdd
BLAST
Propeptidei36 – 164129PRO_0000002051Add
BLAST
Chaini165 – 326162Apolipoprotein FPRO_0000002052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741O-linked (GalNAc...)1 Publication

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ13790.
PRIDEiQ13790.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.1 Publication

Gene expression databases

ArrayExpressiQ13790.
BgeeiQ13790.
CleanExiHS_APOF.
GenevestigatoriQ13790.

Interactioni

Protein-protein interaction databases

BioGridi106816. 2 interactions.
STRINGi9606.ENSP00000381250.

Structurei

3D structure databases

ProteinModelPortaliQ13790.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68175.
HOGENOMiHOG000034007.
HOVERGENiHBG050551.
InParanoidiQ13790.
OMAiPKSLPGF.
PhylomeDBiQ13790.
TreeFamiTF338778.

Family and domain databases

InterProiIPR026114. APOF.
[Graphical view]
PANTHERiPTHR15011. PTHR15011. 1 hit.
PfamiPF15148. Apolipo_F. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13790-1 [UniParc]FASTAAdd to Basket

« Hide

MTGLCGYSAP DMRGLRLIMI PVELLLCYLL LHPVDATSYG KQTNVLMHFP    50
LSLESQTPSS DPLSCQFLHP KSLPGFSHMA PLPKFLVSLA LRNALEEAGC 100
QADVWALQLQ LYRQGGVNAT QVLIQHLRGL QKGRSTERNV SVEALASALQ 150
LLAREQQSTG RVGRSLPTED CENEKEQAVH NVVQLLPGVG TFYNLGTALY 200
YATQNCLGKA RERGRDGAID LGYDLLMTMA GMSGGPMGLA ISAALKPALR 250
SGVQQLIQYY QDQKDANISQ PETTKEGLRA ISDVSDLEET TTLASFISEV 300
VSSAPYWGWA IIKSYDLDPG AGSLEI 326
Length:326
Mass (Da):35,399
Last modified:April 5, 2011 - v2
Checksum:i046A1E775E7D4320
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti178 – 1781A → G.
Corresponds to variant rs11575216 [ dbSNP | Ensembl ].
VAR_055520

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27050 mRNA. Translation: AAA65642.1.
AC025574 Genomic DNA. No translation available.
BC026257 mRNA. Translation: AAH26257.1.
CCDSiCCDS44923.1.
PIRiJC2549.
RefSeqiNP_001629.1. NM_001638.2.
UniGeneiHs.534302.

Genome annotation databases

EnsembliENST00000398189; ENSP00000381250; ENSG00000175336.
GeneIDi319.
KEGGihsa:319.
UCSCiuc001sle.1. human.

Polymorphism databases

DMDMi327478500.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27050 mRNA. Translation: AAA65642.1 .
AC025574 Genomic DNA. No translation available.
BC026257 mRNA. Translation: AAH26257.1 .
CCDSi CCDS44923.1.
PIRi JC2549.
RefSeqi NP_001629.1. NM_001638.2.
UniGenei Hs.534302.

3D structure databases

ProteinModelPortali Q13790.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106816. 2 interactions.
STRINGi 9606.ENSP00000381250.

Polymorphism databases

DMDMi 327478500.

Proteomic databases

PaxDbi Q13790.
PRIDEi Q13790.

Protocols and materials databases

DNASUi 319.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398189 ; ENSP00000381250 ; ENSG00000175336 .
GeneIDi 319.
KEGGi hsa:319.
UCSCi uc001sle.1. human.

Organism-specific databases

CTDi 319.
GeneCardsi GC12M056754.
HGNCi HGNC:615. APOF.
MIMi 107760. gene.
neXtProti NX_Q13790.
PharmGKBi PA24902.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68175.
HOGENOMi HOG000034007.
HOVERGENi HBG050551.
InParanoidi Q13790.
OMAi PKSLPGF.
PhylomeDBi Q13790.
TreeFami TF338778.

Enzyme and pathway databases

Reactomei REACT_6934. LDL-mediated lipid transport.

Miscellaneous databases

GeneWikii APOF.
GenomeRNAii 319.
NextBioi 1307.
PROi Q13790.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13790.
Bgeei Q13790.
CleanExi HS_APOF.
Genevestigatori Q13790.

Family and domain databases

InterProi IPR026114. APOF.
[Graphical view ]
PANTHERi PTHR15011. PTHR15011. 1 hit.
Pfami PF15148. Apolipo_F. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 165-194 AND 251-265, TISSUE SPECIFICITY.
    Tissue: Hepatoma.
  2. "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F."
    Wang X., Driscoll D.M., Morton R.E.
    J. Biol. Chem. 274:1814-1820(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 165-178, FUNCTION.
    Tissue: Liver and Plasma.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  5. "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma."
    Olofsson S.-O., McConathy W.J., Alaupovic P.
    Biochemistry 17:1032-1036(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-274, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiAPOF_HUMAN
AccessioniPrimary (citable) accession number: Q13790
Secondary accession number(s): Q8TC13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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