ID   NCOA4_HUMAN             Reviewed;         614 AA.
AC   Q13772; A8K8W5; B4E260; E9PAV7; J3KQN8; Q14239;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 214.
DE   RecName: Full=Nuclear receptor coactivator 4;
DE            Short=NCoA-4;
DE   AltName: Full=Androgen receptor coactivator 70 kDa protein;
DE            Short=70 kDa AR-activator;
DE            Short=70 kDa androgen receptor coactivator;
DE   AltName: Full=Androgen receptor-associated protein of 70 kDa;
DE   AltName: Full=Ret-activating protein ELE1;
GN   Name=NCOA4; Synonyms=ARA70, ELE1, RFG;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Prostatic carcinoma;
RX   PubMed=8643607; DOI=10.1073/pnas.93.11.5517;
RA   Yeh S., Chang C.;
RT   "Cloning and characterization of a specific coactivator, ARA70, for the
RT   androgen receptor in human prostate cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:5517-5521(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHROMOSOMAL REARRANGEMENT WITH RET.
RC   TISSUE=Thyroid;
RX   PubMed=8290261;
RA   Santoro M., Dathan N.A., Berlingieri M.T., Bongarzone I., Paulin C.,
RA   Grieco M., Pierotti M.A., Vecchio G., Fusco A.;
RT   "Molecular characterization of RET/PTC3; a novel rearranged version of the
RT   RETproto-oncogene in a human thyroid papillary carcinoma.";
RL   Oncogene 9:509-516(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA; 3 AND 4).
RC   TISSUE=Testis, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Melanoma;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-238, AND CHROMOSOMAL REARRANGEMENT WITH
RP   RET.
RC   TISSUE=Thyroid tumor;
RX   PubMed=8187085;
RA   Bongarzone I., Butti M.G., Coronelli S., Borrello M.G., Santoro M.,
RA   Mondellini P., Pilotti S., Fusco A., Della Porta G., Pierotti M.A.;
RT   "Frequent activation of ret protooncogene by fusion with a new activating
RT   gene in papillary thyroid carcinomas.";
RL   Cancer Res. 54:2979-2985(1994).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), AND VARIANTS LEU-94;
RP   LEU-154; ARG-350 AND PRO-561.
RC   TISSUE=Cervix carcinoma, Mammary cancer, and Prostatic carcinoma;
RX   PubMed=9892017; DOI=10.1210/mend.13.1.0214;
RA   Alen P., Claessens F., Schoenmakers E., Swinnen J.V., Verhoeven G.,
RA   Rombauts W., Peeters B.;
RT   "Interaction of the putative androgen receptor-specific coactivator
RT   ARA70/ELE1alpha with multiple steroid receptors and identification of an
RT   internally deleted ELE1beta isoform.";
RL   Mol. Endocrinol. 13:117-128(1999).
RN   [10]
RP   FUNCTION.
RX   PubMed=10347167; DOI=10.1074/jbc.274.23.16147;
RA   Heinlein C.A., Ting H.-J., Yeh S., Chang C.;
RT   "Identification of ARA70 as a ligand-enhanced coactivator for the
RT   peroxisome proliferator-activated receptor gamma.";
RL   J. Biol. Chem. 274:16147-16152(1999).
CC   -!- FUNCTION: Enhances the androgen receptor transcriptional activity in
CC       prostate cancer cells. Ligand-independent coactivator of the peroxisome
CC       proliferator-activated receptor (PPAR) gamma.
CC       {ECO:0000269|PubMed:10347167}.
CC   -!- SUBUNIT: Interacts with the androgen receptor and the retinoid X
CC       receptor (RXR) in a ligand-dependent manner.
CC   -!- INTERACTION:
CC       Q13772-3; Q9UBB4: ATXN10; NbExp=3; IntAct=EBI-12054609, EBI-702390;
CC       Q13772-3; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-12054609, EBI-1055254;
CC       Q13772-3; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-12054609, EBI-10172526;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=Alpha;
CC         IsoId=Q13772-1; Sequence=Displayed;
CC       Name=Beta;
CC         IsoId=Q13772-2; Sequence=VSP_003409;
CC       Name=3;
CC         IsoId=Q13772-3; Sequence=VSP_046348;
CC       Name=4;
CC         IsoId=Q13772-4; Sequence=VSP_046348, VSP_046349;
CC   -!- TISSUE SPECIFICITY: Widely expressed. Also detected in adipose tissues
CC       and in different cell lines. Isoform Beta is only expressed in testis.
CC   -!- DISEASE: Note=A chromosomal aberration involving NCOA4 is found in
CC       papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2)
CC       generates the RET/NCOA4 (PTC3) oncogene. {ECO:0000269|PubMed:8187085,
CC       ECO:0000269|PubMed:8290261}.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="https://atlasgeneticsoncology.org/gene/218/NCOA4";
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DR   EMBL; L49399; AAC37591.1; -; mRNA.
DR   EMBL; X77548; CAA54673.1; -; mRNA.
DR   EMBL; AK292480; BAF85169.1; -; mRNA.
DR   EMBL; AK304123; BAG65022.1; -; mRNA.
DR   EMBL; AK310849; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL162047; CAB82390.1; -; mRNA.
DR   EMBL; AL450342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471260; EAW53686.1; -; Genomic_DNA.
DR   EMBL; BC001562; AAH01562.1; -; mRNA.
DR   EMBL; X71413; CAA50536.1; -; mRNA.
DR   CCDS; CCDS73092.1; -. [Q13772-1]
DR   CCDS; CCDS73093.1; -. [Q13772-3]
DR   CCDS; CCDS73094.1; -. [Q13772-4]
DR   PIR; S61532; S61532.
DR   RefSeq; NP_001138732.1; NM_001145260.1. [Q13772-4]
DR   RefSeq; NP_001138733.1; NM_001145261.1. [Q13772-3]
DR   RefSeq; NP_001138734.1; NM_001145262.1. [Q13772-1]
DR   RefSeq; NP_001138735.1; NM_001145263.1. [Q13772-1]
DR   RefSeq; NP_005428.1; NM_005437.3. [Q13772-1]
DR   PDB; 1T5Z; X-ray; 2.30 A; B=322-336.
DR   PDBsum; 1T5Z; -.
DR   AlphaFoldDB; Q13772; -.
DR   SMR; Q13772; -.
DR   BioGRID; 113726; 55.
DR   DIP; DIP-5957N; -.
DR   IntAct; Q13772; 22.
DR   STRING; 9606.ENSP00000463027; -.
DR   BindingDB; Q13772; -.
DR   GlyCosmos; Q13772; 1 site, 1 glycan.
DR   GlyGen; Q13772; 2 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; Q13772; -.
DR   PhosphoSitePlus; Q13772; -.
DR   BioMuta; NCOA4; -.
DR   DMDM; 8928226; -.
DR   EPD; Q13772; -.
DR   jPOST; Q13772; -.
DR   MassIVE; Q13772; -.
DR   MaxQB; Q13772; -.
DR   PaxDb; 9606-ENSP00000463027; -.
DR   PeptideAtlas; Q13772; -.
DR   ProteomicsDB; 19088; -.
DR   ProteomicsDB; 59681; -. [Q13772-1]
DR   ProteomicsDB; 59682; -. [Q13772-2]
DR   Pumba; Q13772; -.
DR   Antibodypedia; 72715; 485 antibodies from 34 providers.
DR   DNASU; 8031; -.
DR   Ensembl; ENST00000578454.5; ENSP00000463027.1; ENSG00000266412.6. [Q13772-4]
DR   Ensembl; ENST00000579039.2; ENSP00000463455.1; ENSG00000266412.6. [Q13772-3]
DR   Ensembl; ENST00000581486.6; ENSP00000462943.1; ENSG00000266412.6. [Q13772-1]
DR   Ensembl; ENST00000583565.5; ENSP00000463476.1; ENSG00000266412.6. [Q13772-1]
DR   Ensembl; ENST00000585132.5; ENSP00000464054.1; ENSG00000266412.6. [Q13772-1]
DR   GeneID; 8031; -.
DR   KEGG; hsa:8031; -.
DR   MANE-Select; ENST00000581486.6; ENSP00000462943.1; NM_001145263.2; NP_001138735.1.
DR   UCSC; uc001jis.5; human. [Q13772-1]
DR   AGR; HGNC:7671; -.
DR   CTD; 8031; -.
DR   DisGeNET; 8031; -.
DR   GeneCards; NCOA4; -.
DR   HGNC; HGNC:7671; NCOA4.
DR   HPA; ENSG00000266412; Low tissue specificity.
DR   MalaCards; NCOA4; -.
DR   MIM; 601984; gene.
DR   neXtProt; NX_Q13772; -.
DR   OpenTargets; ENSG00000266412; -.
DR   Orphanet; 146; Differentiated thyroid carcinoma.
DR   PharmGKB; PA31473; -.
DR   VEuPathDB; HostDB:ENSG00000266412; -.
DR   eggNOG; ENOG502QQ6V; Eukaryota.
DR   GeneTree; ENSGT00390000008403; -.
DR   HOGENOM; CLU_034170_0_0_1; -.
DR   InParanoid; Q13772; -.
DR   OMA; FPPDCYG; -.
DR   OrthoDB; 3016401at2759; -.
DR   PhylomeDB; Q13772; -.
DR   TreeFam; TF333204; -.
DR   PathwayCommons; Q13772; -.
DR   SignaLink; Q13772; -.
DR   SIGNOR; Q13772; -.
DR   BioGRID-ORCS; 8031; 157 hits in 1161 CRISPR screens.
DR   ChiTaRS; NCOA4; human.
DR   EvolutionaryTrace; Q13772; -.
DR   GeneWiki; NCOA4; -.
DR   GenomeRNAi; 8031; -.
DR   Pharos; Q13772; Tbio.
DR   PRO; PR:Q13772; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q13772; Protein.
DR   Bgee; ENSG00000266412; Expressed in jejunal mucosa and 215 other cell types or tissues.
DR   ExpressionAtlas; Q13772; baseline and differential.
DR   GO; GO:0044754; C:autolysosome; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR   GO; GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
DR   GO; GO:0071391; P:cellular response to estrogen stimulus; NAS:ARUK-UCL.
DR   GO; GO:0071394; P:cellular response to testosterone stimulus; NAS:ARUK-UCL.
DR   GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; NAS:ARUK-UCL.
DR   GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0008584; P:male gonad development; TAS:ProtInc.
DR   GO; GO:0006622; P:protein targeting to lysosome; IDA:MGI.
DR   GO; GO:0009725; P:response to hormone; IBA:GO_Central.
DR   IDEAL; IID00074; -.
DR   InterPro; IPR022174; ARA70.
DR   InterPro; IPR039947; NCoA-4.
DR   PANTHER; PTHR17085; NUCLEAR RECEPTOR COACTIVATOR 4; 1.
DR   PANTHER; PTHR17085:SF5; NUCLEAR RECEPTOR COACTIVATOR 4; 1.
DR   Pfam; PF12489; ARA70; 2.
DR   Genevisible; Q13772; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; Alternative splicing; Chromosomal rearrangement;
KW   Proto-oncogene; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..614
FT                   /note="Nuclear receptor coactivator 4"
FT                   /id="PRO_0000094410"
FT   REGION          501..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            238..239
FT                   /note="Breakpoint for rearrangement to form RET/PTC3
FT                   oncogene"
FT   VAR_SEQ         1
FT                   /note="M -> MGAQLTTFALAGAVRRM (in isoform 3 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_046348"
FT   VAR_SEQ         239..565
FT                   /note="Missing (in isoform Beta)"
FT                   /evidence="ECO:0000303|PubMed:9892017"
FT                   /id="VSP_003409"
FT   VAR_SEQ         614
FT                   /note="M -> AYFKMNFQDVTVGNFQIPCGF (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_046349"
FT   VARIANT         94
FT                   /note="S -> L (in dbSNP:rs782517064)"
FT                   /evidence="ECO:0000269|PubMed:9892017"
FT                   /id="VAR_009190"
FT   VARIANT         154
FT                   /note="F -> L"
FT                   /evidence="ECO:0000269|PubMed:9892017"
FT                   /id="VAR_009191"
FT   VARIANT         350
FT                   /note="C -> R"
FT                   /evidence="ECO:0000269|PubMed:9892017"
FT                   /id="VAR_009192"
FT   VARIANT         474
FT                   /note="P -> R (in dbSNP:rs1132111)"
FT                   /id="VAR_014928"
FT   VARIANT         561
FT                   /note="L -> P"
FT                   /evidence="ECO:0000269|PubMed:9892017"
FT                   /id="VAR_009193"
FT   MUTAGEN         95..96
FT                   /note="LL->AA: Decreased interaction with PPAR and RXR."
FT   CONFLICT        71
FT                   /note="Y -> H (in Ref. 3; BAG65022)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        162
FT                   /note="I -> T (in Ref. 8; CAA50536)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        183
FT                   /note="G -> S (in Ref. 8; CAA50536)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        271
FT                   /note="K -> R (in Ref. 3; AK310849)"
FT                   /evidence="ECO:0000305"
FT   HELIX           327..333
FT                   /evidence="ECO:0007829|PDB:1T5Z"
FT   CONFLICT        Q13772-3:8
FT                   /note="F -> V (in Ref. 3; BAG65022)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        Q13772-4:8
FT                   /note="F -> V (in Ref. 3; AK310849)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   614 AA;  69726 MW;  36B6D97C7D072BFF CRC64;
     MNTFQDQSGS SSNREPLLRC SDARRDLELA IGGVLRAEQQ IKDNLREVKA QIHSCISRHL
     ECLRSREVWL YEQVDLIYQL KEETLQQQAQ QLYSLLGQFN CLTHQLECTQ NKDLANQVSV
     CLERLGSLTL KPEDSTVLLF EADTITLRQT ITTFGSLKTI QIPEHLMAHA SSANIGPFLE
     KRGCISMPEQ KSASGIVAVP FSEWLLGSKP ASGYQAPYIP STDPQDWLTQ KQTLENSQTS
     SRACNFFNNV GGNLKGLENW LLKSEKSSYQ KCNSHSTTSS FSIEMEKVGD QELPDQDEMD
     LSDWLVTPQE SHKLRKPENG SRETSEKFKL LFQSYNVNDW LVKTDSCTNC QGNQPKGVEI
     ENLGNLKCLN DHLEAKKPLS TPSMVTEDWL VQNHQDPCKV EEVCRANEPC TSFAECVCDE
     NCEKEALYKW LLKKEGKDKN GMPVEPKPEP EKHKDSLNMW LCPRKEVIEQ TKAPKAMTPS
     RIADSFQVIK NSPLSEWLIR PPYKEGSPKE VPGTEDRAGK QKFKSPMNTS WCSFNTADWV
     LPGKKMGNLS QLSSGEDKWL LRKKAQEVLL NSPLQEEHNF PPDHYGLPAV CDLFACMQLK
     VDKEKWLYRT PLQM
//