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Protein

Nuclear receptor coactivator 4

Gene

NCOA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei238 – 239Breakpoint for rearrangement to form RET/PTC3 oncogene2

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

  • androgen receptor signaling pathway Source: UniProtKB
  • cellular iron ion homeostasis Source: Ensembl
  • male gonad development Source: ProtInc
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein targeting to lysosome Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ13772

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 4
Short name:
NCoA-4
Alternative name(s):
Androgen receptor coactivator 70 kDa protein
Short name:
70 kDa AR-activator
Short name:
70 kDa androgen receptor coactivator
Androgen receptor-associated protein of 70 kDa
Ret-activating protein ELE1
Gene namesi
Name:NCOA4
Synonyms:ARA70, ELE1, RFG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000266412.5
HGNCiHGNC:7671 NCOA4
MIMi601984 gene
neXtProtiNX_Q13772

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi95 – 96LL → AA: Decreased interaction with PPAR and RXR. 2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8031
MalaCardsiNCOA4
OpenTargetsiENSG00000266412
Orphaneti146 Papillary or follicular thyroid carcinoma
PharmGKBiPA31473

Polymorphism and mutation databases

BioMutaiNCOA4
DMDMi8928226

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944101 – 614Nuclear receptor coactivator 4Add BLAST614

Proteomic databases

MaxQBiQ13772
PaxDbiQ13772
PeptideAtlasiQ13772
PRIDEiQ13772

PTM databases

iPTMnetiQ13772
PhosphoSitePlusiQ13772

Expressioni

Tissue specificityi

Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.

Gene expression databases

BgeeiENSG00000266412
CleanExiHS_NCOA4
ExpressionAtlasiQ13772 baseline and differential
GenevisibleiQ13772 HS

Organism-specific databases

HPAiHPA051260
HPA065208

Interactioni

Subunit structurei

Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113726, 34 interactors
DIPiDIP-5957N
IntActiQ13772, 14 interactors
STRINGi9606.ENSP00000395465

Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi327 – 333Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T5ZX-ray2.30B322-336[»]
ProteinModelPortaliQ13772
SMRiQ13772
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13772

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHT6 Eukaryota
ENOG410YJ5B LUCA
GeneTreeiENSGT00390000008403
HOGENOMiHOG000013175
HOVERGENiHBG052584
InParanoidiQ13772
KOiK09289
OMAiPLQEEHN
OrthoDBiEOG091G049Z
PhylomeDBiQ13772
TreeFamiTF333204

Family and domain databases

InterProiView protein in InterPro
IPR022174 ARA70
PfamiView protein in Pfam
PF12489 ARA70, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Alpha (identifier: Q13772-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTFQDQSGS SSNREPLLRC SDARRDLELA IGGVLRAEQQ IKDNLREVKA
60 70 80 90 100
QIHSCISRHL ECLRSREVWL YEQVDLIYQL KEETLQQQAQ QLYSLLGQFN
110 120 130 140 150
CLTHQLECTQ NKDLANQVSV CLERLGSLTL KPEDSTVLLF EADTITLRQT
160 170 180 190 200
ITTFGSLKTI QIPEHLMAHA SSANIGPFLE KRGCISMPEQ KSASGIVAVP
210 220 230 240 250
FSEWLLGSKP ASGYQAPYIP STDPQDWLTQ KQTLENSQTS SRACNFFNNV
260 270 280 290 300
GGNLKGLENW LLKSEKSSYQ KCNSHSTTSS FSIEMEKVGD QELPDQDEMD
310 320 330 340 350
LSDWLVTPQE SHKLRKPENG SRETSEKFKL LFQSYNVNDW LVKTDSCTNC
360 370 380 390 400
QGNQPKGVEI ENLGNLKCLN DHLEAKKPLS TPSMVTEDWL VQNHQDPCKV
410 420 430 440 450
EEVCRANEPC TSFAECVCDE NCEKEALYKW LLKKEGKDKN GMPVEPKPEP
460 470 480 490 500
EKHKDSLNMW LCPRKEVIEQ TKAPKAMTPS RIADSFQVIK NSPLSEWLIR
510 520 530 540 550
PPYKEGSPKE VPGTEDRAGK QKFKSPMNTS WCSFNTADWV LPGKKMGNLS
560 570 580 590 600
QLSSGEDKWL LRKKAQEVLL NSPLQEEHNF PPDHYGLPAV CDLFACMQLK
610
VDKEKWLYRT PLQM
Length:614
Mass (Da):69,726
Last modified:November 1, 1996 - v1
Checksum:i36B6D97C7D072BFF
GO
Isoform Beta (identifier: Q13772-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-565: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):32,562
Checksum:i411914FCC6AD6387
GO
Isoform 3 (identifier: Q13772-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGAQLTTFALAGAVRRM

Note: No experimental confirmation available.Curated
Show »
Length:630
Mass (Da):71,371
Checksum:iCC77B233C7B8849A
GO
Isoform 4 (identifier: Q13772-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGAQLTTFALAGAVRRM
     614-614: M → AYFKMNFQDVTVGNFQIPCGF

Note: No experimental confirmation available.Curated
Show »
Length:650
Mass (Da):73,649
Checksum:i504B983AA6E76D83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71Y → H in BAG65022 (PubMed:14702039).Curated1
Sequence conflicti162I → T in CAA50536 (PubMed:8187085).Curated1
Sequence conflicti183G → S in CAA50536 (PubMed:8187085).Curated1
Sequence conflicti271K → R in AK310849 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q13772-3)
Sequence conflicti8F → V in BAG65022 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q13772-4)
Sequence conflicti8F → V in AK310849 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00919094S → L1 Publication1
Natural variantiVAR_009191154F → L1 Publication1
Natural variantiVAR_009192350C → R1 Publication1
Natural variantiVAR_014928474P → R. Corresponds to variant dbSNP:rs1132111Ensembl.1
Natural variantiVAR_009193561L → P1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0463481M → MGAQLTTFALAGAVRRM in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_003409239 – 565Missing in isoform Beta. 1 PublicationAdd BLAST327
Alternative sequenceiVSP_046349614M → AYFKMNFQDVTVGNFQIPCG F in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49399 mRNA Translation: AAC37591.1
X77548 mRNA Translation: CAA54673.1
AK292480 mRNA Translation: BAF85169.1
AK304123 mRNA Translation: BAG65022.1
AK310849 mRNA No translation available.
AL162047 mRNA Translation: CAB82390.1
AL450342 Genomic DNA No translation available.
CH471260 Genomic DNA Translation: EAW53686.1
BC001562 mRNA Translation: AAH01562.1
X71413 mRNA Translation: CAA50536.1
CCDSiCCDS73092.1 [Q13772-1]
CCDS73093.1 [Q13772-3]
CCDS73094.1 [Q13772-4]
PIRiS61532
RefSeqiNP_001138732.1, NM_001145260.1 [Q13772-4]
NP_001138733.1, NM_001145261.1 [Q13772-3]
NP_001138734.1, NM_001145262.1 [Q13772-1]
NP_001138735.1, NM_001145263.1 [Q13772-1]
NP_005428.1, NM_005437.3 [Q13772-1]
UniGeneiHs.643658
Hs.709644

Genome annotation databases

EnsembliENST00000578454; ENSP00000463027; ENSG00000266412 [Q13772-4]
ENST00000579039; ENSP00000463455; ENSG00000266412 [Q13772-3]
ENST00000581486; ENSP00000462943; ENSG00000266412 [Q13772-1]
ENST00000583565; ENSP00000463476; ENSG00000266412 [Q13772-1]
ENST00000585132; ENSP00000464054; ENSG00000266412 [Q13772-1]
GeneIDi8031
KEGGihsa:8031
UCSCiuc001jis.5 human [Q13772-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNCOA4_HUMAN
AccessioniPrimary (citable) accession number: Q13772
Secondary accession number(s): A8K8W5
, B4E260, E9PAV7, J3KQN8, Q14239
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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