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Q13772

- NCOA4_HUMAN

UniProt

Q13772 - NCOA4_HUMAN

Protein

Nuclear receptor coactivator 4

Gene

NCOA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei238 – 2392Breakpoint for rearrangement to form RET/PTC3 oncogene

    GO - Molecular functioni

    1. androgen receptor binding Source: UniProtKB
    2. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. androgen receptor signaling pathway Source: UniProtKB
    2. male gonad development Source: ProtInc
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. response to hormone Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor coactivator 4
    Short name:
    NCoA-4
    Alternative name(s):
    Androgen receptor coactivator 70 kDa protein
    Short name:
    70 kDa AR-activator
    Short name:
    70 kDa androgen receptor coactivator
    Androgen receptor-associated protein of 70 kDa
    Ret-activating protein ELE1
    Gene namesi
    Name:NCOA4
    Synonyms:ARA70, ELE1, RFG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:7671. NCOA4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Pathology & Biotechi

    Involvement in diseasei

    Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells.
    Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi95 – 962LL → AA: Decreased interaction with PPAR and RXR.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    MIMi188550. phenotype.
    Orphaneti146. Papillary or follicular thyroid carcinoma.
    PharmGKBiPA31473.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614Nuclear receptor coactivator 4PRO_0000094410Add
    BLAST

    Proteomic databases

    MaxQBiQ13772.
    PaxDbiQ13772.
    PRIDEiQ13772.

    PTM databases

    PhosphoSiteiQ13772.

    Expressioni

    Tissue specificityi

    Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.

    Gene expression databases

    ArrayExpressiQ13772.
    BgeeiQ13772.
    CleanExiHS_NCOA4.
    GenevestigatoriQ13772.

    Organism-specific databases

    HPAiHPA051260.

    Interactioni

    Subunit structurei

    Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.

    Protein-protein interaction databases

    BioGridi113726. 12 interactions.
    DIPiDIP-5957N.
    IntActiQ13772. 5 interactions.
    MINTiMINT-2864695.
    STRINGi9606.ENSP00000395465.

    Structurei

    Secondary structure

    1
    614
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi327 – 3337

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1T5ZX-ray2.30B322-336[»]
    ProteinModelPortaliQ13772.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13772.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG40301.
    HOGENOMiHOG000013175.
    HOVERGENiHBG052584.
    InParanoidiQ13772.
    KOiK09289.
    OMAiECVCDEN.
    PhylomeDBiQ13772.
    TreeFamiTF333204.

    Family and domain databases

    InterProiIPR022174. ARA70.
    [Graphical view]
    PfamiPF12489. ARA70. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform Alpha (identifier: Q13772-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNTFQDQSGS SSNREPLLRC SDARRDLELA IGGVLRAEQQ IKDNLREVKA    50
    QIHSCISRHL ECLRSREVWL YEQVDLIYQL KEETLQQQAQ QLYSLLGQFN 100
    CLTHQLECTQ NKDLANQVSV CLERLGSLTL KPEDSTVLLF EADTITLRQT 150
    ITTFGSLKTI QIPEHLMAHA SSANIGPFLE KRGCISMPEQ KSASGIVAVP 200
    FSEWLLGSKP ASGYQAPYIP STDPQDWLTQ KQTLENSQTS SRACNFFNNV 250
    GGNLKGLENW LLKSEKSSYQ KCNSHSTTSS FSIEMEKVGD QELPDQDEMD 300
    LSDWLVTPQE SHKLRKPENG SRETSEKFKL LFQSYNVNDW LVKTDSCTNC 350
    QGNQPKGVEI ENLGNLKCLN DHLEAKKPLS TPSMVTEDWL VQNHQDPCKV 400
    EEVCRANEPC TSFAECVCDE NCEKEALYKW LLKKEGKDKN GMPVEPKPEP 450
    EKHKDSLNMW LCPRKEVIEQ TKAPKAMTPS RIADSFQVIK NSPLSEWLIR 500
    PPYKEGSPKE VPGTEDRAGK QKFKSPMNTS WCSFNTADWV LPGKKMGNLS 550
    QLSSGEDKWL LRKKAQEVLL NSPLQEEHNF PPDHYGLPAV CDLFACMQLK 600
    VDKEKWLYRT PLQM 614
    Length:614
    Mass (Da):69,726
    Last modified:November 1, 1996 - v1
    Checksum:i36B6D97C7D072BFF
    GO
    Isoform Beta (identifier: Q13772-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         239-565: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:287
    Mass (Da):32,562
    Checksum:i411914FCC6AD6387
    GO
    Isoform 3 (identifier: Q13772-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MGAQLTTFALAGAVRRM

    Note: No experimental confirmation available.Curated

    Show »
    Length:630
    Mass (Da):71,371
    Checksum:iCC77B233C7B8849A
    GO
    Isoform 4 (identifier: Q13772-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MGAQLTTFALAGAVRRM
         614-614: M → AYFKMNFQDVTVGNFQIPCGF

    Note: No experimental confirmation available.Curated

    Show »
    Length:650
    Mass (Da):73,649
    Checksum:i504B983AA6E76D83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711Y → H in BAG65022. (PubMed:14702039)Curated
    Sequence conflicti162 – 1621I → T in CAA50536. (PubMed:8187085)Curated
    Sequence conflicti183 – 1831G → S in CAA50536. (PubMed:8187085)Curated
    Sequence conflicti271 – 2711K → R in AK310849. (PubMed:14702039)Curated
    Isoform 3 (identifier: Q13772-3)
    Sequence conflicti8 – 81F → V in BAG65022. (PubMed:14702039)Curated
    Isoform 4 (identifier: Q13772-4)
    Sequence conflicti8 – 81F → V in AK310849. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 941S → L.1 Publication
    VAR_009190
    Natural varianti154 – 1541F → L.1 Publication
    VAR_009191
    Natural varianti350 – 3501C → R.1 Publication
    VAR_009192
    Natural varianti474 – 4741P → R.
    Corresponds to variant rs1132111 [ dbSNP | Ensembl ].
    VAR_014928
    Natural varianti561 – 5611L → P.1 Publication
    VAR_009193

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MGAQLTTFALAGAVRRM in isoform 3 and isoform 4. 1 PublicationVSP_046348
    Alternative sequencei239 – 565327Missing in isoform Beta. 1 PublicationVSP_003409Add
    BLAST
    Alternative sequencei614 – 6141M → AYFKMNFQDVTVGNFQIPCG F in isoform 4. 1 PublicationVSP_046349

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L49399 mRNA. Translation: AAC37591.1.
    X77548 mRNA. Translation: CAA54673.1.
    AK292480 mRNA. Translation: BAF85169.1.
    AK304123 mRNA. Translation: BAG65022.1.
    AK310849 mRNA. No translation available.
    AL162047 mRNA. Translation: CAB82390.1.
    AL450342 Genomic DNA. Translation: CAI14478.1.
    CH471260 Genomic DNA. Translation: EAW53686.1.
    BC001562 mRNA. Translation: AAH01562.1.
    X71413 mRNA. Translation: CAA50536.1.
    CCDSiCCDS44393.1. [Q13772-3]
    CCDS44394.1. [Q13772-4]
    CCDS7237.1. [Q13772-1]
    PIRiS61532.
    RefSeqiNP_001138732.1. NM_001145260.1. [Q13772-4]
    NP_001138733.1. NM_001145261.1. [Q13772-3]
    NP_001138734.1. NM_001145262.1. [Q13772-1]
    NP_001138735.1. NM_001145263.1. [Q13772-1]
    NP_005428.1. NM_005437.3. [Q13772-1]
    UniGeneiHs.643658.
    Hs.709644.

    Genome annotation databases

    EnsembliENST00000578454; ENSP00000463027; ENSG00000266412. [Q13772-4]
    ENST00000579039; ENSP00000463455; ENSG00000266412. [Q13772-3]
    ENST00000581486; ENSP00000462943; ENSG00000266412. [Q13772-1]
    ENST00000583565; ENSP00000463476; ENSG00000266412. [Q13772-1]
    ENST00000585132; ENSP00000464054; ENSG00000266412. [Q13772-1]
    GeneIDi8031.
    KEGGihsa:8031.
    UCSCiuc001jis.4. human. [Q13772-1]

    Polymorphism databases

    DMDMi8928226.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L49399 mRNA. Translation: AAC37591.1 .
    X77548 mRNA. Translation: CAA54673.1 .
    AK292480 mRNA. Translation: BAF85169.1 .
    AK304123 mRNA. Translation: BAG65022.1 .
    AK310849 mRNA. No translation available.
    AL162047 mRNA. Translation: CAB82390.1 .
    AL450342 Genomic DNA. Translation: CAI14478.1 .
    CH471260 Genomic DNA. Translation: EAW53686.1 .
    BC001562 mRNA. Translation: AAH01562.1 .
    X71413 mRNA. Translation: CAA50536.1 .
    CCDSi CCDS44393.1. [Q13772-3 ]
    CCDS44394.1. [Q13772-4 ]
    CCDS7237.1. [Q13772-1 ]
    PIRi S61532.
    RefSeqi NP_001138732.1. NM_001145260.1. [Q13772-4 ]
    NP_001138733.1. NM_001145261.1. [Q13772-3 ]
    NP_001138734.1. NM_001145262.1. [Q13772-1 ]
    NP_001138735.1. NM_001145263.1. [Q13772-1 ]
    NP_005428.1. NM_005437.3. [Q13772-1 ]
    UniGenei Hs.643658.
    Hs.709644.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1T5Z X-ray 2.30 B 322-336 [» ]
    ProteinModelPortali Q13772.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113726. 12 interactions.
    DIPi DIP-5957N.
    IntActi Q13772. 5 interactions.
    MINTi MINT-2864695.
    STRINGi 9606.ENSP00000395465.

    PTM databases

    PhosphoSitei Q13772.

    Polymorphism databases

    DMDMi 8928226.

    Proteomic databases

    MaxQBi Q13772.
    PaxDbi Q13772.
    PRIDEi Q13772.

    Protocols and materials databases

    DNASUi 8031.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000578454 ; ENSP00000463027 ; ENSG00000266412 . [Q13772-4 ]
    ENST00000579039 ; ENSP00000463455 ; ENSG00000266412 . [Q13772-3 ]
    ENST00000581486 ; ENSP00000462943 ; ENSG00000266412 . [Q13772-1 ]
    ENST00000583565 ; ENSP00000463476 ; ENSG00000266412 . [Q13772-1 ]
    ENST00000585132 ; ENSP00000464054 ; ENSG00000266412 . [Q13772-1 ]
    GeneIDi 8031.
    KEGGi hsa:8031.
    UCSCi uc001jis.4. human. [Q13772-1 ]

    Organism-specific databases

    CTDi 8031.
    GeneCardsi GC10P051565.
    HGNCi HGNC:7671. NCOA4.
    HPAi HPA051260.
    MIMi 188550. phenotype.
    601984. gene.
    neXtProti NX_Q13772.
    Orphaneti 146. Papillary or follicular thyroid carcinoma.
    PharmGKBi PA31473.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40301.
    HOGENOMi HOG000013175.
    HOVERGENi HBG052584.
    InParanoidi Q13772.
    KOi K09289.
    OMAi ECVCDEN.
    PhylomeDBi Q13772.
    TreeFami TF333204.

    Miscellaneous databases

    EvolutionaryTracei Q13772.
    GeneWikii NCOA4.
    GenomeRNAii 8031.
    NextBioi 30615.
    PROi Q13772.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13772.
    Bgeei Q13772.
    CleanExi HS_NCOA4.
    Genevestigatori Q13772.

    Family and domain databases

    InterProi IPR022174. ARA70.
    [Graphical view ]
    Pfami PF12489. ARA70. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells."
      Yeh S., Chang C.
      Proc. Natl. Acad. Sci. U.S.A. 93:5517-5521(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Prostatic carcinoma.
    2. "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma."
      Santoro M., Dathan N.A., Berlingieri M.T., Bongarzone I., Paulin C., Grieco M., Pierotti M.A., Vecchio G., Fusco A.
      Oncogene 9:509-516(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thyroid.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA; 3 AND 4).
      Tissue: Testis and Trachea.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Melanoma.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
      Tissue: Placenta.
    8. "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas."
      Bongarzone I., Butti M.G., Coronelli S., Borrello M.G., Santoro M., Mondellini P., Pilotti S., Fusco A., Della Porta G., Pierotti M.A.
      Cancer Res. 54:2979-2985(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-238.
      Tissue: Thyroid tumor.
    9. "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform."
      Alen P., Claessens F., Schoenmakers E., Swinnen J.V., Verhoeven G., Rombauts W., Peeters B.
      Mol. Endocrinol. 13:117-128(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANTS LEU-94; LEU-154; ARG-350 AND PRO-561.
      Tissue: Cervix carcinoma, Mammary cancer and Prostatic carcinoma.
    10. "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma."
      Heinlein C.A., Ting H.-J., Yeh S., Chang C.
      J. Biol. Chem. 274:16147-16152(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNCOA4_HUMAN
    AccessioniPrimary (citable) accession number: Q13772
    Secondary accession number(s): A8K8W5
    , B4E260, E9PAV7, J3KQN8, Q14239
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3