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Q13772

- NCOA4_HUMAN

UniProt

Q13772 - NCOA4_HUMAN

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Protein
Nuclear receptor coactivator 4
Gene
NCOA4, ARA70, ELE1, RFG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei238 – 2392Breakpoint for rearrangement to form RET/PTC3 oncogene

GO - Molecular functioni

  1. androgen receptor binding Source: UniProtKB
  2. transcription coactivator activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. androgen receptor signaling pathway Source: UniProtKB
  2. male gonad development Source: ProtInc
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. response to hormone Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 4
Short name:
NCoA-4
Alternative name(s):
Androgen receptor coactivator 70 kDa protein
Short name:
70 kDa AR-activator
Short name:
70 kDa androgen receptor coactivator
Androgen receptor-associated protein of 70 kDa
Ret-activating protein ELE1
Gene namesi
Name:NCOA4
Synonyms:ARA70, ELE1, RFG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:7671. NCOA4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells.
Note: The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi95 – 962LL → AA: Decreased interaction with PPAR and RXR.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi188550. phenotype.
Orphaneti146. Papillary or follicular thyroid carcinoma.
PharmGKBiPA31473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Nuclear receptor coactivator 4
PRO_0000094410Add
BLAST

Proteomic databases

MaxQBiQ13772.
PaxDbiQ13772.
PRIDEiQ13772.

PTM databases

PhosphoSiteiQ13772.

Expressioni

Tissue specificityi

Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.

Gene expression databases

ArrayExpressiQ13772.
BgeeiQ13772.
CleanExiHS_NCOA4.
GenevestigatoriQ13772.

Organism-specific databases

HPAiHPA051260.

Interactioni

Subunit structurei

Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.

Protein-protein interaction databases

BioGridi113726. 12 interactions.
DIPiDIP-5957N.
IntActiQ13772. 5 interactions.
MINTiMINT-2864695.
STRINGi9606.ENSP00000395465.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi327 – 3337

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T5ZX-ray2.30B322-336[»]
ProteinModelPortaliQ13772.

Miscellaneous databases

EvolutionaryTraceiQ13772.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG40301.
HOGENOMiHOG000013175.
HOVERGENiHBG052584.
InParanoidiQ13772.
KOiK09289.
OMAiECVCDEN.
PhylomeDBiQ13772.
TreeFamiTF333204.

Family and domain databases

InterProiIPR022174. ARA70.
[Graphical view]
PfamiPF12489. ARA70. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform Alpha (identifier: Q13772-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNTFQDQSGS SSNREPLLRC SDARRDLELA IGGVLRAEQQ IKDNLREVKA    50
QIHSCISRHL ECLRSREVWL YEQVDLIYQL KEETLQQQAQ QLYSLLGQFN 100
CLTHQLECTQ NKDLANQVSV CLERLGSLTL KPEDSTVLLF EADTITLRQT 150
ITTFGSLKTI QIPEHLMAHA SSANIGPFLE KRGCISMPEQ KSASGIVAVP 200
FSEWLLGSKP ASGYQAPYIP STDPQDWLTQ KQTLENSQTS SRACNFFNNV 250
GGNLKGLENW LLKSEKSSYQ KCNSHSTTSS FSIEMEKVGD QELPDQDEMD 300
LSDWLVTPQE SHKLRKPENG SRETSEKFKL LFQSYNVNDW LVKTDSCTNC 350
QGNQPKGVEI ENLGNLKCLN DHLEAKKPLS TPSMVTEDWL VQNHQDPCKV 400
EEVCRANEPC TSFAECVCDE NCEKEALYKW LLKKEGKDKN GMPVEPKPEP 450
EKHKDSLNMW LCPRKEVIEQ TKAPKAMTPS RIADSFQVIK NSPLSEWLIR 500
PPYKEGSPKE VPGTEDRAGK QKFKSPMNTS WCSFNTADWV LPGKKMGNLS 550
QLSSGEDKWL LRKKAQEVLL NSPLQEEHNF PPDHYGLPAV CDLFACMQLK 600
VDKEKWLYRT PLQM 614
Length:614
Mass (Da):69,726
Last modified:November 1, 1996 - v1
Checksum:i36B6D97C7D072BFF
GO
Isoform Beta (identifier: Q13772-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-565: Missing.

Note: No experimental confirmation available.

Show »
Length:287
Mass (Da):32,562
Checksum:i411914FCC6AD6387
GO
Isoform 3 (identifier: Q13772-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGAQLTTFALAGAVRRM

Note: No experimental confirmation available.

Show »
Length:630
Mass (Da):71,371
Checksum:iCC77B233C7B8849A
GO
Isoform 4 (identifier: Q13772-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGAQLTTFALAGAVRRM
     614-614: M → AYFKMNFQDVTVGNFQIPCGF

Note: No experimental confirmation available.

Show »
Length:650
Mass (Da):73,649
Checksum:i504B983AA6E76D83
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941S → L.1 Publication
VAR_009190
Natural varianti154 – 1541F → L.1 Publication
VAR_009191
Natural varianti350 – 3501C → R.1 Publication
VAR_009192
Natural varianti474 – 4741P → R.
Corresponds to variant rs1132111 [ dbSNP | Ensembl ].
VAR_014928
Natural varianti561 – 5611L → P.1 Publication
VAR_009193

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MGAQLTTFALAGAVRRM in isoform 3 and isoform 4.
VSP_046348
Alternative sequencei239 – 565327Missing in isoform Beta.
VSP_003409Add
BLAST
Alternative sequencei614 – 6141M → AYFKMNFQDVTVGNFQIPCG F in isoform 4.
VSP_046349

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711Y → H in BAG65022. 1 Publication
Sequence conflicti162 – 1621I → T in CAA50536. 1 Publication
Sequence conflicti183 – 1831G → S in CAA50536. 1 Publication
Sequence conflicti271 – 2711K → R in AK310849. 1 Publication
Isoform 3 (identifier: Q13772-3)
Sequence conflicti8 – 81F → V in BAG65022. 1 Publication
Isoform 4 (identifier: Q13772-4)
Sequence conflicti8 – 81F → V in AK310849. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L49399 mRNA. Translation: AAC37591.1.
X77548 mRNA. Translation: CAA54673.1.
AK292480 mRNA. Translation: BAF85169.1.
AK304123 mRNA. Translation: BAG65022.1.
AK310849 mRNA. No translation available.
AL162047 mRNA. Translation: CAB82390.1.
AL450342 Genomic DNA. Translation: CAI14478.1.
CH471260 Genomic DNA. Translation: EAW53686.1.
BC001562 mRNA. Translation: AAH01562.1.
X71413 mRNA. Translation: CAA50536.1.
CCDSiCCDS44393.1. [Q13772-3]
CCDS44394.1. [Q13772-4]
CCDS7237.1. [Q13772-1]
PIRiS61532.
RefSeqiNP_001138732.1. NM_001145260.1. [Q13772-4]
NP_001138733.1. NM_001145261.1. [Q13772-3]
NP_001138734.1. NM_001145262.1. [Q13772-1]
NP_001138735.1. NM_001145263.1. [Q13772-1]
NP_005428.1. NM_005437.3. [Q13772-1]
UniGeneiHs.643658.
Hs.709644.

Genome annotation databases

EnsembliENST00000344348; ENSP00000344552; ENSG00000138293. [Q13772-1]
ENST00000374087; ENSP00000363200; ENSG00000138293. [Q13772-1]
ENST00000438493; ENSP00000405146; ENSG00000138293. [Q13772-3]
ENST00000443446; ENSP00000390713; ENSG00000138293. [Q13772-1]
ENST00000452682; ENSP00000395465; ENSG00000138293. [Q13772-4]
ENST00000578454; ENSP00000463027; ENSG00000266412. [Q13772-4]
ENST00000579039; ENSP00000463455; ENSG00000266412. [Q13772-3]
ENST00000581486; ENSP00000462943; ENSG00000266412. [Q13772-1]
ENST00000583565; ENSP00000463476; ENSG00000266412. [Q13772-1]
ENST00000585132; ENSP00000464054; ENSG00000266412. [Q13772-1]
GeneIDi8031.
KEGGihsa:8031.
UCSCiuc001jis.4. human. [Q13772-1]

Polymorphism databases

DMDMi8928226.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L49399 mRNA. Translation: AAC37591.1 .
X77548 mRNA. Translation: CAA54673.1 .
AK292480 mRNA. Translation: BAF85169.1 .
AK304123 mRNA. Translation: BAG65022.1 .
AK310849 mRNA. No translation available.
AL162047 mRNA. Translation: CAB82390.1 .
AL450342 Genomic DNA. Translation: CAI14478.1 .
CH471260 Genomic DNA. Translation: EAW53686.1 .
BC001562 mRNA. Translation: AAH01562.1 .
X71413 mRNA. Translation: CAA50536.1 .
CCDSi CCDS44393.1. [Q13772-3 ]
CCDS44394.1. [Q13772-4 ]
CCDS7237.1. [Q13772-1 ]
PIRi S61532.
RefSeqi NP_001138732.1. NM_001145260.1. [Q13772-4 ]
NP_001138733.1. NM_001145261.1. [Q13772-3 ]
NP_001138734.1. NM_001145262.1. [Q13772-1 ]
NP_001138735.1. NM_001145263.1. [Q13772-1 ]
NP_005428.1. NM_005437.3. [Q13772-1 ]
UniGenei Hs.643658.
Hs.709644.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1T5Z X-ray 2.30 B 322-336 [» ]
ProteinModelPortali Q13772.
ModBasei Search...

Protein-protein interaction databases

BioGridi 113726. 12 interactions.
DIPi DIP-5957N.
IntActi Q13772. 5 interactions.
MINTi MINT-2864695.
STRINGi 9606.ENSP00000395465.

PTM databases

PhosphoSitei Q13772.

Polymorphism databases

DMDMi 8928226.

Proteomic databases

MaxQBi Q13772.
PaxDbi Q13772.
PRIDEi Q13772.

Protocols and materials databases

DNASUi 8031.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344348 ; ENSP00000344552 ; ENSG00000138293 . [Q13772-1 ]
ENST00000374087 ; ENSP00000363200 ; ENSG00000138293 . [Q13772-1 ]
ENST00000438493 ; ENSP00000405146 ; ENSG00000138293 . [Q13772-3 ]
ENST00000443446 ; ENSP00000390713 ; ENSG00000138293 . [Q13772-1 ]
ENST00000452682 ; ENSP00000395465 ; ENSG00000138293 . [Q13772-4 ]
ENST00000578454 ; ENSP00000463027 ; ENSG00000266412 . [Q13772-4 ]
ENST00000579039 ; ENSP00000463455 ; ENSG00000266412 . [Q13772-3 ]
ENST00000581486 ; ENSP00000462943 ; ENSG00000266412 . [Q13772-1 ]
ENST00000583565 ; ENSP00000463476 ; ENSG00000266412 . [Q13772-1 ]
ENST00000585132 ; ENSP00000464054 ; ENSG00000266412 . [Q13772-1 ]
GeneIDi 8031.
KEGGi hsa:8031.
UCSCi uc001jis.4. human. [Q13772-1 ]

Organism-specific databases

CTDi 8031.
GeneCardsi GC10P051565.
HGNCi HGNC:7671. NCOA4.
HPAi HPA051260.
MIMi 188550. phenotype.
601984. gene.
neXtProti NX_Q13772.
Orphaneti 146. Papillary or follicular thyroid carcinoma.
PharmGKBi PA31473.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40301.
HOGENOMi HOG000013175.
HOVERGENi HBG052584.
InParanoidi Q13772.
KOi K09289.
OMAi ECVCDEN.
PhylomeDBi Q13772.
TreeFami TF333204.

Miscellaneous databases

EvolutionaryTracei Q13772.
GeneWikii NCOA4.
GenomeRNAii 8031.
NextBioi 30615.
PROi Q13772.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13772.
Bgeei Q13772.
CleanExi HS_NCOA4.
Genevestigatori Q13772.

Family and domain databases

InterProi IPR022174. ARA70.
[Graphical view ]
Pfami PF12489. ARA70. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells."
    Yeh S., Chang C.
    Proc. Natl. Acad. Sci. U.S.A. 93:5517-5521(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Prostatic carcinoma.
  2. "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma."
    Santoro M., Dathan N.A., Berlingieri M.T., Bongarzone I., Paulin C., Grieco M., Pierotti M.A., Vecchio G., Fusco A.
    Oncogene 9:509-516(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA; 3 AND 4).
    Tissue: Testis and Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Melanoma.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Tissue: Placenta.
  8. "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas."
    Bongarzone I., Butti M.G., Coronelli S., Borrello M.G., Santoro M., Mondellini P., Pilotti S., Fusco A., Della Porta G., Pierotti M.A.
    Cancer Res. 54:2979-2985(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-238.
    Tissue: Thyroid tumor.
  9. "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform."
    Alen P., Claessens F., Schoenmakers E., Swinnen J.V., Verhoeven G., Rombauts W., Peeters B.
    Mol. Endocrinol. 13:117-128(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA), VARIANTS LEU-94; LEU-154; ARG-350 AND PRO-561.
    Tissue: Cervix carcinoma, Mammary cancer and Prostatic carcinoma.
  10. "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma."
    Heinlein C.A., Ting H.-J., Yeh S., Chang C.
    J. Biol. Chem. 274:16147-16152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNCOA4_HUMAN
AccessioniPrimary (citable) accession number: Q13772
Secondary accession number(s): A8K8W5
, B4E260, E9PAV7, J3KQN8, Q14239
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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