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Protein
Submitted name:

Androgen receptor

Gene

AR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi360 – 435Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Androgen receptorImported
Gene namesi
Name:ARImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei613 – 632HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiQ13771
PRIDEiQ13771

Structurei

3D structure databases

ProteinModelPortaliQ13771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini360 – 435Nuclear receptorInterPro annotationAdd BLAST76
Domaini472 – 710NR LBDInterPro annotationAdd BLAST239

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOVERGENiHBG007583

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR001103 Andrgn_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF02166 Androgen_recep, 1 hit
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00521 ANDROGENR
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q13771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLQQQQQE AVSEGSSSGR AREASGAPTS SKDNYLGGTS TISDNAKELC
60 70 80 90 100
KAVSVSMGLG VEALEHLSPG EQLRGDCMYA PLLGVPPAVR PTPCAPLAEC
110 120 130 140 150
KGSLLDDSAG KSTEDTAEYS PFKGGYTKGL EGESLGCSGS AAAGSSGTLE
160 170 180 190 200
LPSTLSLYKS GALDEAAAYQ SRDYYNFPLA LAGPPPPPPP PHPHARIKLE
210 220 230 240 250
NLLDYGSAWA AAAAQCRYGD LASLHGAGAA GPGSGSPSAA ASSSWHTLFT
260 270 280 290 300
AEEGQLYGPC GGGGGGGGGG GGGGGGEAGA VAPYGYTRPP QGLAGQESDF
310 320 330 340 350
TAPDVWYPGG MVSRVPYPSP TCVKSEMGPW MDSYSGPYGD MRLETARDHV
360 370 380 390 400
LPIDYYFPPQ KTCLICGDEA SGCHYGALTC GSCKVFFKRA AEGKQKYLCA
410 420 430 440 450
SRNDCTIDKF RRKNCPSCRL RKCYEAGMTL GARKLKKLGN LKLQEEGEAS
460 470 480 490 500
STTSPTEETT QKLTVSHIEG YECQPIFLNV LEAIEPGVVC AGHDNNQPDS
510 520 530 540 550
FAALLSSLNE LGERQLVHVV KWAKALPGLR NLHVDDQMAV IQYSWMGLMV
560 570 580 590 600
FAMGWRSFTN VNSRMLYFAP DLVFNEYRMH KSRMYSQCVR MRHLSQEFGW
610 620 630 640 650
LQITPQEFLC MKAMLIFFFF LLLFSIIPVD GLKNQKFFDE LRMNYIKELD
660 670 680 690 700
RIIACKRKNP TSCSRRFYQL TKLLDSVQPI ARELHQFTFD LLIKSHMVSV
710 720 730
DFPEMMAEII SVQVPKILSG KVKPIYFHTQ
Length:730
Mass (Da):79,150
Last modified:November 1, 1996 - v1
Checksum:i918B47C3B41B80C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73069 mRNA Translation: AAA51735.1
UniGeneiHs.76704

Similar proteinsi

Entry informationi

Entry nameiQ13771_HUMAN
AccessioniPrimary (citable) accession number: Q13771
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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