Reviewed,
UniProtKB/Swiss-Prot Q13769 (THOC5_HUMAN)
Last modified
November 25, 2008.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: THO complex subunit 5 homolog Alternative name(s): NF2/meningioma region protein pK1.3 Placental protein 39.2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 683 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be involved in the differentiation of granulocytes and adipocytes By similarity. |
| Subunit structure | Interacts with phosphorylated CSF1R By similarity. |
| Subcellular location | NucleusBy similarity. CytoplasmBy similarity. Note= Shuttles between nucleus and cytoplasm By similarity. |
| Tissue specificity | Ubiquitously expressed. |
| Post-translational modification | Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Sequence similarities | Belongs to the THOC5 family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Differentiation |
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleusInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 683 | 683 | THO complex subunit 5 homolog | PRO_0000079577 | |||||
Regions | |||||||||
| Region | 1 – 144 | 144 | Interaction with CSF1R By similarity | ||||||
| Motif | 7 – 10 | 4 | Nuclear localization signal By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 5 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 6 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 307 | 1 | Phosphoserine | ||||||
| Modified residue | 312 | 1 | Phosphoserine | ||||||
| Modified residue | 314 | 1 | Phosphoserine | ||||||
| Modified residue | 328 | 1 | Phosphothreonine By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 380 | 1 | T → K in a breast cancer sample; somatic mutation. | VAR_035692 | |||||
| Natural variant | 475 | 1 | T → S: dbSNP rs8141153. | VAR_037134 | |||||
| Natural variant | 499 | 1 | G → S in a breast cancer sample; somatic mutation. | VAR_035693 | |||||
| Natural variant | 525 | 1 | I → V: dbSNP rs737976. | VAR_037135 | |||||
| Natural variant | 579 | 1 | I → V: dbSNP rs1049534. | VAR_021410 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of a novel, anonymous gene from a megabase-range YAC and cosmid contig in the neurofibromatosis type 2/meningioma region on human chromosome 22q12." Xie Y.G., Han F.Y., Peyrard M., Ruttledge M.H., Fransson I., deJong P., Collins J., Dunham I., Nordenskjold M., Dumanski J.P. Hum. Mol. Genet. 2:1361-1368(1993) [PubMed: 8242058] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Fetus. |
| [2] | "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-579. Tissue: Brain. |
| [3] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. |
| [5] | "Differential expression of placental genes." Page N.M., Butlin D.J., Manyonda I., Bicknell A.B., Lowry P.J. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 548-650, VARIANT VAL-579. Tissue: Placenta. |
| [6] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312 AND SER-314, MASS SPECTROMETRY. Tissue: Epithelium. |
| [7] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-312 AND SER-314, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-312 AND SER-314, MASS SPECTROMETRY. |
| [9] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-380 AND SER-499. |
Cross-references
Sequence databases | |
|---|---|
| L18972 Genomic DNA. Translation: AAC26837.1. AB023200 mRNA. Translation: BAA76827.2. Different initiation. CR456542 mRNA. Translation: CAG30428.1. BC003615 mRNA. Translation: AAH03615.1. AJ006069 mRNA. Translation: CAA06841.1. | |
| PIR | I39463. |
| RefSeq | NP_001002877.1. NP_001002878.1. NP_001002879.1. NP_003669.4. |
| UniGene | Hs.75361 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q13769. |
Genome annotation databases | |
| Ensembl | ENSG00000100296. Homo sapiens. [Contig view] |
| GeneID | 8563. |
| KEGG | hsa:8563. |
Organism-specific databases | |
| HGNC | HGNC:19074. THOC5. |
| PharmGKB | PA38188. |
| HUGE | Search... |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q13769. |
| HOVERGEN | Q13769. |
Gene expression databases | |
| ArrayExpress | Q13769. |
| CleanEx | HS_THOC5. |
| GermOnline | ENSG00000100296. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 32099. |
Entry information
| Entry name | THOC5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13769 Secondary accession number(s): O60839, Q9UPZ5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


