Reviewed, UniProtKB/Swiss-Prot Q13769 (THOC5_HUMAN)

Names and origin

Protein names

Recommended name:
    THO complex subunit 5 homolog
Alternative name(s):
    NF2/meningioma region protein pK1.3
    Placental protein 39.2

Gene names

Name:	THOC5
Synonyms:	C22orf19, KIAA0983

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	683 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in the differentiation of granulocytes and adipocytes By similarity.
Subunit structure	Interacts with phosphorylated CSF1R By similarity.
Subcellular location	NucleusBy similarity. CytoplasmBy similarity. Note= Shuttles between nucleus and cytoplasm By similarity.
Tissue specificity	Ubiquitously expressed.
Post-translational modification	Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR.
Sequence similarities	Belongs to the THOC5 family.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 683	683	THO complex subunit 5 homolog		PRO_0000079577
Regions
	Region	1 – 144	144	Interaction with CSF1R By similarity
	Motif	7 – 10	4	Nuclear localization signal By similarity
Amino acid modifications
	Modified residue	5	1	Phosphoserine By similarity
	Modified residue	6	1	Phosphoserine By similarity
	Modified residue	307	1	Phosphoserine
	Modified residue	312	1	Phosphoserine
	Modified residue	314	1	Phosphoserine
	Modified residue	328	1	Phosphothreonine By similarity
Natural variations
	Natural variant	380	1	T → K in a breast cancer sample; somatic mutation.		VAR_035692
	Natural variant	475	1	T → S: dbSNP rs8141153.		VAR_037134
	Natural variant	499	1	G → S in a breast cancer sample; somatic mutation.		VAR_035693
	Natural variant	525	1	I → V: dbSNP rs737976.		VAR_037135
	Natural variant	579	1	I → V: dbSNP rs1049534.		VAR_021410

Sequences

	Sequence		Length	Mass (Da)
	Q13769-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FADFBE1DF9B1575C	FASTA	683	78,536
	10 20 30 40 50 60 MSSESSKKRK PKVIRSDGAP AEGKRNRSDT EQEGKYYSEE AEVDLRDPGR DYELYKYTCQ 70 80 90 100 110 120 ELQRLMAEIQ DLKSRGGKDV AIEIEERRIQ SCVHFMTLKK LNRLAHIRLK KGRDQTHEAK 130 140 150 160 170 180 QKVDAYHLQL QNLLYEVMHL QKEITKCLEF KSKHEEIDLV SLEEFYKEAP PDISKAEVTM 190 200 210 220 230 240 GDPHQQTLAR LDWELEQRKR LAEKYRECLS NKEKILKEIE VKKEYLSSLQ PRLNSIMQAS 250 260 270 280 290 300 LPVQEYLFMP FDQAHKQYET ARHLPPPLYV LFVQATAYGQ ACDKTLSVAI EGSVDEAKAL 310 320 330 340 350 360 FKPPEDSQDD ESDSDAEEEQ TTKRRRPTLG VQLDDKRKEM LKRHPLSVML DLKCKDDSVL 370 380 390 400 410 420 HLTFYYLMNL NIMTVKAKVT TAMELITPIS AGDLLSPDSV LSCLYPGDHG KKTPNPANQY 430 440 450 460 470 480 QFDKVGILTL SDYVLELGHP YLWVQKLGGL HFPKEQPQQT VIADHSLSAS HMETTMKLLK 490 500 510 520 530 540 TRVQSRLALH KQFASLEHGI VPVTSDCQYL FPAKVVSRLV KWVTIAHEDY MELHFTKDIV 550 560 570 580 590 600 DAGLAGDTNL YYMALIERGT AKLQAAVVLN PGYSSIPPIF QLCLNWKGEK TNSNDDNIRA 610 620 630 640 650 660 MEGEVNVCYK ELCGPWPSHQ LLTNQLQRLC VLLDVYLETE SHDDSVEGPK EFPQEKMCLR 670 680 LFRGPSRMKP FKYNHPQGFF SHR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel, anonymous gene from a megabase-range YAC and cosmid contig in the neurofibromatosis type 2/meningioma region on human chromosome 22q12." Xie Y.G., Han F.Y., Peyrard M., Ruttledge M.H., Fransson I., deJong P., Collins J., Dunham I., Nordenskjold M., Dumanski J.P. Hum. Mol. Genet. 2:1361-1368(1993) [PubMed: 8242058] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Fetus.
[2]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-579. Tissue: Brain.
[3]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[5]	"Differential expression of placental genes." Page N.M., Butlin D.J., Manyonda I., Bicknell A.B., Lowry P.J. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 548-650, VARIANT VAL-579. Tissue: Placenta.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312 AND SER-314, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-312 AND SER-314, MASS SPECTROMETRY.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307; SER-312 AND SER-314, MASS SPECTROMETRY.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-380 AND SER-499.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L18972 Genomic DNA. Translation: AAC26837.1. AB023200 mRNA. Translation: BAA76827.2. Different initiation. CR456542 mRNA. Translation: CAG30428.1. BC003615 mRNA. Translation: AAH03615.1. AJ006069 mRNA. Translation: CAA06841.1.
PIR	I39463.
RefSeq	NP_001002877.1. NP_001002878.1. NP_001002879.1. NP_003669.4.
UniGene	Hs.75361
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q13769.
Genome annotation databases
Ensembl	ENSG00000100296. Homo sapiens. [Contig view]
GeneID	8563.
KEGG	hsa:8563.
Organism-specific databases
HGNC	HGNC:19074. THOC5.
PharmGKB	PA38188.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q13769.
HOVERGEN	Q13769.
Gene expression databases
ArrayExpress	Q13769.
CleanEx	HS_THOC5.
GermOnline	ENSG00000100296. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	32099.

Entry information

Entry name

THOC5_HUMAN

Accession

Primary (citable) accession number: Q13769
Secondary accession number(s): O60839, Q9UPZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)