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Q13765

- NACA_HUMAN

UniProt

Q13765 - NACA_HUMAN

Protein

Nascent polypeptide-associated complex subunit alpha

Gene

NACA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.3 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. TBP-class protein binding Source: BHF-UCL
    4. transcription coactivator activity Source: BHF-UCL

    GO - Biological processi

    1. cardiac ventricle development Source: BHF-UCL
    2. heart trabecula morphogenesis Source: BHF-UCL
    3. negative regulation of striated muscle cell apoptotic process Source: BHF-UCL
    4. negative regulation of transcription from RNA polymerase II promoter involved in heart development Source: BHF-UCL
    5. positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
    6. positive regulation of skeletal muscle tissue growth Source: BHF-UCL
    7. positive regulation of transcription from RNA polymerase II promoter involved in heart development Source: BHF-UCL
    8. protein transport Source: UniProtKB-KW
    9. regulation of skeletal muscle fiber development Source: BHF-UCL
    10. skeletal muscle tissue regeneration Source: BHF-UCL
    11. transcription, DNA-templated Source: UniProtKB-KW
    12. translation Source: ProtInc
    13. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Host-virus interaction, Protein transport, Transcription, Transport

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nascent polypeptide-associated complex subunit alpha
    Short name:
    NAC-alpha
    Alternative name(s):
    Alpha-NAC
    Allergen: Hom s 2
    Gene namesi
    Name:NACA
    ORF Names:HSD48
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:7629. NACA.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. extracellular vesicular exosome Source: UniProt
    3. nascent polypeptide-associated complex Source: ProtInc
    4. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.1 Publication

    Keywords - Diseasei

    Allergen

    Organism-specific databases

    PharmGKBiPA31433.

    Protein family/group databases

    Allergomei3323. Hom s 2.0101.
    412. Hom s 2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Nascent polypeptide-associated complex subunit alphaPRO_0000135576Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431Phosphoserine; by ILK11 Publication
    Modified residuei142 – 1421N6-acetyllysine1 Publication
    Modified residuei159 – 1591Phosphothreonine; by GSK3-betaBy similarity
    Modified residuei161 – 1611Phosphothreonine1 Publication
    Modified residuei166 – 1661Phosphoserine5 Publications
    Modified residuei186 – 1861Phosphoserine2 Publications
    Modified residuei191 – 1911Phosphoserine2 Publications
    Modified residuei203 – 2031Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation By similarity. Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization.By similarity8 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13765.
    PaxDbiQ13765.
    PRIDEiQ13765.

    PTM databases

    PhosphoSiteiQ13765.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ13765.
    BgeeiQ13765.
    CleanExiHS_NACA.
    GenevestigatoriQ13765.

    Interactioni

    Subunit structurei

    Interacts with TBP and JUN By similarity. Part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of NACA and BTF3 (via NAC-A/B domains). NAC associates with ribosomes through the BTF3/NACB subunit and contacts the ribosomal protein L23, which is positioned near the exiting site. Both subunits can contact nascent polypeptide chains. NACA may also form homodimers, and only this form binds DNA. Interacts with ASFV protein H339R.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TXLNAP402222EBI-712216,EBI-359793

    Protein-protein interaction databases

    BioGridi110748. 34 interactions.
    IntActiQ13765. 23 interactions.
    MINTiMINT-5000033.
    STRINGi9606.ENSP00000403817.

    Structurei

    Secondary structure

    1
    215
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi80 – 834
    Beta strandi86 – 883
    Beta strandi91 – 10818
    Beta strandi110 – 1134
    Beta strandi117 – 1248
    Beta strandi126 – 1305

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LKXX-ray2.50B84-136[»]
    3MCBX-ray1.90A79-132[»]
    3MCEX-ray2.40A/B/C/D81-133[»]
    ProteinModelPortaliQ13765.
    SMRiQ13765. Positions 79-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13765.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 13566NAC-A/BPROSITE-ProRule annotationAdd
    BLAST
    Domaini176 – 21338UBAAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 8012Required for DNA-bindingBy similarityAdd
    BLAST
    Regioni93 – 10816RNA/DNA-bindingAdd
    BLAST

    Domaini

    The positively charged inner surface of the NAC-A/B domain is crucial for NACA localization in the nucleus and DNA-binding. This region is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit, it also displays much higher affinity for RNA than DNA.

    Sequence similaritiesi

    Belongs to the NAC-alpha family.Curated
    Contains 1 NAC-A/B (NAC-alpha/beta) domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.Curated

    Phylogenomic databases

    eggNOGiCOG1308.
    HOVERGENiHBG082004.
    KOiK03626.
    OrthoDBiEOG7RNK24.
    PhylomeDBiQ13765.
    TreeFamiTF313348.

    Family and domain databases

    InterProiIPR016641. EGD2/NACA.
    IPR002715. Nas_poly-pep-assoc_cplx_dom.
    [Graphical view]
    PANTHERiPTHR21713. PTHR21713. 1 hit.
    PfamiPF01849. NAC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015901. NAC_alpha. 1 hit.
    PROSITEiPS51151. NAC_AB. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13765-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGEATETVP ATEQELPQPQ AETGSGTESD SDESVPELEE QDSTQATTQQ    50
    AQLAAAAEID EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK 100
    NILFVITKPD VYKSPASDTY IVFGEAKIED LSQQAQLAAA EKFKVQGEAV 150
    SNIQENTQTP TVQEESEEEE VDETGVEVKD IELVMSQANV SRAKAVRALK 200
    NNSNDIVNAI MELTM 215
    Length:215
    Mass (Da):23,384
    Last modified:November 1, 1996 - v1
    Checksum:i05DC563A8BEF307C
    GO
    Isoform 2 (identifier: E9PAV3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry E9PAV3.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:925
    Mass (Da):94,681
    GO
    Isoform skNAC (identifier: E9PAV3-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry E9PAV3.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:2,078
    Mass (Da):205,422
    GO

    Sequence cautioni

    The sequence AAV83778.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti213 – 2131L → S in BAD96805. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY034001 mRNA. Translation: AAK57544.1.
    AY911673 mRNA. Translation: AAX14393.1.
    X80909 mRNA. Translation: CAA56869.1.
    AF054187 mRNA. Translation: AAC99403.1.
    AK090650 mRNA. Translation: BAG52208.1.
    AK311904 mRNA. Translation: BAG34845.1.
    CR450295 mRNA. Translation: CAG29291.1.
    AK223085 mRNA. Translation: BAD96805.1.
    AC117378 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96960.1.
    BC105120 mRNA. Translation: AAI05121.1.
    BC105122 mRNA. Translation: AAI05123.1.
    BC106041 mRNA. Translation: AAI06042.1.
    AY605660 mRNA. Translation: AAV83778.1. Different initiation.
    CCDSiCCDS31837.1. [Q13765-1]
    PIRiS49326.
    RefSeqiNP_001106673.1. NM_001113202.1. [Q13765-1]
    NP_001106674.2. NM_001113203.2.
    XP_006719484.1. XM_006719421.1. [Q13765-1]
    UniGeneiHs.505735.

    Genome annotation databases

    EnsembliENST00000356769; ENSP00000349212; ENSG00000196531. [Q13765-1]
    ENST00000393891; ENSP00000377469; ENSG00000196531. [Q13765-1]
    ENST00000546392; ENSP00000446801; ENSG00000196531. [Q13765-1]
    ENST00000552540; ENSP00000447821; ENSG00000196531. [Q13765-1]
    GeneIDi4666.
    KEGGihsa:4666.
    UCSCiuc001sly.2. human. [Q13765-1]

    Polymorphism databases

    DMDMi71151996.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY034001 mRNA. Translation: AAK57544.1 .
    AY911673 mRNA. Translation: AAX14393.1 .
    X80909 mRNA. Translation: CAA56869.1 .
    AF054187 mRNA. Translation: AAC99403.1 .
    AK090650 mRNA. Translation: BAG52208.1 .
    AK311904 mRNA. Translation: BAG34845.1 .
    CR450295 mRNA. Translation: CAG29291.1 .
    AK223085 mRNA. Translation: BAD96805.1 .
    AC117378 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96960.1 .
    BC105120 mRNA. Translation: AAI05121.1 .
    BC105122 mRNA. Translation: AAI05123.1 .
    BC106041 mRNA. Translation: AAI06042.1 .
    AY605660 mRNA. Translation: AAV83778.1 . Different initiation.
    CCDSi CCDS31837.1. [Q13765-1 ]
    PIRi S49326.
    RefSeqi NP_001106673.1. NM_001113202.1. [Q13765-1 ]
    NP_001106674.2. NM_001113203.2.
    XP_006719484.1. XM_006719421.1. [Q13765-1 ]
    UniGenei Hs.505735.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LKX X-ray 2.50 B 84-136 [» ]
    3MCB X-ray 1.90 A 79-132 [» ]
    3MCE X-ray 2.40 A/B/C/D 81-133 [» ]
    ProteinModelPortali Q13765.
    SMRi Q13765. Positions 79-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110748. 34 interactions.
    IntActi Q13765. 23 interactions.
    MINTi MINT-5000033.
    STRINGi 9606.ENSP00000403817.

    Protein family/group databases

    Allergomei 3323. Hom s 2.0101.
    412. Hom s 2.

    PTM databases

    PhosphoSitei Q13765.

    Polymorphism databases

    DMDMi 71151996.

    Proteomic databases

    MaxQBi Q13765.
    PaxDbi Q13765.
    PRIDEi Q13765.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356769 ; ENSP00000349212 ; ENSG00000196531 . [Q13765-1 ]
    ENST00000393891 ; ENSP00000377469 ; ENSG00000196531 . [Q13765-1 ]
    ENST00000546392 ; ENSP00000446801 ; ENSG00000196531 . [Q13765-1 ]
    ENST00000552540 ; ENSP00000447821 ; ENSG00000196531 . [Q13765-1 ]
    GeneIDi 4666.
    KEGGi hsa:4666.
    UCSCi uc001sly.2. human. [Q13765-1 ]

    Organism-specific databases

    CTDi 4666.
    GeneCardsi GC12M057106.
    H-InvDB HIX0034277.
    HGNCi HGNC:7629. NACA.
    MIMi 601234. gene.
    neXtProti NX_Q13765.
    PharmGKBi PA31433.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1308.
    HOVERGENi HBG082004.
    KOi K03626.
    OrthoDBi EOG7RNK24.
    PhylomeDBi Q13765.
    TreeFami TF313348.

    Miscellaneous databases

    ChiTaRSi NACA. human.
    EvolutionaryTracei Q13765.
    GeneWikii NACA_(gene).
    GenomeRNAii 4666.
    NextBioi 17982.
    PROi Q13765.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13765.
    Bgeei Q13765.
    CleanExi HS_NACA.
    Genevestigatori Q13765.

    Family and domain databases

    InterProi IPR016641. EGD2/NACA.
    IPR002715. Nas_poly-pep-assoc_cplx_dom.
    [Graphical view ]
    PANTHERi PTHR21713. PTHR21713. 1 hit.
    Pfami PF01849. NAC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015901. NAC_alpha. 1 hit.
    PROSITEi PS51151. NAC_AB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library."
      Behrends U., Jandl T., Golbeck A., Lechner B., Mueller-Weihrich S., Schmid I., Till H., Berthold F., Voltz R., Mautner J.M.
      Int. J. Cancer 100:669-677(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Neuroblastoma.
    2. "Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides."
      Al-Shanti N., Steward C.G., Garland R.J., Rowbottom A.W.
      Immunology 112:397-403(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Nascent polypeptide-associate complex (NAC): a novel type of polypeptide binding protein."
      Sakai H., Chew C., Wang S., Wiedmann B., Geromanos S., Tempst P., Wiedmann M.
      Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum and Synovium.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Cervix.
    11. "A new spermatogenesis-related gene."
      Yuan L.G., Tian Y.Q., Qiao Y., Miao S.Y., Wang L.F.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-173 (ISOFORM 1).
      Tissue: Testis.
    12. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 101-142 AND 180-192, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    13. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 101-142; 145-192 AND 201-215, PHOSPHORYLATION AT SER-166, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    14. "Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients."
      Natter S., Seiberler S., Hufnagl P., Binder B.R., Hirschl A.M., Ring J., Abeck D., Schmidt T., Valent P., Valenta R.
      FASEB J. 12:1559-1569(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALLERGEN.
    15. "Unregulated exposure of the ribosomal M-site caused by NAC depletion results in delivery of non-secretory polypeptides to the Sec61 complex."
      Moeller I., Beatrix B., Kreibich G., Sakai H., Lauring B., Wiedmann M.
      FEBS Lett. 441:1-5(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. "The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions."
      Beatrix B., Sakai H., Wiedmann M.
      J. Biol. Chem. 275:37838-37845(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BTF3, ASSOCIATION WITH RIBOSOMES, SUBCELLULAR LOCATION.
    17. "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function."
      Stilo R., Liguoro D., di Jeso B., Leonardi A., Vito P.
      Biochem. Biophys. Res. Commun. 303:1034-1041(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FADD.
    18. "Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas."
      Papachristou D.J., Batistatou A., Sykiotis G.P., Varakis I., Papavassiliou A.G.
      Bone 32:364-371(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, POSSIBLE INVOLVEMENT IN OSTEOSARCOMA.
    19. "Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency."
      Quelo I., Gauthier C., Hannigan G.E., Dedhar S., St-Arnaud R.
      J. Biol. Chem. 279:43893-43899(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-43, SUBCELLULAR LOCATION.
    20. Cited for: FUNCTION.
    21. "Emergence of young human genes after a burst of retroposition in primates."
      Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
      PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    22. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    23. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    24. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    25. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161; SER-166 AND SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    26. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    27. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    28. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    29. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186; SER-191 AND SER-203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    30. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    31. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    32. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    33. "The crystal structure of the human nascent polypeptide-associated complex domain reveals a nucleic acid-binding region on the NACA subunit."
      Liu Y., Hu Y., Li X., Niu L., Teng M.
      Biochemistry 49:2890-2896(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 84-136, SUBUNIT, DNA/RNA-BINDING REGION, SUBCELLULAR LOCATION.
    34. "Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit."
      Wang L., Zhang W., Wang L., Zhang X.C., Li X., Rao Z.
      Protein Cell 1:406-416(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 79-132, SUBUNIT.

    Entry informationi

    Entry nameiNACA_HUMAN
    AccessioniPrimary (citable) accession number: Q13765
    Secondary accession number(s): A8MTN7
    , B2R4P8, F8VU71, Q3KQV4, Q53A18, Q53G46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3