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Q13740

- CD166_HUMAN

UniProt

Q13740 - CD166_HUMAN

Protein

CD166 antigen

Gene

ALCAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. cell adhesion Source: ProtInc
    3. motor neuron axon guidance Source: Ensembl
    4. signal transduction Source: ProtInc

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_22205. L1CAM interactions.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD166 antigen
    Alternative name(s):
    Activated leukocyte cell adhesion molecule
    CD_antigen: CD166
    Gene namesi
    Name:ALCAM
    Synonyms:MEMD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:400. ALCAM.

    Subcellular locationi

    Isoform 3 : Secreted 1 Publication

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. external side of plasma membrane Source: Ensembl
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of membrane Source: UniProtKB-KW
    5. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24691.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 583556CD166 antigenPRO_0000014659Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 113PROSITE-ProRule annotation
    Glycosylationi91 – 911N-linked (GlcNAc...)2 Publications
    Glycosylationi95 – 951N-linked (GlcNAc...)2 Publications
    Disulfide bondi157 ↔ 220PROSITE-ProRule annotation
    Glycosylationi167 – 1671N-linked (GlcNAc...)1 Publication
    Glycosylationi265 – 2651N-linked (GlcNAc...)1 Publication
    Disulfide bondi270 ↔ 313PROSITE-ProRule annotation
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi354 ↔ 392PROSITE-ProRule annotation
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi435 ↔ 485PROSITE-ProRule annotation
    Glycosylationi457 – 4571N-linked (GlcNAc...)2 Publications
    Glycosylationi466 – 4661N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi480 – 4801N-linked (GlcNAc...)2 Publications
    Glycosylationi499 – 4991N-linked (GlcNAc...)2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ13740.
    PaxDbiQ13740.
    PRIDEiQ13740.

    PTM databases

    PhosphoSiteiQ13740.

    Miscellaneous databases

    PMAP-CutDBQ13740.

    Expressioni

    Tissue specificityi

    Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ13740.
    BgeeiQ13740.
    CleanExiHS_ALCAM.
    GenevestigatoriQ13740.

    Organism-specific databases

    HPAiCAB002148.
    HPA010926.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CD6P302032EBI-1188108,EBI-2873748
    LGALS1P093823EBI-1188108,EBI-1048875
    LGALS3P179313EBI-1188108,EBI-1170392

    Protein-protein interaction databases

    BioGridi106716. 4 interactions.
    IntActiQ13740. 5 interactions.
    STRINGi9606.ENSP00000305988.

    Structurei

    Secondary structure

    1
    583
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 446
    Beta strandi51 – 599
    Beta strandi65 – 717
    Beta strandi76 – 805
    Beta strandi86 – 905
    Beta strandi92 – 10211
    Beta strandi105 – 1073
    Beta strandi109 – 1179
    Beta strandi120 – 1234

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KJCmodel-A28-133[»]
    ProteinModelPortaliQ13740.
    SMRiQ13740. Positions 31-224, 376-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 527500ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini550 – 58334CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei528 – 54922HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 12093Ig-like V-type 1Add
    BLAST
    Domaini125 – 234110Ig-like V-type 2Add
    BLAST
    Domaini245 – 32884Ig-like C2-type 1Add
    BLAST
    Domaini333 – 40977Ig-like C2-type 2Add
    BLAST
    Domaini416 – 50186Ig-like C2-type 3Add
    BLAST

    Domaini

    The CD6 binding site is located in the N-terminal Ig-like domain.1 Publication

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148902.
    HOGENOMiHOG000070101.
    HOVERGENiHBG050847.
    InParanoidiQ13740.
    KOiK06547.
    OMAiDIYYPTE.
    OrthoDBiEOG74J97B.
    PhylomeDBiQ13740.
    TreeFamiTF321859.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13740-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN    50
    LMFGKWKYEK PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI 100
    SNARISDEKR FVCMLVTEDN VFEAPTIVKV FKQPSKPEIV SKALFLETEQ 150
    LKKLGDCISE DSYPDGNITW YRNGKVLHPL EGAVVIIFKK EMDPVTQLYT 200
    MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF DIYYPTEQVT 250
    IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL 300
    TDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL 350
    PVSCTISASR NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE 400
    GLKKRESLTL IVEGKPQIKM TKKTDPSGLS KTIICHVEGF PKPAIQWTIT 450
    GSGSVINQTE ESPYINGRYY SKIIISPEEN VTLTCTAENQ LERTVNSLNV 500
    SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA LVAGVVYWLY 550
    MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA 583
    Length:583
    Mass (Da):65,102
    Last modified:November 28, 2006 - v2
    Checksum:i68FEFD67C14B0C57
    GO
    Isoform 2 (identifier: Q13740-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         503-516: ISIPEHDEADEISD → N

    Show »
    Length:570
    Mass (Da):63,665
    Checksum:i4B61C53E7C61CACC
    GO
    Isoform 3 (identifier: Q13740-3) [UniParc]FASTAAdd to Basket

    Also known as: sALCAM

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: KQ → SK
         134-583: Missing.

    Note: Secreted form, inhibits isoform 1 homophilic interaction.

    Show »
    Length:133
    Mass (Da):15,109
    Checksum:iC7B35209EA8BFC35
    GO
    Isoform 4 (identifier: Q13740-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-191: Missing.
         244-330: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:305
    Mass (Da):33,878
    Checksum:iFB5F5FBB6D4E6DCC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti229 – 2291G → D.
    Corresponds to variant rs10933819 [ dbSNP | Ensembl ].
    VAR_029514
    Natural varianti258 – 2581N → S.
    Corresponds to variant rs1044240 [ dbSNP | Ensembl ].
    VAR_003907
    Natural varianti301 – 3011T → M.1 Publication
    Corresponds to variant rs1044243 [ dbSNP | Ensembl ].
    VAR_003908
    Natural varianti315 – 3151L → M.
    Corresponds to variant rs12629872 [ dbSNP | Ensembl ].
    VAR_029515
    Natural varianti352 – 3521V → M.
    Corresponds to variant rs2291375 [ dbSNP | Ensembl ].
    VAR_029516
    Natural varianti367 – 3671M → I.
    Corresponds to variant rs34926152 [ dbSNP | Ensembl ].
    VAR_049856

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 191191Missing in isoform 4. 1 PublicationVSP_053529Add
    BLAST
    Alternative sequencei132 – 1332KQ → SK in isoform 3. 2 PublicationsVSP_053530
    Alternative sequencei134 – 583450Missing in isoform 3. 2 PublicationsVSP_053531Add
    BLAST
    Alternative sequencei244 – 33087Missing in isoform 4. 1 PublicationVSP_053532Add
    BLAST
    Alternative sequencei503 – 51614ISIPE…DEISD → N in isoform 2. 2 PublicationsVSP_021797Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38608 mRNA. Translation: AAB59499.1.
    AY644765 mRNA. Translation: AAV28819.1.
    DQ486139 mRNA. Translation: ABF48405.1.
    DQ486140 mRNA. Translation: ABF48406.1.
    AK127617 mRNA. Translation: BAC87059.1.
    AK300362 mRNA. Translation: BAG62102.1.
    AK316113 mRNA. Translation: BAH14484.1.
    AC023602 Genomic DNA. No translation available.
    AC078806 Genomic DNA. No translation available.
    AC133476 Genomic DNA. No translation available.
    BC057809 mRNA. Translation: AAH57809.1.
    BC137096 mRNA. Translation: AAI37097.1.
    BC137097 mRNA. Translation: AAI37098.1.
    Y10183 mRNA. Translation: CAA71256.1.
    CCDSiCCDS33810.1. [Q13740-1]
    CCDS58841.1. [Q13740-2]
    PIRiI39428.
    RefSeqiNP_001230209.1. NM_001243280.1. [Q13740-2]
    NP_001230212.1. NM_001243283.1. [Q13740-3]
    NP_001618.2. NM_001627.3. [Q13740-1]
    UniGeneiHs.591293.
    Hs.740441.

    Genome annotation databases

    EnsembliENST00000306107; ENSP00000305988; ENSG00000170017. [Q13740-1]
    ENST00000472644; ENSP00000419236; ENSG00000170017. [Q13740-2]
    GeneIDi214.
    KEGGihsa:214.
    UCSCiuc003dvv.3. human.
    uc003dvw.2. human. [Q13740-1]
    uc003dvy.3. human.

    Polymorphism databases

    DMDMi118572629.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38608 mRNA. Translation: AAB59499.1 .
    AY644765 mRNA. Translation: AAV28819.1 .
    DQ486139 mRNA. Translation: ABF48405.1 .
    DQ486140 mRNA. Translation: ABF48406.1 .
    AK127617 mRNA. Translation: BAC87059.1 .
    AK300362 mRNA. Translation: BAG62102.1 .
    AK316113 mRNA. Translation: BAH14484.1 .
    AC023602 Genomic DNA. No translation available.
    AC078806 Genomic DNA. No translation available.
    AC133476 Genomic DNA. No translation available.
    BC057809 mRNA. Translation: AAH57809.1 .
    BC137096 mRNA. Translation: AAI37097.1 .
    BC137097 mRNA. Translation: AAI37098.1 .
    Y10183 mRNA. Translation: CAA71256.1 .
    CCDSi CCDS33810.1. [Q13740-1 ]
    CCDS58841.1. [Q13740-2 ]
    PIRi I39428.
    RefSeqi NP_001230209.1. NM_001243280.1. [Q13740-2 ]
    NP_001230212.1. NM_001243283.1. [Q13740-3 ]
    NP_001618.2. NM_001627.3. [Q13740-1 ]
    UniGenei Hs.591293.
    Hs.740441.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KJC model - A 28-133 [» ]
    ProteinModelPortali Q13740.
    SMRi Q13740. Positions 31-224, 376-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106716. 4 interactions.
    IntActi Q13740. 5 interactions.
    STRINGi 9606.ENSP00000305988.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q13740.

    Polymorphism databases

    DMDMi 118572629.

    Proteomic databases

    MaxQBi Q13740.
    PaxDbi Q13740.
    PRIDEi Q13740.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306107 ; ENSP00000305988 ; ENSG00000170017 . [Q13740-1 ]
    ENST00000472644 ; ENSP00000419236 ; ENSG00000170017 . [Q13740-2 ]
    GeneIDi 214.
    KEGGi hsa:214.
    UCSCi uc003dvv.3. human.
    uc003dvw.2. human. [Q13740-1 ]
    uc003dvy.3. human.

    Organism-specific databases

    CTDi 214.
    GeneCardsi GC03P105085.
    HGNCi HGNC:400. ALCAM.
    HPAi CAB002148.
    HPA010926.
    MIMi 601662. gene.
    neXtProti NX_Q13740.
    PharmGKBi PA24691.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148902.
    HOGENOMi HOG000070101.
    HOVERGENi HBG050847.
    InParanoidi Q13740.
    KOi K06547.
    OMAi DIYYPTE.
    OrthoDBi EOG74J97B.
    PhylomeDBi Q13740.
    TreeFami TF321859.

    Enzyme and pathway databases

    Reactomei REACT_22205. L1CAM interactions.

    Miscellaneous databases

    ChiTaRSi ALCAM. human.
    GeneWikii ALCAM.
    GenomeRNAii 214.
    NextBioi 866.
    PMAP-CutDB Q13740.
    PROi Q13740.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13740.
    Bgeei Q13740.
    CleanExi HS_ALCAM.
    Genevestigatori Q13740.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand."
      Bowen M.A., Patel D.D., Li X., Modrell B., Malacko A.R., Wang W.-C., Marquardt H., Neubauer M., Pesando J.M., Francke U., Haynes B.F., Aruffo A.
      J. Exp. Med. 181:2213-2220(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-301, PARTIAL PROTEIN SEQUENCE.
    2. "Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function."
      Ikeda K., Quertermous T.
      J. Biol. Chem. 279:55315-55323(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION (ISOFORM 3).
    3. "A novel alternatively spliced variant of activated leukocyte cell adhesion molecule (ALCAM/CD166) resulting from a deletion in the extracellular membrane proximal stem."
      Abe Y., Bui-Thanh N.-A., Smith C.W., Ballantyne C.M., Burns A.R.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Lung and Placenta.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain and Lung.
    7. "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule)."
      Degen W.G., van Kempen L.C., Gijzen E.G., van Groningen J.J., van Kooyk Y., Bloemers H.P.J., Swart G.W.
      Am. J. Pathol. 152:805-813(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-583 (ISOFORM 1), TISSUE SPECIFICITY.
    8. "Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM."
      Skonier J.E., Bowen M.A., Emswiler J., Aruffo A., Bajorath J.
      Biochemistry 35:12287-12291(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN CD6 BINDING.
    9. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-91; ASN-167; ASN-480 AND ASN-499.
    10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-95; ASN-265 AND ASN-499.
      Tissue: Plasma.
    11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91; ASN-95; ASN-457 AND ASN-480.
      Tissue: Liver.
    12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-457 AND ASN-466.
      Tissue: Leukemic T-cell.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM."
      Bajorath J., Bowen M.A., Aruffo A.
      Protein Sci. 4:1644-1647(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 28-133.

    Entry informationi

    Entry nameiCD166_HUMAN
    AccessioniPrimary (citable) accession number: Q13740
    Secondary accession number(s): B2RNS3
    , B4DTU0, O60892, Q1HGM8, Q1HGM9, Q6PEY4, Q6ZS95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3