Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q13733

- AT1A4_HUMAN

UniProt

Q13733 - AT1A4_HUMAN

Protein

Sodium/potassium-transporting ATPase subunit alpha-4

Gene

ATP1A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 3 (10 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Enzyme regulationi

    Specifically inhibited by an endogenous cardiac glycoside, ouabain.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei384 – 38414-aspartylphosphate intermediateBy similarity
    Metal bindingi723 – 7231MagnesiumBy similarity
    Metal bindingi727 – 7271MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro
    2. ATP hydrolysis coupled proton transport Source: UniProtKB
    3. fertilization Source: Ensembl
    4. ion transmembrane transport Source: Reactome
    5. potassium ion transport Source: UniProtKB
    6. regulation of cellular pH Source: UniProtKB
    7. regulation of membrane potential Source: Ensembl
    8. sodium ion transmembrane transport Source: GOC
    9. sodium ion transport Source: UniProtKB
    10. spermatogenesis Source: Ensembl
    11. sperm motility Source: UniProtKB
    12. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_25149. Ion transport by P-type ATPases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-4 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-4 subunit
    Alternative name(s):
    Sodium pump subunit alpha-4
    Gene namesi
    Name:ATP1A4
    Synonyms:ATP1AL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14073. ATP1A4.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: In mature sperm, located in the principle piece of the sperm flagellum.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome
    3. sodium:potassium-exchanging ATPase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA65.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10291029Sodium/potassium-transporting ATPase subunit alpha-4PRO_0000046303Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei949 – 9491Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ13733.
    PaxDbiQ13733.
    PRIDEiQ13733.

    PTM databases

    PhosphoSiteiQ13733.

    Expressioni

    Tissue specificityi

    Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level).

    Gene expression databases

    ArrayExpressiQ13733.
    BgeeiQ13733.
    CleanExiHS_ATP1A4.
    GenevestigatoriQ13733.

    Organism-specific databases

    HPAiCAB033628.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Protein-protein interaction databases

    BioGridi106970. 4 interactions.
    STRINGi9606.ENSP00000357060.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13733.
    SMRiQ13733. Positions 38-1029.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9595CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini117 – 13923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini161 – 296136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini317 – 32812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini347 – 778432CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini799 – 80810ExtracellularSequence Analysis
    Topological domaini830 – 84920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini873 – 92452ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini945 – 95713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini977 – 99115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1013 – 102917CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34618HelicalSequence AnalysisAdd
    BLAST
    Transmembranei779 – 79820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei809 – 82921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei850 – 87223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei925 – 94420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei958 – 97619HelicalSequence AnalysisAdd
    BLAST
    Transmembranei992 – 101221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni90 – 923Interaction with phosphoinositide-3 kinaseBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOVERGENiHBG004298.
    InParanoidiQ13733.
    KOiK01539.
    OMAiKSSDTWF.
    OrthoDBiEOG7327N0.
    PhylomeDBiQ13733.
    TreeFamiTF312838.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13733-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLWGKKGTV APHDQSPRRR PKKGLIKKKM VKREKQKRNM EELKKEVVMD     50
    DHKLTLEELS TKYSVDLTKG HSHQRAKEIL TRGGPNTVTP PPTTPEWVKF 100
    CKQLFGGFSL LLWTGAILCF VAYSIQIYFN EEPTKDNLYL SIVLSVVVIV 150
    TGCFSYYQEA KSSKIMESFK NMVPQQALVI RGGEKMQINV QEVVLGDLVE 200
    IKGGDRVPAD LRLISAQGCK VDNSSLTGES EPQSRSPDFT HENPLETRNI 250
    CFFSTNCVEG TARGIVIATG DSTVMGRIAS LTSGLAVGQT PIAAEIEHFI 300
    HLITVVAVFL GVTFFALSLL LGYGWLEAII FLIGIIVANV PEGLLATVTV 350
    CLTLTAKRMA RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW 400
    FDMTVYEADT TEEQTGKTFT KSSDTWFMLA RIAGLCNRAD FKANQEILPI 450
    AKRATTGDAS ESALLKFIEQ SYSSVAEMRE KNPKVAEIPF NSTNKYQMSI 500
    HLREDSSQTH VLMMKGAPER ILEFCSTFLL NGQEYSMNDE MKEAFQNAYL 550
    ELGGLGERVL GFCFLNLPSS FSKGFPFNTD EINFPMDNLC FVGLISMIDP 600
    PRAAVPDAVS KCRSAGIKVI MVTGDHPITA KAIAKGVGII SEGTETAEEV 650
    AARLKIPISK VDASAAKAIV VHGAELKDIQ SKQLDQILQN HPEIVFARTS 700
    PQQKLIIVEG CQRLGAVVAV TGDGVNDSPA LKKADIGIAM GISGSDVSKQ 750
    AADMILLDDN FASIVTGVEE GRLIFDNLKK SIMYTLTSNI PEITPFLMFI 800
    ILGIPLPLGT ITILCIDLGT DMVPAISLAY ESAESDIMKR LPRNPKTDNL 850
    VNHRLIGMAY GQIGMIQALA GFFTYFVILA ENGFRPVDLL GIRLHWEDKY 900
    LNDLEDSYGQ QWTYEQRKVV EFTCQTAFFV TIVVVQWADL IISKTRRNSL 950
    FQQGMRNKVL IFGILEETLL AAFLSYTPGM DVALRMYPLK ITWWLCAIPY 1000
    SILIFVYDEI RKLLIRQHPD GWVERETYY 1029
    Length:1,029
    Mass (Da):114,166
    Last modified:October 10, 2002 - v3
    Checksum:i69958248424D2C0B
    GO
    Isoform 2 (identifier: Q13733-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-864: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:165
    Mass (Da):19,609
    Checksum:i5789093F12A8AC94
    GO

    Sequence cautioni

    The sequence AAQ07964.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC05228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti155 – 1551S → W in AAA60941. (PubMed:7809153)Curated
    Sequence conflicti991 – 101727ITWWL…LLIRQ → WSFALTAQAGVKWRILGLLQ PLPPRFK in BAC05228. (PubMed:14702039)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831G → D.1 Publication
    Corresponds to variant rs6427504 [ dbSNP | Ensembl ].
    VAR_048375
    Natural varianti297 – 2971E → K.
    Corresponds to variant rs17368402 [ dbSNP | Ensembl ].
    VAR_048376
    Natural varianti541 – 5411M → R.
    Corresponds to variant rs16831482 [ dbSNP | Ensembl ].
    VAR_048377
    Natural varianti586 – 5861M → I.
    Corresponds to variant rs7528360 [ dbSNP | Ensembl ].
    VAR_048378

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 864864Missing in isoform 2. 1 PublicationVSP_007364Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF506797 mRNA. Translation: AAQ07964.1. Different initiation.
    AL121987 Genomic DNA. Translation: CAI15274.1.
    AF421887 Genomic DNA. Translation: AAL35818.1.
    AF310646
    , AF430843, AF390027, AY039031 Genomic DNA. Translation: AAK72396.2.
    AF459737 mRNA. Translation: AAL66357.1.
    AF352828 Genomic DNA. Translation: AAM20793.1.
    AH002997 Genomic DNA. Translation: AAA60941.1.
    AK098076 mRNA. Translation: BAC05228.1. Different initiation.
    BC028297 mRNA. Translation: AAH28297.1.
    BC094801 mRNA. Translation: AAH94801.1.
    CCDSiCCDS1197.1. [Q13733-1]
    CCDS44255.1. [Q13733-2]
    RefSeqiNP_001001734.1. NM_001001734.1. [Q13733-2]
    NP_653300.2. NM_144699.3. [Q13733-1]
    UniGeneiHs.662219.

    Genome annotation databases

    EnsembliENST00000368081; ENSP00000357060; ENSG00000132681. [Q13733-1]
    ENST00000470705; ENSP00000433094; ENSG00000132681. [Q13733-2]
    GeneIDi480.
    KEGGihsa:480.
    UCSCiuc001fve.4. human. [Q13733-1]
    uc001fvh.3. human. [Q13733-2]

    Polymorphism databases

    DMDMi23830899.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF506797 mRNA. Translation: AAQ07964.1 . Different initiation.
    AL121987 Genomic DNA. Translation: CAI15274.1 .
    AF421887 Genomic DNA. Translation: AAL35818.1 .
    AF310646
    , AF430843 , AF390027 , AY039031 Genomic DNA. Translation: AAK72396.2 .
    AF459737 mRNA. Translation: AAL66357.1 .
    AF352828 Genomic DNA. Translation: AAM20793.1 .
    AH002997 Genomic DNA. Translation: AAA60941.1 .
    AK098076 mRNA. Translation: BAC05228.1 . Different initiation.
    BC028297 mRNA. Translation: AAH28297.1 .
    BC094801 mRNA. Translation: AAH94801.1 .
    CCDSi CCDS1197.1. [Q13733-1 ]
    CCDS44255.1. [Q13733-2 ]
    RefSeqi NP_001001734.1. NM_001001734.1. [Q13733-2 ]
    NP_653300.2. NM_144699.3. [Q13733-1 ]
    UniGenei Hs.662219.

    3D structure databases

    ProteinModelPortali Q13733.
    SMRi Q13733. Positions 38-1029.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106970. 4 interactions.
    STRINGi 9606.ENSP00000357060.

    Chemistry

    BindingDBi Q13733.
    ChEMBLi CHEMBL2095186.

    PTM databases

    PhosphoSitei Q13733.

    Polymorphism databases

    DMDMi 23830899.

    Proteomic databases

    MaxQBi Q13733.
    PaxDbi Q13733.
    PRIDEi Q13733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368081 ; ENSP00000357060 ; ENSG00000132681 . [Q13733-1 ]
    ENST00000470705 ; ENSP00000433094 ; ENSG00000132681 . [Q13733-2 ]
    GeneIDi 480.
    KEGGi hsa:480.
    UCSCi uc001fve.4. human. [Q13733-1 ]
    uc001fvh.3. human. [Q13733-2 ]

    Organism-specific databases

    CTDi 480.
    GeneCardsi GC01P160121.
    HGNCi HGNC:14073. ATP1A4.
    HPAi CAB033628.
    MIMi 607321. gene.
    neXtProti NX_Q13733.
    PharmGKBi PA65.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOVERGENi HBG004298.
    InParanoidi Q13733.
    KOi K01539.
    OMAi KSSDTWF.
    OrthoDBi EOG7327N0.
    PhylomeDBi Q13733.
    TreeFami TF312838.

    Enzyme and pathway databases

    Reactomei REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    ChiTaRSi ATP1A4. human.
    GeneWikii ATP1A4.
    GenomeRNAii 480.
    NextBioi 1989.
    PROi Q13733.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13733.
    Bgeei Q13733.
    CleanExi HS_ATP1A4.
    Genevestigatori Q13733.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm."
      Hlivko J.T., Chakraborty S., Hlivko T.J., Sengupta A., James P.F.
      Mol. Reprod. Dev. 73:101-115(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, ENZYME REGULATION.
      Tissue: Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis and Urinary bladder.
    4. "Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4."
      Keryanov S., Gardner K.L.
      Gene 292:151-166(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69 AND 138-1029 (ISOFORM 1).
    5. "A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis."
      Shamraj O.I., Lingrel J.B.
      Proc. Natl. Acad. Sci. U.S.A. 91:12952-12956(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-220 (ISOFORM 1), VARIANT ASP-83.
      Tissue: Testis.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1017 (ISOFORM 1).
      Tissue: Trachea.

    Entry informationi

    Entry nameiAT1A4_HUMAN
    AccessioniPrimary (citable) accession number: Q13733
    Secondary accession number(s): Q504T2
    , Q7Z4I9, Q8TBN8, Q8WXA7, Q8WXH7, Q8WY13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 140 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3