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Q13685

- AAMP_HUMAN

UniProt

Q13685 - AAMP_HUMAN

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Protein

Angio-associated migratory cell protein

Gene

AAMP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.2 Publications

GO - Molecular functioni

  1. heparin binding Source: ProtInc

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. cell differentiation Source: UniProtKB-KW
  3. positive regulation of endothelial cell migration Source: UniProtKB
  4. smooth muscle cell migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

SignaLinkiQ13685.

Names & Taxonomyi

Protein namesi
Recommended name:
Angio-associated migratory cell protein
Gene namesi
Name:AAMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:18. AAMP.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Angio-associated migratory cell proteinPRO_0000050832Add
BLAST

Proteomic databases

MaxQBiQ13685.
PaxDbiQ13685.
PRIDEiQ13685.

PTM databases

PhosphoSiteiQ13685.

Expressioni

Tissue specificityi

Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.2 Publications

Gene expression databases

BgeeiQ13685.
CleanExiHS_AAMP.
ExpressionAtlasiQ13685. baseline and differential.
GenevestigatoriQ13685.

Organism-specific databases

HPAiCAB017717.

Interactioni

Protein-protein interaction databases

BioGridi106532. 25 interactions.
IntActiQ13685. 6 interactions.
MINTiMINT-1418005.
STRINGi9606.ENSP00000248450.

Structurei

3D structure databases

ProteinModelPortaliQ13685.
SMRiQ13685. Positions 83-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati89 – 12941WD 1Add
BLAST
Repeati132 – 17140WD 2Add
BLAST
Repeati173 – 21240WD 3Add
BLAST
Repeati214 – 25441WD 4Add
BLAST
Repeati258 – 29942WD 5Add
BLAST
Repeati315 – 35440WD 6Add
BLAST
Repeati356 – 39540WD 7Add
BLAST
Repeati398 – 43336WD 8Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 597Poly-Glu

Sequence similaritiesi

Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119390.
HOGENOMiHOG000261676.
HOVERGENiHBG061307.
InParanoidiQ13685.
OrthoDBiEOG7R56T1.
PhylomeDBiQ13685.
TreeFamiTF314543.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13685 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV
60 70 80 90 100
DFEEEEEEEG NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD
110 120 130 140 150
PKTNTLAVTG GEDDKAFVWR LSDGELLFEC AGHKDSVTCA GFSHDSTLVA
160 170 180 190 200
TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM EWHPRAPVLL AGTADGNTWM
210 220 230 240 250
WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR IWDLKQGSPI
260 270 280 290 300
HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
310 320 330 340 350
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT
360 370 380 390 400
LRHQCQHQSG IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT
410 420 430
AEILDFALSK DASLVVTTSG DHKAKVFCVQ RPDR
Length:434
Mass (Da):46,751
Last modified:April 26, 2005 - v2
Checksum:iA7B8314442EBAF15
GO

Sequence cautioni

The sequence AAA68889.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAG33036.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti250 – 2501I → V.
Corresponds to variant rs2305835 [ dbSNP | Ensembl ].
VAR_037061

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95627 mRNA. Translation: AAA68889.1. Different initiation.
CR456755 mRNA. Translation: CAG33036.1. Different initiation.
BC008809 mRNA. Translation: AAH08809.2.
BC020244 mRNA. Translation: AAH20244.1.
BC039866 mRNA. Translation: AAH39866.2.
CCDSiCCDS33378.1.
PIRiI39383.
RefSeqiNP_001078.2. NM_001087.3.
UniGeneiHs.83347.

Genome annotation databases

EnsembliENST00000248450; ENSP00000248450; ENSG00000127837.
GeneIDi14.
KEGGihsa:14.
UCSCiuc002vhk.3. human.

Polymorphism databases

DMDMi62906874.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95627 mRNA. Translation: AAA68889.1 . Different initiation.
CR456755 mRNA. Translation: CAG33036.1 . Different initiation.
BC008809 mRNA. Translation: AAH08809.2 .
BC020244 mRNA. Translation: AAH20244.1 .
BC039866 mRNA. Translation: AAH39866.2 .
CCDSi CCDS33378.1.
PIRi I39383.
RefSeqi NP_001078.2. NM_001087.3.
UniGenei Hs.83347.

3D structure databases

ProteinModelPortali Q13685.
SMRi Q13685. Positions 83-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106532. 25 interactions.
IntActi Q13685. 6 interactions.
MINTi MINT-1418005.
STRINGi 9606.ENSP00000248450.

PTM databases

PhosphoSitei Q13685.

Polymorphism databases

DMDMi 62906874.

Proteomic databases

MaxQBi Q13685.
PaxDbi Q13685.
PRIDEi Q13685.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248450 ; ENSP00000248450 ; ENSG00000127837 .
GeneIDi 14.
KEGGi hsa:14.
UCSCi uc002vhk.3. human.

Organism-specific databases

CTDi 14.
GeneCardsi GC02M219092.
HGNCi HGNC:18. AAMP.
HPAi CAB017717.
MIMi 603488. gene.
neXtProti NX_Q13685.
PharmGKBi PA24365.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119390.
HOGENOMi HOG000261676.
HOVERGENi HBG061307.
InParanoidi Q13685.
OrthoDBi EOG7R56T1.
PhylomeDBi Q13685.
TreeFami TF314543.

Enzyme and pathway databases

SignaLinki Q13685.

Miscellaneous databases

ChiTaRSi AAMP. human.
GeneWikii AAMP_(gene).
GenomeRNAii 14.
NextBioi 31.
PROi Q13685.
SOURCEi Search...

Gene expression databases

Bgeei Q13685.
CleanExi HS_AAMP.
ExpressionAtlasi Q13685. baseline and differential.
Genevestigatori Q13685.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 6 hits.
[Graphical view ]
SMARTi SM00320. WD40. 8 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence."
    Beckner M.E., Krutzsch H.C., Stracke M.L., Williams S.T., Gallardo J.A., Liotta L.A.
    Cancer Res. 55:2140-2149(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Skin.
  4. "Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells."
    Beckner M.E., Peterson V.A., Moul D.E.
    Microvasc. Res. 57:347-352(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis."
    Vogt F., Zernecke A., Beckner M., Krott N., Bosserhoff A.-K., Hoffmann R., Zandvoort M.A.M.J., Jahnke T., Kelm M., Weber C., Blindt R.
    J. Am. Coll. Cardiol. 52:302-311(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAAMP_HUMAN
AccessioniPrimary (citable) accession number: Q13685
Secondary accession number(s): Q8WUJ9, Q96H92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3