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Q13685

- AAMP_HUMAN

UniProt

Q13685 - AAMP_HUMAN

Protein

Angio-associated migratory cell protein

Gene

AAMP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.2 Publications

    GO - Molecular functioni

    1. heparin binding Source: ProtInc

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. cell differentiation Source: UniProtKB-KW
    3. positive regulation of endothelial cell migration Source: UniProtKB
    4. smooth muscle cell migration Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Enzyme and pathway databases

    SignaLinkiQ13685.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angio-associated migratory cell protein
    Gene namesi
    Name:AAMP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:18. AAMP.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. cytoplasm Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24365.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Angio-associated migratory cell proteinPRO_0000050832Add
    BLAST

    Proteomic databases

    MaxQBiQ13685.
    PaxDbiQ13685.
    PRIDEiQ13685.

    PTM databases

    PhosphoSiteiQ13685.

    Expressioni

    Tissue specificityi

    Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.2 Publications

    Gene expression databases

    ArrayExpressiQ13685.
    BgeeiQ13685.
    CleanExiHS_AAMP.
    GenevestigatoriQ13685.

    Organism-specific databases

    HPAiCAB017717.

    Interactioni

    Protein-protein interaction databases

    BioGridi106532. 15 interactions.
    IntActiQ13685. 6 interactions.
    MINTiMINT-1418005.
    STRINGi9606.ENSP00000248450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13685.
    SMRiQ13685. Positions 86-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati89 – 12941WD 1Add
    BLAST
    Repeati132 – 17140WD 2Add
    BLAST
    Repeati173 – 21240WD 3Add
    BLAST
    Repeati214 – 25441WD 4Add
    BLAST
    Repeati258 – 29942WD 5Add
    BLAST
    Repeati315 – 35440WD 6Add
    BLAST
    Repeati356 – 39540WD 7Add
    BLAST
    Repeati398 – 43336WD 8Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi53 – 597Poly-Glu

    Sequence similaritiesi

    Contains 8 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000261676.
    HOVERGENiHBG061307.
    InParanoidiQ13685.
    OrthoDBiEOG7R56T1.
    PhylomeDBiQ13685.
    TreeFamiTF314543.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 6 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 8 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13685-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV    50
    DFEEEEEEEG NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD 100
    PKTNTLAVTG GEDDKAFVWR LSDGELLFEC AGHKDSVTCA GFSHDSTLVA 150
    TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM EWHPRAPVLL AGTADGNTWM 200
    WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR IWDLKQGSPI 250
    HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 300
    ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT 350
    LRHQCQHQSG IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT 400
    AEILDFALSK DASLVVTTSG DHKAKVFCVQ RPDR 434
    Length:434
    Mass (Da):46,751
    Last modified:April 26, 2005 - v2
    Checksum:iA7B8314442EBAF15
    GO

    Sequence cautioni

    The sequence AAA68889.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAG33036.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti250 – 2501I → V.
    Corresponds to variant rs2305835 [ dbSNP | Ensembl ].
    VAR_037061

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95627 mRNA. Translation: AAA68889.1. Different initiation.
    CR456755 mRNA. Translation: CAG33036.1. Different initiation.
    BC008809 mRNA. Translation: AAH08809.2.
    BC020244 mRNA. Translation: AAH20244.1.
    BC039866 mRNA. Translation: AAH39866.2.
    CCDSiCCDS33378.1.
    PIRiI39383.
    RefSeqiNP_001078.2. NM_001087.3.
    UniGeneiHs.83347.

    Genome annotation databases

    EnsembliENST00000248450; ENSP00000248450; ENSG00000127837.
    GeneIDi14.
    KEGGihsa:14.
    UCSCiuc002vhk.3. human.

    Polymorphism databases

    DMDMi62906874.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95627 mRNA. Translation: AAA68889.1 . Different initiation.
    CR456755 mRNA. Translation: CAG33036.1 . Different initiation.
    BC008809 mRNA. Translation: AAH08809.2 .
    BC020244 mRNA. Translation: AAH20244.1 .
    BC039866 mRNA. Translation: AAH39866.2 .
    CCDSi CCDS33378.1.
    PIRi I39383.
    RefSeqi NP_001078.2. NM_001087.3.
    UniGenei Hs.83347.

    3D structure databases

    ProteinModelPortali Q13685.
    SMRi Q13685. Positions 86-427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106532. 15 interactions.
    IntActi Q13685. 6 interactions.
    MINTi MINT-1418005.
    STRINGi 9606.ENSP00000248450.

    PTM databases

    PhosphoSitei Q13685.

    Polymorphism databases

    DMDMi 62906874.

    Proteomic databases

    MaxQBi Q13685.
    PaxDbi Q13685.
    PRIDEi Q13685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248450 ; ENSP00000248450 ; ENSG00000127837 .
    GeneIDi 14.
    KEGGi hsa:14.
    UCSCi uc002vhk.3. human.

    Organism-specific databases

    CTDi 14.
    GeneCardsi GC02M219092.
    HGNCi HGNC:18. AAMP.
    HPAi CAB017717.
    MIMi 603488. gene.
    neXtProti NX_Q13685.
    PharmGKBi PA24365.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000261676.
    HOVERGENi HBG061307.
    InParanoidi Q13685.
    OrthoDBi EOG7R56T1.
    PhylomeDBi Q13685.
    TreeFami TF314543.

    Enzyme and pathway databases

    SignaLinki Q13685.

    Miscellaneous databases

    ChiTaRSi AAMP. human.
    GeneWikii AAMP_(gene).
    GenomeRNAii 14.
    NextBioi 31.
    PROi Q13685.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13685.
    Bgeei Q13685.
    CleanExi HS_AAMP.
    Genevestigatori Q13685.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 6 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 8 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence."
      Beckner M.E., Krutzsch H.C., Stracke M.L., Williams S.T., Gallardo J.A., Liotta L.A.
      Cancer Res. 55:2140-2149(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary and Skin.
    4. "Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells."
      Beckner M.E., Peterson V.A., Moul D.E.
      Microvasc. Res. 57:347-352(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis."
      Vogt F., Zernecke A., Beckner M., Krott N., Bosserhoff A.-K., Hoffmann R., Zandvoort M.A.M.J., Jahnke T., Kelm M., Weber C., Blindt R.
      J. Am. Coll. Cardiol. 52:302-311(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAAMP_HUMAN
    AccessioniPrimary (citable) accession number: Q13685
    Secondary accession number(s): Q8WUJ9, Q96H92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3