Reviewed, UniProtKB/Swiss-Prot Q13685 (AAMP_HUMAN)

Names and origin

Protein names

Recommended name:
    Angio-associated migratory cell protein

Gene names

Name:

AAMP

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. Ref.4 Ref.5
Subcellular location	Cell membrane. Cytoplasm.
Tissue specificity	Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics. Ref.4 Ref.1
Sequence similarities	Contains 8 WD repeats.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Molecular function	Developmental protein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	angiogenesis Ref.4 Non-traceable author statement. Source: UniProtKB cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of endothelial cell migration Inferred from sequence or structural similarity. Source: UniProtKB smooth muscle cell migration Ref.5 Inferred from expression pattern. Source: UniProtKB
Cellular component	cell surface Ref.4 Inferred from direct assay. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heparin binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Angio-associated migratory cell protein		PRO_0000050832
Regions
	Repeat	89 – 129	41	WD 1
	Repeat	132 – 171	40	WD 2
	Repeat	173 – 212	40	WD 3
	Repeat	214 – 254	41	WD 4
	Repeat	258 – 299	42	WD 5
	Repeat	315 – 354	40	WD 6
	Repeat	356 – 395	40	WD 7
	Repeat	398 – 433	36	WD 8
	Compositional bias	53 – 59	7	Poly-Glu
Natural variations
	Natural variant	250	1	I → V: dbSNP rs2305835.		VAR_037061

Sequences

	Sequence		Length	Mass (Da)
	Q13685-1 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: A7B8314442EBAF15	FASTA	434	46,751
	10 20 30 40 50 60 MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG 70 80 90 100 110 120 NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR 130 140 150 160 170 180 LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM 190 200 210 220 230 240 EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR 250 260 270 280 290 300 IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 310 320 330 340 350 360 ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG 370 380 390 400 410 420 IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG 430 DHKAKVFCVQ RPDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence." Beckner M.E., Krutzsch H.C., Stracke M.L., Williams S.T., Gallardo J.A., Liotta L.A. Cancer Res. 55:2140-2149(1995) [PubMed: 7743515] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Skin.
[4]	"Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells." Beckner M.E., Peterson V.A., Moul D.E. Microvasc. Res. 57:347-352(1999) [PubMed: 10329261] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]	"Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis." Vogt F., Zernecke A., Beckner M., Krott N., Bosserhoff A.-K., Hoffmann R., Zandvoort M.A.M.J., Jahnke T., Kelm M., Weber C., Blindt R. J. Am. Coll. Cardiol. 52:302-311(2008) [PubMed: 18634987] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M95627 mRNA. Translation: AAA68889.1. Different initiation. CR456755 mRNA. Translation: CAG33036.1. Different initiation. BC008809 mRNA. Translation: AAH08809.2. BC020244 mRNA. Translation: AAH20244.1. BC039866 mRNA. Translation: AAH39866.2.
IPI	IPI00014481.
PIR	I39383.
RefSeq	NP_001078.2.
UniGene	Hs.83347
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13685. 1 interaction.
STRING	Q13685.
Proteomic databases
PRIDE	Q13685.
Genome annotation databases
Ensembl	ENST00000248450; ENSP00000248450; ENSG00000127837; Homo sapiens. [Genome view]
GeneID	14.
KEGG	hsa:14.
UCSC	uc002vhj.1. human.
Organism-specific databases
CTD	14.
GeneCards	GC02M218837.
HGNC	HGNC:18. AAMP.
HPA	CAB017717.
MIM	603488. gene.
PharmGKB	PA24365.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q13685.
HOVERGEN	Q13685.
Gene expression databases
ArrayExpress	Q13685.
Bgee	Q13685.
CleanEx	HS_AAMP.
Genevestigator	Q13685.
GermOnline	ENSG00000127837. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF00400. WD40. 6 hits. [Graphical view]
SMART	SM00320. WD40. 8 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	31.
SOURCE	Search...

Entry information

Entry name

AAMP_HUMAN

Accession

Primary (citable) accession number: Q13685
Secondary accession number(s): Q8WUJ9, Q96H92

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	April 26, 2005
Last modified:	November 24, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.