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Q13685 (AAMP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Angio-associated migratory cell protein
Gene names
Name:AAMP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. Ref.4 Ref.5

Subcellular location

Cell membrane. Cytoplasm Ref.4 Ref.5.

Tissue specificity

Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics. Ref.1 Ref.4

Sequence similarities

Contains 8 WD repeats.

Sequence caution

The sequence AAA68889.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAG33036.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Angio-associated migratory cell protein
PRO_0000050832

Regions

Repeat89 – 12941WD 1
Repeat132 – 17140WD 2
Repeat173 – 21240WD 3
Repeat214 – 25441WD 4
Repeat258 – 29942WD 5
Repeat315 – 35440WD 6
Repeat356 – 39540WD 7
Repeat398 – 43336WD 8
Compositional bias53 – 597Poly-Glu

Natural variations

Natural variant2501I → V.
Corresponds to variant rs2305835 [ dbSNP | Ensembl ].
VAR_037061

Sequences

Sequence LengthMass (Da)Tools
Q13685 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: A7B8314442EBAF15

FASTA43446,751
        10         20         30         40         50         60 
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG 

        70         80         90        100        110        120 
NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR 

       130        140        150        160        170        180 
LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM 

       190        200        210        220        230        240 
EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR 

       250        260        270        280        290        300 
IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 

       310        320        330        340        350        360 
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG 

       370        380        390        400        410        420 
IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG 

       430 
DHKAKVFCVQ RPDR 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence."
Beckner M.E., Krutzsch H.C., Stracke M.L., Williams S.T., Gallardo J.A., Liotta L.A.
Cancer Res. 55:2140-2149(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary and Skin.
[4]"Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells."
Beckner M.E., Peterson V.A., Moul D.E.
Microvasc. Res. 57:347-352(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]"Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis."
Vogt F., Zernecke A., Beckner M., Krott N., Bosserhoff A.-K., Hoffmann R., Zandvoort M.A.M.J., Jahnke T., Kelm M., Weber C., Blindt R.
J. Am. Coll. Cardiol. 52:302-311(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95627 mRNA. Translation: AAA68889.1. Different initiation.
CR456755 mRNA. Translation: CAG33036.1. Different initiation.
BC008809 mRNA. Translation: AAH08809.2.
BC020244 mRNA. Translation: AAH20244.1.
BC039866 mRNA. Translation: AAH39866.2.
CCDSCCDS33378.1.
PIRI39383.
RefSeqNP_001078.2. NM_001087.3.
UniGeneHs.83347.

3D structure databases

ProteinModelPortalQ13685.
SMRQ13685. Positions 86-427.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106532. 15 interactions.
IntActQ13685. 6 interactions.
MINTMINT-1418005.
STRING9606.ENSP00000248450.

PTM databases

PhosphoSiteQ13685.

Polymorphism databases

DMDM62906874.

Proteomic databases

MaxQBQ13685.
PaxDbQ13685.
PRIDEQ13685.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248450; ENSP00000248450; ENSG00000127837.
GeneID14.
KEGGhsa:14.
UCSCuc002vhk.3. human.

Organism-specific databases

CTD14.
GeneCardsGC02M219092.
HGNCHGNC:18. AAMP.
HPACAB017717.
MIM603488. gene.
neXtProtNX_Q13685.
PharmGKBPA24365.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000261676.
HOVERGENHBG061307.
InParanoidQ13685.
OrthoDBEOG7R56T1.
PhylomeDBQ13685.
TreeFamTF314543.

Enzyme and pathway databases

SignaLinkQ13685.

Gene expression databases

ArrayExpressQ13685.
BgeeQ13685.
CleanExHS_AAMP.
GenevestigatorQ13685.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 6 hits.
[Graphical view]
SMARTSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAAMP. human.
GeneWikiAAMP_(gene).
GenomeRNAi14.
NextBio31.
PROQ13685.
SOURCESearch...

Entry information

Entry nameAAMP_HUMAN
AccessionPrimary (citable) accession number: Q13685
Secondary accession number(s): Q8WUJ9, Q96H92
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM