Q13685 (AAMP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Angio-associated migratory cell protein

Gene names

Name:

AAMP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. Ref.4 Ref.5
Subcellular location	Cell membrane. Cytoplasm Ref.4 Ref.5.
Tissue specificity	Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics. Ref.1 Ref.4
Sequence similarities	Contains 8 WD repeats.
Sequence caution	The sequence AAA68889.1 differs from that shown. Reason: Erroneous initiation. The sequence CAG33036.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Molecular function	Developmental protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Non-traceable author statement Ref.4. Source: UniProtKB cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of endothelial cell migration Inferred from sequence or structural similarity. Source: UniProtKB smooth muscle cell migration Inferred from expression pattern Ref.5. Source: UniProtKB
Cellular_component	cell surface Inferred from direct assay Ref.4. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heparin binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Angio-associated migratory cell protein		PRO_0000050832
Regions
	Repeat	89 – 129	41	WD 1
	Repeat	132 – 171	40	WD 2
	Repeat	173 – 212	40	WD 3
	Repeat	214 – 254	41	WD 4
	Repeat	258 – 299	42	WD 5
	Repeat	315 – 354	40	WD 6
	Repeat	356 – 395	40	WD 7
	Repeat	398 – 433	36	WD 8
	Compositional bias	53 – 59	7	Poly-Glu
Natural variations
	Natural variant	250	1	I → V. Corresponds to variant rs2305835 [ dbSNP | Ensembl ].		VAR_037061

Sequences

	Sequence		Length	Mass (Da)
	Q13685 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: A7B8314442EBAF15	FASTA	434	46,751
	10 20 30 40 50 60 MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG 70 80 90 100 110 120 NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR 130 140 150 160 170 180 LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM 190 200 210 220 230 240 EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR 250 260 270 280 290 300 IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 310 320 330 340 350 360 ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG 370 380 390 400 410 420 IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG 430 DHKAKVFCVQ RPDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence." Beckner M.E., Krutzsch H.C., Stracke M.L., Williams S.T., Gallardo J.A., Liotta L.A. Cancer Res. 55:2140-2149(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Skin.
[4]	"Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells." Beckner M.E., Peterson V.A., Moul D.E. Microvasc. Res. 57:347-352(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]	"Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis." Vogt F., Zernecke A., Beckner M., Krott N., Bosserhoff A.-K., Hoffmann R., Zandvoort M.A.M.J., Jahnke T., Kelm M., Weber C., Blindt R. J. Am. Coll. Cardiol. 52:302-311(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	M95627 mRNA. Translation: AAA68889.1. Different initiation. CR456755 mRNA. Translation: CAG33036.1. Different initiation. BC008809 mRNA. Translation: AAH08809.2. BC020244 mRNA. Translation: AAH20244.1. BC039866 mRNA. Translation: AAH39866.2.
IPI	IPI00014481.
PIR	I39383.
RefSeq	NP_001078.2. NM_001087.3.
UniGene	Hs.83347.
3D structure databases
ProteinModelPortal	Q13685.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13685. 3 interactions.
MINT	MINT-1418005.
STRING	9606.ENSP00000248450.
PTM databases
PhosphoSite	Q13685.
Polymorphism databases
DMDM	62906874.
Proteomic databases
PaxDb	Q13685.
PRIDE	Q13685.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248450; ENSP00000248450; ENSG00000127837.
GeneID	14.
KEGG	hsa:14.
UCSC	uc002vhk.3. human.
Organism-specific databases
CTD	14.
GeneCards	GC02M219092.
HGNC	HGNC:18. AAMP.
HPA	CAB017717.
MIM	603488. gene.
neXtProt	NX_Q13685.
PharmGKB	PA24365.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000261676.
HOVERGEN	HBG061307.
InParanoid	Q13685.
OrthoDB	EOG4D26PX.
Enzyme and pathway databases
SignaLink	Q13685.
Gene expression databases
ArrayExpress	Q13685.
Bgee	Q13685.
CleanEx	HS_AAMP.
Genevestigator	Q13685.
GermOnline	ENSG00000127837. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 6 hits. [Graphical view]
SMART	SM00320. WD40. 8 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	AAMP. human.
GenomeRNAi	14.
NextBio	31.
SOURCE	Search...

Entry information

Entry name

AAMP_HUMAN

Accession

Primary (citable) accession number: Q13685
Secondary accession number(s): Q8WUJ9, Q96H92

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	April 26, 2005
Last modified:	May 29, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.