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Protein

Integrin alpha-7

Gene

ITGA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi372 – 380Sequence analysis9
Calcium bindingi434 – 442Sequence analysis9
Calcium bindingi492 – 500Sequence analysis9

GO - Molecular functioni

GO - Biological processi

  • cell-matrix adhesion Source: ProtInc
  • endodermal cell differentiation Source: UniProtKB
  • extracellular matrix organization Source: Reactome
  • heterotypic cell-cell adhesion Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • muscle organ development Source: ProtInc
  • regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Cell shape

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135424-MONOMER.
ReactomeiR-HSA-216083. Integrin cell surface interactions.
R-HSA-3000157. Laminin interactions.
R-HSA-3000178. ECM proteoglycans.
SignaLinkiQ13683.
SIGNORiQ13683.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-7
Cleaved into the following 3 chains:
Gene namesi
Name:ITGA7
ORF Names:UNQ406/PRO768
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6143. ITGA7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 1082ExtracellularSequence analysisAdd BLAST1049
Transmembranei1083 – 1103HelicalSequence analysisAdd BLAST21
Topological domaini1104 – 1181CytoplasmicSequence analysisAdd BLAST78

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integrin complex Source: InterPro
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures.
See also OMIM:613204

Keywords - Diseasei

Congenital muscular dystrophy

Organism-specific databases

DisGeNETi3679.
MalaCardsiITGA7.
MIMi613204. phenotype.
OpenTargetsiENSG00000135424.
Orphaneti2020. Congenital fiber-type disproportion myopathy.
34520. Congenital muscular dystrophy with integrin alpha-7 deficiency.
PharmGKBiPA29943.

Polymorphism and mutation databases

BioMutaiITGA7.
DMDMi308153592.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 332 PublicationsAdd BLAST33
ChainiPRO_000001626734 – 1181Integrin alpha-7Add BLAST1148
ChainiPRO_000001626834 – 955Integrin alpha-7 heavy chainSequence analysisAdd BLAST922
ChainiPRO_0000398833648 – 1181Integrin alpha-7 70 kDa formAdd BLAST534
ChainiPRO_0000016269959 – 1181Integrin alpha-7 light chainSequence analysisAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 103By similarity
Disulfide bondi140 ↔ 163By similarity
Disulfide bondi184 ↔ 197By similarity
Disulfide bondi539 ↔ 546By similarity
Disulfide bondi552 ↔ 615By similarity
Disulfide bondi681 ↔ 687By similarity
Disulfide bondi781 ↔ 792By similarity
Glycosylationi786N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi939 ↔ 994Interchain (between heavy and light chains)By similarity
Glycosylationi989N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1001 ↔ 1006By similarity
Glycosylationi1025N-linked (GlcNAc...)1 Publication1
Glycosylationi1045N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes.By similarity
A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei647 – 648Cleavage; by urokinase2

Keywords - PTMi

ADP-ribosylation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13683.
MaxQBiQ13683.
PaxDbiQ13683.
PeptideAtlasiQ13683.
PRIDEiQ13683.

PTM databases

iPTMnetiQ13683.
PhosphoSitePlusiQ13683.

Expressioni

Tissue specificityi

Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle.1 Publication

Developmental stagei

In renewing intestinal epithelium, expression of isoforms containing segment B correlates with the onset of enterocytic differentiation.

Gene expression databases

BgeeiENSG00000135424.
CleanExiHS_ITGA7.
ExpressionAtlasiQ13683. baseline and differential.
GenevisibleiQ13683. HS.

Organism-specific databases

HPAiHPA008427.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-7 associates with beta-1. Interacts with COMP (By similarity). Interacts (via C-terminus intracellular tail region) with CIB1; the interaction is stabilized/increased in a calcium- and magnesium-dependent manner.By similarity1 Publication

Protein-protein interaction databases

BioGridi109885. 28 interactors.
DIPiDIP-5981N.
IntActiQ13683. 1 interactor.
MINTiMINT-140160.
STRINGi9606.ENSP00000452120.

Structurei

3D structure databases

ProteinModelPortaliQ13683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 103FG-GAP 1PROSITE-ProRule annotationAdd BLAST69
Repeati110 – 175FG-GAP 2PROSITE-ProRule annotationAdd BLAST66
Repeati185 – 238FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati292 – 349FG-GAP 4PROSITE-ProRule annotationAdd BLAST58
Repeati350 – 411FG-GAP 5PROSITE-ProRule annotationAdd BLAST62
Repeati412 – 467FG-GAP 6PROSITE-ProRule annotationAdd BLAST56
Repeati471 – 530FG-GAP 7PROSITE-ProRule annotationAdd BLAST60
Repeati1157 – 116014
Repeati1165 – 116824
Repeati1173 – 117634

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1157 – 11763 X 4 AA repeats of D-X-H-PAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1107 – 1111GFFKR motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi953 – 958Poly-Arg6

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBB. Eukaryota.
ENOG410XVGZ. LUCA.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG108011.
InParanoidiQ13683.
KOiK06583.
OMAiHEVFIAP.
OrthoDBiEOG091G012D.
PhylomeDBiQ13683.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. There is a combination of at least five alternatively spliced domains, three extracellular (X1, X2 and D) and two cytoplasmic (A and B). A third potential alternatively spliced cytoplasmic domain (C) does not appear to be expressed.
Isoform Alpha-7X1X2B (identifier: Q13683-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS
60 70 80 90 100
LFGFSVALHR QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE
110 120 130 140 150
TDCYRVDIDQ GADMQKESKE NQWLGVSVRS QGPGGKIVTC AHRYEARQRV
160 170 180 190 200
DQILETRDMI GRCFVLSQDL AIRDELDGGE WKFCEGRPQG HEQFGFCQQG
210 220 230 240 250
TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH LDDGPYEAGG
260 270 280 290 300
EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD
310 320 330 340 350
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV
360 370 380 390 400
PEVMLSGERL TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY
410 420 430 440 450
VYLNQGGHWA GISPLRLCGS PDSMFGISLA VLGDLNQDGF PDIAVGAPFD
460 470 480 490 500
GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI KSFGYSLSGS LDMDGNQYPD
510 520 530 540 550
LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA GGHSVCVDLR
560 570 580 590 600
VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ
610 620 630 640 650
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA
660 670 680 690 700
PGQGLPPVAP ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT
710 720 730 740 750
RVSDTEFQPL PMDVDGTTAL FALSGQPVIG LELMVTNLPS DPAQPQADGD
760 770 780 790 800
DAHEAQLLVM LPDSLHYSGV RALDPAEKPL CLSNENASHV ECELGNPMKR
810 820 830 840 850
GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS ARARVFIELP
860 870 880 890 900
LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL
910 920 930 940 950
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV
960 970 980 990 1000
DSRDRRRREL EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN
1010 1020 1030 1040 1050
CVVFSCPLYS FDRAAVLHVW GRLWNSTFLE EYSAVKSLEV IVRANITVKS
1060 1070 1080 1090 1100
SIKNLMLRDA STVIPVMVYL DPMAVVAEGV PWWVILLAVL AGLLVLALLV
1110 1120 1130 1140 1150
LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT GTILRNNWGS
1160 1170 1180
PRREGPDAHP ILAADGHPEL GPDGHPGPGT A
Note: Gene prediction based on similarity to mouse ortholog.
Length:1,181
Mass (Da):128,948
Last modified:October 5, 2010 - v3
Checksum:i341C0C72CDB8CA57
GO
Isoform Alpha-7X1B (identifier: Q13683-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-307: Missing.

Show »
Length:1,141
Mass (Da):124,690
Checksum:i156565867C8DC8FB
GO
Isoform Alpha-7X2B (identifier: Q13683-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-267: Missing.

Show »
Length:1,137
Mass (Da):124,307
Checksum:i43AB97240F469166
GO
Isoform Alpha-7X2DB (identifier: Q13683-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     702-776: Missing.

Show »
Length:1,106
Mass (Da):121,065
Checksum:iCF40297895F88BD2
GO
Isoform Alpha-7X1X2A (identifier: Q13683-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1181: MGFFKRAKHP...PDGHPGPGTA → CGFFHRSSQS...PRPPCPSTMR

Show »
Length:1,162
Mass (Da):126,631
Checksum:iFC25805EDFC23D68
GO
Isoform 2 (identifier: Q13683-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-138: LEETDCYRVD...RSQGPGGKIV → MAPFATPMVQ...TRRSPFEGKE
     268-307: Missing.

Show »
Length:1,044
Mass (Da):114,545
Checksum:i84DF3FB44EE2A31D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti873A → T in AAC18968 (PubMed:9590299).Curated1
Sequence conflicti1005S → I in AAC18968 (PubMed:9590299).Curated1
Sequence conflicti1013R → H in AAH50280 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067015457I → V.1 PublicationCorresponds to variant rs17857367dbSNPEnsembl.1
Natural variantiVAR_067016506L → M.1 PublicationCorresponds to variant rs17854599dbSNPEnsembl.1
Natural variantiVAR_067017586R → H.1 PublicationCorresponds to variant rs17854598dbSNPEnsembl.1
Natural variantiVAR_014759695R → H.6 PublicationsCorresponds to variant rs1800974dbSNPEnsembl.1
Natural variantiVAR_067018696A → V.1 PublicationCorresponds to variant rs17855684dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0404871 – 97Missing in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_04048898 – 138LEETD…GGKIV → MAPFATPMVQALTTTRIQRQ AEGFQCWRECGTRRSPFEGK E in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_002727224 – 267Missing in isoform Alpha-7X2B. 4 PublicationsAdd BLAST44
Alternative sequenceiVSP_002728268 – 307Missing in isoform Alpha-7X1B and isoform 2. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_042364702 – 776Missing in isoform Alpha-7X2DB. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_0027301106 – 1181MGFFK…GPGTA → CGFFHRSSQSSSFPTNYHRA CLAVQPSAMEVGGPGTVGWD SSNGRSTPRPPCPSTMR in isoform Alpha-7X1X2A. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032108 mRNA. Translation: AAC39708.1.
AF052050 mRNA. Translation: AAC18968.1.
AF072132 mRNA. Translation: AAC80458.1.
AJ228836
, AJ228837, AJ228838, AJ228839, AJ228840, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA. Translation: CAB41534.1.
AJ228836
, AJ228837, AJ228838, AJ228839, AJ228841, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA. Translation: CAB41535.1.
AY358882 mRNA. Translation: AAQ89241.1.
AK304864 mRNA. Translation: BAG65602.1.
AC009779 Genomic DNA. No translation available.
BC050280 mRNA. Translation: AAH50280.1.
X74295 mRNA. Translation: CAA52348.1.
AF034833 mRNA. Translation: AAB87696.1.
CCDSiCCDS44914.1. [Q13683-13]
CCDS55832.1. [Q13683-3]
CCDS8888.1. [Q13683-7]
PIRiJC5950.
RefSeqiNP_001138468.1. NM_001144996.1. [Q13683-3]
NP_001138469.1. NM_001144997.1. [Q13683-13]
NP_002197.2. NM_002206.2. [Q13683-7]
XP_005268896.1. XM_005268839.1. [Q13683-1]
XP_005268898.1. XM_005268841.1. [Q13683-10]
UniGeneiHs.524484.

Genome annotation databases

EnsembliENST00000257879; ENSP00000257879; ENSG00000135424. [Q13683-7]
ENST00000452168; ENSP00000393844; ENSG00000135424. [Q13683-13]
ENST00000553804; ENSP00000452120; ENSG00000135424. [Q13683-3]
ENST00000555728; ENSP00000452387; ENSG00000135424. [Q13683-1]
GeneIDi3679.
KEGGihsa:3679.
UCSCiuc001shg.4. human. [Q13683-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032108 mRNA. Translation: AAC39708.1.
AF052050 mRNA. Translation: AAC18968.1.
AF072132 mRNA. Translation: AAC80458.1.
AJ228836
, AJ228837, AJ228838, AJ228839, AJ228840, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA. Translation: CAB41534.1.
AJ228836
, AJ228837, AJ228838, AJ228839, AJ228841, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA. Translation: CAB41535.1.
AY358882 mRNA. Translation: AAQ89241.1.
AK304864 mRNA. Translation: BAG65602.1.
AC009779 Genomic DNA. No translation available.
BC050280 mRNA. Translation: AAH50280.1.
X74295 mRNA. Translation: CAA52348.1.
AF034833 mRNA. Translation: AAB87696.1.
CCDSiCCDS44914.1. [Q13683-13]
CCDS55832.1. [Q13683-3]
CCDS8888.1. [Q13683-7]
PIRiJC5950.
RefSeqiNP_001138468.1. NM_001144996.1. [Q13683-3]
NP_001138469.1. NM_001144997.1. [Q13683-13]
NP_002197.2. NM_002206.2. [Q13683-7]
XP_005268896.1. XM_005268839.1. [Q13683-1]
XP_005268898.1. XM_005268841.1. [Q13683-10]
UniGeneiHs.524484.

3D structure databases

ProteinModelPortaliQ13683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109885. 28 interactors.
DIPiDIP-5981N.
IntActiQ13683. 1 interactor.
MINTiMINT-140160.
STRINGi9606.ENSP00000452120.

PTM databases

iPTMnetiQ13683.
PhosphoSitePlusiQ13683.

Polymorphism and mutation databases

BioMutaiITGA7.
DMDMi308153592.

Proteomic databases

EPDiQ13683.
MaxQBiQ13683.
PaxDbiQ13683.
PeptideAtlasiQ13683.
PRIDEiQ13683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257879; ENSP00000257879; ENSG00000135424. [Q13683-7]
ENST00000452168; ENSP00000393844; ENSG00000135424. [Q13683-13]
ENST00000553804; ENSP00000452120; ENSG00000135424. [Q13683-3]
ENST00000555728; ENSP00000452387; ENSG00000135424. [Q13683-1]
GeneIDi3679.
KEGGihsa:3679.
UCSCiuc001shg.4. human. [Q13683-1]

Organism-specific databases

CTDi3679.
DisGeNETi3679.
GeneCardsiITGA7.
GeneReviewsiITGA7.
H-InvDBHIX0010702.
HIX0201958.
HGNCiHGNC:6143. ITGA7.
HPAiHPA008427.
MalaCardsiITGA7.
MIMi600536. gene.
613204. phenotype.
neXtProtiNX_Q13683.
OpenTargetsiENSG00000135424.
Orphaneti2020. Congenital fiber-type disproportion myopathy.
34520. Congenital muscular dystrophy with integrin alpha-7 deficiency.
PharmGKBiPA29943.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPBB. Eukaryota.
ENOG410XVGZ. LUCA.
GeneTreeiENSGT00760000118782.
HOVERGENiHBG108011.
InParanoidiQ13683.
KOiK06583.
OMAiHEVFIAP.
OrthoDBiEOG091G012D.
PhylomeDBiQ13683.
TreeFamiTF105391.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135424-MONOMER.
ReactomeiR-HSA-216083. Integrin cell surface interactions.
R-HSA-3000157. Laminin interactions.
R-HSA-3000178. ECM proteoglycans.
SignaLinkiQ13683.
SIGNORiQ13683.

Miscellaneous databases

ChiTaRSiITGA7. human.
GeneWikiiITGA7.
GenomeRNAii3679.
PROiQ13683.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135424.
CleanExiHS_ITGA7.
ExpressionAtlasiQ13683. baseline and differential.
GenevisibleiQ13683. HS.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA7_HUMAN
AccessioniPrimary (citable) accession number: Q13683
Secondary accession number(s): B4E3U0
, C9JMD3, C9JMZ6, O43197, Q86W93, Q9NY89, Q9UET0, Q9UEV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 169 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.