Q13683 (ITA7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integrin alpha-7

Cleaved into the following 3 chains:

1. Integrin alpha-7 heavy chain
2. Integrin alpha-7 light chain
3. Integrin alpha-7 70 kDa form

Gene names

Name:	ITGA7
ORF Names:	UNQ406/PRO768

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation By similarity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Ref.13 Ref.14 Ref.16
Subunit structure	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-7 associates with beta-1. Interacts with COMP By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle. Ref.15
Developmental stage	In renewing intestinal epithelium, expression of isoforms containing segment B correlates with the onset of enterocytic differentiation.
Post-translational modification	ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes By similarity. A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin. Ref.17
Involvement in disease	Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI) [MIM:613204]: A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2
Sequence similarities	Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats.

Ontologies

Keywords
Biological process	Cell adhesion Cell shape
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Congenital muscular dystrophy
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Molecular function	Integrin Receptor
PTM	ADP-ribosylation Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood vessel morphogenesis Inferred from electronic annotation. Source: Compara cell migration Inferred from electronic annotation. Source: Compara cell-matrix adhesion Traceable author statement PubMed 9354797. Source: ProtInc integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW muscle organ development Traceable author statement PubMed 9354797Ref.2. Source: ProtInc regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW skeletal muscle tissue development Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara integrin complex Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist. There is a combination of at least five alternatively spliced domains, three extracellular (X1, X2 and D) and two cytoplasmic (A and B). A third potential alternatively spliced cytoplasmic domain (C) does not appear to be expressed.

Isoform Alpha-7X1X2B (identifier: Q13683-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on similarity to mouse ortholog.

Isoform Alpha-7X1B (identifier: Q13683-3)

The sequence of this isoform differs from the canonical sequence as follows:
     268-307: Missing.

Isoform Alpha-7X2B (identifier: Q13683-7)

The sequence of this isoform differs from the canonical sequence as follows:
     224-267: Missing.

Isoform Alpha-7X2DB (identifier: Q13683-9)

The sequence of this isoform differs from the canonical sequence as follows:
     702-776: Missing.

Isoform Alpha-7X1X2A (identifier: Q13683-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1181: MGFFKRAKHP...PDGHPGPGTA → CGFFHRSSQS...PRPPCPSTMR

Isoform 2 (identifier: Q13683-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-138: LEETDCYRVD...RSQGPGGKIV → MAPFATPMVQ...TRRSPFEGKE
     268-307: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Ref.11 Ref.12
	Chain	34 – 1181	1148	Integrin alpha-7		PRO_0000016267
	Chain	34 – 955	922	Integrin alpha-7 heavy chain Potential		PRO_0000016268
	Chain	648 – 1181	534	Integrin alpha-7 70 kDa form		PRO_0000398833
	Chain	959 – 1181	223	Integrin alpha-7 light chain Potential		PRO_0000016269
Regions
	Topological domain	34 – 1082	1049	Extracellular Potential
	Transmembrane	1083 – 1103	21	Helical; Potential
	Topological domain	1104 – 1181	78	Cytoplasmic Potential
	Repeat	35 – 103	69	FG-GAP 1
	Repeat	110 – 175	66	FG-GAP 2
	Repeat	185 – 238	54	FG-GAP 3
	Repeat	292 – 350	59	FG-GAP 4
	Repeat	351 – 411	61	FG-GAP 5
	Repeat	412 – 467	56	FG-GAP 6
	Repeat	471 – 530	60	FG-GAP 7
	Repeat	1157 – 1160	4	1
	Repeat	1165 – 1168	4	2
	Repeat	1173 – 1176	4	3
	Calcium binding	372 – 380	9	Potential
	Calcium binding	434 – 442	9	Potential
	Calcium binding	492 – 500	9	Potential
	Region	1157 – 1176	20	3 X 4 AA repeats of D-X-H-P
	Motif	1107 – 1111	5	GFFKR motif
	Compositional bias	953 – 958	6	Poly-Arg
Sites
	Site	647 – 648	2	Cleavage; by urokinase
Amino acid modifications
	Glycosylation	86	1	N-linked (GlcNAc...) Potential
	Glycosylation	786	1	N-linked (GlcNAc...) Potential
	Glycosylation	989	1	N-linked (GlcNAc...) Potential
	Glycosylation	1025	1	N-linked (GlcNAc...) Ref.18
	Glycosylation	1045	1	N-linked (GlcNAc...) Potential
	Disulfide bond	94 ↔ 103		By similarity
	Disulfide bond	140 ↔ 163		By similarity
	Disulfide bond	184 ↔ 197		By similarity
	Disulfide bond	539 ↔ 546		By similarity
	Disulfide bond	552 ↔ 615		By similarity
	Disulfide bond	681 ↔ 687		By similarity
	Disulfide bond	781 ↔ 792		By similarity
	Disulfide bond	939 ↔ 994		Interchain (between heavy and light chains) By similarity
	Disulfide bond	1001 ↔ 1006		By similarity
Natural variations
	Alternative sequence	1 – 97	97	Missing in isoform 2.		VSP_040487
	Alternative sequence	98 – 138	41	LEETD…GGKIV → MAPFATPMVQALTTTRIQRQ AEGFQCWRECGTRRSPFEGK E in isoform 2.		VSP_040488
	Alternative sequence	224 – 267	44	Missing in isoform Alpha-7X2B.		VSP_002727
	Alternative sequence	268 – 307	40	Missing in isoform Alpha-7X1B and isoform 2.		VSP_002728
	Alternative sequence	702 – 776	75	Missing in isoform Alpha-7X2DB.		VSP_042364
	Alternative sequence	1106 – 1181	76	MGFFK…GPGTA → CGFFHRSSQSSSFPTNYHRA CLAVQPSAMEVGGPGTVGWD SSNGRSTPRPPCPSTMR in isoform Alpha-7X1X2A.		VSP_002730
	Natural variant	457	1	I → V. Ref.8 Corresponds to variant rs17857367 [ dbSNP | Ensembl ].		VAR_067015
	Natural variant	506	1	L → M. Ref.8 Corresponds to variant rs17854599 [ dbSNP | Ensembl ].		VAR_067016
	Natural variant	586	1	R → H. Ref.8 Corresponds to variant rs17854598 [ dbSNP | Ensembl ].		VAR_067017
	Natural variant	695	1	R → H. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Corresponds to variant rs1800974 [ dbSNP | Ensembl ].		VAR_014759
	Natural variant	696	1	A → V. Ref.8 Corresponds to variant rs17855684 [ dbSNP | Ensembl ].		VAR_067018
Experimental info
	Sequence conflict	873	1	A → T in AAC18968. Ref.2
	Sequence conflict	1005	1	S → I in AAC18968. Ref.2
	Sequence conflict	1013	1	R → H in AAH50280. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha-7X1X2B [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 341C0C72CDB8CA57	FASTA	1,181	128,948
	10 20 30 40 50 60 MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR 70 80 90 100 110 120 QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE 130 140 150 160 170 180 NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE 190 200 210 220 230 240 WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH 250 260 270 280 290 300 LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 310 320 330 340 350 360 LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL 370 380 390 400 410 420 TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS 430 440 450 460 470 480 PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI 490 500 510 520 530 540 KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA 550 560 570 580 590 600 GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 610 620 630 640 650 660 ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP 670 680 690 700 710 720 ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL 730 740 750 760 770 780 FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL 790 800 810 820 830 840 CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS 850 860 870 880 890 900 ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL 910 920 930 940 950 960 GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL 970 980 990 1000 1010 1020 EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW 1030 1040 1050 1060 1070 1080 GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV 1090 1100 1110 1120 1130 1140 PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT 1150 1160 1170 1180 GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A
	Isoform Alpha-7X1B [UniParc]. Checksum: 156565867C8DC8FB	FASTA	1,141	124,690
	10 20 30 40 50 60 MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR 70 80 90 100 110 120 QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE 130 140 150 160 170 180 NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE 190 200 210 220 230 240 WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH 250 260 270 280 290 300 LDDGPYEAGG EKEQDPRLIP VPANSYFGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI 310 320 330 340 350 360 LRKDSASRLV PEVMLSGERL TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY 370 380 390 400 410 420 VYLNQGGHWA GISPLRLCGS PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG 430 440 450 460 470 480 SSLGVVAKPS QVLEGEAVGI KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH 490 500 510 520 530 540 VSHEVSIAPR SIDLEQPNCA GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL 550 560 570 580 590 600 RGQVPRVTFL SRNLEEPKHQ ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS 610 620 630 640 650 660 LQTPRLRRQA PGQGLPPVAP ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT 670 680 690 700 710 720 RVSDTEFQPL PMDVDGTTAL FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM 730 740 750 760 770 780 LPDSLHYSGV RALDPAEKPL CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT 790 800 810 820 830 840 ELEVELLLAT ISEQELHPVS ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV 850 860 870 880 890 900 GSKVKYEVTV SNQGQSLRTL GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS 910 920 930 940 950 960 PRPNILHLDV DSRDRRRREL EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN 970 980 990 1000 1010 1020 CVVFSCPLYS FDRAAVLHVW GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA 1030 1040 1050 1060 1070 1080 STVIPVMVYL DPMAVVAEGV PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP 1090 1100 1110 1120 1130 1140 QYHAVKIPRE DRQQFKEEKT GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A
	Isoform Alpha-7X2B [UniParc]. Checksum: 43AB97240F469166	FASTA	1,137	124,307
	10 20 30 40 50 60 MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR 70 80 90 100 110 120 QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE 130 140 150 160 170 180 NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE 190 200 210 220 230 240 WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGLLFVTN IDSSDPDQLV 250 260 270 280 290 300 YKTLDPADRL PGPAGDLALN SYLGFSIDSG KGLVRAEELS FVAGAPRANH KGAVVILRKD 310 320 330 340 350 360 SASRLVPEVM LSGERLTSGF GYSLAVADLN SDGWPDLIVG APYFFERQEE LGGAVYVYLN 370 380 390 400 410 420 QGGHWAGISP LRLCGSPDSM FGISLAVLGD LNQDGFPDIA VGAPFDGDGK VFIYHGSSLG 430 440 450 460 470 480 VVAKPSQVLE GEAVGIKSFG YSLSGSLDMD GNQYPDLLVG SLADTAVLFR ARPILHVSHE 490 500 510 520 530 540 VSIAPRSIDL EQPNCAGGHS VCVDLRVCFS YIAVPSSYSP TVALDYVLDA DTDRRLRGQV 550 560 570 580 590 600 PRVTFLSRNL EEPKHQASGT VWLKHQHDRV CGDAMFQLQE NVKDKLRAIV VTLSYSLQTP 610 620 630 640 650 660 RLRRQAPGQG LPPVAPILNA HQPSTQRAEI HFLKQGCGED KICQSNLQLV RARFCTRVSD 670 680 690 700 710 720 TEFQPLPMDV DGTTALFALS GQPVIGLELM VTNLPSDPAQ PQADGDDAHE AQLLVMLPDS 730 740 750 760 770 780 LHYSGVRALD PAEKPLCLSN ENASHVECEL GNPMKRGAQV TFYLILSTSG ISIETTELEV 790 800 810 820 830 840 ELLLATISEQ ELHPVSARAR VFIELPLSIA GMAIPQQLFF SGVVRGERAM QSERDVGSKV 850 860 870 880 890 900 KYEVTVSNQG QSLRTLGSAF LNIMWPHEIA NGKWLLYPMQ VELEGGQGPG QKGLCSPRPN 910 920 930 940 950 960 ILHLDVDSRD RRRRELEPPE QQEPGERQEP SMSWWPVSSA EKKKNITLDC ARGTANCVVF 970 980 990 1000 1010 1020 SCPLYSFDRA AVLHVWGRLW NSTFLEEYSA VKSLEVIVRA NITVKSSIKN LMLRDASTVI 1030 1040 1050 1060 1070 1080 PVMVYLDPMA VVAEGVPWWV ILLAVLAGLL VLALLVLLLW KMGFFKRAKH PEATVPQYHA 1090 1100 1110 1120 1130 VKIPREDRQQ FKEEKTGTIL RNNWGSPRRE GPDAHPILAA DGHPELGPDG HPGPGTA
	Isoform Alpha-7X2DB [UniParc]. Checksum: CF40297895F88BD2	FASTA	1,106	121,065
	10 20 30 40 50 60 MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR 70 80 90 100 110 120 QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE 130 140 150 160 170 180 NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE 190 200 210 220 230 240 WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH 250 260 270 280 290 300 LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 310 320 330 340 350 360 LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL 370 380 390 400 410 420 TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS 430 440 450 460 470 480 PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI 490 500 510 520 530 540 KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA 550 560 570 580 590 600 GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 610 620 630 640 650 660 ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP 670 680 690 700 710 720 ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT REKPLCLSNE NASHVECELG 730 740 750 760 770 780 NPMKRGAQVT FYLILSTSGI SIETTELEVE LLLATISEQE LHPVSARARV FIELPLSIAG 790 800 810 820 830 840 MAIPQQLFFS GVVRGERAMQ SERDVGSKVK YEVTVSNQGQ SLRTLGSAFL NIMWPHEIAN 850 860 870 880 890 900 GKWLLYPMQV ELEGGQGPGQ KGLCSPRPNI LHLDVDSRDR RRRELEPPEQ QEPGERQEPS 910 920 930 940 950 960 MSWWPVSSAE KKKNITLDCA RGTANCVVFS CPLYSFDRAA VLHVWGRLWN STFLEEYSAV 970 980 990 1000 1010 1020 KSLEVIVRAN ITVKSSIKNL MLRDASTVIP VMVYLDPMAV VAEGVPWWVI LLAVLAGLLV 1030 1040 1050 1060 1070 1080 LALLVLLLWK MGFFKRAKHP EATVPQYHAV KIPREDRQQF KEEKTGTILR NNWGSPRREG 1090 1100 PDAHPILAAD GHPELGPDGH PGPGTA
	Isoform Alpha-7X1X2A [UniParc]. Checksum: FC25805EDFC23D68	FASTA	1,162	126,631
	10 20 30 40 50 60 MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR 70 80 90 100 110 120 QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE 130 140 150 160 170 180 NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE 190 200 210 220 230 240 WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH 250 260 270 280 290 300 LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 310 320 330 340 350 360 LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL 370 380 390 400 410 420 TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS 430 440 450 460 470 480 PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI 490 500 510 520 530 540 KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA 550 560 570 580 590 600 GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 610 620 630 640 650 660 ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP 670 680 690 700 710 720 ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL 730 740 750 760 770 780 FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL 790 800 810 820 830 840 CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS 850 860 870 880 890 900 ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL 910 920 930 940 950 960 GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL 970 980 990 1000 1010 1020 EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW 1030 1040 1050 1060 1070 1080 GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV 1090 1100 1110 1120 1130 1140 PWWVILLAVL AGLLVLALLV LLLWKCGFFH RSSQSSSFPT NYHRACLAVQ PSAMEVGGPG 1150 1160 TVGWDSSNGR STPRPPCPST MR
	Isoform 2 [UniParc]. Checksum: 84DF3FB44EE2A31D	FASTA	1,044	114,545
	10 20 30 40 50 60 MAPFATPMVQ ALTTTRIQRQ AEGFQCWREC GTRRSPFEGK ETCAHRYEAR QRVDQILETR 70 80 90 100 110 120 DMIGRCFVLS QDLAIRDELD GGEWKFCEGR PQGHEQFGFC QQGTAAAFSP DSHYLLFGAP 130 140 150 160 170 180 GTYNWKGTAR VELCAQGSAD LAHLDDGPYE AGGEKEQDPR LIPVPANSYF GFSIDSGKGL 190 200 210 220 230 240 VRAEELSFVA GAPRANHKGA VVILRKDSAS RLVPEVMLSG ERLTSGFGYS LAVADLNSDG 250 260 270 280 290 300 WPDLIVGAPY FFERQEELGG AVYVYLNQGG HWAGISPLRL CGSPDSMFGI SLAVLGDLNQ 310 320 330 340 350 360 DGFPDIAVGA PFDGDGKVFI YHGSSLGVVA KPSQVLEGEA VGIKSFGYSL SGSLDMDGNQ 370 380 390 400 410 420 YPDLLVGSLA DTAVLFRARP ILHVSHEVSI APRSIDLEQP NCAGGHSVCV DLRVCFSYIA 430 440 450 460 470 480 VPSSYSPTVA LDYVLDADTD RRLRGQVPRV TFLSRNLEEP KHQASGTVWL KHQHDRVCGD 490 500 510 520 530 540 AMFQLQENVK DKLRAIVVTL SYSLQTPRLR RQAPGQGLPP VAPILNAHQP STQRAEIHFL 550 560 570 580 590 600 KQGCGEDKIC QSNLQLVRAR FCTRVSDTEF QPLPMDVDGT TALFALSGQP VIGLELMVTN 610 620 630 640 650 660 LPSDPAQPQA DGDDAHEAQL LVMLPDSLHY SGVRALDPAE KPLCLSNENA SHVECELGNP 670 680 690 700 710 720 MKRGAQVTFY LILSTSGISI ETTELEVELL LATISEQELH PVSARARVFI ELPLSIAGMA 730 740 750 760 770 780 IPQQLFFSGV VRGERAMQSE RDVGSKVKYE VTVSNQGQSL RTLGSAFLNI MWPHEIANGK 790 800 810 820 830 840 WLLYPMQVEL EGGQGPGQKG LCSPRPNILH LDVDSRDRRR RELEPPEQQE PGERQEPSMS 850 860 870 880 890 900 WWPVSSAEKK KNITLDCARG TANCVVFSCP LYSFDRAAVL HVWGRLWNST FLEEYSAVKS 910 920 930 940 950 960 LEVIVRANIT VKSSIKNLML RDASTVIPVM VYLDPMAVVA EGVPWWVILL AVLAGLLVLA 970 980 990 1000 1010 1020 LLVLLLWKMG FFKRAKHPEA TVPQYHAVKI PREDRQQFKE EKTGTILRNN WGSPRREGPD 1030 1040 AHPILAADGH PELGPDGHPG PGTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing." Leung E., Lim S.P., Berg R., Yang Y., Ni J., Wang S.-X., Krissansen G.W. Biochem. Biophys. Res. Commun. 243:317-325(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA-7X2B AND ALPHA-7X2DB), VARIANT HIS-695. Tissue: Fetal heart and Osteoblast.
[2]	"Mutations in the integrin alpha7 gene cause congenital myopathy." Hayashi Y.K., Chou F.-L., Engvall E., Ogawa M., Matsuda C., Hirabayashi S., Yokochi K., Ziober B.L., Kramer R.H., Kaufman S.J., Ozawa E., Goto Y., Nonaka I., Tsukahara T., Wang J.Z., Hoffman E.P., Arahata K. Nat. Genet. 19:94-97(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-7X2B), INVOLVEMENT IN MDCI, VARIANT HIS-695.
[3]	"Cloning of human integrin alpha-7 cDNA." Vizirianakis I.S., Ziober B.L., Kramer R.H. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-7X2B), VARIANT HIS-695.
[4]	"Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha7 gene (ITGA7)." Vignier N., Moghadaszadeh B., Gary F., Beckmann J., Mayer U., Guicheney P. Biochem. Biophys. Res. Commun. 260:357-364(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANT HIS-695. Tissue: Skeletal muscle.
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-7X1B), VARIANT HIS-695.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT HIS-695. Tissue: Uterus.
[7]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-7X2B), VARIANTS VAL-457; MET-506; HIS-586 AND VAL-696. Tissue: Brain.
[9]	"Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases." Song W.K., Wang W., Sato H., Bielser D.A., Kaufman S.J. J. Cell Sci. 106:1139-1152(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1105-1181 (ISOFORMS ALPHA-7X1B/ALPHA-7X2B/ALPHA-7X2DB/ALPHA-7X1X2B/2). Tissue: Fetal muscle.
[10]	"Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation." Basora N., Vachon P.H., Herring-Gillam F.E., Perreault N., Beaulieu J.-F. Gastroenterology 113:1510-1521(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1105-1181 (ISOFORMS ALPHA-7X1X2B AND ALPHA-7X1X2A). Tissue: Skeletal muscle.
[11]	"Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes." Kramer R.H., Vu M.P., Cheng Y.F., Ramos D.M., Timpl R., Waleh N. Cell Regul. 2:805-817(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 34-45. Tissue: Melanoma.
[12]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 34-48.
[13]	"The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain." Ziober B.L., Chen Y.Q., Kramer R.H. Mol. Biol. Cell 8:1723-1734(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[14]	"The role of extracellular and cytoplasmic splice domains of alpha7-integrin in cell adhesion and migration on laminins." Schoeber S., Mielenz D., Echtermeyer F., Hapke S., Poeschl E., von der Mark H., Moch H., von der Mark K. Exp. Cell Res. 255:303-313(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[15]	"Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction." Martin P.T., Kaufman S.J., Kramer R.H., Sanes J.R. Dev. Biol. 174:125-139(1996) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[16]	"Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes." Tran T., Ens-Blackie K., Rector E.S., Stelmack G.L., McNeill K.D., Tarone G., Gerthoffer W.T., Unruh H., Halayko A.J. Am. J. Respir. Cell Mol. Biol. 37:668-680(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[17]	"Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function." Liu J., Gurpur P.B., Kaufman S.J. J. Biol. Chem. 283:35668-35678(2008) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE BY UROKINASE.
[18]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1025, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF032108 mRNA. Translation: AAC39708.1. AF052050 mRNA. Translation: AAC18968.1. AF072132 mRNA. Translation: AAC80458.1. AJ228836 , AJ228837, AJ228838, AJ228839, AJ228840, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA. Translation: CAB41534.1. AJ228836 , AJ228837, AJ228838, AJ228839, AJ228841, AJ228842, AJ228843, AJ228844, AJ228845, AJ228846, AJ228847, AJ228848, AJ228849, AJ228850, AJ228851, AJ228852, AJ228853, AJ228854, AJ228855, AJ228856, AJ228857, AJ228858, AJ228859, AJ228860, AJ228862 Genomic DNA. Translation: CAB41535.1. AY358882 mRNA. Translation: AAQ89241.1. AK304864 mRNA. Translation: BAG65602.1. AC009779 Genomic DNA. No translation available. BC050280 mRNA. Translation: AAH50280.1. X74295 mRNA. Translation: CAA52348.1. AF034833 mRNA. Translation: AAB87696.1.
IPI	IPI00014478. IPI00216421. IPI00216422. IPI00220748. IPI00220749. IPI00220750. IPI00220751. IPI00220752. IPI00220755. IPI00220756. IPI00220757. IPI00411446. IPI00973410.
PIR	JC5950.
RefSeq	NP_001138468.1. NM_001144996.1. NP_001138469.1. NM_001144997.1. NP_002197.2. NM_002206.2.
UniGene	Hs.524484.
3D structure databases
ProteinModelPortal	Q13683.
SMR	Q13683. Positions 34-662, 824-857.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5981N.
MINT	MINT-140160.
STRING	9606.ENSP00000257879.
PTM databases
PhosphoSite	Q13683.
Polymorphism databases
DMDM	308153592.
Proteomic databases
PaxDb	Q13683.
PRIDE	Q13683.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257879; ENSP00000257879; ENSG00000135424. ENST00000257880; ENSP00000257880; ENSG00000135424. ENST00000452168; ENSP00000393844; ENSG00000135424. ENST00000553804; ENSP00000452120; ENSG00000135424. ENST00000555728; ENSP00000452387; ENSG00000135424.
GeneID	3679.
KEGG	hsa:3679.
UCSC	uc001shg.3. human. uc001shh.3. human. uc010sps.2. human.
Organism-specific databases
CTD	3679.
GeneCards	GC12M056078.
H-InvDB	HIX0010702. HIX0201958.
HGNC	HGNC:6143. ITGA7.
HPA	HPA008427.
MIM	600536. gene. 613204. phenotype.
neXtProt	NX_Q13683.
Orphanet	34520. Congenital muscular dystrophy with integrin deficiency.
PharmGKB	PA29943.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26407.
HOVERGEN	HBG108011.
InParanoid	Q13683.
KO	K06583.
OMA	TCAHLYE.
OrthoDB	EOG4GTKC6.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6_traffickingpathway. Arf6 trafficking events.
Reactome	REACT_111102. Signal Transduction.
SignaLink	Q13683.
Gene expression databases
ArrayExpress	Q13683.
Bgee	Q13683.
CleanEx	HS_ITGA7.
Genevestigator	Q13683.
GermOnline	ENSG00000135424. Homo sapiens.
Family and domain databases
InterPro	IPR013517. FG-GAP. IPR013519. Int_alpha_beta-p. IPR000413. Integrin_alpha. IPR013649. Integrin_alpha-2. IPR018184. Integrin_alpha_C_CS. [Graphical view]
Pfam	PF01839. FG-GAP. 2 hits. PF08441. Integrin_alpha2. 1 hit. [Graphical view]
PRINTS	PR01185. INTEGRINA.
SMART	SM00191. Int_alpha. 5 hits. [Graphical view]
PROSITE	PS51470. FG_GAP. 7 hits. PS00242. INTEGRIN_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3679.
NextBio	14399.
SOURCE	Search...

Entry information

Entry name

ITA7_HUMAN

Accession

Primary (citable) accession number: Q13683
Secondary accession number(s): B4E3U0 , C9JMD3, C9JMZ6, O43197, Q86W93, Q9NY89, Q9UET0, Q9UEV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	October 5, 2010
Last modified:	May 29, 2013
This is version 136 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.