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Q13651

- I10R1_HUMAN

UniProt

Q13651 - I10R1_HUMAN

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Protein

Interleukin-10 receptor subunit alpha

Gene
IL10RA, IL10R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for IL10; binds IL10 with a high affinity.

GO - Molecular functioni

  1. interleukin-10 receptor activity Source: ProtInc
  2. protein binding Source: IntAct
  3. receptor activity Source: ProtInc
  4. signal transducer activity Source: ProtInc

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. response to lipopolysaccharide Source: Ensembl
  3. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ13651.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit alpha
Short name:
IL-10 receptor subunit alpha
Short name:
IL-10R subunit alpha
Short name:
IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name:
IL-10R subunit 1
Short name:
IL-10R1
CD_antigen: CD210
Gene namesi
Name:IL10RA
Synonyms:IL10R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:5964. IL10RA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 235214Extracellular Reviewed predictionAdd
BLAST
Transmembranei236 – 25621Helical; Reviewed predictionAdd
BLAST
Topological domaini257 – 578322Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841T → I in IBD28. 1 Publication
VAR_063542
Natural varianti141 – 1411G → R in IBD28. 1 Publication
VAR_063543

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi613148. phenotype.
Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBiPA29779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 578557Interleukin-10 receptor subunit alphaPRO_0000011012Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi56 ↔ 751 Publication
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi154 – 1541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi189 – 1891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi202 ↔ 2231 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13651.
PRIDEiQ13651.

PTM databases

PhosphoSiteiQ13651.

Expressioni

Tissue specificityi

Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

Gene expression databases

ArrayExpressiQ13651.
BgeeiQ13651.
CleanExiHS_IL10RA.
GenevestigatoriQ13651.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BCRF1P031802EBI-1031656,EBI-1042167From a different organism.
NSP034952EBI-1031656,EBI-2548993From a different organism.

Protein-protein interaction databases

BioGridi109801. 5 interactions.
DIPiDIP-3512N.
IntActiQ13651. 7 interactions.
MINTiMINT-206772.
STRINGi9606.ENSP00000227752.

Structurei

Secondary structure

1
578
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 376
Beta strandi40 – 456
Beta strandi56 – 638
Beta strandi70 – 8213
Helixi84 – 874
Helixi90 – 923
Beta strandi96 – 1049
Helixi120 – 1223
Beta strandi123 – 1253
Beta strandi128 – 1347
Beta strandi136 – 1449
Beta strandi149 – 1513
Helixi157 – 1604
Beta strandi165 – 17612
Beta strandi181 – 19313
Beta strandi199 – 20911
Beta strandi222 – 2254

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J7VX-ray2.90R22-235[»]
1LQSX-ray2.70R/S22-235[»]
1Y6KX-ray2.52R22-235[»]
1Y6MX-ray2.80R22-235[»]
1Y6NX-ray2.70R22-235[»]
ProteinModelPortaliQ13651.
SMRiQ13651. Positions 23-229.

Miscellaneous databases

EvolutionaryTraceiQ13651.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43158.
HOGENOMiHOG000112980.
HOVERGENiHBG052056.
InParanoidiQ13651.
KOiK05134.
OMAiWFEAEFF.
OrthoDBiEOG7DJSMD.
PhylomeDBiQ13651.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13651-1 [UniParc]FASTAAdd to Basket

« Hide

MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN    50
QSESTCYEVA LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV 100
RAVDGSRHSN WTVTNTRFSV DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM 150
APANDTYESI FSHFREYEIA IRKVPGNFTF THKKVKHENF SLLTSGEVGE 200
FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF AFVLLLSGAL 250
AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA 300
FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN 350
REPPVLGDSC SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD 400
SGIDLVQNSE GRAGDTQGGS ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT 450
RCAEEKATKT GCLEEESPLT DGLGPKFGRC LVDEAGLHPP ALAKGYLKQD 500
PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS FAHDLAPLGC 550
VAAPGGLLGS FNSDLVTLPL ISSLQSSE 578
Length:578
Mass (Da):63,003
Last modified:February 8, 2011 - v2
Checksum:i54B183ABE84808DB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611L → V.1 Publication
Corresponds to variant rs4252250 [ dbSNP | Ensembl ].
VAR_016294
Natural varianti84 – 841T → I in IBD28. 1 Publication
VAR_063542
Natural varianti113 – 1131V → I.1 Publication
Corresponds to variant rs4252303 [ dbSNP | Ensembl ].
VAR_016295
Natural varianti141 – 1411G → R in IBD28. 1 Publication
VAR_063543
Natural varianti159 – 1591S → G.1 Publication
Corresponds to variant rs3135932 [ dbSNP | Ensembl ].
VAR_016296
Natural varianti212 – 2121R → Q.1 Publication
Corresponds to variant rs4252273 [ dbSNP | Ensembl ].
VAR_016297
Natural varianti224 – 2241I → V.
Corresponds to variant rs2228055 [ dbSNP | Ensembl ].
VAR_020004
Natural varianti351 – 3511R → G.5 Publications
Corresponds to variant rs2229113 [ dbSNP | Ensembl ].
VAR_016298
Natural varianti353 – 3531P → S.
Corresponds to variant rs35235073 [ dbSNP | Ensembl ].
VAR_049175
Natural varianti420 – 4201S → L.1 Publication
Corresponds to variant rs2229114 [ dbSNP | Ensembl ].
VAR_016299

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00672 mRNA. Translation: AAA17896.1.
AY195619 Genomic DNA. Translation: AAN86349.1.
EF444988 Genomic DNA. Translation: ACA06005.1.
AK291645 mRNA. Translation: BAF84334.1.
AP002962 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67343.1.
BC028082 mRNA. Translation: AAH28082.1.
CCDSiCCDS8388.1.
PIRiI56215.
RefSeqiNP_001549.2. NM_001558.3.
UniGeneiHs.504035.

Genome annotation databases

EnsembliENST00000227752; ENSP00000227752; ENSG00000110324.
GeneIDi3587.
KEGGihsa:3587.
UCSCiuc001prv.3. human.

Polymorphism databases

DMDMi322510034.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00672 mRNA. Translation: AAA17896.1 .
AY195619 Genomic DNA. Translation: AAN86349.1 .
EF444988 Genomic DNA. Translation: ACA06005.1 .
AK291645 mRNA. Translation: BAF84334.1 .
AP002962 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67343.1 .
BC028082 mRNA. Translation: AAH28082.1 .
CCDSi CCDS8388.1.
PIRi I56215.
RefSeqi NP_001549.2. NM_001558.3.
UniGenei Hs.504035.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1J7V X-ray 2.90 R 22-235 [» ]
1LQS X-ray 2.70 R/S 22-235 [» ]
1Y6K X-ray 2.52 R 22-235 [» ]
1Y6M X-ray 2.80 R 22-235 [» ]
1Y6N X-ray 2.70 R 22-235 [» ]
ProteinModelPortali Q13651.
SMRi Q13651. Positions 23-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109801. 5 interactions.
DIPi DIP-3512N.
IntActi Q13651. 7 interactions.
MINTi MINT-206772.
STRINGi 9606.ENSP00000227752.

PTM databases

PhosphoSitei Q13651.

Polymorphism databases

DMDMi 322510034.

Proteomic databases

PaxDbi Q13651.
PRIDEi Q13651.

Protocols and materials databases

DNASUi 3587.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227752 ; ENSP00000227752 ; ENSG00000110324 .
GeneIDi 3587.
KEGGi hsa:3587.
UCSCi uc001prv.3. human.

Organism-specific databases

CTDi 3587.
GeneCardsi GC11P117891.
H-InvDB HIX0010172.
HGNCi HGNC:5964. IL10RA.
MIMi 146933. gene.
613148. phenotype.
neXtProti NX_Q13651.
Orphaneti 238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBi PA29779.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43158.
HOGENOMi HOG000112980.
HOVERGENi HBG052056.
InParanoidi Q13651.
KOi K05134.
OMAi WFEAEFF.
OrthoDBi EOG7DJSMD.
PhylomeDBi Q13651.
TreeFami TF334107.

Enzyme and pathway databases

SignaLinki Q13651.

Miscellaneous databases

ChiTaRSi IL10RA. human.
EvolutionaryTracei Q13651.
GeneWikii Interleukin_10_receptor,_alpha_subunit.
GenomeRNAii 3587.
NextBioi 14015.
PROi Q13651.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13651.
Bgeei Q13651.
CleanExi HS_IL10RA.
Genevestigatori Q13651.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning and characterization of a human IL-10 receptor."
    Liu Y., Wei S.H.-Y., Ho A.S.-Y., de Waal Malefyt R., Moore K.W.
    J. Immunol. 152:1821-1829(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-351.
    Tissue: Lymphoma.
  2. SeattleSNPs variation discovery resource
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-61; ILE-113; GLY-159; GLN-212; GLY-351 AND LEU-420.
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-351.
    Tissue: Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-351.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-351.
    Tissue: Blood.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  9. "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site."
    Josephson K., Logsdon N.J., Walter M.R.
    Immunity 15:35-46(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 22-235 IN COMPLEX WITH IL10, DISULFIDE BONDS.
  10. "Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1."
    Jones B.C., Logsdon N.J., Josephson K., Cook J., Barry P.A., Walter M.R.
    Proc. Natl. Acad. Sci. U.S.A. 99:9404-9409(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 22-235 IN COMPLEX WITH CYTOMEGALOVIRUS IL10.
  11. "Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain."
    Yoon S.I., Jones B.C., Logsdon N.J., Walter M.R.
    Structure 13:551-564(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 22-335 IN COMPLEX WITH IL10 AND EPSTEIN-BARR VIRUS IL10.
  12. Cited for: VARIANTS IBD28 ILE-84 AND ARG-141.

Entry informationi

Entry nameiI10R1_HUMAN
AccessioniPrimary (citable) accession number: Q13651
Secondary accession number(s): A8K6I0, B0YJ27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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