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Q13651

- I10R1_HUMAN

UniProt

Q13651 - I10R1_HUMAN

Protein

Interleukin-10 receptor subunit alpha

Gene

IL10RA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Receptor for IL10; binds IL10 with a high affinity.

    GO - Molecular functioni

    1. interleukin-10 receptor activity Source: ProtInc
    2. protein binding Source: IntAct
    3. receptor activity Source: ProtInc
    4. signal transducer activity Source: ProtInc

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. response to lipopolysaccharide Source: Ensembl
    3. signal transduction Source: GOC

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiQ13651.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-10 receptor subunit alpha
    Short name:
    IL-10 receptor subunit alpha
    Short name:
    IL-10R subunit alpha
    Short name:
    IL-10RA
    Alternative name(s):
    CDw210a
    Interleukin-10 receptor subunit 1
    Short name:
    IL-10R subunit 1
    Short name:
    IL-10R1
    CD_antigen: CD210
    Gene namesi
    Name:IL10RA
    Synonyms:IL10R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:5964. IL10RA.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti84 – 841T → I in IBD28. 1 Publication
    VAR_063542
    Natural varianti141 – 1411G → R in IBD28. 1 Publication
    VAR_063543

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi613148. phenotype.
    Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
    PharmGKBiPA29779.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 578557Interleukin-10 receptor subunit alphaPRO_0000011012Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi56 ↔ 751 Publication
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi202 ↔ 2231 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ13651.
    PRIDEiQ13651.

    PTM databases

    PhosphoSiteiQ13651.

    Expressioni

    Tissue specificityi

    Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

    Gene expression databases

    ArrayExpressiQ13651.
    BgeeiQ13651.
    CleanExiHS_IL10RA.
    GenevestigatoriQ13651.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BCRF1P031802EBI-1031656,EBI-1042167From a different organism.
    NSP034952EBI-1031656,EBI-2548993From a different organism.

    Protein-protein interaction databases

    BioGridi109801. 5 interactions.
    DIPiDIP-3512N.
    IntActiQ13651. 7 interactions.
    MINTiMINT-206772.
    STRINGi9606.ENSP00000227752.

    Structurei

    Secondary structure

    1
    578
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi32 – 376
    Beta strandi40 – 456
    Beta strandi56 – 638
    Beta strandi70 – 8213
    Helixi84 – 874
    Helixi90 – 923
    Beta strandi96 – 1049
    Helixi120 – 1223
    Beta strandi123 – 1253
    Beta strandi128 – 1347
    Beta strandi136 – 1449
    Beta strandi149 – 1513
    Helixi157 – 1604
    Beta strandi165 – 17612
    Beta strandi181 – 19313
    Beta strandi199 – 20911
    Beta strandi222 – 2254

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1J7VX-ray2.90R22-235[»]
    1LQSX-ray2.70R/S22-235[»]
    1Y6KX-ray2.52R22-235[»]
    1Y6MX-ray2.80R22-235[»]
    1Y6NX-ray2.70R22-235[»]
    ProteinModelPortaliQ13651.
    SMRiQ13651. Positions 23-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13651.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 235214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 578322CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43158.
    HOGENOMiHOG000112980.
    HOVERGENiHBG052056.
    InParanoidiQ13651.
    KOiK05134.
    OMAiWFEAEFF.
    OrthoDBiEOG7DJSMD.
    PhylomeDBiQ13651.
    TreeFamiTF334107.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13651-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN    50
    QSESTCYEVA LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV 100
    RAVDGSRHSN WTVTNTRFSV DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM 150
    APANDTYESI FSHFREYEIA IRKVPGNFTF THKKVKHENF SLLTSGEVGE 200
    FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF AFVLLLSGAL 250
    AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA 300
    FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN 350
    REPPVLGDSC SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD 400
    SGIDLVQNSE GRAGDTQGGS ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT 450
    RCAEEKATKT GCLEEESPLT DGLGPKFGRC LVDEAGLHPP ALAKGYLKQD 500
    PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS FAHDLAPLGC 550
    VAAPGGLLGS FNSDLVTLPL ISSLQSSE 578
    Length:578
    Mass (Da):63,003
    Last modified:February 8, 2011 - v2
    Checksum:i54B183ABE84808DB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611L → V.1 Publication
    Corresponds to variant rs4252250 [ dbSNP | Ensembl ].
    VAR_016294
    Natural varianti84 – 841T → I in IBD28. 1 Publication
    VAR_063542
    Natural varianti113 – 1131V → I.1 Publication
    Corresponds to variant rs4252303 [ dbSNP | Ensembl ].
    VAR_016295
    Natural varianti141 – 1411G → R in IBD28. 1 Publication
    VAR_063543
    Natural varianti159 – 1591S → G.1 Publication
    Corresponds to variant rs3135932 [ dbSNP | Ensembl ].
    VAR_016296
    Natural varianti212 – 2121R → Q.1 Publication
    Corresponds to variant rs4252273 [ dbSNP | Ensembl ].
    VAR_016297
    Natural varianti224 – 2241I → V.
    Corresponds to variant rs2228055 [ dbSNP | Ensembl ].
    VAR_020004
    Natural varianti351 – 3511R → G.5 Publications
    Corresponds to variant rs2229113 [ dbSNP | Ensembl ].
    VAR_016298
    Natural varianti353 – 3531P → S.
    Corresponds to variant rs35235073 [ dbSNP | Ensembl ].
    VAR_049175
    Natural varianti420 – 4201S → L.1 Publication
    Corresponds to variant rs2229114 [ dbSNP | Ensembl ].
    VAR_016299

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00672 mRNA. Translation: AAA17896.1.
    AY195619 Genomic DNA. Translation: AAN86349.1.
    EF444988 Genomic DNA. Translation: ACA06005.1.
    AK291645 mRNA. Translation: BAF84334.1.
    AP002962 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67343.1.
    BC028082 mRNA. Translation: AAH28082.1.
    CCDSiCCDS8388.1.
    PIRiI56215.
    RefSeqiNP_001549.2. NM_001558.3.
    UniGeneiHs.504035.

    Genome annotation databases

    EnsembliENST00000227752; ENSP00000227752; ENSG00000110324.
    GeneIDi3587.
    KEGGihsa:3587.
    UCSCiuc001prv.3. human.

    Polymorphism databases

    DMDMi322510034.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00672 mRNA. Translation: AAA17896.1 .
    AY195619 Genomic DNA. Translation: AAN86349.1 .
    EF444988 Genomic DNA. Translation: ACA06005.1 .
    AK291645 mRNA. Translation: BAF84334.1 .
    AP002962 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67343.1 .
    BC028082 mRNA. Translation: AAH28082.1 .
    CCDSi CCDS8388.1.
    PIRi I56215.
    RefSeqi NP_001549.2. NM_001558.3.
    UniGenei Hs.504035.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1J7V X-ray 2.90 R 22-235 [» ]
    1LQS X-ray 2.70 R/S 22-235 [» ]
    1Y6K X-ray 2.52 R 22-235 [» ]
    1Y6M X-ray 2.80 R 22-235 [» ]
    1Y6N X-ray 2.70 R 22-235 [» ]
    ProteinModelPortali Q13651.
    SMRi Q13651. Positions 23-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109801. 5 interactions.
    DIPi DIP-3512N.
    IntActi Q13651. 7 interactions.
    MINTi MINT-206772.
    STRINGi 9606.ENSP00000227752.

    PTM databases

    PhosphoSitei Q13651.

    Polymorphism databases

    DMDMi 322510034.

    Proteomic databases

    PaxDbi Q13651.
    PRIDEi Q13651.

    Protocols and materials databases

    DNASUi 3587.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000227752 ; ENSP00000227752 ; ENSG00000110324 .
    GeneIDi 3587.
    KEGGi hsa:3587.
    UCSCi uc001prv.3. human.

    Organism-specific databases

    CTDi 3587.
    GeneCardsi GC11P117891.
    H-InvDB HIX0010172.
    HGNCi HGNC:5964. IL10RA.
    MIMi 146933. gene.
    613148. phenotype.
    neXtProti NX_Q13651.
    Orphaneti 238569. Autosomal recessive early-onset inflammatory bowel disease.
    PharmGKBi PA29779.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43158.
    HOGENOMi HOG000112980.
    HOVERGENi HBG052056.
    InParanoidi Q13651.
    KOi K05134.
    OMAi WFEAEFF.
    OrthoDBi EOG7DJSMD.
    PhylomeDBi Q13651.
    TreeFami TF334107.

    Enzyme and pathway databases

    SignaLinki Q13651.

    Miscellaneous databases

    ChiTaRSi IL10RA. human.
    EvolutionaryTracei Q13651.
    GeneWikii Interleukin_10_receptor,_alpha_subunit.
    GenomeRNAii 3587.
    NextBioi 14015.
    PROi Q13651.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13651.
    Bgeei Q13651.
    CleanExi HS_IL10RA.
    Genevestigatori Q13651.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning and characterization of a human IL-10 receptor."
      Liu Y., Wei S.H.-Y., Ho A.S.-Y., de Waal Malefyt R., Moore K.W.
      J. Immunol. 152:1821-1829(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-351.
      Tissue: Lymphoma.
    2. SeattleSNPs variation discovery resource
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-61; ILE-113; GLY-159; GLN-212; GLY-351 AND LEU-420.
    3. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-351.
      Tissue: Placenta.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-351.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-351.
      Tissue: Blood.
    8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.
    9. "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site."
      Josephson K., Logsdon N.J., Walter M.R.
      Immunity 15:35-46(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 22-235 IN COMPLEX WITH IL10, DISULFIDE BONDS.
    10. "Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1."
      Jones B.C., Logsdon N.J., Josephson K., Cook J., Barry P.A., Walter M.R.
      Proc. Natl. Acad. Sci. U.S.A. 99:9404-9409(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 22-235 IN COMPLEX WITH CYTOMEGALOVIRUS IL10.
    11. "Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain."
      Yoon S.I., Jones B.C., Logsdon N.J., Walter M.R.
      Structure 13:551-564(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 22-335 IN COMPLEX WITH IL10 AND EPSTEIN-BARR VIRUS IL10.
    12. Cited for: VARIANTS IBD28 ILE-84 AND ARG-141.

    Entry informationi

    Entry nameiI10R1_HUMAN
    AccessioniPrimary (citable) accession number: Q13651
    Secondary accession number(s): A8K6I0, B0YJ27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3