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Q13651 (I10R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-10 receptor subunit alpha

Short name=IL-10 receptor subunit alpha
Short name=IL-10R subunit alpha
Short name=IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name=IL-10R subunit 1
Short name=IL-10R1
CD_antigen=CD210
Gene names
Name:IL10RA
Synonyms:IL10R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length578 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for IL10; binds IL10 with a high affinity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

Involvement in disease

Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12

Sequence similarities

Belongs to the type II cytokine receptor family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BCRF1P031802EBI-1031656,EBI-1042167From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.8
Chain22 – 578557Interleukin-10 receptor subunit alpha
PRO_0000011012

Regions

Topological domain22 – 235214Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 578322Cytoplasmic Potential

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation1891N-linked (GlcNAc...) Potential
Disulfide bond56 ↔ 75 Ref.9
Disulfide bond202 ↔ 223 Ref.9

Natural variations

Natural variant611L → V. Ref.2
Corresponds to variant rs4252250 [ dbSNP | Ensembl ].
VAR_016294
Natural variant841T → I in IBD28. Ref.12
VAR_063542
Natural variant1131V → I. Ref.2
Corresponds to variant rs4252303 [ dbSNP | Ensembl ].
VAR_016295
Natural variant1411G → R in IBD28. Ref.12
VAR_063543
Natural variant1591S → G. Ref.2
Corresponds to variant rs3135932 [ dbSNP | Ensembl ].
VAR_016296
Natural variant2121R → Q. Ref.2
Corresponds to variant rs4252273 [ dbSNP | Ensembl ].
VAR_016297
Natural variant2241I → V.
Corresponds to variant rs2228055 [ dbSNP | Ensembl ].
VAR_020004
Natural variant3511R → G. Ref.1 Ref.2 Ref.4 Ref.6 Ref.7
Corresponds to variant rs2229113 [ dbSNP | Ensembl ].
VAR_016298
Natural variant3531P → S.
Corresponds to variant rs35235073 [ dbSNP | Ensembl ].
VAR_049175
Natural variant4201S → L. Ref.2
Corresponds to variant rs2229114 [ dbSNP | Ensembl ].
VAR_016299

Secondary structure

.................................. 578
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q13651 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: 54B183ABE84808DB

FASTA57863,003
        10         20         30         40         50         60 
MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA 

        70         80         90        100        110        120 
LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV 

       130        140        150        160        170        180 
DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF 

       190        200        210        220        230        240 
THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF 

       250        260        270        280        290        300 
AFVLLLSGAL AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA 

       310        320        330        340        350        360 
FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN REPPVLGDSC 

       370        380        390        400        410        420 
SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD SGIDLVQNSE GRAGDTQGGS 

       430        440        450        460        470        480 
ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT RCAEEKATKT GCLEEESPLT DGLGPKFGRC 

       490        500        510        520        530        540 
LVDEAGLHPP ALAKGYLKQD PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS 

       550        560        570 
FAHDLAPLGC VAAPGGLLGS FNSDLVTLPL ISSLQSSE 

« Hide

References

« Hide 'large scale' references
[1]"Expression cloning and characterization of a human IL-10 receptor."
Liu Y., Wei S.H.-Y., Ho A.S.-Y., de Waal Malefyt R., Moore K.W.
J. Immunol. 152:1821-1829(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-351.
Tissue: Lymphoma.
[2]SeattleSNPs variation discovery resource
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-61; ILE-113; GLY-159; GLN-212; GLY-351 AND LEU-420.
[3]NHLBI resequencing and genotyping service (RS&G)
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-351.
Tissue: Placenta.
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-351.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-351.
Tissue: Blood.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
[9]"Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site."
Josephson K., Logsdon N.J., Walter M.R.
Immunity 15:35-46(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 22-235 IN COMPLEX WITH IL10, DISULFIDE BONDS.
[10]"Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1."
Jones B.C., Logsdon N.J., Josephson K., Cook J., Barry P.A., Walter M.R.
Proc. Natl. Acad. Sci. U.S.A. 99:9404-9409(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 22-235 IN COMPLEX WITH CYTOMEGALOVIRUS IL10.
[11]"Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain."
Yoon S.I., Jones B.C., Logsdon N.J., Walter M.R.
Structure 13:551-564(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 22-335 IN COMPLEX WITH IL10 AND EPSTEIN-BARR VIRUS IL10.
[12]"Inflammatory bowel disease and mutations affecting the interleukin-10 receptor."
Glocker E.O., Kotlarz D., Boztug K., Gertz E.M., Schaffer A.A., Noyan F., Perro M., Diestelhorst J., Allroth A., Murugan D., Hatscher N., Pfeifer D., Sykora K.W., Sauer M., Kreipe H., Lacher M., Nustede R., Woellner C. expand/collapse author list , Baumann U., Salzer U., Koletzko S., Shah N., Segal A.W., Sauerbrey A., Buderus S., Snapper S.B., Grimbacher B., Klein C.
N. Engl. J. Med. 361:2033-2045(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS IBD28 ILE-84 AND ARG-141.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00672 mRNA. Translation: AAA17896.1.
AY195619 Genomic DNA. Translation: AAN86349.1.
EF444988 Genomic DNA. Translation: ACA06005.1.
AK291645 mRNA. Translation: BAF84334.1.
AP002962 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67343.1.
BC028082 mRNA. Translation: AAH28082.1.
PIRI56215.
RefSeqNP_001549.2. NM_001558.3.
UniGeneHs.504035.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1J7VX-ray2.90R22-235[»]
1LQSX-ray2.70R/S22-235[»]
1Y6KX-ray2.52R22-235[»]
1Y6MX-ray2.80R22-235[»]
1Y6NX-ray2.70R22-235[»]
ProteinModelPortalQ13651.
SMRQ13651. Positions 23-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109801. 5 interactions.
DIPDIP-3512N.
IntActQ13651. 7 interactions.
MINTMINT-206772.
STRING9606.ENSP00000227752.

PTM databases

PhosphoSiteQ13651.

Polymorphism databases

DMDM322510034.

Proteomic databases

PaxDbQ13651.
PRIDEQ13651.

Protocols and materials databases

DNASU3587.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000227752; ENSP00000227752; ENSG00000110324.
GeneID3587.
KEGGhsa:3587.
UCSCuc001prv.3. human.

Organism-specific databases

CTD3587.
GeneCardsGC11P117891.
H-InvDBHIX0010172.
HGNCHGNC:5964. IL10RA.
MIM146933. gene.
613148. phenotype.
neXtProtNX_Q13651.
Orphanet238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBPA29779.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43158.
HOGENOMHOG000112980.
HOVERGENHBG052056.
InParanoidQ13651.
KOK05134.
OMAWFEAEFF.
OrthoDBEOG7DJSMD.
PhylomeDBQ13651.
TreeFamTF334107.

Enzyme and pathway databases

SignaLinkQ13651.

Gene expression databases

ArrayExpressQ13651.
BgeeQ13651.
CleanExHS_IL10RA.
GenevestigatorQ13651.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
ProtoNetSearch...

Other

ChiTaRSIL10RA. human.
EvolutionaryTraceQ13651.
GeneWikiInterleukin_10_receptor,_alpha_subunit.
GenomeRNAi3587.
NextBio14015.
PROQ13651.
SOURCESearch...

Entry information

Entry nameI10R1_HUMAN
AccessionPrimary (citable) accession number: Q13651
Secondary accession number(s): A8K6I0, B0YJ27
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries