Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-10 receptor subunit alpha

Gene

IL10RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for IL10; binds IL10 with a high affinity.

GO - Molecular functioni

  • interleukin-10 binding Source: Ensembl
  • interleukin-10 receptor activity Source: GO_Central
  • receptor activity Source: ProtInc
  • signal transducer activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-6783783. Interleukin-10 signaling.
SignaLinkiQ13651.
SIGNORiQ13651.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10 receptor subunit alpha
Short name:
IL-10 receptor subunit alpha
Short name:
IL-10R subunit alpha
Short name:
IL-10RA
Alternative name(s):
CDw210a
Interleukin-10 receptor subunit 1
Short name:
IL-10R subunit 1
Short name:
IL-10R1
CD_antigen: CD210
Gene namesi
Name:IL10RA
Synonyms:IL10R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110324.9.
HGNCiHGNC:5964. IL10RA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 235ExtracellularSequence analysisAdd BLAST214
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 578CytoplasmicSequence analysisAdd BLAST322

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 28 (IBD28)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
See also OMIM:613148
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07166369W → R in IBD28. 1 Publication1
Natural variantiVAR_06354284T → I in IBD28. 1 PublicationCorresponds to variant dbSNP:rs137853580Ensembl.1
Natural variantiVAR_07166491Y → C in IBD28. 2 Publications1
Natural variantiVAR_071665101R → W in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs368287711Ensembl.1
Natural variantiVAR_071666117R → H in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs199989396Ensembl.1
Natural variantiVAR_063543141G → R in IBD28. 1 PublicationCorresponds to variant dbSNP:rs137853579Ensembl.1
Natural variantiVAR_071667262R → C in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs149491038Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3587.
MalaCardsiIL10RA.
MIMi613148. phenotype.
OpenTargetsiENSG00000110324.
Orphaneti238569. Autosomal recessive early-onset inflammatory bowel disease.
PharmGKBiPA29779.

Chemistry databases

GuidetoPHARMACOLOGYi1727.

Polymorphism and mutation databases

BioMutaiIL10RA.
DMDMi322510034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001101222 – 578Interleukin-10 receptor subunit alphaAdd BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi56 ↔ 751 Publication
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi202 ↔ 2231 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13651.
PeptideAtlasiQ13651.
PRIDEiQ13651.

PTM databases

iPTMnetiQ13651.
PhosphoSitePlusiQ13651.

Expressioni

Tissue specificityi

Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

Gene expression databases

BgeeiENSG00000110324.
CleanExiHS_IL10RA.
ExpressionAtlasiQ13651. baseline and differential.
GenevisibleiQ13651. HS.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109801. 4 interactors.
CORUMiQ13651.
DIPiDIP-3512N.
IntActiQ13651. 7 interactors.
MINTiMINT-206772.
STRINGi9606.ENSP00000227752.

Structurei

Secondary structure

1578
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 37Combined sources6
Beta strandi40 – 45Combined sources6
Beta strandi56 – 63Combined sources8
Beta strandi70 – 82Combined sources13
Helixi84 – 87Combined sources4
Helixi90 – 92Combined sources3
Beta strandi96 – 104Combined sources9
Helixi120 – 122Combined sources3
Beta strandi123 – 125Combined sources3
Beta strandi128 – 134Combined sources7
Beta strandi136 – 144Combined sources9
Beta strandi149 – 151Combined sources3
Helixi157 – 160Combined sources4
Beta strandi165 – 176Combined sources12
Beta strandi181 – 193Combined sources13
Beta strandi199 – 209Combined sources11
Beta strandi222 – 225Combined sources4
Helixi268 – 270Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J7VX-ray2.90R22-235[»]
1LQSX-ray2.70R/S22-235[»]
1Y6KX-ray2.52R22-235[»]
1Y6MX-ray2.80R22-235[»]
1Y6NX-ray2.70R22-235[»]
5IXIX-ray2.57B263-303[»]
ProteinModelPortaliQ13651.
SMRiQ13651.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13651.

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAG. Eukaryota.
ENOG410YMSK. LUCA.
GeneTreeiENSGT00510000048847.
HOGENOMiHOG000112980.
HOVERGENiHBG052056.
InParanoidiQ13651.
KOiK05134.
OMAiTEEPQFL.
OrthoDBiEOG091G04DG.
PhylomeDBiQ13651.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
PfamiView protein in Pfam
PF01108. Tissue_fac. 1 hit.
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPCLVVLLA ALLSLRLGSD AHGTELPSPP SVWFEAEFFH HILHWTPIPN
60 70 80 90 100
QSESTCYEVA LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV
110 120 130 140 150
RAVDGSRHSN WTVTNTRFSV DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM
160 170 180 190 200
APANDTYESI FSHFREYEIA IRKVPGNFTF THKKVKHENF SLLTSGEVGE
210 220 230 240 250
FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTNVIIFF AFVLLLSGAL
260 270 280 290 300
AYCLALQLYV RRRKKLPSVL LFKKPSPFIF ISQRPSPETQ DTIHPLDEEA
310 320 330 340 350
FLKVSPELKN LDLHGSTDSG FGSTKPSLQT EEPQFLLPDP HPQADRTLGN
360 370 380 390 400
REPPVLGDSC SSGSSNSTDS GICLQEPSLS PSTGPTWEQQ VGSNSRGQDD
410 420 430 440 450
SGIDLVQNSE GRAGDTQGGS ALGHHSPPEP EVPGEEDPAA VAFQGYLRQT
460 470 480 490 500
RCAEEKATKT GCLEEESPLT DGLGPKFGRC LVDEAGLHPP ALAKGYLKQD
510 520 530 540 550
PLEMTLASSG APTGQWNQPT EEWSLLALSS CSDLGISDWS FAHDLAPLGC
560 570
VAAPGGLLGS FNSDLVTLPL ISSLQSSE
Length:578
Mass (Da):63,003
Last modified:February 8, 2011 - v2
Checksum:i54B183ABE84808DB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01629461L → V1 PublicationCorresponds to variant dbSNP:rs4252250Ensembl.1
Natural variantiVAR_07166369W → R in IBD28. 1 Publication1
Natural variantiVAR_06354284T → I in IBD28. 1 PublicationCorresponds to variant dbSNP:rs137853580Ensembl.1
Natural variantiVAR_07166491Y → C in IBD28. 2 Publications1
Natural variantiVAR_071665101R → W in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs368287711Ensembl.1
Natural variantiVAR_016295113V → I1 PublicationCorresponds to variant dbSNP:rs4252303Ensembl.1
Natural variantiVAR_071666117R → H in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs199989396Ensembl.1
Natural variantiVAR_063543141G → R in IBD28. 1 PublicationCorresponds to variant dbSNP:rs137853579Ensembl.1
Natural variantiVAR_016296159S → G1 PublicationCorresponds to variant dbSNP:rs3135932Ensembl.1
Natural variantiVAR_016297212R → Q1 PublicationCorresponds to variant dbSNP:rs4252273Ensembl.1
Natural variantiVAR_020004224I → V. Corresponds to variant dbSNP:rs2228055Ensembl.1
Natural variantiVAR_071667262R → C in IBD28. 2 PublicationsCorresponds to variant dbSNP:rs149491038Ensembl.1
Natural variantiVAR_016298351R → G5 PublicationsCorresponds to variant dbSNP:rs2229113Ensembl.1
Natural variantiVAR_049175353P → S. Corresponds to variant dbSNP:rs35235073Ensembl.1
Natural variantiVAR_016299420S → L1 PublicationCorresponds to variant dbSNP:rs2229114Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00672 mRNA. Translation: AAA17896.1.
AY195619 Genomic DNA. Translation: AAN86349.1.
EF444988 Genomic DNA. Translation: ACA06005.1.
AK291645 mRNA. Translation: BAF84334.1.
AP002962 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67343.1.
BC028082 mRNA. Translation: AAH28082.1.
CCDSiCCDS8388.1.
PIRiI56215.
RefSeqiNP_001549.2. NM_001558.3.
UniGeneiHs.504035.

Genome annotation databases

EnsembliENST00000227752; ENSP00000227752; ENSG00000110324.
GeneIDi3587.
KEGGihsa:3587.
UCSCiuc001prv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiI10R1_HUMAN
AccessioniPrimary (citable) accession number: Q13651
Secondary accession number(s): A8K6I0, B0YJ27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 8, 2011
Last modified: September 27, 2017
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families