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Protein

Four and a half LIM domains protein 3

Gene

FHL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: Ensembl
  • muscle organ development Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33442-MONOMER.
SignaLinkiQ13643.

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 3
Short name:
FHL-3
Alternative name(s):
Skeletal muscle LIM-protein 2
Short name:
SLIM-2
Gene namesi
Name:FHL3
Synonyms:SLIM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3704. FHL3.

Subcellular locationi

GO - Cellular componenti

  • focal adhesion Source: UniProtKB
  • nucleus Source: Ensembl
  • stress fiber Source: Ensembl
  • Z disc Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi2275.
MalaCardsiFHL3.
OpenTargetsiENSG00000183386.
PharmGKBiPA28142.

Polymorphism and mutation databases

BioMutaiFHL3.
DMDMi209572768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000757402 – 280Four and a half LIM domains protein 3Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei157N6-acetyllysineBy similarity1
Modified residuei235N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ13643.
MaxQBiQ13643.
PaxDbiQ13643.
PeptideAtlasiQ13643.
PRIDEiQ13643.

PTM databases

iPTMnetiQ13643.
PhosphoSitePlusiQ13643.

Expressioni

Tissue specificityi

Expressed only in skeletal muscle.

Gene expression databases

BgeeiENSG00000183386.
CleanExiHS_FHL3.
GenevisibleiQ13643. HS.

Organism-specific databases

HPAiHPA045723.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A1CFQ9NQ943EBI-741101,EBI-2809489
ADAM15Q134443EBI-741101,EBI-77818
AESQ08117-24EBI-741101,EBI-11741437
AIMP2Q1315511EBI-741101,EBI-745226
AMBPP027603EBI-741101,EBI-2115136
ANKHD1A0A0A0MQZ84EBI-741101,EBI-11531560
C14orf105Q17R993EBI-741101,EBI-10238351
C16orf35Q9BTE23EBI-741101,EBI-10298364
C9orf116Q5BN463EBI-741101,EBI-10243636
CCDC36Q8IYA84EBI-741101,EBI-8638439
CNNM3Q8NE016EBI-741101,EBI-741032
CNNM3Q8NE01-33EBI-741101,EBI-10269984
CSF1P096033EBI-741101,EBI-2872294
CTBP2Q5SQP84EBI-741101,EBI-11742664
DCDC2BA2VCK25EBI-741101,EBI-10173222
E2F8A0AVK63EBI-741101,EBI-7779316
EFCAB12Q6NXP03EBI-741101,EBI-10251535
EPHA10Q5JZY3-33EBI-741101,EBI-10244652
EPM2AIP1Q7L7753EBI-741101,EBI-6255981
FAM71CQ8NEG03EBI-741101,EBI-752049
FAM90A1Q86YD75EBI-741101,EBI-6658203
FBXL18Q96D163EBI-741101,EBI-744419
FOSL2P154083EBI-741101,EBI-3893419
FOXN4Q96NZ14EBI-741101,EBI-11749712
GATA1P15976-24EBI-741101,EBI-9090198
GATA2P237693EBI-741101,EBI-2806671
GCM2O756035EBI-741101,EBI-10188645
HIPK1Q86Z023EBI-741101,EBI-692891
HYAL2Q128913EBI-741101,EBI-2806068
IKZF3Q9UKT94EBI-741101,EBI-747204
KIRREL2Q6UWL63EBI-741101,EBI-10254473
KLF3P5768210EBI-741101,EBI-8472267
KPRPQ5T7494EBI-741101,EBI-10981970
KRTAP12-1P599905EBI-741101,EBI-10210845
KRTAP12-2P599915EBI-741101,EBI-10176379
KTI12Q96EK93EBI-741101,EBI-7951092
LATS2Q9NRM74EBI-741101,EBI-3506895
LMO2P257913EBI-741101,EBI-739696
LNX2Q8N4484EBI-741101,EBI-2340947
MRM3Q9HC365EBI-741101,EBI-1045440
MRPL27Q9P0M95EBI-741101,EBI-5325236
MYBPHLA2RUH73EBI-741101,EBI-9088235
P4HA2O15460-23EBI-741101,EBI-10182841
PATL1Q86TB95EBI-741101,EBI-2562092
PHF21AQ96BD55EBI-741101,EBI-745085
PLEKHG4BQ96PX94EBI-741101,EBI-11741362
PTPN6P293503EBI-741101,EBI-78260
QRICH1Q2TAL85EBI-741101,EBI-2798044
RAD21O602163EBI-741101,EBI-80739
RFX3P483803EBI-741101,EBI-742557
RHEBL1Q8TAI73EBI-741101,EBI-746555
SAP30BPQ9UHR53EBI-741101,EBI-751683
SAXO1Q8IYX75EBI-741101,EBI-3957636
SLAIN1Q8ND833EBI-741101,EBI-10269374
SLC25A46Q96AG35EBI-741101,EBI-10281975
SLC44A3Q8N4M13EBI-741101,EBI-10265585
SNRPGP623085EBI-741101,EBI-624585
TMX3Q96JJ73EBI-741101,EBI-2514069
TROG5E9N23EBI-741101,EBI-10178070
TTLL10Q6ZVT03EBI-741101,EBI-7844656
TYK2P295975EBI-741101,EBI-1383454
TYMSOSQ8TAI15EBI-741101,EBI-742060
UBE2Q1Q7Z7E8-23EBI-741101,EBI-10258181
VWC2LB2RUY74EBI-741101,EBI-11747707
WNK1A0A0B4J2995EBI-741101,EBI-10230525
ZFP36M0QY764EBI-741101,EBI-11743638
ZNF417Q8TAU33EBI-741101,EBI-740727
ZNF512BQ96KM65EBI-741101,EBI-1049952

Protein-protein interaction databases

BioGridi108566. 117 interactors.
DIPiDIP-42030N.
IntActiQ13643. 110 interactors.
MINTiMINT-155453.
STRINGi9606.ENSP00000362107.

Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni41 – 43Combined sources3
Turni63 – 65Combined sources3
Turni69 – 71Combined sources3
Beta strandi80 – 83Combined sources4
Beta strandi86 – 89Combined sources4
Turni90 – 92Combined sources3
Helixi97 – 99Combined sources3
Beta strandi102 – 104Combined sources3
Beta strandi110 – 112Combined sources3
Turni124 – 126Combined sources3
Turni130 – 132Combined sources3
Turni136 – 138Combined sources3
Beta strandi141 – 144Combined sources4
Beta strandi147 – 150Combined sources4
Helixi151 – 157Combined sources7
Turni163 – 165Combined sources3
Beta strandi174 – 181Combined sources8
Turni183 – 185Combined sources3
Beta strandi189 – 191Combined sources3
Beta strandi200 – 202Combined sources3
Beta strandi204 – 209Combined sources6
Helixi210 – 216Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYHNMR-A101-159[»]
2CUQNMR-A152-218[»]
2EHENMR-A30-99[»]
ProteinModelPortaliQ13643.
SMRiQ13643.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13643.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 92LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini101 – 153LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53
Domaini162 – 212LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51
Domaini221 – 275LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST55

Sequence similaritiesi

Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ13643.
OMAiYEDRHYH.
OrthoDBiEOG091G07C5.
PhylomeDBiQ13643.
TreeFamiTF314113.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD
60 70 80 90 100
SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ
110 120 130 140 150
CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC
160 170 180 190 200
VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CQTPLAGQQF
210 220 230 240 250
TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE DRHWHHNCFS
260 270 280
CARCSTSLVG QGFVPDGDQV LCQGCSQAGP
Length:280
Mass (Da):31,192
Last modified:October 14, 2008 - v4
Checksum:iD1A037C260370DFD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82C → R in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti130S → I in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti140S → P in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti157K → N in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti166S → T in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti174V → L in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti179Q → L in AAC04466 (PubMed:10049693).Curated1
Sequence conflicti183 – 184RE → PK in AAC04466 (PubMed:10049693).Curated2
Sequence conflicti250 – 252SCA → TCD in AAC04466 (PubMed:10049693).Curated3
Sequence conflicti252A → D in CAG33706 (Ref. 4) Curated1
Sequence conflicti256T → N in AAC04466 (PubMed:10049693).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60116 mRNA. Translation: AAC04466.2.
AK290641 mRNA. Translation: BAF83330.1.
BT007052 mRNA. Translation: AAP35701.1.
CR457425 mRNA. Translation: CAG33706.1.
AL603790 Genomic DNA. Translation: CAH69931.1.
CH471059 Genomic DNA. Translation: EAX07301.1.
CH471059 Genomic DNA. Translation: EAX07302.1.
BC001351 mRNA. Translation: AAH01351.1.
BC011697 mRNA. Translation: AAH11697.1.
CCDSiCCDS30678.1.
PIRiT09504.
RefSeqiNP_001230807.1. NM_001243878.1.
NP_004459.2. NM_004468.4.
UniGeneiHs.57687.

Genome annotation databases

EnsembliENST00000373016; ENSP00000362107; ENSG00000183386.
GeneIDi2275.
KEGGihsa:2275.
UCSCiuc001cck.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60116 mRNA. Translation: AAC04466.2.
AK290641 mRNA. Translation: BAF83330.1.
BT007052 mRNA. Translation: AAP35701.1.
CR457425 mRNA. Translation: CAG33706.1.
AL603790 Genomic DNA. Translation: CAH69931.1.
CH471059 Genomic DNA. Translation: EAX07301.1.
CH471059 Genomic DNA. Translation: EAX07302.1.
BC001351 mRNA. Translation: AAH01351.1.
BC011697 mRNA. Translation: AAH11697.1.
CCDSiCCDS30678.1.
PIRiT09504.
RefSeqiNP_001230807.1. NM_001243878.1.
NP_004459.2. NM_004468.4.
UniGeneiHs.57687.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYHNMR-A101-159[»]
2CUQNMR-A152-218[»]
2EHENMR-A30-99[»]
ProteinModelPortaliQ13643.
SMRiQ13643.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108566. 117 interactors.
DIPiDIP-42030N.
IntActiQ13643. 110 interactors.
MINTiMINT-155453.
STRINGi9606.ENSP00000362107.

PTM databases

iPTMnetiQ13643.
PhosphoSitePlusiQ13643.

Polymorphism and mutation databases

BioMutaiFHL3.
DMDMi209572768.

Proteomic databases

EPDiQ13643.
MaxQBiQ13643.
PaxDbiQ13643.
PeptideAtlasiQ13643.
PRIDEiQ13643.

Protocols and materials databases

DNASUi2275.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373016; ENSP00000362107; ENSG00000183386.
GeneIDi2275.
KEGGihsa:2275.
UCSCiuc001cck.4. human.

Organism-specific databases

CTDi2275.
DisGeNETi2275.
GeneCardsiFHL3.
HGNCiHGNC:3704. FHL3.
HPAiHPA045723.
MalaCardsiFHL3.
MIMi602790. gene.
neXtProtiNX_Q13643.
OpenTargetsiENSG00000183386.
PharmGKBiPA28142.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ13643.
OMAiYEDRHYH.
OrthoDBiEOG091G07C5.
PhylomeDBiQ13643.
TreeFamiTF314113.

Enzyme and pathway databases

BioCyciZFISH:G66-33442-MONOMER.
SignaLinkiQ13643.

Miscellaneous databases

ChiTaRSiFHL3. human.
EvolutionaryTraceiQ13643.
GeneWikiiFHL3.
GenomeRNAii2275.
PROiQ13643.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183386.
CleanExiHS_FHL3.
GenevisibleiQ13643. HS.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFHL3_HUMAN
AccessioniPrimary (citable) accession number: Q13643
Secondary accession number(s): D3DPT6, Q6I9T0, Q9BVA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.