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Q13643

- FHL3_HUMAN

UniProt

Q13643 - FHL3_HUMAN

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Protein
Four and a half LIM domains protein 3
Gene
FHL3, SLIM2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 3125C4-type Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. muscle organ development Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ13643.

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 3
Short name:
FHL-3
Alternative name(s):
Skeletal muscle LIM-protein 2
Short name:
SLIM-2
Gene namesi
Name:FHL3
Synonyms:SLIM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3704. FHL3.

Subcellular locationi

GO - Cellular componenti

  1. Z disc Source: Ensembl
  2. nucleus Source: Ensembl
  3. stress fiber Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 280279Four and a half LIM domains protein 3
PRO_0000075740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei157 – 1571N6-acetyllysine By similarity
Modified residuei235 – 2351N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ13643.
PaxDbiQ13643.
PRIDEiQ13643.

PTM databases

PhosphoSiteiQ13643.

Expressioni

Tissue specificityi

Expressed only in skeletal muscle.

Gene expression databases

ArrayExpressiQ13643.
BgeeiQ13643.
CleanExiHS_FHL3.
GenevestigatoriQ13643.

Organism-specific databases

HPAiHPA045723.

Interactioni

Protein-protein interaction databases

BioGridi108566. 27 interactions.
IntActiQ13643. 16 interactions.
MINTiMINT-155453.
STRINGi9606.ENSP00000362107.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni41 – 433
Turni63 – 653
Turni69 – 713
Beta strandi80 – 834
Beta strandi86 – 894
Turni90 – 923
Helixi97 – 993
Beta strandi102 – 1043
Beta strandi110 – 1123
Turni124 – 1263
Turni130 – 1323
Turni136 – 1383
Beta strandi141 – 1444
Beta strandi147 – 1504
Helixi151 – 1577
Turni163 – 1653
Beta strandi174 – 1818
Turni183 – 1853
Beta strandi189 – 1913
Beta strandi200 – 2023
Beta strandi204 – 2096
Helixi210 – 2167

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WYHNMR-A101-159[»]
2CUQNMR-A152-218[»]
2EHENMR-A30-99[»]
ProteinModelPortaliQ13643.
SMRiQ13643. Positions 1-277.

Miscellaneous databases

EvolutionaryTraceiQ13643.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 9253LIM zinc-binding 1
Add
BLAST
Domaini101 – 15353LIM zinc-binding 2
Add
BLAST
Domaini162 – 21251LIM zinc-binding 3
Add
BLAST
Domaini221 – 27555LIM zinc-binding 4
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG314122.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ13643.
OMAiRDDDPYC.
OrthoDBiEOG7P8P7M.
PhylomeDBiQ13643.
TreeFamiTF314113.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13643-1 [UniParc]FASTAAdd to Basket

« Hide

MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD    50
SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ 100
CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC 150
VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CQTPLAGQQF 200
TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE DRHWHHNCFS 250
CARCSTSLVG QGFVPDGDQV LCQGCSQAGP 280
Length:280
Mass (Da):31,192
Last modified:October 14, 2008 - v4
Checksum:iD1A037C260370DFD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821C → R in AAC04466. 1 Publication
Sequence conflicti130 – 1301S → I in AAC04466. 1 Publication
Sequence conflicti140 – 1401S → P in AAC04466. 1 Publication
Sequence conflicti157 – 1571K → N in AAC04466. 1 Publication
Sequence conflicti166 – 1661S → T in AAC04466. 1 Publication
Sequence conflicti174 – 1741V → L in AAC04466. 1 Publication
Sequence conflicti179 – 1791Q → L in AAC04466. 1 Publication
Sequence conflicti183 – 1842RE → PK in AAC04466. 1 Publication
Sequence conflicti250 – 2523SCA → TCD in AAC04466. 1 Publication
Sequence conflicti252 – 2521A → D in CAG33706. 1 Publication
Sequence conflicti256 – 2561T → N in AAC04466. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U60116 mRNA. Translation: AAC04466.2.
AK290641 mRNA. Translation: BAF83330.1.
BT007052 mRNA. Translation: AAP35701.1.
CR457425 mRNA. Translation: CAG33706.1.
AL603790 Genomic DNA. Translation: CAH69931.1.
CH471059 Genomic DNA. Translation: EAX07301.1.
CH471059 Genomic DNA. Translation: EAX07302.1.
BC001351 mRNA. Translation: AAH01351.1.
BC011697 mRNA. Translation: AAH11697.1.
CCDSiCCDS30678.1.
PIRiT09504.
RefSeqiNP_001230807.1. NM_001243878.1.
NP_004459.2. NM_004468.4.
XP_005270683.1. XM_005270626.1.
UniGeneiHs.57687.

Genome annotation databases

EnsembliENST00000373016; ENSP00000362107; ENSG00000183386.
GeneIDi2275.
KEGGihsa:2275.
UCSCiuc001cck.3. human.

Polymorphism databases

DMDMi209572768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U60116 mRNA. Translation: AAC04466.2 .
AK290641 mRNA. Translation: BAF83330.1 .
BT007052 mRNA. Translation: AAP35701.1 .
CR457425 mRNA. Translation: CAG33706.1 .
AL603790 Genomic DNA. Translation: CAH69931.1 .
CH471059 Genomic DNA. Translation: EAX07301.1 .
CH471059 Genomic DNA. Translation: EAX07302.1 .
BC001351 mRNA. Translation: AAH01351.1 .
BC011697 mRNA. Translation: AAH11697.1 .
CCDSi CCDS30678.1.
PIRi T09504.
RefSeqi NP_001230807.1. NM_001243878.1.
NP_004459.2. NM_004468.4.
XP_005270683.1. XM_005270626.1.
UniGenei Hs.57687.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WYH NMR - A 101-159 [» ]
2CUQ NMR - A 152-218 [» ]
2EHE NMR - A 30-99 [» ]
ProteinModelPortali Q13643.
SMRi Q13643. Positions 1-277.
ModBasei Search...

Protein-protein interaction databases

BioGridi 108566. 27 interactions.
IntActi Q13643. 16 interactions.
MINTi MINT-155453.
STRINGi 9606.ENSP00000362107.

PTM databases

PhosphoSitei Q13643.

Polymorphism databases

DMDMi 209572768.

Proteomic databases

MaxQBi Q13643.
PaxDbi Q13643.
PRIDEi Q13643.

Protocols and materials databases

DNASUi 2275.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373016 ; ENSP00000362107 ; ENSG00000183386 .
GeneIDi 2275.
KEGGi hsa:2275.
UCSCi uc001cck.3. human.

Organism-specific databases

CTDi 2275.
GeneCardsi GC01M038462.
HGNCi HGNC:3704. FHL3.
HPAi HPA045723.
MIMi 602790. gene.
neXtProti NX_Q13643.
PharmGKBi PA28142.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314122.
HOGENOMi HOG000231075.
HOVERGENi HBG074526.
InParanoidi Q13643.
OMAi RDDDPYC.
OrthoDBi EOG7P8P7M.
PhylomeDBi Q13643.
TreeFami TF314113.

Enzyme and pathway databases

SignaLinki Q13643.

Miscellaneous databases

ChiTaRSi FHL3. human.
EvolutionaryTracei Q13643.
GeneWikii FHL3.
GenomeRNAii 2275.
NextBioi 9257.
PROi Q13643.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13643.
Bgeei Q13643.
CleanExi HS_FHL3.
Genevestigatori Q13643.

Family and domain databases

Gene3Di 2.10.110.10. 5 hits.
InterProi IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00412. LIM. 4 hits.
[Graphical view ]
SMARTi SM00132. LIM. 4 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle."
    Morgan M.J., Madgwick A.J.A.
    Biochem. Biophys. Res. Commun. 255:245-250(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  8. "Slim defines a novel family of LIM-proteins expressed in skeletal muscle."
    Morgan M.J., Madgwick A.J.A.
    Biochem. Biophys. Res. Commun. 225:632-638(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 16-280.
    Tissue: Skeletal muscle.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. "Solution structure of LIM domains from human skeletal muscle LIM-protein 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 98-218 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiFHL3_HUMAN
AccessioniPrimary (citable) accession number: Q13643
Secondary accession number(s): D3DPT6, Q6I9T0, Q9BVA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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