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Q13643

- FHL3_HUMAN

UniProt

Q13643 - FHL3_HUMAN

Protein

Four and a half LIM domains protein 3

Gene

FHL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 4 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 3125C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. muscle organ development Source: ProtInc

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ13643.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Four and a half LIM domains protein 3
    Short name:
    FHL-3
    Alternative name(s):
    Skeletal muscle LIM-protein 2
    Short name:
    SLIM-2
    Gene namesi
    Name:FHL3
    Synonyms:SLIM2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3704. FHL3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: Ensembl
    2. stress fiber Source: Ensembl
    3. Z disc Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28142.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 280279Four and a half LIM domains protein 3PRO_0000075740Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei157 – 1571N6-acetyllysineBy similarity
    Modified residuei235 – 2351N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ13643.
    PaxDbiQ13643.
    PRIDEiQ13643.

    PTM databases

    PhosphoSiteiQ13643.

    Expressioni

    Tissue specificityi

    Expressed only in skeletal muscle.

    Gene expression databases

    ArrayExpressiQ13643.
    BgeeiQ13643.
    CleanExiHS_FHL3.
    GenevestigatoriQ13643.

    Organism-specific databases

    HPAiHPA045723.

    Interactioni

    Protein-protein interaction databases

    BioGridi108566. 27 interactions.
    IntActiQ13643. 16 interactions.
    MINTiMINT-155453.
    STRINGi9606.ENSP00000362107.

    Structurei

    Secondary structure

    1
    280
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni41 – 433
    Turni63 – 653
    Turni69 – 713
    Beta strandi80 – 834
    Beta strandi86 – 894
    Turni90 – 923
    Helixi97 – 993
    Beta strandi102 – 1043
    Beta strandi110 – 1123
    Turni124 – 1263
    Turni130 – 1323
    Turni136 – 1383
    Beta strandi141 – 1444
    Beta strandi147 – 1504
    Helixi151 – 1577
    Turni163 – 1653
    Beta strandi174 – 1818
    Turni183 – 1853
    Beta strandi189 – 1913
    Beta strandi200 – 2023
    Beta strandi204 – 2096
    Helixi210 – 2167

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WYHNMR-A101-159[»]
    2CUQNMR-A152-218[»]
    2EHENMR-A30-99[»]
    ProteinModelPortaliQ13643.
    SMRiQ13643. Positions 1-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13643.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 9253LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini101 – 15353LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini162 – 21251LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini221 – 27555LIM zinc-binding 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 3125C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    LIM domain, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG314122.
    HOGENOMiHOG000231075.
    HOVERGENiHBG074526.
    InParanoidiQ13643.
    OMAiRDDDPYC.
    OrthoDBiEOG7P8P7M.
    PhylomeDBiQ13643.
    TreeFamiTF314113.

    Family and domain databases

    Gene3Di2.10.110.10. 5 hits.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 4 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 4 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13643-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESFDCAKC NESLYGRKYI QTDSGPYCVP CYDNTFANTC AECQQLIGHD    50
    SRELFYEDRH FHEGCFRCCR CQRSLADEPF TCQDSELLCN DCYCSAFSSQ 100
    CSACGETVMP GSRKLEYGGQ TWHEHCFLCS GCEQPLGSRS FVPDKGAHYC 150
    VPCYENKFAP RCARCSKTLT QGGVTYRDQP WHRECLVCTG CQTPLAGQQF 200
    TSRDEDPYCV ACFGELFAPK CSSCKRPIVG LGGGKYVSFE DRHWHHNCFS 250
    CARCSTSLVG QGFVPDGDQV LCQGCSQAGP 280
    Length:280
    Mass (Da):31,192
    Last modified:October 14, 2008 - v4
    Checksum:iD1A037C260370DFD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821C → R in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti130 – 1301S → I in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti140 – 1401S → P in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti157 – 1571K → N in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti166 – 1661S → T in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti174 – 1741V → L in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti179 – 1791Q → L in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti183 – 1842RE → PK in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti250 – 2523SCA → TCD in AAC04466. (PubMed:10049693)Curated
    Sequence conflicti252 – 2521A → D in CAG33706. 1 PublicationCurated
    Sequence conflicti256 – 2561T → N in AAC04466. (PubMed:10049693)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60116 mRNA. Translation: AAC04466.2.
    AK290641 mRNA. Translation: BAF83330.1.
    BT007052 mRNA. Translation: AAP35701.1.
    CR457425 mRNA. Translation: CAG33706.1.
    AL603790 Genomic DNA. Translation: CAH69931.1.
    CH471059 Genomic DNA. Translation: EAX07301.1.
    CH471059 Genomic DNA. Translation: EAX07302.1.
    BC001351 mRNA. Translation: AAH01351.1.
    BC011697 mRNA. Translation: AAH11697.1.
    CCDSiCCDS30678.1.
    PIRiT09504.
    RefSeqiNP_001230807.1. NM_001243878.1.
    NP_004459.2. NM_004468.4.
    XP_005270683.1. XM_005270626.1.
    UniGeneiHs.57687.

    Genome annotation databases

    EnsembliENST00000373016; ENSP00000362107; ENSG00000183386.
    GeneIDi2275.
    KEGGihsa:2275.
    UCSCiuc001cck.3. human.

    Polymorphism databases

    DMDMi209572768.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60116 mRNA. Translation: AAC04466.2 .
    AK290641 mRNA. Translation: BAF83330.1 .
    BT007052 mRNA. Translation: AAP35701.1 .
    CR457425 mRNA. Translation: CAG33706.1 .
    AL603790 Genomic DNA. Translation: CAH69931.1 .
    CH471059 Genomic DNA. Translation: EAX07301.1 .
    CH471059 Genomic DNA. Translation: EAX07302.1 .
    BC001351 mRNA. Translation: AAH01351.1 .
    BC011697 mRNA. Translation: AAH11697.1 .
    CCDSi CCDS30678.1.
    PIRi T09504.
    RefSeqi NP_001230807.1. NM_001243878.1.
    NP_004459.2. NM_004468.4.
    XP_005270683.1. XM_005270626.1.
    UniGenei Hs.57687.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WYH NMR - A 101-159 [» ]
    2CUQ NMR - A 152-218 [» ]
    2EHE NMR - A 30-99 [» ]
    ProteinModelPortali Q13643.
    SMRi Q13643. Positions 1-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108566. 27 interactions.
    IntActi Q13643. 16 interactions.
    MINTi MINT-155453.
    STRINGi 9606.ENSP00000362107.

    PTM databases

    PhosphoSitei Q13643.

    Polymorphism databases

    DMDMi 209572768.

    Proteomic databases

    MaxQBi Q13643.
    PaxDbi Q13643.
    PRIDEi Q13643.

    Protocols and materials databases

    DNASUi 2275.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373016 ; ENSP00000362107 ; ENSG00000183386 .
    GeneIDi 2275.
    KEGGi hsa:2275.
    UCSCi uc001cck.3. human.

    Organism-specific databases

    CTDi 2275.
    GeneCardsi GC01M038462.
    HGNCi HGNC:3704. FHL3.
    HPAi HPA045723.
    MIMi 602790. gene.
    neXtProti NX_Q13643.
    PharmGKBi PA28142.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314122.
    HOGENOMi HOG000231075.
    HOVERGENi HBG074526.
    InParanoidi Q13643.
    OMAi RDDDPYC.
    OrthoDBi EOG7P8P7M.
    PhylomeDBi Q13643.
    TreeFami TF314113.

    Enzyme and pathway databases

    SignaLinki Q13643.

    Miscellaneous databases

    ChiTaRSi FHL3. human.
    EvolutionaryTracei Q13643.
    GeneWikii FHL3.
    GenomeRNAii 2275.
    NextBioi 9257.
    PROi Q13643.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13643.
    Bgeei Q13643.
    CleanExi HS_FHL3.
    Genevestigatori Q13643.

    Family and domain databases

    Gene3Di 2.10.110.10. 5 hits.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 4 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 4 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle."
      Morgan M.J., Madgwick A.J.A.
      Biochem. Biophys. Res. Commun. 255:245-250(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    8. "Slim defines a novel family of LIM-proteins expressed in skeletal muscle."
      Morgan M.J., Madgwick A.J.A.
      Biochem. Biophys. Res. Commun. 225:632-638(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 16-280.
      Tissue: Skeletal muscle.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    11. "Solution structure of LIM domains from human skeletal muscle LIM-protein 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (AUG-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 98-218 IN COMPLEX WITH ZINC IONS.

    Entry informationi

    Entry nameiFHL3_HUMAN
    AccessioniPrimary (citable) accession number: Q13643
    Secondary accession number(s): D3DPT6, Q6I9T0, Q9BVA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 125 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3