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Q13641

- TPBG_HUMAN

UniProt

Q13641 - TPBG_HUMAN

Protein

Trophoblast glycoprotein

Gene

TPBG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.1 Publication

    GO - Biological processi

    1. cell adhesion Source: ProtInc

    Enzyme and pathway databases

    SignaLinkiQ13641.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trophoblast glycoprotein
    Alternative name(s):
    5T4 oncofetal antigen
    5T4 oncofetal trophoblast glycoprotein
    Short name:
    5T4 oncotrophoblast glycoprotein
    M6P1
    Wnt-activated inhibitory factor 1
    Short name:
    WAIF1
    Gene namesi
    Name:TPBG
    Synonyms:5T4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:12004. TPBG.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi76 – 761K → A: Strongly reduces Wnt inhibitory function. 1 Publication
    Mutagenesisi97 – 971F → T: Strongly reduces Wnt inhibitory function. 1 Publication
    Mutagenesisi124 – 1241N → Q: Impaired trafficking to the cell surface. 1 Publication
    Mutagenesisi214 – 2141R → E: Impaired trafficking to the cell surface. 1 Publication
    Mutagenesisi325 – 3251Y → A: Reduces Wnt inhibitory function. 1 Publication

    Organism-specific databases

    PharmGKBiPA36685.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 420389Trophoblast glycoproteinPRO_0000019591Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi62 ↔ 681 Publication
    Disulfide bondi66 ↔ 771 Publication
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi124 – 1241N-linked (GlcNAc...)2 Publications
    Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi298 ↔ 3231 Publication
    Disulfide bondi300 ↔ 3441 Publication

    Post-translational modificationi

    Highly glycosylated.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ13641.
    PaxDbiQ13641.
    PeptideAtlasiQ13641.
    PRIDEiQ13641.

    PTM databases

    PhosphoSiteiQ13641.

    Expressioni

    Tissue specificityi

    Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

    Gene expression databases

    ArrayExpressiQ13641.
    BgeeiQ13641.
    CleanExiHS_TPBG.
    GenevestigatoriQ13641.

    Organism-specific databases

    HPAiHPA010554.

    Interactioni

    Protein-protein interaction databases

    BioGridi113015. 25 interactions.
    IntActiQ13641. 1 interaction.
    MINTiMINT-230707.
    STRINGi9606.ENSP00000358765.

    Structurei

    Secondary structure

    1
    420
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi67 – 693
    Turni70 – 734
    Beta strandi74 – 763
    Beta strandi94 – 974
    Beta strandi104 – 1063
    Turni108 – 1114
    Beta strandi122 – 1243
    Beta strandi130 – 1334
    Turni135 – 1406
    Beta strandi146 – 1483
    Beta strandi155 – 1573
    Turni159 – 1635
    Beta strandi177 – 1793
    Helixi188 – 1903
    Beta strandi191 – 1933
    Helixi195 – 20410
    Helixi205 – 2073
    Turni208 – 2114
    Beta strandi214 – 2163
    Helixi227 – 2326
    Beta strandi238 – 2403
    Beta strandi262 – 2643
    Helixi275 – 2817
    Beta strandi288 – 2903
    Helixi300 – 3023
    Helixi303 – 3119
    Beta strandi313 – 3164
    Helixi318 – 3203
    Beta strandi322 – 3265
    Helixi327 – 3293
    Helixi334 – 3363
    Helixi339 – 3413

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CNCX-ray1.77A/B60-345[»]
    4CNMX-ray1.75A60-345[»]
    ProteinModelPortaliQ13641.
    SMRiQ13641. Positions 16-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 355324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini377 – 42044CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 9139LRRNTAdd
    BLAST
    Repeati92 – 11322LRR 11 PublicationAdd
    BLAST
    Repeati116 – 13924LRR 21 PublicationAdd
    BLAST
    Repeati141 – 16323LRR 31 PublicationAdd
    BLAST
    Repeati172 – 20433LRR 41 PublicationAdd
    BLAST
    Repeati209 – 23224LRR 51 PublicationAdd
    BLAST
    Repeati233 – 25523LRR 61 PublicationAdd
    BLAST
    Repeati256 – 27520LRR 71 PublicationAdd
    BLAST
    Domaini283 – 34664LRRCTAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 5322Ser-richAdd
    BLAST

    Domaini

    The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.1 Publication

    Sequence similaritiesi

    Contains 7 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301461.
    HOGENOMiHOG000013090.
    HOVERGENiHBG053843.
    InParanoidiQ13641.
    OMAiSFRNLTH.
    OrthoDBiEOG7QNVM8.
    PhylomeDBiQ13641.
    TreeFamiTF351115.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 2 hits.
    PF01463. LRRCT. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13641-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS    50
    AVSAQPPLPD QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG 100
    NQLAVLPAGA FARRPPLAEL AALNLSGSRL DEVRAGAFEH LPSLRQLDLS 150
    HNPLADLSPF AFSGSNASVS APSPLVELIL NHIVPPEDER QNRSFEGMVV 200
    AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD LSNNSLVSLT 250
    YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC 300
    HMADMVTWLK ETEVVQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP 350
    SLQTSYVFLG IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH 400
    YRYEINADPR LTNLSSNSDV 420
    Length:420
    Mass (Da):46,032
    Last modified:November 1, 1996 - v1
    Checksum:i3C403211F40F18BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z29083 mRNA. Translation: CAA82324.1.
    AK291170 mRNA. Translation: BAF83859.1.
    AK074790 mRNA. Translation: BAG52001.1.
    CH471051 Genomic DNA. Translation: EAW48683.1.
    AL121977 Genomic DNA. Translation: CAI21546.1.
    AJ012159 Genomic DNA. Translation: CAA09930.1.
    BC037161 mRNA. Translation: AAH37161.1.
    CCDSiCCDS4995.1.
    PIRiA53531.
    RefSeqiNP_001159864.1. NM_001166392.1.
    NP_006661.1. NM_006670.4.
    XP_005248820.1. XM_005248763.1.
    UniGeneiHs.82128.

    Genome annotation databases

    EnsembliENST00000369750; ENSP00000358765; ENSG00000146242.
    ENST00000535040; ENSP00000441219; ENSG00000146242.
    ENST00000543496; ENSP00000440049; ENSG00000146242.
    GeneIDi7162.
    KEGGihsa:7162.
    UCSCiuc003pjn.4. human.

    Polymorphism databases

    DMDMi73621980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z29083 mRNA. Translation: CAA82324.1 .
    AK291170 mRNA. Translation: BAF83859.1 .
    AK074790 mRNA. Translation: BAG52001.1 .
    CH471051 Genomic DNA. Translation: EAW48683.1 .
    AL121977 Genomic DNA. Translation: CAI21546.1 .
    AJ012159 Genomic DNA. Translation: CAA09930.1 .
    BC037161 mRNA. Translation: AAH37161.1 .
    CCDSi CCDS4995.1.
    PIRi A53531.
    RefSeqi NP_001159864.1. NM_001166392.1.
    NP_006661.1. NM_006670.4.
    XP_005248820.1. XM_005248763.1.
    UniGenei Hs.82128.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4CNC X-ray 1.77 A/B 60-345 [» ]
    4CNM X-ray 1.75 A 60-345 [» ]
    ProteinModelPortali Q13641.
    SMRi Q13641. Positions 16-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113015. 25 interactions.
    IntActi Q13641. 1 interaction.
    MINTi MINT-230707.
    STRINGi 9606.ENSP00000358765.

    PTM databases

    PhosphoSitei Q13641.

    Polymorphism databases

    DMDMi 73621980.

    Proteomic databases

    MaxQBi Q13641.
    PaxDbi Q13641.
    PeptideAtlasi Q13641.
    PRIDEi Q13641.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369750 ; ENSP00000358765 ; ENSG00000146242 .
    ENST00000535040 ; ENSP00000441219 ; ENSG00000146242 .
    ENST00000543496 ; ENSP00000440049 ; ENSG00000146242 .
    GeneIDi 7162.
    KEGGi hsa:7162.
    UCSCi uc003pjn.4. human.

    Organism-specific databases

    CTDi 7162.
    GeneCardsi GC06P083072.
    HGNCi HGNC:12004. TPBG.
    HPAi HPA010554.
    MIMi 190920. gene.
    neXtProti NX_Q13641.
    PharmGKBi PA36685.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301461.
    HOGENOMi HOG000013090.
    HOVERGENi HBG053843.
    InParanoidi Q13641.
    OMAi SFRNLTH.
    OrthoDBi EOG7QNVM8.
    PhylomeDBi Q13641.
    TreeFami TF351115.

    Enzyme and pathway databases

    SignaLinki Q13641.

    Miscellaneous databases

    GeneWikii TPBG.
    GenomeRNAii 7162.
    NextBioi 28026.
    PROi Q13641.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13641.
    Bgeei Q13641.
    CleanExi HS_TPBG.
    Genevestigatori Q13641.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 2 hits.
    PF01463. LRRCT. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats."
      Myers K.A., Rahi-Saund V., Davison M.D., Young J.A., Cheater A.J., Stern P.L.
      J. Biol. Chem. 269:9319-9324(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 52-75 AND 199-235.
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    7. "Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors."
      Mulryan K., Ryan M.G., Myers K.A., Shaw D., Wang W., Kingsman S.M., Stern P.L., Carroll M.W.
      Mol. Cancer Ther. 1:1129-1137(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: USE IN TUMOR IMMUNOTHERAPHY.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124.
      Tissue: Liver.
    9. "Waif1/5T4 inhibits Wnt/beta-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization."
      Kagermeier-Schenk B., Wehner D., Ozhan-Kizil G., Yamamoto H., Li J., Kirchner K., Hoffmann C., Stern P., Kikuchi A., Schambony A., Weidinger G.
      Dev. Cell 21:1129-1143(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MISCELLANEOUS.
    10. "Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1."
      Zhao Y., Malinauskas T., Harlos K., Jones E.Y.
      Structure 22:612-620(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 60-345, SUBCELLULAR LOCATION, LRR REPEATS, GLYCOSYLATION, DISULFIDE BONDS, MUTAGENESIS OF LYS-76; PHE-97; ASN-124; ARG-214 AND TYR-325.

    Entry informationi

    Entry nameiTPBG_HUMAN
    AccessioniPrimary (citable) accession number: Q13641
    Secondary accession number(s): A8K555
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy.
    Reduction of TPBG levels by siRNA significantly enhanced the beta-catenin/TCF transcription-based reporter pBAR activation in response to Wnt stimulation.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3