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Q13641

- TPBG_HUMAN

UniProt

Q13641 - TPBG_HUMAN

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Protein

Trophoblast glycoprotein

Gene

TPBG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.1 Publication

GO - Biological processi

  1. cell adhesion Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ13641.

Names & Taxonomyi

Protein namesi
Recommended name:
Trophoblast glycoprotein
Alternative name(s):
5T4 oncofetal antigen
5T4 oncofetal trophoblast glycoprotein
Short name:
5T4 oncotrophoblast glycoprotein
M6P1
Wnt-activated inhibitory factor 1
Short name:
WAIF1
Gene namesi
Name:TPBG
Synonyms:5T4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:12004. TPBG.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. endoplasmic reticulum Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi76 – 761K → A: Strongly reduces Wnt inhibitory function. 1 Publication
Mutagenesisi97 – 971F → T: Strongly reduces Wnt inhibitory function. 1 Publication
Mutagenesisi124 – 1241N → Q: Impaired trafficking to the cell surface. 1 Publication
Mutagenesisi214 – 2141R → E: Impaired trafficking to the cell surface. 1 Publication
Mutagenesisi325 – 3251Y → A: Reduces Wnt inhibitory function. 1 Publication

Organism-specific databases

PharmGKBiPA36685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 420389Trophoblast glycoproteinPRO_0000019591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 681 Publication
Disulfide bondi66 ↔ 771 Publication
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)1 Publication
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi298 ↔ 3231 Publication
Disulfide bondi300 ↔ 3441 Publication

Post-translational modificationi

Highly glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ13641.
PaxDbiQ13641.
PeptideAtlasiQ13641.
PRIDEiQ13641.

PTM databases

PhosphoSiteiQ13641.

Expressioni

Tissue specificityi

Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Gene expression databases

BgeeiQ13641.
CleanExiHS_TPBG.
GenevestigatoriQ13641.

Organism-specific databases

HPAiHPA010554.

Interactioni

Protein-protein interaction databases

BioGridi113015. 25 interactions.
IntActiQ13641. 1 interaction.
MINTiMINT-230707.
STRINGi9606.ENSP00000358765.

Structurei

Secondary structure

1
420
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi67 – 693
Turni70 – 734
Beta strandi74 – 763
Beta strandi94 – 974
Beta strandi104 – 1063
Turni108 – 1114
Beta strandi122 – 1243
Beta strandi130 – 1334
Turni135 – 1406
Beta strandi146 – 1483
Beta strandi155 – 1573
Turni159 – 1635
Beta strandi177 – 1793
Helixi188 – 1903
Beta strandi191 – 1933
Helixi195 – 20410
Helixi205 – 2073
Turni208 – 2114
Beta strandi214 – 2163
Helixi227 – 2326
Beta strandi238 – 2403
Beta strandi262 – 2643
Helixi275 – 2817
Beta strandi288 – 2903
Helixi300 – 3023
Helixi303 – 3119
Beta strandi313 – 3164
Helixi318 – 3203
Beta strandi322 – 3265
Helixi327 – 3293
Helixi334 – 3363
Helixi339 – 3413

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CNCX-ray1.77A/B60-345[»]
4CNMX-ray1.75A60-345[»]
ProteinModelPortaliQ13641.
SMRiQ13641. Positions 17-344.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 355324ExtracellularSequence AnalysisAdd
BLAST
Topological domaini377 – 42044CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 9139LRRNTAdd
BLAST
Repeati92 – 11322LRR 11 PublicationAdd
BLAST
Repeati116 – 13924LRR 21 PublicationAdd
BLAST
Repeati141 – 16323LRR 31 PublicationAdd
BLAST
Repeati172 – 20433LRR 41 PublicationAdd
BLAST
Repeati209 – 23224LRR 51 PublicationAdd
BLAST
Repeati233 – 25523LRR 61 PublicationAdd
BLAST
Repeati256 – 27520LRR 71 PublicationAdd
BLAST
Domaini283 – 34664LRRCTAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 5322Ser-richAdd
BLAST

Domaini

The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.1 Publication

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301461.
GeneTreeiENSGT00620000088023.
HOGENOMiHOG000013090.
HOVERGENiHBG053843.
InParanoidiQ13641.
OMAiSFRNLTH.
OrthoDBiEOG7QNVM8.
PhylomeDBiQ13641.
TreeFamiTF351115.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13641 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS
60 70 80 90 100
AVSAQPPLPD QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG
110 120 130 140 150
NQLAVLPAGA FARRPPLAEL AALNLSGSRL DEVRAGAFEH LPSLRQLDLS
160 170 180 190 200
HNPLADLSPF AFSGSNASVS APSPLVELIL NHIVPPEDER QNRSFEGMVV
210 220 230 240 250
AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD LSNNSLVSLT
260 270 280 290 300
YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC
310 320 330 340 350
HMADMVTWLK ETEVVQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP
360 370 380 390 400
SLQTSYVFLG IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH
410 420
YRYEINADPR LTNLSSNSDV
Length:420
Mass (Da):46,032
Last modified:November 1, 1996 - v1
Checksum:i3C403211F40F18BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z29083 mRNA. Translation: CAA82324.1.
AK291170 mRNA. Translation: BAF83859.1.
AK074790 mRNA. Translation: BAG52001.1.
CH471051 Genomic DNA. Translation: EAW48683.1.
AL121977 Genomic DNA. Translation: CAI21546.1.
AJ012159 Genomic DNA. Translation: CAA09930.1.
BC037161 mRNA. Translation: AAH37161.1.
CCDSiCCDS4995.1.
PIRiA53531.
RefSeqiNP_001159864.1. NM_001166392.1.
NP_006661.1. NM_006670.4.
XP_005248820.1. XM_005248763.1.
UniGeneiHs.82128.

Genome annotation databases

EnsembliENST00000369750; ENSP00000358765; ENSG00000146242.
ENST00000535040; ENSP00000441219; ENSG00000146242.
ENST00000543496; ENSP00000440049; ENSG00000146242.
GeneIDi7162.
KEGGihsa:7162.
UCSCiuc003pjn.4. human.

Polymorphism databases

DMDMi73621980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z29083 mRNA. Translation: CAA82324.1 .
AK291170 mRNA. Translation: BAF83859.1 .
AK074790 mRNA. Translation: BAG52001.1 .
CH471051 Genomic DNA. Translation: EAW48683.1 .
AL121977 Genomic DNA. Translation: CAI21546.1 .
AJ012159 Genomic DNA. Translation: CAA09930.1 .
BC037161 mRNA. Translation: AAH37161.1 .
CCDSi CCDS4995.1.
PIRi A53531.
RefSeqi NP_001159864.1. NM_001166392.1.
NP_006661.1. NM_006670.4.
XP_005248820.1. XM_005248763.1.
UniGenei Hs.82128.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CNC X-ray 1.77 A/B 60-345 [» ]
4CNM X-ray 1.75 A 60-345 [» ]
ProteinModelPortali Q13641.
SMRi Q13641. Positions 17-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113015. 25 interactions.
IntActi Q13641. 1 interaction.
MINTi MINT-230707.
STRINGi 9606.ENSP00000358765.

PTM databases

PhosphoSitei Q13641.

Polymorphism databases

DMDMi 73621980.

Proteomic databases

MaxQBi Q13641.
PaxDbi Q13641.
PeptideAtlasi Q13641.
PRIDEi Q13641.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369750 ; ENSP00000358765 ; ENSG00000146242 .
ENST00000535040 ; ENSP00000441219 ; ENSG00000146242 .
ENST00000543496 ; ENSP00000440049 ; ENSG00000146242 .
GeneIDi 7162.
KEGGi hsa:7162.
UCSCi uc003pjn.4. human.

Organism-specific databases

CTDi 7162.
GeneCardsi GC06P083072.
HGNCi HGNC:12004. TPBG.
HPAi HPA010554.
MIMi 190920. gene.
neXtProti NX_Q13641.
PharmGKBi PA36685.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301461.
GeneTreei ENSGT00620000088023.
HOGENOMi HOG000013090.
HOVERGENi HBG053843.
InParanoidi Q13641.
OMAi SFRNLTH.
OrthoDBi EOG7QNVM8.
PhylomeDBi Q13641.
TreeFami TF351115.

Enzyme and pathway databases

SignaLinki Q13641.

Miscellaneous databases

GeneWikii TPBG.
GenomeRNAii 7162.
NextBioi 28026.
PROi Q13641.
SOURCEi Search...

Gene expression databases

Bgeei Q13641.
CleanExi HS_TPBG.
Genevestigatori Q13641.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats."
    Myers K.A., Rahi-Saund V., Davison M.D., Young J.A., Cheater A.J., Stern P.L.
    J. Biol. Chem. 269:9319-9324(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 52-75 AND 199-235.
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  7. "Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors."
    Mulryan K., Ryan M.G., Myers K.A., Shaw D., Wang W., Kingsman S.M., Stern P.L., Carroll M.W.
    Mol. Cancer Ther. 1:1129-1137(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: USE IN TUMOR IMMUNOTHERAPHY.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124.
    Tissue: Liver.
  9. "Waif1/5T4 inhibits Wnt/beta-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization."
    Kagermeier-Schenk B., Wehner D., Ozhan-Kizil G., Yamamoto H., Li J., Kirchner K., Hoffmann C., Stern P., Kikuchi A., Schambony A., Weidinger G.
    Dev. Cell 21:1129-1143(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MISCELLANEOUS.
  10. "Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1."
    Zhao Y., Malinauskas T., Harlos K., Jones E.Y.
    Structure 22:612-620(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 60-345, SUBCELLULAR LOCATION, LRR REPEATS, GLYCOSYLATION, DISULFIDE BONDS, MUTAGENESIS OF LYS-76; PHE-97; ASN-124; ARG-214 AND TYR-325.

Entry informationi

Entry nameiTPBG_HUMAN
AccessioniPrimary (citable) accession number: Q13641
Secondary accession number(s): A8K555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy.
Reduction of TPBG levels by siRNA significantly enhanced the beta-catenin/TCF transcription-based reporter pBAR activation in response to Wnt stimulation.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3