Q13639 (5HT4R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 4
Short name=5-HT-4
Short name=5-HT4

Alternative name(s):
Serotonin receptor 4

Gene names

Name:

HTR4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Subunit structure	Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR By similarity. Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin). Ref.13
Subcellular location	Cell membrane; Multi-pass membrane protein. Endosome. Note: Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli By similarity.
Tissue specificity	Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. Ref.7
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Endosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.1. Source: ProtInc positive regulation of cell proliferation Inferred from mutant phenotype PubMed 15925089. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay PubMed 15925089. Source: UniProtKB endosome Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement PubMed 9276448. Source: ProtInc
Molecular_function	serotonin receptor activity Inferred from direct assay PubMed 16102731. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 5-HT4(B) (identifier: Q13639-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 5-HT4(A) (identifier: Q13639-2)

Also known as: 5-HT4S;

The sequence of this isoform differs from the canonical sequence as follows:
     360-388: DAVECGGQWESQCHPPATSPLVAAQPSDT → YTVLHRGHHQELEKLPIHNDPESLESCF

Isoform 5-HT4(C) (identifier: Q13639-3)

The sequence of this isoform differs from the canonical sequence as follows:
     360-388: DAVECGGQWESQCHPPATSPLVAAQPSDT → F

Isoform 5-HT4(D) (identifier: Q13639-4)

The sequence of this isoform differs from the canonical sequence as follows:
     359-388: RDAVECGGQWESQCHPPATSPLVAAQPSDT → SSGTETDRRNFGIRKRRLTKPS

Isoform 5-HT4(E) (identifier: Q13639-5)

Also known as: H5-HT4(g);

The sequence of this isoform differs from the canonical sequence as follows:
     359-388: RDAVECGGQWESQCHPPATSPLVAAQPSDT → SGCSPVSSFLLLFCNRPVPV

Note: Mainly expressed in atria and cardiac ventricle.

Isoform 5-HT4(F) (identifier: Q13639-6)

The sequence of this isoform differs from the canonical sequence as follows:
     169-169: L → LERSLNQGLGQDFHA

Isoform 5-HT4(G) (identifier: Q13639-7)

The sequence of this isoform differs from the canonical sequence as follows:
     360-388: Missing.

Isoform 5-HT4(I) (identifier: Q13639-8)

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: R → RTDFLFDRDILARYWTKPARAGPFSGTLSIRCLTARKPVLG

Note: Expressed in all cardiovascular tissues analyzed.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	5-hydroxytryptamine receptor 4		PRO_0000068965
Regions
	Topological domain	1 – 19	19	Extracellular By similarity
	Transmembrane	20 – 40	21	Helical; Name=1; By similarity
	Topological domain	41 – 58	18	Cytoplasmic By similarity
	Transmembrane	59 – 79	21	Helical; Name=2; By similarity
	Topological domain	80 – 93	14	Extracellular By similarity
	Transmembrane	94 – 116	23	Helical; Name=3; By similarity
	Topological domain	117 – 137	21	Cytoplasmic By similarity
	Transmembrane	138 – 158	21	Helical; Name=4; By similarity
	Topological domain	159 – 192	34	Extracellular By similarity
	Transmembrane	193 – 213	21	Helical; Name=5; By similarity
	Topological domain	214 – 260	47	Cytoplasmic By similarity
	Transmembrane	261 – 281	21	Helical; Name=6; By similarity
	Topological domain	282 – 294	13	Extracellular By similarity
	Transmembrane	295 – 315	21	Helical; Name=7; By similarity
	Topological domain	316 – 388	73	Cytoplasmic By similarity
Amino acid modifications
	Lipidation	329	1	S-palmitoyl cysteine By similarity
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Disulfide bond	93 ↔ 184		By similarity
Natural variations
	Alternative sequence	169	1	L → LERSLNQGLGQDFHA in isoform 5-HT4(F).		VSP_001845
	Alternative sequence	359 – 388	30	RDAVE…QPSDT → SSGTETDRRNFGIRKRRLTK PS in isoform 5-HT4(D).		VSP_001847
	Alternative sequence	359 – 388	30	RDAVE…QPSDT → SGCSPVSSFLLLFCNRPVPV in isoform 5-HT4(E).		VSP_001846
	Alternative sequence	359	1	R → RTDFLFDRDILARYWTKPAR AGPFSGTLSIRCLTARKPVL G in isoform 5-HT4(I).		VSP_043316
	Alternative sequence	360 – 388	29	DAVEC…QPSDT → YTVLHRGHHQELEKLPIHND PESLESCF in isoform 5-HT4(A).		VSP_001849
	Alternative sequence	360 – 388	29	DAVEC…QPSDT → F in isoform 5-HT4(C).		VSP_001848
	Alternative sequence	360 – 388	29	Missing in isoform 5-HT4(G).		VSP_001850
	Natural variant	27	1	S → L in a patient with diffuse leukoencephalopathy with spheroids; unknown pathological significance. Ref.14		VAR_067412
	Natural variant	372	1	C → Y. Corresponds to variant rs34826744 [ dbSNP | Ensembl ].		VAR_049364

Sequences

	Sequence		Length	Mass (Da)
	Isoform 5-HT4(B) [UniParc]. Last modified January 11, 2001. Version 2. Checksum: 7FCFEC60E7BDF560	FASTA	388	43,761
	10 20 30 40 50 60 MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 70 80 90 100 110 120 SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 130 140 150 160 170 180 AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 190 200 210 220 230 240 STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 250 260 270 280 290 300 QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 310 320 330 340 350 360 GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD 370 380 AVECGGQWES QCHPPATSPL VAAQPSDT
	Isoform 5-HT4(A) (5-HT4S) [UniParc]. Checksum: 43019BED75AC9D0F	FASTA	387	44,109
	10 20 30 40 50 60 MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 70 80 90 100 110 120 SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 130 140 150 160 170 180 AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 190 200 210 220 230 240 STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 250 260 270 280 290 300 QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 310 320 330 340 350 360 GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRY 370 380 TVLHRGHHQE LEKLPIHNDP ESLESCF
	Isoform 5-HT4(C) [UniParc]. Checksum: F2BE6033F518178A	FASTA	360	40,944
	10 20 30 40 50 60 MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 70 80 90 100 110 120 SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 130 140 150 160 170 180 AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 190 200 210 220 230 240 STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 250 260 270 280 290 300 QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 310 320 330 340 350 360 GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRF
	Isoform 5-HT4(D) [UniParc]. Checksum: C7591BFE6A9C1D62	FASTA	380	43,186
	10 20 30 40 50 60 MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 70 80 90 100 110 120 SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 130 140 150 160 170 180 AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 190 200 210 220 230 240 STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 250 260 270 280 290 300 QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 310 320 330 340 350 360 GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLSS 370 380 GTETDRRNFG IRKRRLTKPS
	Isoform 5-HT4(E) (H5-HT4(g)) [UniParc]. Checksum: E45038FEF832270D	FASTA	378	42,746
	10 20 30 40 50 60 MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 70 80 90 100 110 120 SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 130 140 150 160 170 180 AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 190 200 210 220 230 240 STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 250 260 270 280 290 300 QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 310 320 330 340 350 360 GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLSG 370 CSPVSSFLLL FCNRPVPV
	Isoform 5-HT4(F) [UniParc]. Checksum: 243F4AE87A6F77FA	FASTA	402	45,315
	10 20 30 40 50 60 MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 70 80 90 100 110 120 SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 130 140 150 160 170 180 AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLE RSLNQGLGQD 190 200 210 220 230 240 FHAIEKRKFN QNSNSTYCVF MVNKPYAITC SVVAFYIPFL LMVLAYYRIY VTAKEHAHQI 250 260 270 280 290 300 QMLQRAGASS ESRPQSADQH STHRMRTETK AAKTLCIIMG CFCLCWAPFF VTNIVDPFID 310 320 330 340 350 360 YTVPGQVWTA FLWLGYINSG LNPFLYAFLN KSFRRAFLII LCCDDERYRR PSILGQTVPC 370 380 390 400 STTTINGSTH VLRDAVECGG QWESQCHPPA TSPLVAAQPS DT
	Isoform 5-HT4(G) [UniParc]. Checksum: CE6033F518178AF3	FASTA	359	40,797
	10 20 30 40 50 60 MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 70 80 90 100 110 120 SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 130 140 150 160 170 180 AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 190 200 210 220 230 240 STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 250 260 270 280 290 300 QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 310 320 330 340 350 GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLR
	Isoform 5-HT4(I) [UniParc]. Checksum: 463644AFC1C7D882	FASTA	428	48,255
	10 20 30 40 50 60 MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 70 80 90 100 110 120 SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 130 140 150 160 170 180 AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 190 200 210 220 230 240 STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 250 260 270 280 290 300 QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 310 320 330 340 350 360 GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRT 370 380 390 400 410 420 DFLFDRDILA RYWTKPARAG PFSGTLSIRC LTARKPVLGD AVECGGQWES QCHPPATSPL VAAQPSDT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus." Blondel O., Gastineau M., Dahmoune Y., Langlois M., Fischmeister R. J. Neurochem. 70:2252-2261(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5-HT4(A); 5-HT4(B); 5-HT4(C) AND 5-HT4(D)). Tissue: Intestine.
[2]	"Cloning and expression of 5-HT4 receptor species and splice variants." Van den Wyngaert I., Gommeren W., Jurzak M., Verhasselt P., Gordon R., Leysen J., Luyten W., Bender E. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5-HT4(A) AND 5-HT4(B)). Tissue: Brain.
[3]	"Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase." Claeysen S., Faye P., Sebben M., Lemaire S., Bockaert J., Dumuis A. NeuroReport 8:3189-3195(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5-HT4(A)). Tissue: Heart.
[4]	"Molecular cloning of the human serotonin receptor 5-HT4(b) and pharmacological comparison with the cloned human 5-HT4(a) receptor." Syversveen T., Bach T., Kvingedal A.M., Krobert K.A., Kaumann A.J., Levy F.O. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5-HT4(B)).
[5]	"Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain." Claeysen S., Sebben M., Becamel C., Bockaert J., Dumuis A. Mol. Pharmacol. 55:910-920(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5-HT4(E)). Tissue: Brain.
[6]	"Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants." Vilaro M.T., Domenech T., Palacios J.M., Mengod G. Neuropharmacology 42:60-73(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5-HT4(A); 5-HT4(B); 5-HT4(E) AND 5-HT4(G)). Tissue: Brain and Hippocampus.
[7]	"Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)." Brattelid T., Kvingedal A.M., Krobert K.A., Andressen K.W., Bach T., Hystad M.E., Kaumann A.J., Levy F.O. Naunyn Schmiedebergs Arch. Pharmacol. 369:616-628(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5-HT4(E) AND 5-HT4(I)), TISSUE SPECIFICITY.
[8]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5-HT4(B)).
[11]	"Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant." Bender E., Pindon A., van Oers I., Zhang Y.B., Gommeren W., Verhasselt P., Jurzak M., Leysen J., Luyten W. J. Neurochem. 74:478-489(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-388 (ISOFORM 5-HT4(F)).
[12]	"Expression of serotonin receptor mRNAs in blood vessels." Ullmer C., Schmuck K., Kalkman H.O., Luebbert H. FEBS Lett. 370:215-221(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 112-255. Tissue: Brain.
[13]	"Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling." Barthet G., Carrat G., Cassier E., Barker B., Gaven F., Pillot M., Framery B., Pellissier L.P., Augier J., Kang D.S., Claeysen S., Reiter E., Baneres J.L., Benovic J.L., Marin P., Bockaert J., Dumuis A. EMBO J. 28:2706-2718(2009) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY, INTERACTION WITH GRK5.
[14]	"Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids." Rademakers R., Baker M., Nicholson A.M., Rutherford N.J., Finch N., Soto-Ortolaza A., Lash J., Wider C., Wojtas A., DeJesus-Hernandez M., Adamson J., Kouri N., Sundal C., Shuster E.A., Aasly J., MacKenzie J., Roeber S., Kretzschmar H.A. , Boeve B.F., Knopman D.S., Petersen R.C., Cairns N.J., Ghetti B., Spina S., Garbern J., Tselis A.C., Uitti R., Das P., Van Gerpen J.A., Meschia J.F., Levy S., Broderick D.F., Graff-Radford N., Ross O.A., Miller B.B., Swerdlow R.H., Dickson D.W., Wszolek Z.K. Nat. Genet. 44:200-205(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LEU-27.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08756 mRNA. Translation: CAA70002.1. Y12505 mRNA. Translation: CAA73107.1. Y12506 mRNA. Translation: CAA73108.1. Y12507 mRNA. Translation: CAA73109.1. Y10437 mRNA. Translation: CAA71462.1. Y13584 mRNA. Translation: CAA73911.1. Y09586 mRNA. Translation: CAA70774.1. AJ131724 mRNA. Translation: CAC20411.1. AJ011371 mRNA. Translation: CAA09600.1. AJ278979 mRNA. Translation: CAC22248.1. AJ278980 mRNA. Translation: CAC22249.1. AJ278981 mRNA. Translation: CAC22250.1. AJ278982 mRNA. Translation: CAC22251.1. AJ131725 mRNA. Translation: CAC79533.1. AJ131726 mRNA. Translation: CAC79538.1. AJ633645 mRNA. Translation: CAG17627.1. AC008627 Genomic DNA. No translation available. AC011390 Genomic DNA. No translation available. AC091971 Genomic DNA. No translation available. AC114939 Genomic DNA. No translation available. CH471062 Genomic DNA. Translation: EAW61800.1. CH471062 Genomic DNA. Translation: EAW61801.1. CH471062 Genomic DNA. Translation: EAW61804.1. BC074755 mRNA. Translation: AAH74755.1. BC095497 mRNA. Translation: AAH95497.1. AJ243213 Genomic DNA. Translation: CAB71316.1. Z48150 mRNA. Translation: CAA88167.1.
IPI	IPI00014378. IPI00064638. IPI00186777. IPI00216427. IPI00216428. IPI00216429. IPI00291659. IPI00748585.
PIR	S66493.
RefSeq	NP_000861.1. NM_000870.5. NP_001035259.1. NM_001040169.2. NP_001035262.2. NM_001040172.2. NP_001035263.1. NM_001040173.2. NP_955525.1. NM_199453.3.
UniGene	Hs.483773.
3D structure databases
ProteinModelPortal	Q13639.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1347413.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q13639.
Polymorphism databases
DMDM	12644029.
Proteomic databases
PaxDb	Q13639.
PRIDE	Q13639.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314512; ENSP00000314906; ENSG00000164270. ENST00000354217; ENSP00000346156; ENSG00000164270. ENST00000360693; ENSP00000353915; ENSG00000164270. ENST00000362016; ENSP00000355037; ENSG00000164270. ENST00000377888; ENSP00000367120; ENSG00000164270. ENST00000517929; ENSP00000435904; ENSG00000164270. ENST00000521530; ENSP00000428320; ENSG00000164270. ENST00000521735; ENSP00000430979; ENSG00000164270. ENST00000522588; ENSP00000430874; ENSG00000164270.
GeneID	3360.
KEGG	hsa:3360.
UCSC	uc003lpn.3. human. uc021yfh.1. human. uc021yfi.1. human.
Organism-specific databases
CTD	3360.
GeneCards	GC05M147810.
H-InvDB	HIX0078165.
HGNC	HGNC:5299. HTR4.
HPA	HPA040591.
MIM	602164. gene.
neXtProt	NX_Q13639.
PharmGKB	PA29557.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG262978.
HOGENOM	HOG000239242.
HOVERGEN	HBG106962.
KO	K04160.
OrthoDB	EOG4933HZ.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q13639.
Bgee	Q13639.
Genevestigator	Q13639.
GermOnline	ENSG00000164270. Homo sapiens.
Family and domain databases
InterPro	IPR001520. 5HT4_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01059. 5HT4RECEPTR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q13639.
ChEMBL	CHEMBL1875.
DrugBank	DB00604. Cisapride. DB00953. Rizatriptan. DB01079. Tegaserod. DB00315. Zolmitriptan.
GenomeRNAi	3360.
NextBio	13288.
SOURCE	Search...

Entry information

Entry name

5HT4R_HUMAN

Accession

Primary (citable) accession number: Q13639
Secondary accession number(s): Q546Q1 , Q684M0, Q712M9, Q96KH9, Q96KI0, Q9H199, Q9NY73, Q9UBM6, Q9UBT4, Q9UE22, Q9UE23, Q9UQR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 11, 2001
Last modified:	May 1, 2013
This is version 126 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.