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UniProtKB - Q13636 (RAB31_HUMAN)

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Protein

Ras-related protein Rab-31

Gene

RAB31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTP8
Nucleotide bindingi60 – 64GTP5
Nucleotide bindingi118 – 121GTP4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • cellular response to insulin stimulus Source: UniProtKB
  • Golgi to plasma membrane protein transport Source: UniProtKB
  • membrane organization Source: Reactome
  • neutrophil degranulation Source: Reactome
  • phagosome maturation Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulated exocytosis Source: UniProtKB
Complete GO annotation...

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-8873719. RAB geranylgeranylation.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-31
Alternative name(s):
Ras-related protein Rab-22B
Gene namesi
Name:RAB31
Synonyms:RAB22B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:9771. RAB31.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • early endosome Source: UniProtKB
  • early endosome membrane Source: Reactome
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: Reactome
  • secretory granule membrane Source: Reactome
  • trans-Golgi network membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64Q → L: No change in GTPase activity. 1 Publication1

Organism-specific databases

DisGeNETi11031.
PharmGKBiPA34122.

Polymorphism and mutation databases

BioMutaiRAB31.
DMDMi2500069.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212321 – 194Ras-related protein Rab-31Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineCombined sources1
Lipidationi193S-geranylgeranyl cysteineBy similarity1
Lipidationi194S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ13636.
MaxQBiQ13636.
PaxDbiQ13636.
PeptideAtlasiQ13636.
PRIDEiQ13636.

PTM databases

iPTMnetiQ13636.
PhosphoSitePlusiQ13636.

Expressioni

Tissue specificityi

Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas.1 Publication

Gene expression databases

BgeeiENSG00000168461.
CleanExiHS_RAB31.
ExpressionAtlasiQ13636. baseline and differential.
GenevisibleiQ13636. HS.

Organism-specific databases

HPAiHPA019717.

Interactioni

Subunit structurei

Interacts with OCRL. Interacts with NGFR (By similarity). Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with EGFR.By similarity4 Publications

Protein-protein interaction databases

BioGridi116221. 29 interactors.
IntActiQ13636. 6 interactors.
MINTiMINT-1404598.
STRINGi9606.ENSP00000304565.

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 12Combined sources9
Helixi18 – 27Combined sources10
Beta strandi38 – 48Combined sources11
Beta strandi50 – 61Combined sources12
Helixi65 – 71Combined sources7
Helixi72 – 75Combined sources4
Beta strandi79 – 86Combined sources8
Helixi91 – 106Combined sources16
Beta strandi112 – 118Combined sources7
Helixi120 – 125Combined sources6
Helixi130 – 138Combined sources9
Turni139 – 141Combined sources3
Beta strandi143 – 146Combined sources4
Turni149 – 152Combined sources4
Helixi155 – 164Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FG5X-ray2.80A2-174[»]
ProteinModelPortaliQ13636.
SMRiQ13636.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13636.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
HOVERGENiHBG009351.
InParanoidiQ13636.
KOiK07891.
OMAiQTGRRCC.
OrthoDBiEOG091G0HKN.
PhylomeDBiQ13636.
TreeFamiTF331262.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG 
        60         70         80         90        100
NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFYTLKKWV 
       110        120        130        140        150
KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK 
       160        170        180        190 
NAINIEELFQ GISRQIPPLD PHENGNNGTI KVEKPTMQAS RRCC
Length:194
Mass (Da):21,569
Last modified:November 1, 1997 - v1
Checksum:i19825648A9C214B9
GO

Sequence cautioni

The sequence AAG09690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH01148 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189A → S in AAC50773 (PubMed:8863739).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57091 mRNA. Translation: AAC50773.1.
U59877 mRNA. Translation: AAB02832.1.
AF234995 mRNA. Translation: AAG13847.1.
AF183421 mRNA. Translation: AAG09690.1. Different initiation.
AF498957 mRNA. Translation: AAM21105.1.
AK314809 mRNA. Translation: BAG37334.1.
BT020027 mRNA. Translation: AAV38830.1.
BT020028 mRNA. Translation: AAV38831.1.
CR407659 mRNA. Translation: CAG28587.1.
AC006238 Genomic DNA. No translation available.
AP000902 Genomic DNA. No translation available.
BC001148 mRNA. Translation: AAH01148.1. Different initiation.
PIRiJC4961.
RefSeqiNP_006859.2. NM_006868.3.
UniGeneiHs.744887.
Hs.99528.

Genome annotation databases

EnsembliENST00000578921; ENSP00000461945; ENSG00000168461.
GeneIDi11031.
KEGGihsa:11031.
UCSCiuc002kog.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRAB31_HUMAN
AccessioniPrimary (citable) accession number: Q13636
Secondary accession number(s): B2RBT7, Q15770, Q9HC00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 10, 2017
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families