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Protein

Ras-related protein Rab-31

Gene

RAB31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTP8
Nucleotide bindingi60 – 64GTP5
Nucleotide bindingi118 – 121GTP4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB

GO - Biological processi

  • cellular response to insulin stimulus Source: UniProtKB
  • Golgi to plasma membrane protein transport Source: UniProtKB
  • neutrophil degranulation Source: Reactome
  • phagosome maturation Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulated exocytosis Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-31
Alternative name(s):
Ras-related protein Rab-22B
Gene namesi
Name:RAB31
Synonyms:RAB22B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000168461.12
HGNCiHGNC:9771 RAB31
MIMi605694 gene
neXtProtiNX_Q13636

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64Q → L: No change in GTPase activity. 1 Publication1

Organism-specific databases

DisGeNETi11031
PharmGKBiPA34122

Polymorphism and mutation databases

BioMutaiRAB31
DMDMi2500069

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212321 – 194Ras-related protein Rab-31Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineCombined sources1
Lipidationi193S-geranylgeranyl cysteineBy similarity1
Lipidationi194S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ13636
MaxQBiQ13636
PaxDbiQ13636
PeptideAtlasiQ13636
PRIDEiQ13636
ProteomicsDBi59631

PTM databases

iPTMnetiQ13636
PhosphoSitePlusiQ13636

Expressioni

Tissue specificityi

Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas.1 Publication

Gene expression databases

BgeeiENSG00000168461
CleanExiHS_RAB31
ExpressionAtlasiQ13636 baseline and differential
GenevisibleiQ13636 HS

Organism-specific databases

HPAiHPA019717

Interactioni

Subunit structurei

Interacts with OCRL. Interacts with NGFR (By similarity). Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with EGFR.By similarity4 Publications

Protein-protein interaction databases

BioGridi116221, 32 interactors
IntActiQ13636, 6 interactors
MINTiQ13636
STRINGi9606.ENSP00000304565

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 12Combined sources9
Helixi18 – 27Combined sources10
Beta strandi38 – 48Combined sources11
Beta strandi50 – 61Combined sources12
Helixi65 – 71Combined sources7
Helixi72 – 75Combined sources4
Beta strandi79 – 86Combined sources8
Helixi91 – 106Combined sources16
Beta strandi112 – 118Combined sources7
Helixi120 – 125Combined sources6
Helixi130 – 138Combined sources9
Turni139 – 141Combined sources3
Beta strandi143 – 146Combined sources4
Turni149 – 152Combined sources4
Helixi155 – 164Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FG5X-ray2.80A2-174[»]
ProteinModelPortaliQ13636
SMRiQ13636
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13636

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
HOVERGENiHBG009351
InParanoidiQ13636
KOiK07891
OMAiQTGRRCC
OrthoDBiEOG091G0HKN
PhylomeDBiQ13636
TreeFamiTF331262

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q13636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG
60 70 80 90 100
NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFYTLKKWV
110 120 130 140 150
KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK
160 170 180 190
NAINIEELFQ GISRQIPPLD PHENGNNGTI KVEKPTMQAS RRCC
Length:194
Mass (Da):21,569
Last modified:November 1, 1997 - v1
Checksum:i19825648A9C214B9
GO

Sequence cautioni

The sequence AAG09690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH01148 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189A → S in AAC50773 (PubMed:8863739).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57091 mRNA Translation: AAC50773.1
U59877 mRNA Translation: AAB02832.1
AF234995 mRNA Translation: AAG13847.1
AF183421 mRNA Translation: AAG09690.1 Different initiation.
AF498957 mRNA Translation: AAM21105.1
AK314809 mRNA Translation: BAG37334.1
BT020027 mRNA Translation: AAV38830.1
BT020028 mRNA Translation: AAV38831.1
CR407659 mRNA Translation: CAG28587.1
AC006238 Genomic DNA No translation available.
AP000902 Genomic DNA No translation available.
BC001148 mRNA Translation: AAH01148.1 Different initiation.
PIRiJC4961
RefSeqiNP_006859.2, NM_006868.3
UniGeneiHs.744887
Hs.99528

Genome annotation databases

EnsembliENST00000578921; ENSP00000461945; ENSG00000168461
GeneIDi11031
KEGGihsa:11031
UCSCiuc002kog.3 human

Similar proteinsi

Entry informationi

Entry nameiRAB31_HUMAN
AccessioniPrimary (citable) accession number: Q13636
Secondary accession number(s): B2RBT7, Q15770, Q9HC00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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