UniProtKB - Q13636 (RAB31_HUMAN)
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Protein
Ras-related protein Rab-31
Gene
RAB31
Organism
Homo sapiens (Human)
Status
Functioni
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.5 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 19 | GTP | 8 | |
Nucleotide bindingi | 60 – 64 | GTP | 5 | |
Nucleotide bindingi | 118 – 121 | GTP | 4 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: ProtInc
- GTP binding Source: UniProtKB
GO - Biological processi
- cellular response to insulin stimulus Source: UniProtKB
- Golgi to plasma membrane protein transport Source: UniProtKB
- neutrophil degranulation Source: Reactome
- phagosome maturation Source: UniProtKB
- receptor internalization Source: UniProtKB
- regulated exocytosis Source: UniProtKB
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-6798695. Neutrophil degranulation. R-HSA-8873719. RAB geranylgeranylation. R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs. |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-31Alternative name(s): Ras-related protein Rab-22B |
Gene namesi | Name:RAB31 Synonyms:RAB22B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168461.12. |
HGNCi | HGNC:9771. RAB31. |
MIMi | 605694. gene. |
neXtProti | NX_Q13636. |
Subcellular locationi
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 64 | Q → L: No change in GTPase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 11031. |
PharmGKBi | PA34122. |
Polymorphism and mutation databases
BioMutai | RAB31. |
DMDMi | 2500069. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121232 | 1 – 194 | Ras-related protein Rab-31Add BLAST | 194 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | PhosphoserineCombined sources | 1 | |
Lipidationi | 193 | S-geranylgeranyl cysteineBy similarity | 1 | |
Lipidationi | 194 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Phosphoprotein, PrenylationProteomic databases
EPDi | Q13636. |
MaxQBi | Q13636. |
PaxDbi | Q13636. |
PeptideAtlasi | Q13636. |
PRIDEi | Q13636. |
PTM databases
iPTMneti | Q13636. |
PhosphoSitePlusi | Q13636. |
Expressioni
Tissue specificityi
Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000168461. |
CleanExi | HS_RAB31. |
ExpressionAtlasi | Q13636. baseline and differential. |
Genevisiblei | Q13636. HS. |
Organism-specific databases
HPAi | HPA019717. |
Interactioni
Subunit structurei
Interacts with OCRL. Interacts with NGFR (By similarity). Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with EGFR.By similarity4 Publications
Protein-protein interaction databases
BioGridi | 116221. 32 interactors. |
IntActi | Q13636. 6 interactors. |
MINTi | Q13636. |
STRINGi | 9606.ENSP00000304565. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 4 – 12 | Combined sources | 9 | |
Helixi | 18 – 27 | Combined sources | 10 | |
Beta strandi | 38 – 48 | Combined sources | 11 | |
Beta strandi | 50 – 61 | Combined sources | 12 | |
Helixi | 65 – 71 | Combined sources | 7 | |
Helixi | 72 – 75 | Combined sources | 4 | |
Beta strandi | 79 – 86 | Combined sources | 8 | |
Helixi | 91 – 106 | Combined sources | 16 | |
Beta strandi | 112 – 118 | Combined sources | 7 | |
Helixi | 120 – 125 | Combined sources | 6 | |
Helixi | 130 – 138 | Combined sources | 9 | |
Turni | 139 – 141 | Combined sources | 3 | |
Beta strandi | 143 – 146 | Combined sources | 4 | |
Turni | 149 – 152 | Combined sources | 4 | |
Helixi | 155 – 164 | Combined sources | 10 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FG5 | X-ray | 2.80 | A | 2-174 | [»] | |
ProteinModelPortali | Q13636. | |||||
SMRi | Q13636. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q13636. |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 34 – 42 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0092. Eukaryota. ENOG410YCCP. LUCA. |
HOVERGENi | HBG009351. |
InParanoidi | Q13636. |
KOi | K07891. |
OMAi | QTGRRCC. |
OrthoDBi | EOG091G0HKN. |
PhylomeDBi | Q13636. |
TreeFami | TF331262. |
Family and domain databases
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. |
Pfami | View protein in Pfam PF00071. Ras. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
TIGRFAMsi | TIGR00231. small_GTP. 1 hit. |
PROSITEi | View protein in PROSITE PS51419. RAB. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q13636-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG
60 70 80 90 100
NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFYTLKKWV
110 120 130 140 150
KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK
160 170 180 190
NAINIEELFQ GISRQIPPLD PHENGNNGTI KVEKPTMQAS RRCC
Sequence cautioni
The sequence AAG09690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH01148 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 189 | A → S in AAC50773 (PubMed:8863739).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57091 mRNA. Translation: AAC50773.1. U59877 mRNA. Translation: AAB02832.1. AF234995 mRNA. Translation: AAG13847.1. AF183421 mRNA. Translation: AAG09690.1. Different initiation. AF498957 mRNA. Translation: AAM21105.1. AK314809 mRNA. Translation: BAG37334.1. BT020027 mRNA. Translation: AAV38830.1. BT020028 mRNA. Translation: AAV38831.1. CR407659 mRNA. Translation: CAG28587.1. AC006238 Genomic DNA. No translation available. AP000902 Genomic DNA. No translation available. BC001148 mRNA. Translation: AAH01148.1. Different initiation. |
PIRi | JC4961. |
RefSeqi | NP_006859.2. NM_006868.3. |
UniGenei | Hs.744887. Hs.99528. |
Genome annotation databases
Ensembli | ENST00000578921; ENSP00000461945; ENSG00000168461. |
GeneIDi | 11031. |
KEGGi | hsa:11031. |
UCSCi | uc002kog.3. human. |
Similar proteinsi
Entry informationi
Entry namei | RAB31_HUMAN | |
Accessioni | Q13636Primary (citable) accession number: Q13636 Secondary accession number(s): B2RBT7, Q15770, Q9HC00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |