Reviewed,
UniProtKB/Swiss-Prot Q13636 (RAB31_HUMAN)
Last modified
June 16, 2009.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ras-related protein Rab-31 Alternative name(s): Rab-22B | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 194 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subcellular location | Cell membrane; Lipid-anchor; Cytoplasmic side Potential. |
| Tissue specificity | Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. Ref.2 |
| Sequence similarities | Belongs to the small GTPase superfamily. Rab family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Ligand | GTP-binding Nucleotide-binding |
| PTM | Lipoprotein Phosphoprotein Prenylation |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 194 | 194 | Ras-related protein Rab-31 | PRO_0000121232 | |||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 12 – 19 | 8 | GTP By similarity | ||||||||||||||||||||||||||||||||||
| Nucleotide binding | 60 – 64 | 5 | GTP By similarity | ||||||||||||||||||||||||||||||||||
| Nucleotide binding | 118 – 121 | 4 | GTP By similarity | ||||||||||||||||||||||||||||||||||
| Motif | 34 – 42 | 9 | Effector region By similarity | ||||||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||||||
| Modified residue | 35 | 1 | Phosphoserine Ref.10 Ref.11 | ||||||||||||||||||||||||||||||||||
| Lipidation | 193 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||
| Lipidation | 194 | 1 | S-geranylgeranyl cysteine By similarity | ||||||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||||
| Mutagenesis | 64 | 1 | Q → L: No change in GTPase activity. Ref.2 | ||||||||||||||||||||||||||||||||||
| Sequence conflict | 189 | 1 | A → S in AAC50773. Ref.1 | ||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||
| Beta strand | 4 – 12 | 9 | |||||||||||||||||||||||||||||||||||
| Helix | 18 – 27 | 10 | |||||||||||||||||||||||||||||||||||
| Beta strand | 38 – 48 | 11 | |||||||||||||||||||||||||||||||||||
| Beta strand | 50 – 61 | 12 | |||||||||||||||||||||||||||||||||||
| Helix | 65 – 71 | 7 | |||||||||||||||||||||||||||||||||||
| Helix | 72 – 75 | 4 | |||||||||||||||||||||||||||||||||||
| Beta strand | 79 – 86 | 8 | |||||||||||||||||||||||||||||||||||
| Helix | 91 – 106 | 16 | |||||||||||||||||||||||||||||||||||
| Beta strand | 112 – 118 | 7 | |||||||||||||||||||||||||||||||||||
| Helix | 120 – 125 | 6 | |||||||||||||||||||||||||||||||||||
| Helix | 130 – 138 | 9 | |||||||||||||||||||||||||||||||||||
| Turn | 139 – 141 | 3 | |||||||||||||||||||||||||||||||||||
| Beta strand | 143 – 146 | 4 | |||||||||||||||||||||||||||||||||||
| Turn | 149 – 152 | 4 | |||||||||||||||||||||||||||||||||||
| Helix | 155 – 164 | 10 | |||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of two novel rab genes from human melanocytes." Chen D., Guo J., Miki T., Tachibana M., Gahl W.A. Gene 174:129-134(1996) [PubMed: 8863739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Melanocyte. |
| [2] | "Molecular cloning, bacterial expression and properties of Rab31 and Rab32." Bao X., Faris A.E., Jang E.K., Haslam R.J. Eur. J. Biochem. 269:259-271(2002) [PubMed: 11784320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, MUTAGENESIS OF GLN-64. Tissue: Platelet. |
| [3] | "Small GTPase Rab22B is expressed in intestinal epithelial Caco-2 cells." Opdam F.J.M., van den Vorstenbosch R., Booltink E., Fransen J.A.M. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "A novel gene expressed in human pheochromocytoma." Peng Y., Gu Y., Tu Y., Xu S., Han Z., Fu G., Chen Z. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pheochromocytoma. |
| [5] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [8] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [9] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [10] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, MASS SPECTROMETRY. Tissue: Epithelium. |
| [11] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U57091 mRNA. Translation: AAC50773.1. U59877 mRNA. Translation: AAB02832.1. AF234995 mRNA. Translation: AAG13847.1. AF183421 mRNA. Translation: AAG09690.1. Different initiation. AF498957 mRNA. Translation: AAM21105.1. AK314809 mRNA. Translation: BAG37334.1. BT020027 mRNA. Translation: AAV38830.1. BT020028 mRNA. Translation: AAV38831.1. CR407659 mRNA. Translation: CAG28587.1. BC001148 mRNA. Translation: AAH01148.1. Different initiation. | |||||||||||||
| IPI | IPI00014376. | ||||||||||||
| PIR | JC4961. | ||||||||||||
| RefSeq | NP_006859.2. | ||||||||||||
| UniGene | Hs.714730 Hs.99528 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q13636. 1 interaction. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q13636. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q13636. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000168461. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 11031. | ||||||||||||
| KEGG | hsa:11031. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC18P009701. | ||||||||||||
| H-InvDB | HIX0014328. | ||||||||||||
| HGNC | HGNC:9771. RAB31. | ||||||||||||
| MIM | 605694. gene. | ||||||||||||
| PharmGKB | PA34122. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOVERGEN | Q13636. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q13636. | ||||||||||||
| Bgee | Q13636. | ||||||||||||
| CleanEx | HS_RAB31. | ||||||||||||
| GermOnline | ENSG00000168461. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR003579. GTPase_Rab. IPR015594. Rab22-like. IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view] | ||||||||||||
| PANTHER | PTHR11708:SF190. Rab22_like. 1 hit. | ||||||||||||
| Pfam | PF00071. Ras. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00449. RASTRNSFRMNG. | ||||||||||||
| SMART | SM00175. RAB. 1 hit. [Graphical view] | ||||||||||||
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. | ||||||||||||
| PROSITE | PS51419. RAB. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 41922. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | RAB31_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13636 Secondary accession number(s): B2RBT7, Q15770, Q9HC00 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 18 Human chromosome 18: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


