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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Gene

DYRK1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3.By similarity4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.4 Publications

Enzyme regulationi

Inhibited by RANBP9. Inhibited by harmine, leucettamine B and leucettine L41.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei188ATPCurated1
Active sitei287Proton acceptor1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi165 – 173ATPCurated9
Nucleotide bindingi238 – 241ATPCurated4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08219-MONOMER.
BRENDAi2.7.12.1. 2681.
ReactomeiR-HSA-1538133. G0 and Early G1.
SignaLinkiQ13627.
SIGNORiQ13627.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC:2.7.12.1)
Alternative name(s):
Dual specificity YAK1-related kinase
HP86
Protein kinase minibrain homolog
Short name:
MNBH
Short name:
hMNB
Gene namesi
Name:DYRK1A
Synonyms:DYRK, MNB, MNBH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:3091. DYRK1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 7 (MRD7)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:614104

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi188K → R: Abolishes kinase activity. 1 Publication1
Mutagenesisi321Y → F: Mildly reduces kinase activity. Does not abolish autophosphorylation on tyrosine residues. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNETi1859.
MalaCardsiDYRK1A.
MIMi614104. phenotype.
OpenTargetsiENSG00000157540.
Orphaneti178469. Autosomal dominant non-syndromic intellectual disability.
PharmGKBiPA27545.

Chemistry databases

ChEMBLiCHEMBL2292.
GuidetoPHARMACOLOGYi2009.

Polymorphism and mutation databases

BioMutaiDYRK1A.
DMDMi3219996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859311 – 763Dual specificity tyrosine-phosphorylation-regulated kinase 1AAdd BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei111Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei140Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei145PhosphotyrosineCombined sources1
Modified residuei159Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei177Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei219Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei310Phosphoserine; by autocatalysis1 Publication1
Modified residuei319Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei321Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei402Phosphothreonine; by autocatalysis1 Publication1
Modified residuei449Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei529PhosphoserineCombined sources1
Modified residuei538PhosphoserineBy similarity1
Modified residuei748PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13627.
MaxQBiQ13627.
PaxDbiQ13627.
PeptideAtlasiQ13627.
PRIDEiQ13627.

PTM databases

iPTMnetiQ13627.
PhosphoSitePlusiQ13627.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.4 Publications

Developmental stagei

Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.1 Publication

Gene expression databases

BgeeiENSG00000157540.
CleanExiHS_DYRK1A.
ExpressionAtlasiQ13627. baseline and differential.
GenevisibleiQ13627. HS.

Organism-specific databases

HPAiHPA015323.
HPA015810.

Interactioni

Subunit structurei

Interacts RAD54L2/ARIP4. Interacts with CRY2 (By similarity). Interacts with RANBP9. Interacts with WDR68. Interacts with SRSF6. Interacts with human adenovirus 5 E1A protein (PubMed:23864635).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DCAF7P619625EBI-1053596,EBI-359808
LZTS2Q9BRK43EBI-1053596,EBI-741037
RB1P064003EBI-1053596,EBI-491274
RBL1P287493EBI-1053596,EBI-971402
TROAPQ128153EBI-1053596,EBI-2349743
YWHABP319463EBI-1053621,EBI-359815

GO - Molecular functioni

  • protein self-association Source: UniProtKB
  • tau protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi108192. 72 interactors.
DIPiDIP-39750N.
IntActiQ13627. 35 interactors.
MINTiMINT-1205413.
STRINGi9606.ENSP00000381932.

Chemistry databases

BindingDBiQ13627.

Structurei

Secondary structure

1763
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi137 – 139Combined sources3
Turni156 – 158Combined sources3
Beta strandi159 – 168Combined sources10
Beta strandi171 – 178Combined sources8
Turni179 – 182Combined sources4
Beta strandi183 – 190Combined sources8
Helixi194 – 212Combined sources19
Turni214 – 217Combined sources4
Beta strandi219 – 221Combined sources3
Beta strandi224 – 230Combined sources7
Beta strandi233 – 239Combined sources7
Helixi245 – 251Combined sources7
Turni252 – 254Combined sources3
Helixi259 – 276Combined sources18
Turni279 – 281Combined sources3
Helixi290 – 292Combined sources3
Beta strandi293 – 297Combined sources5
Beta strandi303 – 305Combined sources3
Helixi308 – 310Combined sources3
Helixi314 – 316Combined sources3
Helixi325 – 327Combined sources3
Helixi330 – 333Combined sources4
Helixi341 – 356Combined sources16
Helixi366 – 377Combined sources12
Helixi382 – 385Combined sources4
Helixi391 – 394Combined sources4
Beta strandi395 – 397Combined sources3
Beta strandi403 – 405Combined sources3
Helixi423 – 426Combined sources4
Turni427 – 432Combined sources6
Helixi434 – 436Combined sources3
Turni437 – 440Combined sources4
Helixi446 – 459Combined sources14
Turni464 – 466Combined sources3
Helixi470 – 475Combined sources6
Helixi477 – 479Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VX3X-ray2.40A/B/C/D127-485[»]
2WO6X-ray2.50A/B127-485[»]
3ANQX-ray2.60A/B/C/D126-490[»]
3ANRX-ray2.60A/B/C/D126-490[»]
4AZEX-ray3.15A/B/C128-485[»]
4MQ1X-ray2.35A/B/C/D127-485[»]
4MQ2X-ray2.80A/B/C/D127-485[»]
4NCTX-ray2.60A/B/C/D126-490[»]
4YLJX-ray2.58A/B/C/D127-485[»]
4YLKX-ray1.40A127-485[»]
4YLLX-ray1.40A127-485[»]
4YU2X-ray2.90A/B/C/D127-485[»]
5A3XX-ray2.26A/B/C/D126-490[»]
5A4EX-ray2.68A/B/C/D126-490[»]
5A4LX-ray2.73A/B/C/D126-490[»]
5A4QX-ray2.37A/B/C/D126-490[»]
5A4TX-ray2.15A/B/C/D126-490[»]
5A54X-ray2.63A/B/C/D126-490[»]
5AIKX-ray2.70A/B/C/D128-485[»]
ProteinModelPortaliQ13627.
SMRiQ13627.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13627.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 479Protein kinasePROSITE-ProRule annotationAdd BLAST321

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi117 – 134Bipartite nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi509 – 515Poly-Ser7
Compositional biasi599 – 602Poly-His4
Compositional biasi607 – 619Poly-HisAdd BLAST13
Compositional biasi656 – 672Ser/Thr-richAdd BLAST17
Compositional biasi664 – 671Poly-Ser8

Domaini

The polyhistidine repeats act as targeting signals to nuclear speckles.1 Publication

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000220863.
HOVERGENiHBG051425.
InParanoidiQ13627.
KOiK08825.
OMAiRQGIDRE.
OrthoDBiEOG091G03J7.
PhylomeDBiQ13627.
TreeFamiTF314624.

Family and domain databases

InterProiIPR028318. DYRK1A.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24058:SF28. PTHR24058:SF28. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Long (identifier: Q13627-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD
60 70 80 90 100
QQVSALSYSD QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL
110 120 130 140 150
IKTYKHINEV YYAKKKRRHQ QGQGDDSSHK KERKVYNDGY DDDNYDYIVK
160 170 180 190 200
NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV EQEWVAIKII KNKKAFLNQA
210 220 230 240 250
QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM LSYNLYDLLR
260 270 280 290 300
NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR
310 320 330 340 350
SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI
360 370 380 390 400
LVEMHTGEPL FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD
410 420 430 440 450
GTWNLKKTKD GKREYKPPGT RKLHNILGVE TGGPGGRRAG ESGHTVADYL
460 470 480 490 500
KFKDLILRML DYDPKTRIQP YYALQHSFFK KTADEGTNTS NSVSTSPAME
510 520 530 540 550
QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG HFTAAVQAMD
560 570 580 590 600
CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH
610 620 630 640 650
HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH
660 670 680 690 700
SHHSMTSLSS STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV
710 720 730 740 750
NLTVYSNPRQ ETGIAGHPTY QFSANTGPAH YMTEGHLTMR QGADREESPM
760
TGVCVQQSPV ASS
Length:763
Mass (Da):85,584
Last modified:July 15, 1998 - v2
Checksum:i7C3A52A3CBB04FB5
GO
Isoform 1 (identifier: Q13627-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-78: Missing.

Show »
Length:754
Mass (Da):84,556
Checksum:i59518E25F1D4FF96
GO
Isoform 2 (identifier: Q13627-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-529: GGSSGTSNSGRARS → GASAISCSSWLVRH
     530-763: Missing.

Show »
Length:529
Mass (Da):60,330
Checksum:iF639B3152ACC7750
GO
Isoform 3 (identifier: Q13627-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-540: GGSSGTSNSGRARSDPTHQHRHSGG → VEQHWMPGAFRMTVSFTLEVHDVPV
     541-763: Missing.

Show »
Length:540
Mass (Da):61,770
Checksum:iE02CE08DF1AE0AED
GO
Isoform 4 (identifier: Q13627-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     559-584: RQQFPAPLGWSGTEAPTQVTVETHPV → SSHVVHLLVSPAILRWSSTGCQVPLE
     585-763: Missing.

Show »
Length:584
Mass (Da):66,099
Checksum:iBA2480B34BAB2878
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32G → A in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti47N → S in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti57S → P in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti123Q → R in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti266A → V in CAA05059 (PubMed:9503011).Curated1
Sequence conflicti357G → R in CAA05059 (PubMed:9503011).Curated1
Sequence conflicti397K → N in AAC50939 (PubMed:8975710).Curated1
Sequence conflicti592A → G in AAC50939 (PubMed:8975710).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009395415Y → F.1 Publication1
Natural variantiVAR_040453679A → P.2 PublicationsCorresponds to variant rs55720916dbSNPEnsembl.1
Natural variantiVAR_009396681Q → H.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00491770 – 78Missing in isoform 1. 2 Publications9
Alternative sequenceiVSP_004920516 – 540GGSSG…RHSGG → VEQHWMPGAFRMTVSFTLEV HDVPV in isoform 3. CuratedAdd BLAST25
Alternative sequenceiVSP_004918516 – 529GGSSG…GRARS → GASAISCSSWLVRH in isoform 2. CuratedAdd BLAST14
Alternative sequenceiVSP_004919530 – 763Missing in isoform 2. CuratedAdd BLAST234
Alternative sequenceiVSP_004921541 – 763Missing in isoform 3. CuratedAdd BLAST223
Alternative sequenceiVSP_004922559 – 584RQQFP…ETHPV → SSHVVHLLVSPAILRWSSTG CQVPLE in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_004923585 – 763Missing in isoform 4. 1 PublicationAdd BLAST179

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58496 mRNA. Translation: AAC50939.1.
U52373 mRNA. Translation: AAB18639.1.
D85759 mRNA. Translation: BAA12866.1.
D86550 mRNA. Translation: BAA13110.1.
AF108830 mRNA. Translation: AAD31169.1.
AJ001870 mRNA. Translation: CAA05059.1.
CCDSiCCDS13653.1. [Q13627-2]
CCDS13654.1. [Q13627-3]
CCDS42925.1. [Q13627-1]
CCDS42926.1. [Q13627-5]
PIRiJC4898.
RefSeqiNP_001387.2. NM_001396.3. [Q13627-1]
NP_567824.1. NM_101395.2. [Q13627-5]
NP_569120.1. NM_130436.2. [Q13627-2]
NP_569122.1. NM_130438.2. [Q13627-3]
XP_006724039.1. XM_006723976.3. [Q13627-1]
XP_006724040.1. XM_006723977.3. [Q13627-1]
XP_006724041.1. XM_006723978.3. [Q13627-1]
XP_006724042.1. XM_006723979.3. [Q13627-2]
XP_011527785.1. XM_011529483.2. [Q13627-1]
XP_016883773.1. XM_017028284.1. [Q13627-2]
XP_016883774.1. XM_017028285.1. [Q13627-2]
UniGeneiHs.368240.

Genome annotation databases

EnsembliENST00000338785; ENSP00000342690; ENSG00000157540. [Q13627-5]
ENST00000339659; ENSP00000340373; ENSG00000157540. [Q13627-2]
ENST00000398956; ENSP00000381929; ENSG00000157540. [Q13627-3]
ENST00000398960; ENSP00000381932; ENSG00000157540. [Q13627-1]
GeneIDi1859.
KEGGihsa:1859.
UCSCiuc002ywi.4. human. [Q13627-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58496 mRNA. Translation: AAC50939.1.
U52373 mRNA. Translation: AAB18639.1.
D85759 mRNA. Translation: BAA12866.1.
D86550 mRNA. Translation: BAA13110.1.
AF108830 mRNA. Translation: AAD31169.1.
AJ001870 mRNA. Translation: CAA05059.1.
CCDSiCCDS13653.1. [Q13627-2]
CCDS13654.1. [Q13627-3]
CCDS42925.1. [Q13627-1]
CCDS42926.1. [Q13627-5]
PIRiJC4898.
RefSeqiNP_001387.2. NM_001396.3. [Q13627-1]
NP_567824.1. NM_101395.2. [Q13627-5]
NP_569120.1. NM_130436.2. [Q13627-2]
NP_569122.1. NM_130438.2. [Q13627-3]
XP_006724039.1. XM_006723976.3. [Q13627-1]
XP_006724040.1. XM_006723977.3. [Q13627-1]
XP_006724041.1. XM_006723978.3. [Q13627-1]
XP_006724042.1. XM_006723979.3. [Q13627-2]
XP_011527785.1. XM_011529483.2. [Q13627-1]
XP_016883773.1. XM_017028284.1. [Q13627-2]
XP_016883774.1. XM_017028285.1. [Q13627-2]
UniGeneiHs.368240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VX3X-ray2.40A/B/C/D127-485[»]
2WO6X-ray2.50A/B127-485[»]
3ANQX-ray2.60A/B/C/D126-490[»]
3ANRX-ray2.60A/B/C/D126-490[»]
4AZEX-ray3.15A/B/C128-485[»]
4MQ1X-ray2.35A/B/C/D127-485[»]
4MQ2X-ray2.80A/B/C/D127-485[»]
4NCTX-ray2.60A/B/C/D126-490[»]
4YLJX-ray2.58A/B/C/D127-485[»]
4YLKX-ray1.40A127-485[»]
4YLLX-ray1.40A127-485[»]
4YU2X-ray2.90A/B/C/D127-485[»]
5A3XX-ray2.26A/B/C/D126-490[»]
5A4EX-ray2.68A/B/C/D126-490[»]
5A4LX-ray2.73A/B/C/D126-490[»]
5A4QX-ray2.37A/B/C/D126-490[»]
5A4TX-ray2.15A/B/C/D126-490[»]
5A54X-ray2.63A/B/C/D126-490[»]
5AIKX-ray2.70A/B/C/D128-485[»]
ProteinModelPortaliQ13627.
SMRiQ13627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108192. 72 interactors.
DIPiDIP-39750N.
IntActiQ13627. 35 interactors.
MINTiMINT-1205413.
STRINGi9606.ENSP00000381932.

Chemistry databases

BindingDBiQ13627.
ChEMBLiCHEMBL2292.
GuidetoPHARMACOLOGYi2009.

PTM databases

iPTMnetiQ13627.
PhosphoSitePlusiQ13627.

Polymorphism and mutation databases

BioMutaiDYRK1A.
DMDMi3219996.

Proteomic databases

EPDiQ13627.
MaxQBiQ13627.
PaxDbiQ13627.
PeptideAtlasiQ13627.
PRIDEiQ13627.

Protocols and materials databases

DNASUi1859.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338785; ENSP00000342690; ENSG00000157540. [Q13627-5]
ENST00000339659; ENSP00000340373; ENSG00000157540. [Q13627-2]
ENST00000398956; ENSP00000381929; ENSG00000157540. [Q13627-3]
ENST00000398960; ENSP00000381932; ENSG00000157540. [Q13627-1]
GeneIDi1859.
KEGGihsa:1859.
UCSCiuc002ywi.4. human. [Q13627-1]

Organism-specific databases

CTDi1859.
DisGeNETi1859.
GeneCardsiDYRK1A.
HGNCiHGNC:3091. DYRK1A.
HPAiHPA015323.
HPA015810.
MalaCardsiDYRK1A.
MIMi600855. gene.
614104. phenotype.
neXtProtiNX_Q13627.
OpenTargetsiENSG00000157540.
Orphaneti178469. Autosomal dominant non-syndromic intellectual disability.
PharmGKBiPA27545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000220863.
HOVERGENiHBG051425.
InParanoidiQ13627.
KOiK08825.
OMAiRQGIDRE.
OrthoDBiEOG091G03J7.
PhylomeDBiQ13627.
TreeFamiTF314624.

Enzyme and pathway databases

BioCyciZFISH:HS08219-MONOMER.
BRENDAi2.7.12.1. 2681.
ReactomeiR-HSA-1538133. G0 and Early G1.
SignaLinkiQ13627.
SIGNORiQ13627.

Miscellaneous databases

ChiTaRSiDYRK1A. human.
EvolutionaryTraceiQ13627.
GeneWikiiDYRK1A.
GenomeRNAii1859.
PROiQ13627.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157540.
CleanExiHS_DYRK1A.
ExpressionAtlasiQ13627. baseline and differential.
GenevisibleiQ13627. HS.

Family and domain databases

InterProiIPR028318. DYRK1A.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24058:SF28. PTHR24058:SF28. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYR1A_HUMAN
AccessioniPrimary (citable) accession number: Q13627
Secondary accession number(s): O60769
, Q92582, Q92810, Q9UNM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 179 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.