true
1997-11-01
2024-03-27
205
MTMR3_HUMAN
FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain.
Zhao R.
Qi Y.
Zhao Z.J.
doi:10.1006/bbrc.2000.2417
2000
Biochem. Biophys. Res. Commun.
270
222-229
NUCLEOTIDE SEQUENCE (ISOFORMS A; B AND C)
CHARACTERIZATION
CATALYTIC ACTIVITY
FUNCTION
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Nagase T.
Ishikawa K.
Nakajima D.
Ohira M.
Seki N.
Miyajima N.
Tanaka A.
Kotani H.
Nomura N.
Ohara O.
doi:10.1093/dnares/4.2.141
1997
DNA Res.
4
141-150
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
Brain
A genome annotation-driven approach to cloning the human ORFeome.
Collins J.E.
Wright C.L.
Edwards C.A.
Davis M.P.
Grinham J.A.
Cole C.G.
Goward M.E.
Aguado B.
Mallya M.
Mokrab Y.
Huckle E.J.
Beare D.M.
Dunham I.
doi:10.1186/gb-2004-5-10-r84
2004
Genome Biol.
5
R84.1-R84.11
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
The DNA sequence of human chromosome 22.
Dunham I.
Hunt A.R.
Collins J.E.
Bruskiewich R.
Beare D.M.
Clamp M.
Smink L.J.
Ainscough R.
Almeida J.P.
Babbage A.K.
Bagguley C.
Bailey J.
Barlow K.F.
Bates K.N.
Beasley O.P.
Bird C.P.
Blakey S.E.
Bridgeman A.M.
Buck D.
Burgess J.
Burrill W.D.
Burton J.
Carder C.
Carter N.P.
Chen Y.
Clark G.
Clegg S.M.
Cobley V.E.
Cole C.G.
Collier R.E.
Connor R.
Conroy D.
Corby N.R.
Coville G.J.
Cox A.V.
Davis J.
Dawson E.
Dhami P.D.
Dockree C.
Dodsworth S.J.
Durbin R.M.
Ellington A.G.
Evans K.L.
Fey J.M.
Fleming K.
French L.
Garner A.A.
Gilbert J.G.R.
Goward M.E.
Grafham D.V.
Griffiths M.N.D.
Hall C.
Hall R.E.
Hall-Tamlyn G.
Heathcott R.W.
Ho S.
Holmes S.
Hunt S.E.
Jones M.C.
Kershaw J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.F.
Leversha M.A.
Lloyd C.
Lloyd D.M.
Martyn I.D.
Mashreghi-Mohammadi M.
Matthews L.H.
Mccann O.T.
Mcclay J.
Mclaren S.
McMurray A.A.
Milne S.A.
Mortimore B.J.
Odell C.N.
Pavitt R.
Pearce A.V.
Pearson D.
Phillimore B.J.C.T.
Phillips S.H.
Plumb R.W.
Ramsay H.
Ramsey Y.
Rogers L.
Ross M.T.
Scott C.E.
Sehra H.K.
Skuce C.D.
Smalley S.
Smith M.L.
Soderlund C.
Spragon L.
Steward C.A.
Sulston J.E.
Swann R.M.
Vaudin M.
Wall M.
Wallis J.M.
Whiteley M.N.
Willey D.L.
Williams L.
Williams S.A.
Williamson H.
Wilmer T.E.
Wilming L.
Wright C.L.
Hubbard T.
Bentley D.R.
Beck S.
Rogers J.
Shimizu N.
Minoshima S.
Kawasaki K.
Sasaki T.
Asakawa S.
Kudoh J.
Shintani A.
Shibuya K.
Yoshizaki Y.
Aoki N.
Mitsuyama S.
Roe B.A.
Chen F.
Chu L.
Crabtree J.
Deschamps S.
Do A.
Do T.
Dorman A.
Fang F.
Fu Y.
Hu P.
Hua A.
Kenton S.
Lai H.
Lao H.I.
Lewis J.
Lewis S.
Lin S.-P.
Loh P.
Malaj E.
Nguyen T.
Pan H.
Phan S.
Qi S.
Qian Y.
Ray L.
Ren Q.
Shaull S.
Sloan D.
Song L.
Wang Q.
Wang Y.
Wang Z.
White J.
Willingham D.
Wu H.
Yao Z.
Zhan M.
Zhang G.
Chissoe S.
Murray J.
Miller N.
Minx P.
Fulton R.
Johnson D.
Bemis G.
Bentley D.
Bradshaw H.
Bourne S.
Cordes M.
Du Z.
Fulton L.
Goela D.
Graves T.
Hawkins J.
Hinds K.
Kemp K.
Latreille P.
Layman D.
Ozersky P.
Rohlfing T.
Scheet P.
Walker C.
Wamsley A.
Wohldmann P.
Pepin K.
Nelson J.
Korf I.
Bedell J.A.
Hillier L.W.
Mardis E.
Waterston R.
Wilson R.
Emanuel B.S.
Shaikh T.
Kurahashi H.
Saitta S.
Budarf M.L.
McDermid H.E.
Johnson A.
Wong A.C.C.
Morrow B.E.
Edelmann L.
Kim U.J.
Shizuya H.
Simon M.I.
Dumanski J.P.
Peyrard M.
Kedra D.
Seroussi E.
Fransson I.
Tapia I.
Bruder C.E.
O'Brien K.P.
Wilkinson P.
Bodenteich A.
Hartman K.
Hu X.
Khan A.S.
Lane L.
Tilahun Y.
Wright H.
doi:10.1038/990031
1999
Nature
402
489-495
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Mural R.J.
Istrail S.
Sutton G.G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.
2005-07
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C)
Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.
Laporte J.
Blondeau F.
Buj-Bello A.
Tentler D.
Kretz C.
Dahl N.
Mandel J.-L.
doi:10.1093/hmg/7.11.1703
1998
Hum. Mol. Genet.
7
1703-1712
NUCLEOTIDE SEQUENCE OF 374-578
A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.
Laporte J.
Hu L.-J.
Kretz C.
Mandel J.-L.
Kioschis P.
Coy J.
Klauck S.M.
Poutska A.
Dahl N.
doi:10.1038/ng0696-175
1996
Nat. Genet.
13
175-182
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-463
Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity.
Walker D.M.
Urbe S.
Dove S.K.
Tenza D.
Raposo G.
Clague M.J.
doi:10.1016/s0960-9822(01)00501-2
2001
Curr. Biol.
11
1600-1605
FUNCTION
MUTAGENESIS OF CYS-413
CATALYTIC ACTIVITY
SUBCELLULAR LOCATION
Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.
Schaletzky J.
Dove S.K.
Short B.
Lorenzo O.
Clague M.J.
Barr F.A.
doi:10.1016/s0960-9822(03)00132-5
2003
Curr. Biol.
13
504-509
CATALYTIC ACTIVITY
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin G.T.
Yi W.
Lu B.
Park S.K.
Xu T.
Lee J.-D.
Yates J.R. III
doi:10.1021/pr0705441
2008
J. Proteome Res.
7
1346-1351
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-647
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Cervix carcinoma
A quantitative atlas of mitotic phosphorylation.
Dephoure N.
Zhou C.
Villen J.
Beausoleil S.A.
Bakalarski C.E.
Elledge S.J.
Gygi S.P.
doi:10.1073/pnas.0805139105
2008
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633; SER-647 AND THR-731
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V.
Lundgren D.H.
Hwang S.-I.
Rezaul K.
Wu L.
Eng J.K.
Rodionov V.
Han D.K.
doi:10.1126/scisignal.2000007
2009
Sci. Signal.
2
RA46
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Leukemic T-cell
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Zhou H.
Di Palma S.
Preisinger C.
Peng M.
Polat A.N.
Heck A.J.
Mohammed S.
doi:10.1021/pr300630k
2013
J. Proteome Res.
12
260-271
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8; SER-613; SER-647; SER-651; THR-731; SER-906 AND SER-909
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Erythroleukemia
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
Bian Y.
Song C.
Cheng K.
Dong M.
Wang F.
Huang J.
Sun D.
Wang L.
Ye M.
Zou H.
doi:10.1016/j.jprot.2013.11.014
2014
J. Proteomics
96
253-262
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-731
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Liver
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.
Jones S.
Wood L.D.
Parsons D.W.
Lin J.
Barber T.D.
Mandelker D.
Leary R.J.
Ptak J.
Silliman N.
Szabo S.
Buckhaults P.
Farrell C.
Meeh P.
Markowitz S.D.
Willis J.
Dawson D.
Willson J.K.V.
Gazdar A.F.
Hartigan J.
Wu L.
Liu C.
Parmigiani G.
Park B.H.
Bachman K.E.
Papadopoulos N.
Vogelstein B.
Kinzler K.W.
Velculescu V.E.
doi:10.1126/science.1133427
2006
Science
314
268-274
VARIANT [LARGE SCALE ANALYSIS] LEU-221
STEEP mediates STING ER exit and activation of signaling.
Zhang B.C.
Nandakumar R.
Reinert L.S.
Huang J.
Laustsen A.
Gao Z.L.
Sun C.L.
Jensen S.B.
Troldborg A.
Assil S.
Berthelsen M.F.
Scavenius C.
Zhang Y.
Windross S.J.
Olagnier D.
Prabakaran T.
Bodda C.
Narita R.
Cai Y.
Zhang C.G.
Stenmark H.
Doucet C.M.
Noda T.
Guo Z.
Goldbach-Mansky R.
Hartmann R.
Chen Z.J.
Enghild J.J.
Bak R.O.
Thomsen M.K.
Paludan S.R.
doi:10.1038/s41590-020-0730-5
2020
Nat. Immunol.
21
868-879
Zhang B.C.
Nandakumar R.
Reinert L.S.
Huang J.
Laustsen A.
Gao Z.L.
Sun C.L.
Jensen S.B.
Troldborg A.
Assil S.
Berthelsen M.F.
Scavenius C.
Zhang Y.
Windross S.J.
Olagnier D.
Prabakaran T.
Bodda C.
Narita R.
Cai Y.
Zhang C.G.
Stenmark H.
Doucet C.M.
Noda T.
Guo Z.
Goldbach-Mansky R.
Hartmann R.
Chen Z.J.
Enghild J.J.
Bak R.O.
Thomsen M.K.
Paludan S.R.
doi:10.1038/s41590-020-0803-5
2020
Nat. Immunol.
21
1468-1469
MUTAGENESIS OF CYS-413
Different initiation.
68
34
3 sites, 1 glycan
3 sites, 1 O-linked glycan (3 sites)
91 antibodies from 20 providers
human
MTMR3
Tissue enhanced (bone)
gene
Eukaryota
2681
Macroautophagy
Synthesis of PIPs at the plasma membrane
26 hits in 1176 CRISPR screens
human
Tbio
Protein
Expressed in oocyte and 197 other cell types or tissues
baseline and differential
FYVE_MTMR3
PH-GRAM_MTMR3
PTP-MTMR3
Protein tyrosine phosphatase superfamily
Zinc/RING finger domain, C3HC4 (zinc finger)
MTMR3_PH-GRAM
MTMR3_PTP
Myotubularin-like_Pase_dom
Myotubularin_fam
Prot-tyrosine_phosphatase-like
Tyr_Pase_AS
Tyr_Pase_cat
Znf_FYVE
Znf_FYVE-rel
Znf_FYVE_PHD
Znf_RING/FYVE/PHD
MYOTUBULARIN-RELATED
MYOTUBULARIN-RELATED PROTEIN 3
FYVE
Myotub-related
FYVE
PTPc_motif
(Phosphotyrosine protein) phosphatases II
FYVE/PHD zinc finger
PH domain-like
PPASE_MYOTUBULARIN
TYR_PHOSPHATASE_1
ZF_FYVE
HS
Myotubularin-related protein 3
3.1.3.48
FYVE domain-containing dual specificity protein phosphatase 1
FYVE-DSP1
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase
3.1.3.95
Phosphatidylinositol-3-phosphate phosphatase
3.1.3.64
Zinc finger FYVE domain-containing protein 10
MTMR3
KIAA0371
ZFYVE10
Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11676921). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Myotubularin-related protein 3
133619
1
1198
Myotubularin phosphatase
155
576
FYVE-type
1119
1179
Disordered
265
285
Disordered
590
612
Disordered
650
669
Disordered
716
735
Disordered
855
891
Disordered
933
974
Disordered
993
1019
1029
1062
Polar residues
283
Polar residues
872
Polar residues
934
954
Phosphocysteine intermediate
413
326
329
351
352
419
459
1125
1128
1141
1144
1149
1152
1171
1174
Phosphoserine
8
Phosphoserine
613
Phosphoserine
633
Phosphoserine
647
Phosphoserine
651
Phosphothreonine
731
Phosphoserine
906
Phosphoserine
909
Phosphoserine
1064
In isoform A and isoform C.
1076
1112
In isoform A.
RDTDRVDQTW
1142
In a breast cancer sample; somatic mutation.
L
221
Loss of lipid phosphatase activity.
S
CILQPFHCGQQKEFGVGYI
560
578
substrate
1
2
false
3
false
3
false
3
false
3
EXOSC5
LONRF1
MTOR
RPTOR
2003-07-19
3
133619
432c438e6fc5b415c3dea8825f4e2dd2
B
FYVE-DSP1b
MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
A
FYVE-DSP1a
MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWLPDHLAAHCYACDSAFWLASRKHHCRDTDRVDQTWNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
C
FYVE-DSP1c
MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true