Reviewed,
UniProtKB/Swiss-Prot Q13615 (MTMR3_HUMAN)
Last modified
November 25, 2008.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Myotubularin-related protein 3 EC=3.1.3.48 Alternative name(s): FYVE domain-containing dual specificity protein phosphatase 1 Short name=FYVE-DSP1 Zinc finger FYVE domain-containing protein 10 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1198 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. |
| Catalytic activity | Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Contains 1 FYVE-type zinc finger. Contains 1 myotubularin phosphatase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Coiled coil Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase Protein phosphatase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | protein amino acid dephosphorylation Ref.1 Inferred from direct assay. Source: UniProtKB |
| Cellular component | cytoplasm Ref.1 Inferred from direct assay. Source: UniProtKB membraneInferred from electronic annotation. Source: UniProtKB-KW membrane fraction Ref.1Inferred from direct assay. Source: UniProtKB |
| Molecular function | protein serine/threonine phosphatase activity Ref.1 Inferred from direct assay. Source: UniProtKB protein tyrosine phosphatase activity Ref.1Inferred from direct assay. Source: UniProtKB zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform B (identifier: Q13615-1) Also known as: FYVE-DSP1b; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform A (identifier: Q13615-2) Also known as: FYVE-DSP1a; The sequence of this isoform differs from the canonical sequence as follows: 1076-1112: Missing. 1142-1142: R → RDTDRVDQTW | ||||||
| Isoform C (identifier: Q13615-3) Also known as: FYVE-DSP1c; The sequence of this isoform differs from the canonical sequence as follows: 1076-1112: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1198 | 1198 | Myotubularin-related protein 3 | PRO_0000094936 | |||||
Regions | |||||||||
| Domain | 155 – 576 | 422 | Myotubularin phosphatase | ||||||
| Zinc finger | 1119 – 1179 | 61 | FYVE-type | ||||||
| Coiled coil | 1029 – 1062 | 34 | Potential | ||||||
Sites | |||||||||
| Active site | 413 | 1 | Phosphocysteine intermediate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 613 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 633 | 1 | Phosphoserine | ||||||
| Modified residue | 647 | 1 | Phosphoserine | ||||||
| Modified residue | 731 | 1 | Phosphothreonine | ||||||
| Modified residue | 913 | 1 | Phosphoserine | ||||||
| Modified residue | 1181 | 1 | Phosphothreonine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1076 – 1112 | 37 | Missing in isoform A and isoform C. | VSP_007781 | |||||
| Alternative sequence | 1142 | 1 | R → RDTDRVDQTW in isoform A. | VSP_007782 | |||||
| Natural variant | 221 | 1 | V → L in a breast cancer sample; somatic mutation. | VAR_035656 | |||||
Experimental info | |||||||||
| Sequence conflict | 560 – 578 | 19 | LYPVC…AVYLP → CILQPFHCGQQKEFGVGYI Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain." Zhao R., Qi Y., Zhao Z.J. Biochem. Biophys. Res. Commun. 270:222-229(2000) [PubMed: 10733931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS A; B AND C), CHARACTERIZATION. |
| [2] | "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Tissue: Brain. |
| [3] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). |
| [4] | "The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. Wright H.Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human." Laporte J., Blondeau F., Buj-Bello A., Tentler D., Kretz C., Dahl N., Mandel J.-L. Hum. Mol. Genet. 7:1703-1712(1998) [PubMed: 9736772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 374-578. |
| [6] | "A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast." Laporte J., Hu L.-J., Kretz C., Mandel J.-L., Kioschis P., Coy J., Klauck S.M., Poutska A., Dahl N. Nat. Genet. 13:175-182(1996) [PubMed: 8640223] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-463. |
| [7] | "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-647, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633; SER-647; THR-731 AND SER-913, MASS SPECTROMETRY. |
| [9] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-221. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF233436 mRNA. Translation: AAF40203.2. AF233437 mRNA. Translation: AAF40204.1. AF233438 mRNA. Translation: AAF40205.1. AB002369 mRNA. Translation: BAA20826.2. Different initiation. CR456525 mRNA. Translation: CAG30411.1. AC003071 Genomic DNA. Translation: AAB83949.1. U58034 Genomic DNA. Translation: AAC79119.1. | |
| RefSeq | NP_066576.1. NP_694690.1. NP_694691.1. |
| UniGene | Hs.474536 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q13615. |
PTM databases | |
| PhosphoSite | Q13615. |
Genome annotation databases | |
| Ensembl | ENSG00000100330. Homo sapiens. [Contig view] |
| GeneID | 8897. |
| KEGG | hsa:8897. |
Organism-specific databases | |
| H-InvDB | HIX0016359. |
| HGNC | HGNC:7451. MTMR3. |
| MIM | 603558. gene. |
| PharmGKB | PA31254. |
| HUGE | Search... |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q13615. |
| HOVERGEN | Q13615. |
Gene expression databases | |
| ArrayExpress | Q13615. |
| CleanEx | HS_MTMR3. |
| GermOnline | ENSG00000100330. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR010569. Myotub-related. IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR013083. Znf_RING/FYVE/PHD. [Graphical view] |
| Gene3D | G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit. |
| Pfam | PF01363. FYVE. 1 hit. PF06602. Myotub-related. 1 hit. [Graphical view] |
| SMART | SM00064. FYVE. 1 hit. [Graphical view] |
| PROSITE | PS51339. PPASE_MYOTUBULARIN. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. False negative. PS50178. ZF_FYVE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 33415. |
| SOURCE | Search... |
Entry information
| Entry name | MTMR3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13615 Secondary accession number(s): Q9NYN5 Q9UEG3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


