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Protein

Myotubularin-related protein 3

Gene

MTMR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).2 Publications

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.1 Publication
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.1 Publication
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei413Phosphocysteine intermediatePROSITE-ProRule annotationCurated1
Binding sitei459SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1119 – 1179FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Source: UniProtKB
  • phosphatidylinositol-3-phosphatase activity Source: UniProtKB
  • protein phosphatase binding Source: UniProtKB
  • protein serine/threonine phosphatase activity Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  • cellular response to glucose starvation Source: ParkinsonsUK-UCL
  • macroautophagy Source: Reactome
  • phosphatidylinositol 5-phosphate metabolic process Source: ParkinsonsUK-UCL
  • phosphatidylinositol biosynthetic process Source: Reactome
  • phosphatidylinositol dephosphorylation Source: UniProtKB
  • protein dephosphorylation Source: UniProtKB
  • regulation of autophagosome assembly Source: ParkinsonsUK-UCL
  • regulation of phosphatidylinositol dephosphorylation Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processLipid metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS02045-MONOMER
BRENDAi3.1.3.95 2681
ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
SIGNORiQ13615

Chemistry databases

SwissLipidsiSLP:000001134

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 3 (EC:3.1.3.481 Publication)
Alternative name(s):
FYVE domain-containing dual specificity protein phosphatase 1
Short name:
FYVE-DSP1
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.951 Publication)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.641 Publication)
Zinc finger FYVE domain-containing protein 10
Gene namesi
Name:MTMR3
Synonyms:KIAA0371, ZFYVE10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100330.15
HGNCiHGNC:7451 MTMR3
MIMi603558 gene
neXtProtiNX_Q13615

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi413C → S: Loss of lipid phosphatase activity. 1 Publication1

Organism-specific databases

DisGeNETi8897
OpenTargetsiENSG00000100330
PharmGKBiPA31254

Polymorphism and mutation databases

BioMutaiMTMR3
DMDMi33112668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949361 – 1198Myotubularin-related protein 3Add BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei651PhosphoserineCombined sources1
Modified residuei731PhosphothreonineCombined sources1
Modified residuei906PhosphoserineCombined sources1
Modified residuei909PhosphoserineCombined sources1
Modified residuei1064PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13615
MaxQBiQ13615
PaxDbiQ13615
PeptideAtlasiQ13615
PRIDEiQ13615
ProteomicsDBi59601
59602 [Q13615-2]
59603 [Q13615-3]

PTM databases

DEPODiQ13615
iPTMnetiQ13615
PhosphoSitePlusiQ13615

Expressioni

Gene expression databases

BgeeiENSG00000100330
CleanExiHS_MTMR3
ExpressionAtlasiQ13615 baseline and differential
GenevisibleiQ13615 HS

Organism-specific databases

HPAiHPA034515
HPA034516
HPA061399

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114414, 36 interactors
IntActiQ13615, 16 interactors
MINTiQ13615
STRINGi9606.ENSP00000384651

Structurei

3D structure databases

ProteinModelPortaliQ13615
SMRiQ13615
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 576Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 329Substrate bindingBy similarity4
Regioni351 – 352Substrate bindingBy similarity2
Regioni413 – 419Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1029 – 1062Sequence analysisAdd BLAST34

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1119 – 1179FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410INM7 Eukaryota
ENOG410YU6P LUCA
GeneTreeiENSGT00760000118832
HOVERGENiHBG052526
InParanoidiQ13615
KOiK18082
OMAiQIESGHQ
OrthoDBiEOG091G0TBM
PhylomeDBiQ13615
TreeFamiTF315197

Family and domain databases

CDDicd13341 PH-GRAM_MTMR3, 1 hit
Gene3Di3.30.40.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR035888 MTMR3_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: Q13615-1) [UniParc]FASTAAdd to basket
Also known as: FYVE-DSP1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEETRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEFVGRAED
60 70 80 90 100
AIIALSNYRL HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ
110 120 130 140 150
FSTFEQCQEW LKRLNNAIRP PAKIEDLFSF AYHAWCMEVY ASEKEQHGDL
160 170 180 190 200
CRPGEHVTSR FKNEVERMGF DMNNAWRISN INEKYKLCGS YPQELIVPAW
210 220 230 240 250
ITDKELESVS SFRSWKRIPA VIYRHQSNGA VIARCGQPEV SWWGWRNADD
260 270 280 290 300
EHLVQSVAKA CASDSRSSGS KLSTRNTSRD FPNGGDLSDV EFDSSLSNAS
310 320 330 340 350
GAESLAIQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA
360 370 380 390 400
NIHSIRRSFQ SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH
410 420 430 440 450
AVDQDQRPVL VHCSDGWDRT PQIVALAKLL LDPYYRTIEG FQVLVEMEWL
460 470 480 490 500
DFGHKFADRC GHGENSDDLN ERCPVFLQWL DCVHQLQRQF PCSFEFNEAF
510 520 530 540 550
LVKLVQHTYS CLFGTFLCNN AKERGEKHTQ ERTCSVWSLL RAGNKAFKNL
560 570 580 590 600
LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPTTPVDDSC APYPAPGTSP
610 620 630 640 650
DDPPLSRLPK TRSYDNLTTA CDNTVPLASR RCSDPSLNEK WQEHRRSLEL
660 670 680 690 700
SSLAGPGEDP LSADSLGKPT RVPGGAELSV AAGVAEGQME NILQEATKEE
710 720 730 740 750
SGVEEPAHRA GIEIQEGKED PLLEKESRRK TPEASAIGLH QDPELGDAAL
760 770 780 790 800
RSHLDMSWPL FSQGISEQQS GLSVLLSSLQ VPPRGEDSLE VPVEQFRIEE
810 820 830 840 850
IAEGREEAVL PIPVDAKVGY GTSQSCSLLP SQVPFETRGP NVDSSTDMLV
860 870 880 890 900
EDKVKSVSGP QGHHRSCLVN SGKDRLPQTM EPSPSETSLV ERPQVGSVVH
910 920 930 940 950
RTSLGSTLSL TRSPCALPLA ECKEGLVCNG APETENRASE QPPGLSTLQM
960 970 980 990 1000
YPTPNGHCAN GEAGRSKDSL SRQLSAMSCS SAHLHSRNLH HKWLHSHSGR
1010 1020 1030 1040 1050
PSATSSPDQP SRSHLDDDGM SVYTDTIQQR LRQIESGHQQ EVETLKKQVQ
1060 1070 1080 1090 1100
ELKSRLESQY LTSSLHFNGD FGDEVTSIPD SESNLDQNCL SRCSTEIFSE
1110 1120 1130 1140 1150
ASWEQVDKQD TEMTRWLPDH LAAHCYACDS AFWLASRKHH CRNCGNVFCS
1160 1170 1180 1190
SCCNQKVPVP SQQLFEPSRV CKSCYSSLHP TSSSIDLELD KPIAATSN
Length:1,198
Mass (Da):133,619
Last modified:July 19, 2003 - v3
Checksum:iFE6F4B165074D5F8
GO
Isoform A (identifier: Q13615-2) [UniParc]FASTAAdd to basket
Also known as: FYVE-DSP1a

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1112: Missing.
     1142-1142: R → RDTDRVDQTW

Show »
Length:1,170
Mass (Da):130,561
Checksum:iB51B10E3E7245433
GO
Isoform C (identifier: Q13615-3) [UniParc]FASTAAdd to basket
Also known as: FYVE-DSP1c

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1112: Missing.

Show »
Length:1,161
Mass (Da):129,444
Checksum:i18C795D42EFB1177
GO

Sequence cautioni

The sequence BAA20826 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti560 – 578LYPVC…AVYLP → CILQPFHCGQQKEFGVGYI (PubMed:9736772).CuratedAdd BLAST19

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035656221V → L in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0077811076 – 1112Missing in isoform A and isoform C. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_0077821142R → RDTDRVDQTW in isoform A. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233436 mRNA Translation: AAF40203.2
AF233437 mRNA Translation: AAF40204.1
AF233438 mRNA Translation: AAF40205.1
AB002369 mRNA Translation: BAA20826.2 Different initiation.
CR456525 mRNA Translation: CAG30411.1
CH471095 Genomic DNA Translation: EAW59852.1
CH471095 Genomic DNA Translation: EAW59855.1
BC142713 mRNA Translation: AAI42714.1
BC148216 mRNA Translation: AAI48217.1
BC152455 mRNA Translation: AAI52456.1
AC003071 Genomic DNA Translation: AAB83949.1
U58034 Genomic DNA Translation: AAC79119.1
CCDSiCCDS13870.1 [Q13615-1]
CCDS13871.1 [Q13615-2]
CCDS46682.1 [Q13615-3]
RefSeqiNP_066576.1, NM_021090.3 [Q13615-1]
NP_694690.1, NM_153050.2 [Q13615-2]
NP_694691.1, NM_153051.2 [Q13615-3]
XP_016884521.1, XM_017029032.1 [Q13615-3]
UniGeneiHs.474536

Genome annotation databases

EnsembliENST00000333027; ENSP00000331649; ENSG00000100330 [Q13615-2]
ENST00000351488; ENSP00000307271; ENSG00000100330 [Q13615-3]
ENST00000401950; ENSP00000384651; ENSG00000100330 [Q13615-1]
ENST00000406629; ENSP00000384077; ENSG00000100330 [Q13615-2]
GeneIDi8897
KEGGihsa:8897
UCSCiuc003agu.5 human [Q13615-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMTMR3_HUMAN
AccessioniPrimary (citable) accession number: Q13615
Secondary accession number(s): A5PL26
, A7MD32, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2003
Last modified: June 20, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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