Q13615 (MTMR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myotubularin-related protein 3
EC=3.1.3.48

Alternative name(s):
FYVE domain-containing dual specificity protein phosphatase 1
Short name=FYVE-DSP1
Zinc finger FYVE domain-containing protein 10

Gene names

Name:	MTMR3
Synonyms:	KIAA0371, ZFYVE10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Ref.9
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Contains 1 FYVE-type zinc finger. Contains 1 myotubularin phosphatase domain.
Sequence caution	The sequence BAA20826.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phosphatidylinositol dephosphorylation Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane fraction Inferred from direct assay Ref.1. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-3-phosphatase activity Inferred from direct assay. Source: UniProtKB protein serine/threonine phosphatase activity Inferred from direct assay Ref.1. Source: UniProtKB protein tyrosine phosphatase activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: Q13615-1)

Also known as: FYVE-DSP1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: Q13615-2)

Also known as: FYVE-DSP1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1112: Missing.
     1142-1142: R → RDTDRVDQTW

Isoform C (identifier: Q13615-3)

Also known as: FYVE-DSP1c;

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1112: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1198	1198	Myotubularin-related protein 3		PRO_0000094936
Regions
	Domain	155 – 576	422	Myotubularin phosphatase
	Zinc finger	1119 – 1179	61	FYVE-type
	Region	326 – 329	4	Substrate binding By similarity
	Region	351 – 352	2	Substrate binding By similarity
	Region	413 – 419	7	Substrate binding By similarity
	Coiled coil	1029 – 1062	34	Potential
Sites
	Active site	413	1	Phosphocysteine intermediate By similarity
	Binding site	459	1	Substrate By similarity
Amino acid modifications
	Modified residue	613	1	Phosphoserine By similarity
	Modified residue	633	1	Phosphoserine Ref.11
	Modified residue	647	1	Phosphoserine Ref.10 Ref.11 Ref.12
	Modified residue	731	1	Phosphothreonine Ref.11
	Modified residue	913	1	Phosphoserine Ref.11
	Modified residue	1181	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1076 – 1112	37	Missing in isoform A and isoform C.		VSP_007781
	Alternative sequence	1142	1	R → RDTDRVDQTW in isoform A.		VSP_007782
	Natural variant	221	1	V → L in a breast cancer sample; somatic mutation. Ref.13		VAR_035656
Experimental info
	Mutagenesis	413	1	C → S: Loss of activity. Ref.9
	Sequence conflict	560 – 578	19	LYPVC…AVYLP → CILQPFHCGQQKEFGVGYI Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform B (FYVE-DSP1b) [UniParc]. Last modified July 19, 2003. Version 3. Checksum: FE6F4B165074D5F8	FASTA	1,198	133,619
	10 20 30 40 50 60 MDEETRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEFVGRAED AIIALSNYRL 70 80 90 100 110 120 HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ FSTFEQCQEW LKRLNNAIRP 130 140 150 160 170 180 PAKIEDLFSF AYHAWCMEVY ASEKEQHGDL CRPGEHVTSR FKNEVERMGF DMNNAWRISN 190 200 210 220 230 240 INEKYKLCGS YPQELIVPAW ITDKELESVS SFRSWKRIPA VIYRHQSNGA VIARCGQPEV 250 260 270 280 290 300 SWWGWRNADD EHLVQSVAKA CASDSRSSGS KLSTRNTSRD FPNGGDLSDV EFDSSLSNAS 310 320 330 340 350 360 GAESLAIQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA NIHSIRRSFQ 370 380 390 400 410 420 SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH AVDQDQRPVL VHCSDGWDRT 430 440 450 460 470 480 PQIVALAKLL LDPYYRTIEG FQVLVEMEWL DFGHKFADRC GHGENSDDLN ERCPVFLQWL 490 500 510 520 530 540 DCVHQLQRQF PCSFEFNEAF LVKLVQHTYS CLFGTFLCNN AKERGEKHTQ ERTCSVWSLL 550 560 570 580 590 600 RAGNKAFKNL LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPTTPVDDSC APYPAPGTSP 610 620 630 640 650 660 DDPPLSRLPK TRSYDNLTTA CDNTVPLASR RCSDPSLNEK WQEHRRSLEL SSLAGPGEDP 670 680 690 700 710 720 LSADSLGKPT RVPGGAELSV AAGVAEGQME NILQEATKEE SGVEEPAHRA GIEIQEGKED 730 740 750 760 770 780 PLLEKESRRK TPEASAIGLH QDPELGDAAL RSHLDMSWPL FSQGISEQQS GLSVLLSSLQ 790 800 810 820 830 840 VPPRGEDSLE VPVEQFRIEE IAEGREEAVL PIPVDAKVGY GTSQSCSLLP SQVPFETRGP 850 860 870 880 890 900 NVDSSTDMLV EDKVKSVSGP QGHHRSCLVN SGKDRLPQTM EPSPSETSLV ERPQVGSVVH 910 920 930 940 950 960 RTSLGSTLSL TRSPCALPLA ECKEGLVCNG APETENRASE QPPGLSTLQM YPTPNGHCAN 970 980 990 1000 1010 1020 GEAGRSKDSL SRQLSAMSCS SAHLHSRNLH HKWLHSHSGR PSATSSPDQP SRSHLDDDGM 1030 1040 1050 1060 1070 1080 SVYTDTIQQR LRQIESGHQQ EVETLKKQVQ ELKSRLESQY LTSSLHFNGD FGDEVTSIPD 1090 1100 1110 1120 1130 1140 SESNLDQNCL SRCSTEIFSE ASWEQVDKQD TEMTRWLPDH LAAHCYACDS AFWLASRKHH 1150 1160 1170 1180 1190 CRNCGNVFCS SCCNQKVPVP SQQLFEPSRV CKSCYSSLHP TSSSIDLELD KPIAATSN
	Isoform A (FYVE-DSP1a) [UniParc]. Checksum: B51B10E3E7245433	FASTA	1,170	130,561
	10 20 30 40 50 60 MDEETRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEFVGRAED AIIALSNYRL 70 80 90 100 110 120 HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ FSTFEQCQEW LKRLNNAIRP 130 140 150 160 170 180 PAKIEDLFSF AYHAWCMEVY ASEKEQHGDL CRPGEHVTSR FKNEVERMGF DMNNAWRISN 190 200 210 220 230 240 INEKYKLCGS YPQELIVPAW ITDKELESVS SFRSWKRIPA VIYRHQSNGA VIARCGQPEV 250 260 270 280 290 300 SWWGWRNADD EHLVQSVAKA CASDSRSSGS KLSTRNTSRD FPNGGDLSDV EFDSSLSNAS 310 320 330 340 350 360 GAESLAIQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA NIHSIRRSFQ 370 380 390 400 410 420 SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH AVDQDQRPVL VHCSDGWDRT 430 440 450 460 470 480 PQIVALAKLL LDPYYRTIEG FQVLVEMEWL DFGHKFADRC GHGENSDDLN ERCPVFLQWL 490 500 510 520 530 540 DCVHQLQRQF PCSFEFNEAF LVKLVQHTYS CLFGTFLCNN AKERGEKHTQ ERTCSVWSLL 550 560 570 580 590 600 RAGNKAFKNL LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPTTPVDDSC APYPAPGTSP 610 620 630 640 650 660 DDPPLSRLPK TRSYDNLTTA CDNTVPLASR RCSDPSLNEK WQEHRRSLEL SSLAGPGEDP 670 680 690 700 710 720 LSADSLGKPT RVPGGAELSV AAGVAEGQME NILQEATKEE SGVEEPAHRA GIEIQEGKED 730 740 750 760 770 780 PLLEKESRRK TPEASAIGLH QDPELGDAAL RSHLDMSWPL FSQGISEQQS GLSVLLSSLQ 790 800 810 820 830 840 VPPRGEDSLE VPVEQFRIEE IAEGREEAVL PIPVDAKVGY GTSQSCSLLP SQVPFETRGP 850 860 870 880 890 900 NVDSSTDMLV EDKVKSVSGP QGHHRSCLVN SGKDRLPQTM EPSPSETSLV ERPQVGSVVH 910 920 930 940 950 960 RTSLGSTLSL TRSPCALPLA ECKEGLVCNG APETENRASE QPPGLSTLQM YPTPNGHCAN 970 980 990 1000 1010 1020 GEAGRSKDSL SRQLSAMSCS SAHLHSRNLH HKWLHSHSGR PSATSSPDQP SRSHLDDDGM 1030 1040 1050 1060 1070 1080 SVYTDTIQQR LRQIESGHQQ EVETLKKQVQ ELKSRLESQY LTSSLHFNGD FGDEVMTRWL 1090 1100 1110 1120 1130 1140 PDHLAAHCYA CDSAFWLASR KHHCRDTDRV DQTWNCGNVF CSSCCNQKVP VPSQQLFEPS 1150 1160 1170 RVCKSCYSSL HPTSSSIDLE LDKPIAATSN
	Isoform C (FYVE-DSP1c) [UniParc]. Checksum: 18C795D42EFB1177	FASTA	1,161	129,444
	10 20 30 40 50 60 MDEETRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEFVGRAED AIIALSNYRL 70 80 90 100 110 120 HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ FSTFEQCQEW LKRLNNAIRP 130 140 150 160 170 180 PAKIEDLFSF AYHAWCMEVY ASEKEQHGDL CRPGEHVTSR FKNEVERMGF DMNNAWRISN 190 200 210 220 230 240 INEKYKLCGS YPQELIVPAW ITDKELESVS SFRSWKRIPA VIYRHQSNGA VIARCGQPEV 250 260 270 280 290 300 SWWGWRNADD EHLVQSVAKA CASDSRSSGS KLSTRNTSRD FPNGGDLSDV EFDSSLSNAS 310 320 330 340 350 360 GAESLAIQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA NIHSIRRSFQ 370 380 390 400 410 420 SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH AVDQDQRPVL VHCSDGWDRT 430 440 450 460 470 480 PQIVALAKLL LDPYYRTIEG FQVLVEMEWL DFGHKFADRC GHGENSDDLN ERCPVFLQWL 490 500 510 520 530 540 DCVHQLQRQF PCSFEFNEAF LVKLVQHTYS CLFGTFLCNN AKERGEKHTQ ERTCSVWSLL 550 560 570 580 590 600 RAGNKAFKNL LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPTTPVDDSC APYPAPGTSP 610 620 630 640 650 660 DDPPLSRLPK TRSYDNLTTA CDNTVPLASR RCSDPSLNEK WQEHRRSLEL SSLAGPGEDP 670 680 690 700 710 720 LSADSLGKPT RVPGGAELSV AAGVAEGQME NILQEATKEE SGVEEPAHRA GIEIQEGKED 730 740 750 760 770 780 PLLEKESRRK TPEASAIGLH QDPELGDAAL RSHLDMSWPL FSQGISEQQS GLSVLLSSLQ 790 800 810 820 830 840 VPPRGEDSLE VPVEQFRIEE IAEGREEAVL PIPVDAKVGY GTSQSCSLLP SQVPFETRGP 850 860 870 880 890 900 NVDSSTDMLV EDKVKSVSGP QGHHRSCLVN SGKDRLPQTM EPSPSETSLV ERPQVGSVVH 910 920 930 940 950 960 RTSLGSTLSL TRSPCALPLA ECKEGLVCNG APETENRASE QPPGLSTLQM YPTPNGHCAN 970 980 990 1000 1010 1020 GEAGRSKDSL SRQLSAMSCS SAHLHSRNLH HKWLHSHSGR PSATSSPDQP SRSHLDDDGM 1030 1040 1050 1060 1070 1080 SVYTDTIQQR LRQIESGHQQ EVETLKKQVQ ELKSRLESQY LTSSLHFNGD FGDEVMTRWL 1090 1100 1110 1120 1130 1140 PDHLAAHCYA CDSAFWLASR KHHCRNCGNV FCSSCCNQKV PVPSQQLFEP SRVCKSCYSS 1150 1160 LHPTSSSIDL ELDKPIAATS N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain." Zhao R., Qi Y., Zhao Z.J. Biochem. Biophys. Res. Commun. 270:222-229(2000) [PubMed: 10733931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS A; B AND C), CHARACTERIZATION.
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B). Tissue: Brain.
[3]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[4]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C).
[7]	"Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human." Laporte J., Blondeau F., Buj-Bello A., Tentler D., Kretz C., Dahl N., Mandel J.-L. Hum. Mol. Genet. 7:1703-1712(1998) [PubMed: 9736772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 374-578.
[8]	"A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast." Laporte J., Hu L.-J., Kretz C., Mandel J.-L., Kioschis P., Coy J., Klauck S.M., Poutska A., Dahl N. Nat. Genet. 13:175-182(1996) [PubMed: 8640223] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-463.
[9]	"Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity." Walker D.M., Urbe S., Dove S.K., Tenza D., Raposo G., Clague M.J. Curr. Biol. 11:1600-1605(2001) [PubMed: 11676921] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF CYS-413.
[10]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-647, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633; SER-647; THR-731 AND SER-913, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-647, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-221.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF233436 mRNA. Translation: AAF40203.2. AF233437 mRNA. Translation: AAF40204.1. AF233438 mRNA. Translation: AAF40205.1. AB002369 mRNA. Translation: BAA20826.2. Different initiation. CR456525 mRNA. Translation: CAG30411.1. CH471095 Genomic DNA. Translation: EAW59852.1. CH471095 Genomic DNA. Translation: EAW59855.1. BC142713 mRNA. Translation: AAI42714.1. BC148216 mRNA. Translation: AAI48217.1. BC152455 mRNA. Translation: AAI52456.1. AC003071 Genomic DNA. Translation: AAB83949.1. U58034 Genomic DNA. Translation: AAC79119.1.
IPI	IPI00171273. IPI00171274. IPI00185018.
RefSeq	NP_066576.1. NM_021090.3. NP_694690.1. NM_153050.2. NP_694691.1. NM_153051.2.
UniGene	Hs.474536.
3D structure databases
ProteinModelPortal	Q13615.
SMR	Q13615. Positions 35-579, 1111-1181.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13615. 5 interactions.
STRING	Q13615.
PTM databases
PhosphoSite	Q13615.
Polymorphism databases
DMDM	33112668.
Proteomic databases
PRIDE	Q13615.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000401950; ENSP00000384651; ENSG00000100330.
GeneID	8897.
KEGG	hsa:8897.
UCSC	uc003agu.2. human. uc003agv.2. human. uc003agw.2. human.
Organism-specific databases
CTD	8897.
GeneCards	GC22P030279.
H-InvDB	HIX0016359.
HGNC	HGNC:7451. MTMR3.
HPA	HPA034515. HPA034516.
MIM	603558. gene.
neXtProt	NX_Q13615.
PharmGKB	PA31254.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13553.
HOGENOM	HBG715843.
HOVERGEN	HBG052526.
InParanoid	Q13615.
OMA	RLESQYL.
OrthoDB	EOG4H19V0.
PhylomeDB	Q13615.
Enzyme and pathway databases
BioCyc	MetaCyc:ENSG00000100330-MONOMER.
Gene expression databases
ArrayExpress	Q13615.
Bgee	Q13615.
CleanEx	HS_MTMR3.
Genevestigator	Q13615.
GermOnline	ENSG00000100330. Homo sapiens.
Family and domain databases
InterPro	IPR010569. Myotub-related. IPR017906. Myotubularin_phosphatase_dom. IPR016130. Tyr_Pase_AS. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KO	K01104.
Pfam	PF01363. FYVE. 1 hit. PF06602. Myotub-related. 1 hit. [Graphical view]
SMART	SM00064. FYVE. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS51339. PPASE_MYOTUBULARIN. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. False negative. PS50178. ZF_FYVE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	33415.
SOURCE	Search...

Entry information

Entry name

MTMR3_HUMAN

Accession

Primary (citable) accession number: Q13615
Secondary accession number(s): A5PL26 , A7MD32, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 19, 2003
Last modified:	January 25, 2012
This is version 112 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.