Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Periodic tryptophan protein 1 homolog

Gene

PWP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in cell growth and/or transcription.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136045-MONOMER.
SignaLinkiQ13610.

Names & Taxonomyi

Protein namesi
Recommended name:
Periodic tryptophan protein 1 homolog
Alternative name(s):
Keratinocyte protein IEF SSP 9502
Gene namesi
Name:PWP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17015. PWP1.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136045.
PharmGKBiPA142671112.

Polymorphism and mutation databases

BioMutaiPWP1.
DMDMi2494897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511711 – 501Periodic tryptophan protein 1 homologAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphothreonineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei55PhosphothreonineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei86PhosphothreonineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Modified residuei494PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13610.
MaxQBiQ13610.
PaxDbiQ13610.
PeptideAtlasiQ13610.
PRIDEiQ13610.

PTM databases

iPTMnetiQ13610.
PhosphoSitePlusiQ13610.

Expressioni

Tissue specificityi

High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung.

Gene expression databases

BgeeiENSG00000136045.
CleanExiHS_PWP1.
ExpressionAtlasiQ13610. baseline and differential.
GenevisibleiQ13610. HS.

Organism-specific databases

HPAiHPA038708.

Interactioni

Protein-protein interaction databases

BioGridi116310. 41 interactors.
IntActiQ13610. 12 interactors.
MINTiMINT-3028185.
STRINGi9606.ENSP00000387365.

Structurei

3D structure databases

ProteinModelPortaliQ13610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati116 – 171WD 1Add BLAST56
Repeati177 – 222WD 2Add BLAST46
Repeati247 – 286WD 3Add BLAST40
Repeati290 – 329WD 4Add BLAST40
Repeati334 – 372WD 5Add BLAST39
Repeati376 – 415WD 6Add BLAST40
Repeati421 – 460WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat PWP1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0270. Eukaryota.
ENOG410XT1V. LUCA.
GeneTreeiENSGT00390000017324.
HOGENOMiHOG000212580.
HOVERGENiHBG001543.
InParanoidiQ13610.
KOiK14791.
OMAiCVEWLDI.
OrthoDBiEOG091G07TA.
PhylomeDBiQ13610.
TreeFamiTF314868.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13610-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRSRQVTCV AWVRCGVAKE TPDKVELSKE EVKRLIAEAK EKLQEEGGGS
60 70 80 90 100
DEEETGSPSE DGMQSARTQA RPREPLEDGD PEDDRTLDDD ELAEYDLDKY
110 120 130 140 150
DEEGDPDAET LGESLLGLTV YGSNDQDPYV TLKDTEQYER EDFLIKPSDN
160 170 180 190 200
LIVCGRAEQD QCNLEVHVYN QEEDSFYVHH DILLSAYPLS VEWLNFDPSP
210 220 230 240 250
DDSTGNYIAV GNMTPVIEVW DLDIVDSLEP VFTLGSKLSK KKKKKGKKSS
260 270 280 290 300
SAEGHTDAVL DLSWNKLIRN VLASASADNT VILWDMSLGK PAASLAVHTD
310 320 330 340 350
KVQTLQFHPF EAQTLISGSY DKSVALYDCR SPDESHRMWR FSGQIERVTW
360 370 380 390 400
NHFSPCHFLA STDDGFVYNL DARSDKPIFT LNAHNDEISG LDLSSQIKGC
410 420 430 440 450
LVTASADKYV KIWDILGDRP SLVHSRDMKM GVLFCSSCCP DLPFIYAFGG
460 470 480 490 500
QKEGLRVWDI STVSSVNEAF GRRERLVLGS ARNSSISGPF GSRSSDTPME

S
Length:501
Mass (Da):55,828
Last modified:November 1, 1996 - v1
Checksum:i16CC8EF2BAC8DFF0
GO
Isoform 2 (identifier: Q13610-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-147: EQYEREDFLIKP → SMTFFSSHLGTI
     148-501: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,309
Checksum:i1D2C28C708204ED3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033808288L → F.Corresponds to variant rs11547907dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056168136 – 147EQYER…FLIKP → SMTFFSSHLGTI in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_056169148 – 501Missing in isoform 2. 1 PublicationAdd BLAST354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07758 mRNA. Translation: AAA65201.1.
AK290681 mRNA. Translation: BAF83370.1.
AC007622 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97802.1.
BC010921 mRNA. Translation: AAH10921.1.
CCDSiCCDS9114.1. [Q13610-1]
PIRiI39360.
RefSeqiNP_001304892.1. NM_001317963.1.
NP_008993.1. NM_007062.2. [Q13610-1]
UniGeneiHs.506652.

Genome annotation databases

EnsembliENST00000412830; ENSP00000387365; ENSG00000136045. [Q13610-1]
ENST00000552760; ENSP00000448227; ENSG00000136045. [Q13610-2]
GeneIDi11137.
KEGGihsa:11137.
UCSCiuc001tmo.2. human. [Q13610-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07758 mRNA. Translation: AAA65201.1.
AK290681 mRNA. Translation: BAF83370.1.
AC007622 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97802.1.
BC010921 mRNA. Translation: AAH10921.1.
CCDSiCCDS9114.1. [Q13610-1]
PIRiI39360.
RefSeqiNP_001304892.1. NM_001317963.1.
NP_008993.1. NM_007062.2. [Q13610-1]
UniGeneiHs.506652.

3D structure databases

ProteinModelPortaliQ13610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116310. 41 interactors.
IntActiQ13610. 12 interactors.
MINTiMINT-3028185.
STRINGi9606.ENSP00000387365.

PTM databases

iPTMnetiQ13610.
PhosphoSitePlusiQ13610.

Polymorphism and mutation databases

BioMutaiPWP1.
DMDMi2494897.

Proteomic databases

EPDiQ13610.
MaxQBiQ13610.
PaxDbiQ13610.
PeptideAtlasiQ13610.
PRIDEiQ13610.

Protocols and materials databases

DNASUi11137.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412830; ENSP00000387365; ENSG00000136045. [Q13610-1]
ENST00000552760; ENSP00000448227; ENSG00000136045. [Q13610-2]
GeneIDi11137.
KEGGihsa:11137.
UCSCiuc001tmo.2. human. [Q13610-1]

Organism-specific databases

CTDi11137.
GeneCardsiPWP1.
HGNCiHGNC:17015. PWP1.
HPAiHPA038708.
neXtProtiNX_Q13610.
OpenTargetsiENSG00000136045.
PharmGKBiPA142671112.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0270. Eukaryota.
ENOG410XT1V. LUCA.
GeneTreeiENSGT00390000017324.
HOGENOMiHOG000212580.
HOVERGENiHBG001543.
InParanoidiQ13610.
KOiK14791.
OMAiCVEWLDI.
OrthoDBiEOG091G07TA.
PhylomeDBiQ13610.
TreeFamiTF314868.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136045-MONOMER.
SignaLinkiQ13610.

Miscellaneous databases

ChiTaRSiPWP1. human.
GeneWikiiPWP1.
GenomeRNAii11137.
PROiQ13610.

Gene expression databases

BgeeiENSG00000136045.
CleanExiHS_PWP1.
ExpressionAtlasiQ13610. baseline and differential.
GenevisibleiQ13610. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPWP1_HUMAN
AccessioniPrimary (citable) accession number: Q13610
Secondary accession number(s): A8K3R6, Q7Z3X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.