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Protein

Periodic tryptophan protein 1 homolog

Gene

PWP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in cell growth and/or transcription.

Caution

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ13610

Names & Taxonomyi

Protein namesi
Recommended name:
Periodic tryptophan protein 1 homolog
Alternative name(s):
Keratinocyte protein IEF SSP 9502
Gene namesi
Name:PWP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000136045.11
HGNCiHGNC:17015 PWP1
neXtProtiNX_Q13610

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136045
PharmGKBiPA142671112

Polymorphism and mutation databases

BioMutaiPWP1
DMDMi2494897

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511711 – 501Periodic tryptophan protein 1 homologAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphothreonineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei55PhosphothreonineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei86PhosphothreonineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Modified residuei494PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13610
MaxQBiQ13610
PaxDbiQ13610
PeptideAtlasiQ13610
PRIDEiQ13610

PTM databases

iPTMnetiQ13610
PhosphoSitePlusiQ13610

Expressioni

Tissue specificityi

High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung.

Gene expression databases

BgeeiENSG00000136045
CleanExiHS_PWP1
ExpressionAtlasiQ13610 baseline and differential
GenevisibleiQ13610 HS

Organism-specific databases

HPAiHPA038708

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi11631044 interactors.
CORUMiQ13610
IntActiQ13610 14 interactors.
MINTiQ13610
STRINGi9606.ENSP00000387365

Structurei

3D structure databases

ProteinModelPortaliQ13610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati116 – 171WD 1Add BLAST56
Repeati177 – 222WD 2Add BLAST46
Repeati247 – 286WD 3Add BLAST40
Repeati290 – 329WD 4Add BLAST40
Repeati334 – 372WD 5Add BLAST39
Repeati376 – 415WD 6Add BLAST40
Repeati421 – 460WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat PWP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0270 Eukaryota
ENOG410XT1V LUCA
GeneTreeiENSGT00390000017324
HOGENOMiHOG000212580
HOVERGENiHBG001543
InParanoidiQ13610
KOiK14791
OMAiPLCVEWL
OrthoDBiEOG091G07TA
PhylomeDBiQ13610
TreeFamiTF314868

Family and domain databases

Gene3Di2.130.10.101 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13610-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRSRQVTCV AWVRCGVAKE TPDKVELSKE EVKRLIAEAK EKLQEEGGGS
60 70 80 90 100
DEEETGSPSE DGMQSARTQA RPREPLEDGD PEDDRTLDDD ELAEYDLDKY
110 120 130 140 150
DEEGDPDAET LGESLLGLTV YGSNDQDPYV TLKDTEQYER EDFLIKPSDN
160 170 180 190 200
LIVCGRAEQD QCNLEVHVYN QEEDSFYVHH DILLSAYPLS VEWLNFDPSP
210 220 230 240 250
DDSTGNYIAV GNMTPVIEVW DLDIVDSLEP VFTLGSKLSK KKKKKGKKSS
260 270 280 290 300
SAEGHTDAVL DLSWNKLIRN VLASASADNT VILWDMSLGK PAASLAVHTD
310 320 330 340 350
KVQTLQFHPF EAQTLISGSY DKSVALYDCR SPDESHRMWR FSGQIERVTW
360 370 380 390 400
NHFSPCHFLA STDDGFVYNL DARSDKPIFT LNAHNDEISG LDLSSQIKGC
410 420 430 440 450
LVTASADKYV KIWDILGDRP SLVHSRDMKM GVLFCSSCCP DLPFIYAFGG
460 470 480 490 500
QKEGLRVWDI STVSSVNEAF GRRERLVLGS ARNSSISGPF GSRSSDTPME

S
Length:501
Mass (Da):55,828
Last modified:November 1, 1996 - v1
Checksum:i16CC8EF2BAC8DFF0
GO
Isoform 2 (identifier: Q13610-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-147: EQYEREDFLIKP → SMTFFSSHLGTI
     148-501: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,309
Checksum:i1D2C28C708204ED3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033808288L → F. Corresponds to variant dbSNP:rs11547907Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056168136 – 147EQYER…FLIKP → SMTFFSSHLGTI in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_056169148 – 501Missing in isoform 2. 1 PublicationAdd BLAST354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07758 mRNA Translation: AAA65201.1
AK290681 mRNA Translation: BAF83370.1
AC007622 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97802.1
BC010921 mRNA Translation: AAH10921.1
CCDSiCCDS9114.1 [Q13610-1]
PIRiI39360
RefSeqiNP_001304892.1, NM_001317963.1
NP_008993.1, NM_007062.2 [Q13610-1]
UniGeneiHs.506652

Genome annotation databases

EnsembliENST00000412830; ENSP00000387365; ENSG00000136045 [Q13610-1]
ENST00000552760; ENSP00000448227; ENSG00000136045 [Q13610-2]
GeneIDi11137
KEGGihsa:11137
UCSCiuc001tmo.2 human [Q13610-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPWP1_HUMAN
AccessioniPrimary (citable) accession number: Q13610
Secondary accession number(s): A8K3R6, Q7Z3X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome