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Protein

Olfactory receptor 2F1

Gene

OR2F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127356-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2F1
Alternative name(s):
Olfactory receptor 2F3
Olfactory receptor 2F4
Olfactory receptor 2F5
Olfactory receptor-like protein OLF3
Gene namesi
Name:OR2F1
Synonyms:OLF3, OR2F3, OR2F3P, OR2F4, OR2F5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:8246. OR2F1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 57CytoplasmicSequence analysis9
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 200ExtracellularSequence analysisAdd BLAST40
Transmembranei201 – 222Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini223 – 236CytoplasmicSequence analysisAdd BLAST14
Transmembranei237 – 261Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini262 – 272ExtracellularSequence analysisAdd BLAST11
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 317CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213215.
PharmGKBiPA32155.

Polymorphism and mutation databases

BioMutaiOR2F1.
DMDMi9297120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504691 – 317Olfactory receptor 2F1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13607.
PRIDEiQ13607.

PTM databases

iPTMnetiQ13607.
PhosphoSitePlusiQ13607.

Expressioni

Gene expression databases

BgeeiENSG00000213215.
CleanExiHS_OR2F1.
GenevisibleiQ13607. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376633.

Structurei

3D structure databases

ProteinModelPortaliQ13607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9H7. Eukaryota.
ENOG4111DQU. LUCA.
GeneTreeiENSGT00820000126998.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ13607.
KOiK04257.
OMAiAWQKLLW.
PhylomeDBiQ13607.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTDNQTWVS EFILLGLSSD WDTRVSLFVL FLVMYVVTVL GNCLIVLLIR
60 70 80 90 100
LDSRLHTPMY FFLTNLSLVD VSYATSVVPQ LLAHFLAEHK AIPFQSCAAQ
110 120 130 140 150
LFFSLALGGI EFVLLAVMAY DRYVAVCDAL RYSAIMHGGL CARLAITSWV
160 170 180 190 200
SGFISSPVQT AITFQLPMCR NKFIDHISCE LLAVVRLACV DTSSNEVTIM
210 220 230 240 250
VSSIVLLMTP FCLVLLSYIQ IISTILKIQS REGRKKAFHT CASHLTVVAL
260 270 280 290 300
CYGVAIFTYI QPHSSPSVLQ EKLFSVFYAI LTPMLNPMIY SLRNKEVKGA
310
WQKLLWKFSG LTSKLAT
Length:317
Mass (Da):35,350
Last modified:December 1, 2000 - v2
Checksum:iA72ADE1AEB6680CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211F → L in AAB01215 (PubMed:9017400).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053136122R → C.Corresponds to variant rs2072164dbSNPEnsembl.1
Natural variantiVAR_053137137H → R.Corresponds to variant rs2072165dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56421 Genomic DNA. Translation: AAB01215.1.
AC004853 Genomic DNA. Translation: AAC64376.1.
CH236959 Genomic DNA. Translation: EAL23795.1.
CH878732 Genomic DNA. Translation: EAW55625.1.
BC104975 mRNA. Translation: AAI04976.1.
AF399594 Genomic DNA. Translation: AAK95079.1.
BK004215 Genomic DNA. Translation: DAA04613.1.
RefSeqiNP_036501.2. NM_012369.2.
XP_011514321.1. XM_011516019.2.
XP_011514322.1. XM_011516020.2.
UniGeneiHs.553595.
Hs.623929.

Genome annotation databases

EnsembliENST00000624504; ENSP00000485483; ENSG00000213215.
GeneIDi26211.
KEGGihsa:26211.
UCSCiuc003wds.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56421 Genomic DNA. Translation: AAB01215.1.
AC004853 Genomic DNA. Translation: AAC64376.1.
CH236959 Genomic DNA. Translation: EAL23795.1.
CH878732 Genomic DNA. Translation: EAW55625.1.
BC104975 mRNA. Translation: AAI04976.1.
AF399594 Genomic DNA. Translation: AAK95079.1.
BK004215 Genomic DNA. Translation: DAA04613.1.
RefSeqiNP_036501.2. NM_012369.2.
XP_011514321.1. XM_011516019.2.
XP_011514322.1. XM_011516020.2.
UniGeneiHs.553595.
Hs.623929.

3D structure databases

ProteinModelPortaliQ13607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376633.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ13607.
PhosphoSitePlusiQ13607.

Polymorphism and mutation databases

BioMutaiOR2F1.
DMDMi9297120.

Proteomic databases

PaxDbiQ13607.
PRIDEiQ13607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624504; ENSP00000485483; ENSG00000213215.
GeneIDi26211.
KEGGihsa:26211.
UCSCiuc003wds.1. human.

Organism-specific databases

CTDi26211.
GeneCardsiOR2F1.
HGNCiHGNC:8246. OR2F1.
MIMi608497. gene.
neXtProtiNX_Q13607.
OpenTargetsiENSG00000213215.
PharmGKBiPA32155.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9H7. Eukaryota.
ENOG4111DQU. LUCA.
GeneTreeiENSGT00820000126998.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ13607.
KOiK04257.
OMAiAWQKLLW.
PhylomeDBiQ13607.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127356-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2F1.
GenomeRNAii26211.
PROiQ13607.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213215.
CleanExiHS_OR2F1.
GenevisibleiQ13607. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2F1_HUMAN
AccessioniPrimary (citable) accession number: Q13607
Secondary accession number(s): A4D2G1
, Q6IFP7, Q96R49, Q9UDX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.