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Protein

Olfactory receptor 2F1

Gene

OR2F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2F1
Alternative name(s):
Olfactory receptor 2F3
Olfactory receptor 2F4
Olfactory receptor 2F5
Olfactory receptor-like protein OLF3
Gene namesi
Name:OR2F1
Synonyms:OLF3, OR2F3, OR2F3P, OR2F4, OR2F5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:8246. OR2F1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 579CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 20040ExtracellularSequence analysisAdd
BLAST
Transmembranei201 – 22222Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini223 – 23614CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 26125Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini262 – 27211ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31725CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32155.

Polymorphism and mutation databases

BioMutaiOR2F1.
DMDMi9297120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 2F1PRO_0000150469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13607.
PRIDEiQ13607.

PTM databases

PhosphoSiteiQ13607.

Expressioni

Gene expression databases

BgeeiQ13607.
CleanExiHS_OR2F1.
GenevisibleiQ13607. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376633.

Structurei

3D structure databases

ProteinModelPortaliQ13607.
SMRiQ13607. Positions 15-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9H7. Eukaryota.
ENOG4111DQU. LUCA.
GeneTreeiENSGT00820000126998.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ13607.
KOiK04257.
OMAiAWQKLLW.
OrthoDBiEOG7SV0VR.
PhylomeDBiQ13607.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTDNQTWVS EFILLGLSSD WDTRVSLFVL FLVMYVVTVL GNCLIVLLIR
60 70 80 90 100
LDSRLHTPMY FFLTNLSLVD VSYATSVVPQ LLAHFLAEHK AIPFQSCAAQ
110 120 130 140 150
LFFSLALGGI EFVLLAVMAY DRYVAVCDAL RYSAIMHGGL CARLAITSWV
160 170 180 190 200
SGFISSPVQT AITFQLPMCR NKFIDHISCE LLAVVRLACV DTSSNEVTIM
210 220 230 240 250
VSSIVLLMTP FCLVLLSYIQ IISTILKIQS REGRKKAFHT CASHLTVVAL
260 270 280 290 300
CYGVAIFTYI QPHSSPSVLQ EKLFSVFYAI LTPMLNPMIY SLRNKEVKGA
310
WQKLLWKFSG LTSKLAT
Length:317
Mass (Da):35,350
Last modified:December 1, 2000 - v2
Checksum:iA72ADE1AEB6680CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111F → L in AAB01215 (PubMed:9017400).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221R → C.
Corresponds to variant rs2072164 [ dbSNP | Ensembl ].
VAR_053136
Natural varianti137 – 1371H → R.
Corresponds to variant rs2072165 [ dbSNP | Ensembl ].
VAR_053137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56421 Genomic DNA. Translation: AAB01215.1.
AC004853 Genomic DNA. Translation: AAC64376.1.
CH236959 Genomic DNA. Translation: EAL23795.1.
CH878732 Genomic DNA. Translation: EAW55625.1.
BC104975 mRNA. Translation: AAI04976.1.
AF399594 Genomic DNA. Translation: AAK95079.1.
BK004215 Genomic DNA. Translation: DAA04613.1.
CCDSiCCDS5887.1.
RefSeqiNP_036501.2. NM_012369.2.
XP_011514321.1. XM_011516019.1.
XP_011514322.1. XM_011516020.1.
XP_011514323.1. XM_011516021.1.
UniGeneiHs.553595.
Hs.623929.

Genome annotation databases

EnsembliENST00000392899; ENSP00000376633; ENSG00000213215.
ENST00000624504; ENSP00000485483; ENSG00000213215.
GeneIDi26211.
KEGGihsa:26211.
UCSCiuc003wds.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56421 Genomic DNA. Translation: AAB01215.1.
AC004853 Genomic DNA. Translation: AAC64376.1.
CH236959 Genomic DNA. Translation: EAL23795.1.
CH878732 Genomic DNA. Translation: EAW55625.1.
BC104975 mRNA. Translation: AAI04976.1.
AF399594 Genomic DNA. Translation: AAK95079.1.
BK004215 Genomic DNA. Translation: DAA04613.1.
CCDSiCCDS5887.1.
RefSeqiNP_036501.2. NM_012369.2.
XP_011514321.1. XM_011516019.1.
XP_011514322.1. XM_011516020.1.
XP_011514323.1. XM_011516021.1.
UniGeneiHs.553595.
Hs.623929.

3D structure databases

ProteinModelPortaliQ13607.
SMRiQ13607. Positions 15-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376633.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ13607.

Polymorphism and mutation databases

BioMutaiOR2F1.
DMDMi9297120.

Proteomic databases

PaxDbiQ13607.
PRIDEiQ13607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392899; ENSP00000376633; ENSG00000213215.
ENST00000624504; ENSP00000485483; ENSG00000213215.
GeneIDi26211.
KEGGihsa:26211.
UCSCiuc003wds.1. human.

Organism-specific databases

CTDi26211.
GeneCardsiOR2F1.
HGNCiHGNC:8246. OR2F1.
MIMi608497. gene.
neXtProtiNX_Q13607.
PharmGKBiPA32155.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9H7. Eukaryota.
ENOG4111DQU. LUCA.
GeneTreeiENSGT00820000126998.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ13607.
KOiK04257.
OMAiAWQKLLW.
OrthoDBiEOG7SV0VR.
PhylomeDBiQ13607.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2F1.
GenomeRNAii26211.
NextBioi48348.
PROiQ13607.
SOURCEiSearch...

Gene expression databases

BgeeiQ13607.
CleanExiHS_OR2F1.
GenevisibleiQ13607. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The evolution of mammalian olfactory receptor genes."
    Issel-Tarver L., Rine J.
    Genetics 145:185-195(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2F1_HUMAN
AccessioniPrimary (citable) accession number: Q13607
Secondary accession number(s): A4D2G1
, Q6IFP7, Q96R49, Q9UDX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: December 9, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.