ID   OR5I1_HUMAN             Reviewed;         314 AA.
AC   Q13606; Q6IEU4;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   24-JAN-2024, entry version 179.
DE   RecName: Full=Olfactory receptor 5I1;
DE   AltName: Full=Olfactory receptor OR11-159;
DE   AltName: Full=Olfactory receptor-like protein OLF1;
GN   Name=OR5I1; Synonyms=OLF1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9017400; DOI=10.1093/genetics/145.1.185;
RA   Issel-Tarver L., Rine J.;
RT   "The evolution of mammalian olfactory receptor genes.";
RL   Genetics 145:185-195(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5I1";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U56420; AAB01214.1; -; Genomic_DNA.
DR   EMBL; BC069093; AAH69093.1; -; mRNA.
DR   EMBL; BK004518; DAA04916.1; -; Genomic_DNA.
DR   CCDS; CCDS7949.1; -.
DR   RefSeq; NP_006628.1; NM_006637.1.
DR   AlphaFoldDB; Q13606; -.
DR   SMR; Q13606; -.
DR   STRING; 9606.ENSP00000301532; -.
DR   GlyCosmos; Q13606; 1 site, No reported glycans.
DR   GlyGen; Q13606; 1 site.
DR   iPTMnet; Q13606; -.
DR   PhosphoSitePlus; Q13606; -.
DR   BioMuta; OR5I1; -.
DR   DMDM; 2495050; -.
DR   MassIVE; Q13606; -.
DR   PaxDb; 9606-ENSP00000301532; -.
DR   PeptideAtlas; Q13606; -.
DR   Antibodypedia; 58950; 115 antibodies from 22 providers.
DR   DNASU; 10798; -.
DR   Ensembl; ENST00000301532.3; ENSP00000301532.3; ENSG00000167825.3.
DR   GeneID; 10798; -.
DR   KEGG; hsa:10798; -.
DR   MANE-Select; ENST00000301532.3; ENSP00000301532.3; NM_006637.1; NP_006628.1.
DR   UCSC; uc010ris.2; human.
DR   AGR; HGNC:8347; -.
DR   CTD; 10798; -.
DR   GeneCards; OR5I1; -.
DR   HGNC; HGNC:8347; OR5I1.
DR   HPA; ENSG00000167825; Not detected.
DR   MIM; 608496; gene.
DR   neXtProt; NX_Q13606; -.
DR   OpenTargets; ENSG00000167825; -.
DR   PharmGKB; PA32540; -.
DR   VEuPathDB; HostDB:ENSG00000167825; -.
DR   eggNOG; ENOG502SIQS; Eukaryota.
DR   GeneTree; ENSGT01100000263496; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q13606; -.
DR   OMA; EFTDGNY; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q13606; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q13606; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 10798; 10 hits in 744 CRISPR screens.
DR   GeneWiki; OR5I1; -.
DR   GenomeRNAi; 10798; -.
DR   Pharos; Q13606; Tdark.
DR   PRO; PR:Q13606; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q13606; Protein.
DR   Bgee; ENSG00000167825; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 3 other cell types or tissues.
DR   ExpressionAtlas; Q13606; differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF76; OLFACTORY RECEPTOR 5I1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q13606; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 5I1"
FT                   /id="PRO_0000150598"
FT   TOPO_DOM        1..27
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..273
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        99..191
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         6
FT                   /note="R -> G (in dbSNP:rs17597625)"
FT                   /id="VAR_053198"
FT   VARIANT         50
FT                   /note="L -> S (in dbSNP:rs4367963)"
FT                   /id="VAR_053199"
FT   VARIANT         76
FT                   /note="F -> S (in dbSNP:rs9666086)"
FT                   /id="VAR_024101"
FT   VARIANT         306
FT                   /note="V -> I (in dbSNP:rs9665861)"
FT                   /id="VAR_053200"
SQ   SEQUENCE   314 AA;  36049 MW;  334BE9BF3D9A4D63 CRC64;
     MEFTDRNYTL VTEFILLGFP TRPELQIVLF LMFLTLYAII LIGNIGLMLL IRIDPHLQTP
     MYFFLSNLSF VDLCYFSDIV PKMLVNFLSE NKSISYYGCA LQFYFFCTFA DTESFILAAM
     AYDRYVAICN PLLYTVVMSR GICMRLIVLS YLGGNMSSLV HTSFAFILKY CDKNVINHFF
     CDLPPLLKLS CTDTTINEWL LSTYGSSVEI ICFIIIIISY FFILLSVLKI RSFSGRKKTF
     STCASHLTSV TIYQGTLLFI YSRPSYLYSP NTDKIISVFY TIFIPVLNPL IYSLRNKDVK
     DAAEKVLRSK VDSS
//