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Protein

Olfactory receptor 5I1

Gene

OR5I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167825-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5I1
Alternative name(s):
Olfactory receptor OR11-159
Olfactory receptor-like protein OLF1
Gene namesi
Name:OR5I1
Synonyms:OLF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8347. OR5I1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 314CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167825.
PharmGKBiPA32540.

Polymorphism and mutation databases

BioMutaiOR5I1.
DMDMi2495050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505981 – 314Olfactory receptor 5I1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13606.
PeptideAtlasiQ13606.
PRIDEiQ13606.

PTM databases

iPTMnetiQ13606.
PhosphoSitePlusiQ13606.

Expressioni

Gene expression databases

BgeeiENSG00000167825.
CleanExiHS_OR5I1.
ExpressionAtlasiQ13606. baseline.
GenevisibleiQ13606. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301532.

Structurei

3D structure databases

ProteinModelPortaliQ13606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8ZQ. Eukaryota.
ENOG41113BS. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ13606.
KOiK04257.
OMAiYVGGNMS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ13606.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFTDRNYTL VTEFILLGFP TRPELQIVLF LMFLTLYAII LIGNIGLMLL
60 70 80 90 100
IRIDPHLQTP MYFFLSNLSF VDLCYFSDIV PKMLVNFLSE NKSISYYGCA
110 120 130 140 150
LQFYFFCTFA DTESFILAAM AYDRYVAICN PLLYTVVMSR GICMRLIVLS
160 170 180 190 200
YLGGNMSSLV HTSFAFILKY CDKNVINHFF CDLPPLLKLS CTDTTINEWL
210 220 230 240 250
LSTYGSSVEI ICFIIIIISY FFILLSVLKI RSFSGRKKTF STCASHLTSV
260 270 280 290 300
TIYQGTLLFI YSRPSYLYSP NTDKIISVFY TIFIPVLNPL IYSLRNKDVK
310
DAAEKVLRSK VDSS
Length:314
Mass (Da):36,049
Last modified:November 1, 1997 - v1
Checksum:i334BE9BF3D9A4D63
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0531986R → G.Corresponds to variant rs17597625dbSNPEnsembl.1
Natural variantiVAR_05319950L → S.Corresponds to variant rs4367963dbSNPEnsembl.1
Natural variantiVAR_02410176F → S.Corresponds to variant rs9666086dbSNPEnsembl.1
Natural variantiVAR_053200306V → I.Corresponds to variant rs9665861dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56420 Genomic DNA. Translation: AAB01214.1.
BC069093 mRNA. Translation: AAH69093.1.
BK004518 Genomic DNA. Translation: DAA04916.1.
CCDSiCCDS7949.1.
RefSeqiNP_006628.1. NM_006637.1.
UniGeneiHs.533706.

Genome annotation databases

EnsembliENST00000301532; ENSP00000301532; ENSG00000167825.
GeneIDi10798.
KEGGihsa:10798.
UCSCiuc010ris.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56420 Genomic DNA. Translation: AAB01214.1.
BC069093 mRNA. Translation: AAH69093.1.
BK004518 Genomic DNA. Translation: DAA04916.1.
CCDSiCCDS7949.1.
RefSeqiNP_006628.1. NM_006637.1.
UniGeneiHs.533706.

3D structure databases

ProteinModelPortaliQ13606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301532.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ13606.
PhosphoSitePlusiQ13606.

Polymorphism and mutation databases

BioMutaiOR5I1.
DMDMi2495050.

Proteomic databases

PaxDbiQ13606.
PeptideAtlasiQ13606.
PRIDEiQ13606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301532; ENSP00000301532; ENSG00000167825.
GeneIDi10798.
KEGGihsa:10798.
UCSCiuc010ris.2. human.

Organism-specific databases

CTDi10798.
GeneCardsiOR5I1.
HGNCiHGNC:8347. OR5I1.
MIMi608496. gene.
neXtProtiNX_Q13606.
OpenTargetsiENSG00000167825.
PharmGKBiPA32540.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8ZQ. Eukaryota.
ENOG41113BS. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ13606.
KOiK04257.
OMAiYVGGNMS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ13606.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167825-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5I1.
GenomeRNAii10798.
PROiQ13606.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167825.
CleanExiHS_OR5I1.
ExpressionAtlasiQ13606. baseline.
GenevisibleiQ13606. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5I1_HUMAN
AccessioniPrimary (citable) accession number: Q13606
Secondary accession number(s): Q6IEU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.