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Protein

Olfactory receptor 5I1

Gene

OR5I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5I1
Alternative name(s):
Olfactory receptor OR11-159
Olfactory receptor-like protein OLF1
Gene namesi
Name:OR5I1
Synonyms:OLF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8347. OR5I1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini295 – 31420CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32540.

Polymorphism and mutation databases

BioMutaiOR5I1.
DMDMi2495050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 5I1PRO_0000150598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ13606.

PTM databases

PhosphoSiteiQ13606.

Expressioni

Gene expression databases

BgeeiQ13606.
CleanExiHS_OR5I1.
GenevisibleiQ13606. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301532.

Structurei

3D structure databases

ProteinModelPortaliQ13606.
SMRiQ13606. Positions 24-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46580.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ13606.
KOiK04257.
OMAiYVGGNMS.
OrthoDBiEOG71K63J.
PhylomeDBiQ13606.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFTDRNYTL VTEFILLGFP TRPELQIVLF LMFLTLYAII LIGNIGLMLL
60 70 80 90 100
IRIDPHLQTP MYFFLSNLSF VDLCYFSDIV PKMLVNFLSE NKSISYYGCA
110 120 130 140 150
LQFYFFCTFA DTESFILAAM AYDRYVAICN PLLYTVVMSR GICMRLIVLS
160 170 180 190 200
YLGGNMSSLV HTSFAFILKY CDKNVINHFF CDLPPLLKLS CTDTTINEWL
210 220 230 240 250
LSTYGSSVEI ICFIIIIISY FFILLSVLKI RSFSGRKKTF STCASHLTSV
260 270 280 290 300
TIYQGTLLFI YSRPSYLYSP NTDKIISVFY TIFIPVLNPL IYSLRNKDVK
310
DAAEKVLRSK VDSS
Length:314
Mass (Da):36,049
Last modified:November 1, 1997 - v1
Checksum:i334BE9BF3D9A4D63
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → G.
Corresponds to variant rs17597625 [ dbSNP | Ensembl ].
VAR_053198
Natural varianti50 – 501L → S.
Corresponds to variant rs4367963 [ dbSNP | Ensembl ].
VAR_053199
Natural varianti76 – 761F → S.
Corresponds to variant rs9666086 [ dbSNP | Ensembl ].
VAR_024101
Natural varianti306 – 3061V → I.
Corresponds to variant rs9665861 [ dbSNP | Ensembl ].
VAR_053200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56420 Genomic DNA. Translation: AAB01214.1.
BC069093 mRNA. Translation: AAH69093.1.
BK004518 Genomic DNA. Translation: DAA04916.1.
CCDSiCCDS7949.1.
RefSeqiNP_006628.1. NM_006637.1.
UniGeneiHs.533706.

Genome annotation databases

EnsembliENST00000301532; ENSP00000301532; ENSG00000167825.
GeneIDi10798.
KEGGihsa:10798.
UCSCiuc010ris.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56420 Genomic DNA. Translation: AAB01214.1.
BC069093 mRNA. Translation: AAH69093.1.
BK004518 Genomic DNA. Translation: DAA04916.1.
CCDSiCCDS7949.1.
RefSeqiNP_006628.1. NM_006637.1.
UniGeneiHs.533706.

3D structure databases

ProteinModelPortaliQ13606.
SMRiQ13606. Positions 24-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301532.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ13606.

Polymorphism and mutation databases

BioMutaiOR5I1.
DMDMi2495050.

Proteomic databases

PRIDEiQ13606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301532; ENSP00000301532; ENSG00000167825.
GeneIDi10798.
KEGGihsa:10798.
UCSCiuc010ris.2. human.

Organism-specific databases

CTDi10798.
GeneCardsiGC11M055703.
HGNCiHGNC:8347. OR5I1.
MIMi608496. gene.
neXtProtiNX_Q13606.
PharmGKBiPA32540.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46580.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ13606.
KOiK04257.
OMAiYVGGNMS.
OrthoDBiEOG71K63J.
PhylomeDBiQ13606.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5I1.
GenomeRNAii10798.
NextBioi41009.
PROiQ13606.
SOURCEiSearch...

Gene expression databases

BgeeiQ13606.
CleanExiHS_OR5I1.
GenevisibleiQ13606. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The evolution of mammalian olfactory receptor genes."
    Issel-Tarver L., Rine J.
    Genetics 145:185-195(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5I1_HUMAN
AccessioniPrimary (citable) accession number: Q13606
Secondary accession number(s): Q6IEU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.