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Q13606

- OR5I1_HUMAN

UniProt

Q13606 - OR5I1_HUMAN

Protein

Olfactory receptor 5I1

Gene

OR5I1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    GO - Biological processi

    1. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5I1
    Alternative name(s):
    Olfactory receptor OR11-159
    Olfactory receptor-like protein OLF1
    Gene namesi
    Name:OR5I1
    Synonyms:OLF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8347. OR5I1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32540.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 5I1PRO_0000150598Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ13606.

    PTM databases

    PhosphoSiteiQ13606.

    Expressioni

    Gene expression databases

    BgeeiQ13606.
    CleanExiHS_OR5I1.
    GenevestigatoriQ13606.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000301532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13606.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini295 – 31420CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46580.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ13606.
    KOiK04257.
    OMAiEIICFIV.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ13606.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13606-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFTDRNYTL VTEFILLGFP TRPELQIVLF LMFLTLYAII LIGNIGLMLL    50
    IRIDPHLQTP MYFFLSNLSF VDLCYFSDIV PKMLVNFLSE NKSISYYGCA 100
    LQFYFFCTFA DTESFILAAM AYDRYVAICN PLLYTVVMSR GICMRLIVLS 150
    YLGGNMSSLV HTSFAFILKY CDKNVINHFF CDLPPLLKLS CTDTTINEWL 200
    LSTYGSSVEI ICFIIIIISY FFILLSVLKI RSFSGRKKTF STCASHLTSV 250
    TIYQGTLLFI YSRPSYLYSP NTDKIISVFY TIFIPVLNPL IYSLRNKDVK 300
    DAAEKVLRSK VDSS 314
    Length:314
    Mass (Da):36,049
    Last modified:November 1, 1997 - v1
    Checksum:i334BE9BF3D9A4D63
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61R → G.
    Corresponds to variant rs17597625 [ dbSNP | Ensembl ].
    VAR_053198
    Natural varianti50 – 501L → S.
    Corresponds to variant rs4367963 [ dbSNP | Ensembl ].
    VAR_053199
    Natural varianti76 – 761F → S.
    Corresponds to variant rs9666086 [ dbSNP | Ensembl ].
    VAR_024101
    Natural varianti306 – 3061V → I.
    Corresponds to variant rs9665861 [ dbSNP | Ensembl ].
    VAR_053200

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56420 Genomic DNA. Translation: AAB01214.1.
    BC069093 mRNA. Translation: AAH69093.1.
    BK004518 Genomic DNA. Translation: DAA04916.1.
    CCDSiCCDS7949.1.
    RefSeqiNP_006628.1. NM_006637.1.
    UniGeneiHs.533706.

    Genome annotation databases

    EnsembliENST00000301532; ENSP00000301532; ENSG00000167825.
    GeneIDi10798.
    KEGGihsa:10798.
    UCSCiuc010ris.2. human.

    Polymorphism databases

    DMDMi2495050.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56420 Genomic DNA. Translation: AAB01214.1 .
    BC069093 mRNA. Translation: AAH69093.1 .
    BK004518 Genomic DNA. Translation: DAA04916.1 .
    CCDSi CCDS7949.1.
    RefSeqi NP_006628.1. NM_006637.1.
    UniGenei Hs.533706.

    3D structure databases

    ProteinModelPortali Q13606.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000301532.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q13606.

    Polymorphism databases

    DMDMi 2495050.

    Proteomic databases

    PRIDEi Q13606.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301532 ; ENSP00000301532 ; ENSG00000167825 .
    GeneIDi 10798.
    KEGGi hsa:10798.
    UCSCi uc010ris.2. human.

    Organism-specific databases

    CTDi 10798.
    GeneCardsi GC11M055703.
    HGNCi HGNC:8347. OR5I1.
    MIMi 608496. gene.
    neXtProti NX_Q13606.
    PharmGKBi PA32540.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46580.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q13606.
    KOi K04257.
    OMAi EIICFIV.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q13606.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5I1.
    GenomeRNAii 10798.
    NextBioi 41009.
    PROi Q13606.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13606.
    CleanExi HS_OR5I1.
    Genevestigatori Q13606.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The evolution of mammalian olfactory receptor genes."
      Issel-Tarver L., Rine J.
      Genetics 145:185-195(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5I1_HUMAN
    AccessioniPrimary (citable) accession number: Q13606
    Secondary accession number(s): Q6IEU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3