Q13606 (OR5I1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 5I1

Alternative name(s):
Olfactory receptor OR11-159
Olfactory receptor-like protein OLF1

Gene names

Name:	OR5I1
Synonyms:	OLF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC signal transduction Non-traceable author statement PubMed 9787077. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 5I1		PRO_0000150598
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 48	21	Helical; Name=1; Potential
	Topological domain	49 – 56	8	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 101	24	Extracellular Potential
	Transmembrane	102 – 122	21	Helical; Name=3; Potential
	Topological domain	123 – 141	19	Cytoplasmic Potential
	Transmembrane	142 – 162	21	Helical; Name=4; Potential
	Topological domain	163 – 198	36	Extracellular Potential
	Transmembrane	199 – 219	21	Helical; Name=5; Potential
	Topological domain	220 – 239	20	Cytoplasmic Potential
	Transmembrane	240 – 260	21	Helical; Name=6; Potential
	Topological domain	261 – 273	13	Extracellular Potential
	Transmembrane	274 – 294	21	Helical; Name=7; Potential
	Topological domain	295 – 314	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 191		By similarity
Natural variations
	Natural variant	6	1	R → G. Corresponds to variant rs17597625 [ dbSNP | Ensembl ].		VAR_053198
	Natural variant	50	1	L → S. Corresponds to variant rs4367963 [ dbSNP | Ensembl ].		VAR_053199
	Natural variant	76	1	F → S. Corresponds to variant rs9666086 [ dbSNP | Ensembl ].		VAR_024101
	Natural variant	306	1	V → I. Corresponds to variant rs9665861 [ dbSNP | Ensembl ].		VAR_053200

Sequences

	Sequence		Length	Mass (Da)
	Q13606 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 334BE9BF3D9A4D63	FASTA	314	36,049
	10 20 30 40 50 60 MEFTDRNYTL VTEFILLGFP TRPELQIVLF LMFLTLYAII LIGNIGLMLL IRIDPHLQTP 70 80 90 100 110 120 MYFFLSNLSF VDLCYFSDIV PKMLVNFLSE NKSISYYGCA LQFYFFCTFA DTESFILAAM 130 140 150 160 170 180 AYDRYVAICN PLLYTVVMSR GICMRLIVLS YLGGNMSSLV HTSFAFILKY CDKNVINHFF 190 200 210 220 230 240 CDLPPLLKLS CTDTTINEWL LSTYGSSVEI ICFIIIIISY FFILLSVLKI RSFSGRKKTF 250 260 270 280 290 300 STCASHLTSV TIYQGTLLFI YSRPSYLYSP NTDKIISVFY TIFIPVLNPL IYSLRNKDVK 310 DAAEKVLRSK VDSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The evolution of mammalian olfactory receptor genes." Issel-Tarver L., Rine J. Genetics 145:185-195(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	U56420 Genomic DNA. Translation: AAB01214.1. BC069093 mRNA. Translation: AAH69093.1. BK004518 Genomic DNA. Translation: DAA04916.1.
IPI	IPI00014282.
RefSeq	NP_006628.1. NM_006637.1.
UniGene	Hs.533706.
3D structure databases
ProteinModelPortal	Q13606.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000301532.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q13606.
Polymorphism databases
DMDM	2495050.
Proteomic databases
PRIDE	Q13606.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301532; ENSP00000301532; ENSG00000167825.
GeneID	10798.
KEGG	hsa:10798.
UCSC	uc010ris.2. human.
Organism-specific databases
CTD	10798.
GeneCards	GC11M055703.
HGNC	HGNC:8347. OR5I1.
MIM	608496. gene.
neXtProt	NX_Q13606.
PharmGKB	PA32540.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46580.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q13606.
KO	K04257.
OMA	RIDPHLQ.
OrthoDB	EOG47H5QK.
PhylomeDB	Q13606.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q13606.
CleanEx	HS_OR5I1.
Genevestigator	Q13606.
GermOnline	ENSG00000167825. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10798.
NextBio	41009.
SOURCE	Search...

Entry information

Entry name

OR5I1_HUMAN

Accession

Primary (citable) accession number: Q13606
Secondary accession number(s): Q6IEU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.