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Protein

KRR1 small subunit processome component homolog

Gene

KRR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
KRR1 small subunit processome component homolog
Alternative name(s):
HIV-1 Rev-binding protein 2
KRR-R motif-containing protein 1
Rev-interacting protein 1
Short name:
Rip-1
Gene namesi
Name:KRR1
Synonyms:HRB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5176. KRR1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication
  • Nucleusnucleolus 1 Publication

  • Note: Translocates from cytoplasm to nucleus after exposure to HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR (Ref. 6).

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • intercellular bridge Source: HPA
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
  • small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29450.

Polymorphism and mutation databases

BioMutaiKRR1.
DMDMi50400303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 381380KRR1 small subunit processome component homologPRO_0000050114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Modified residuei3 – 31PhosphoserineCombined sources
Modified residuei5 – 51PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13601.
MaxQBiQ13601.
PaxDbiQ13601.
PeptideAtlasiQ13601.
PRIDEiQ13601.

2D gel databases

SWISS-2DPAGEQ13601.

PTM databases

iPTMnetiQ13601.
PhosphoSiteiQ13601.
SwissPalmiQ13601.

Miscellaneous databases

PMAP-CutDBQ13601.

Expressioni

Gene expression databases

BgeeiENSG00000111615.
CleanExiHS_KRR1.
ExpressionAtlasiQ13601. baseline and differential.
GenevisibleiQ13601. HS.

Organism-specific databases

HPAiHPA043433.
HPA051690.

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZBP1Q9H1713EBI-744525,EBI-6264672

Protein-protein interaction databases

BioGridi116284. 75 interactions.
IntActiQ13601. 16 interactions.
MINTiMINT-1464394.
STRINGi9606.ENSP00000229214.

Structurei

3D structure databases

ProteinModelPortaliQ13601.
SMRiQ13601. Positions 57-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 20653KHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi247 – 381135Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the KRR1 family.Curated
Contains 1 KH domain.Curated

Phylogenomic databases

eggNOGiKOG2874. Eukaryota.
COG1094. LUCA.
GeneTreeiENSGT00390000018775.
HOGENOMiHOG000116208.
HOVERGENiHBG051924.
InParanoidiQ13601.
KOiK06961.
OMAiETMNNVH.
OrthoDBiEOG091G0BTX.
PhylomeDBiQ13601.
TreeFamiTF105745.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR024166. rRNA_assembly_KRR1.
[Graphical view]
PANTHERiPTHR12581. PTHR12581. 1 hit.
PIRSFiPIRSF006515. KRR1. 1 hit.
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13601-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPSLERPE KGAGKSEFRN QKPKPENQDE SELLTVPDGW KEPAFSKEDN
60 70 80 90 100
PRGLLEESSF ATLFPKYREA YLKECWPLVQ KALNEHHVNA TLDLIEGSMT
110 120 130 140 150
VCTTKKTFDP YIIIRARDLI KLLARSVSFE QAVRILQDDV ACDIIKIGSL
160 170 180 190 200
VRNKERFVKR RQRLIGPKGS TLKALELLTN CYIMVQGNTV SAIGPFSGLK
210 220 230 240 250
EVRKVVLDTM KNIHPIYNIK SLMIKRELAK DSELRSQSWE RFLPQFKHKN
260 270 280 290 300
VNKRKEPKKK TVKKEYTPFP PPQPESQIDK ELASGEYFLK ANQKKRQKME
310 320 330 340 350
AIKAKQAEAI SKRQEERNKA FIPPKEKPIV KPKEASTETK IDVASIKEKV
360 370 380
KKAKNKKLGA LTAEEIALKM EADEKKKKKK K
Length:381
Mass (Da):43,665
Last modified:January 23, 2007 - v4
Checksum:i8F242FCC36BF079B
GO
Isoform 2 (identifier: Q13601-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-277: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):36,788
Checksum:iFE9A271F5ABBBB6F
GO

Sequence cautioni

The sequence AAB00557 differs from that shown. Reason: Frameshift at positions 265 and 300. Curated
The sequence AAH05225 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131A → V in ABJ97679 (Ref. 1) Curated
Sequence conflicti57 – 571E → K in BAG36436 (PubMed:14702039).Curated
Sequence conflicti69 – 691E → G in AAH16778 (PubMed:15489334).Curated
Sequence conflicti161 – 1611R → G in ABJ97679 (Ref. 1) Curated
Sequence conflicti165 – 1651I → V in ABJ97679 (Ref. 1) Curated
Sequence conflicti206 – 2061V → A in AAH26107 (PubMed:15489334).Curated
Sequence conflicti275 – 2751E → G in AAH33887 (PubMed:15489334).Curated
Sequence conflicti339 – 3391T → A in ABJ97679 (Ref. 1) Curated
Sequence conflicti339 – 3391T → A in AAH33887 (PubMed:15489334).Curated
Sequence conflicti353 – 3531A → G in AAH05225 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341R → Q.
Corresponds to variant rs11540407 [ dbSNP | Ensembl ].
VAR_049680

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei221 – 27757Missing in isoform 2. 1 PublicationVSP_042223Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF010919 mRNA. Translation: ABJ97679.1.
AK313687 mRNA. Translation: BAG36436.1.
AC022507 Genomic DNA. No translation available.
AC121761 Genomic DNA. No translation available.
BC005225 mRNA. Translation: AAH05225.1. Sequence problems.
BC016778 mRNA. Translation: AAH16778.1.
BC026107 mRNA. Translation: AAH26107.1.
BC033887 mRNA. Translation: AAH33887.1.
U55766 mRNA. Translation: AAB00557.1. Frameshift.
CCDSiCCDS9012.1. [Q13601-1]
PIRiG02629.
RefSeqiNP_008974.5. NM_007043.6. [Q13601-1]
UniGeneiHs.645517.

Genome annotation databases

EnsembliENST00000229214; ENSP00000229214; ENSG00000111615. [Q13601-1]
ENST00000438169; ENSP00000411740; ENSG00000111615. [Q13601-2]
GeneIDi11103.
KEGGihsa:11103.
UCSCiuc001sxt.4. human. [Q13601-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF010919 mRNA. Translation: ABJ97679.1.
AK313687 mRNA. Translation: BAG36436.1.
AC022507 Genomic DNA. No translation available.
AC121761 Genomic DNA. No translation available.
BC005225 mRNA. Translation: AAH05225.1. Sequence problems.
BC016778 mRNA. Translation: AAH16778.1.
BC026107 mRNA. Translation: AAH26107.1.
BC033887 mRNA. Translation: AAH33887.1.
U55766 mRNA. Translation: AAB00557.1. Frameshift.
CCDSiCCDS9012.1. [Q13601-1]
PIRiG02629.
RefSeqiNP_008974.5. NM_007043.6. [Q13601-1]
UniGeneiHs.645517.

3D structure databases

ProteinModelPortaliQ13601.
SMRiQ13601. Positions 57-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116284. 75 interactions.
IntActiQ13601. 16 interactions.
MINTiMINT-1464394.
STRINGi9606.ENSP00000229214.

PTM databases

iPTMnetiQ13601.
PhosphoSiteiQ13601.
SwissPalmiQ13601.

Polymorphism and mutation databases

BioMutaiKRR1.
DMDMi50400303.

2D gel databases

SWISS-2DPAGEQ13601.

Proteomic databases

EPDiQ13601.
MaxQBiQ13601.
PaxDbiQ13601.
PeptideAtlasiQ13601.
PRIDEiQ13601.

Protocols and materials databases

DNASUi11103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229214; ENSP00000229214; ENSG00000111615. [Q13601-1]
ENST00000438169; ENSP00000411740; ENSG00000111615. [Q13601-2]
GeneIDi11103.
KEGGihsa:11103.
UCSCiuc001sxt.4. human. [Q13601-1]

Organism-specific databases

CTDi11103.
GeneCardsiKRR1.
H-InvDBHIX0010835.
HGNCiHGNC:5176. KRR1.
HPAiHPA043433.
HPA051690.
MIMi612817. gene.
neXtProtiNX_Q13601.
PharmGKBiPA29450.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2874. Eukaryota.
COG1094. LUCA.
GeneTreeiENSGT00390000018775.
HOGENOMiHOG000116208.
HOVERGENiHBG051924.
InParanoidiQ13601.
KOiK06961.
OMAiETMNNVH.
OrthoDBiEOG091G0BTX.
PhylomeDBiQ13601.
TreeFamiTF105745.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

GeneWikiiKRR1.
GenomeRNAii11103.
PMAP-CutDBQ13601.
PROiQ13601.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111615.
CleanExiHS_KRR1.
ExpressionAtlasiQ13601. baseline and differential.
GenevisibleiQ13601. HS.

Family and domain databases

Gene3Di3.30.1370.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR024166. rRNA_assembly_KRR1.
[Graphical view]
PANTHERiPTHR12581. PTHR12581. 1 hit.
PIRSFiPIRSF006515. KRR1. 1 hit.
SMARTiSM00322. KH. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKRR1_HUMAN
AccessioniPrimary (citable) accession number: Q13601
Secondary accession number(s): A0FIK6
, A0JLP0, B2R989, E7EUQ0, Q8NEA8, Q8TC37, Q96AT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.