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Protein

Alanine racemase

Gene

RPD_2992

Organism
Rhodopseudomonas palustris (strain BisB5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei162 – 1621SubstrateUniRule annotation
Active sitei283 – 2831Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei336 – 3361Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRPAL316057:GHDC-3041-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:RPD_2992Imported
OrganismiRhodopseudomonas palustris (strain BisB5)Imported
Taxonomic identifieri316057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001818 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi316057.RPD_2992.

Structurei

3D structure databases

ProteinModelPortaliQ135M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiTLMAHFA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q135M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILPDPNAT VASLLTPEAA KAAALAAATA TAPGVLTVDL DAIVANWRKI
60 70 80 90 100
EKTAVPAEAA AVVKGDAYGC GIGPVSKALA AAGCKTFFVA TLGEAGAVRA
110 120 130 140 150
IAPDAVIYVL DGFFQTTGDE FARLNCRPVI GDLYELAEWD VYCRRTRWSG
160 170 180 190 200
GAAIHIDTGM NRLGLTVAEA QGIVPRIAAG DHGITLVISH LAAAEALNHP
210 220 230 240 250
MNARQVTAFR EIASLFTGVA ASLSASSGVF LGPQFAFDMV RPGAALYGIN
260 270 280 290 300
PTPEADNPMK PVVDLKARIV QVRSVERGDS VGYGGTWTAR RPTRIAVLSA
310 320 330 340 350
GYADGYFRAA GSNDGTRGAD VVIAGQRCPI AGRVSMDLLA VDVTDLPANA
360 370 380 390 400
ARRGLMATLI GDGITVDELG HHFGTIGYEV LTSLGARYAR IYSGGDAKPE

ETPAEQSGA
Length:409
Mass (Da):42,362
Last modified:October 30, 2006 - v1
Checksum:iE4B30512358D9895
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000283 Genomic DNA. Translation: ABE40218.1.
RefSeqiYP_570119.1. NC_007958.1.

Genome annotation databases

EnsemblBacteriaiABE40218; ABE40218; RPD_2992.
KEGGirpd:RPD_2992.
PATRICi23281049. VBIRhoPal120395_3087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000283 Genomic DNA. Translation: ABE40218.1.
RefSeqiYP_570119.1. NC_007958.1.

3D structure databases

ProteinModelPortaliQ135M1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316057.RPD_2992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE40218; ABE40218; RPD_2992.
KEGGirpd:RPD_2992.
PATRICi23281049. VBIRhoPal120395_3087.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiTLMAHFA.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciRPAL316057:GHDC-3041-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB5Imported.

Entry informationi

Entry nameiQ135M1_RHOPS
AccessioniPrimary (citable) accession number: Q135M1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 30, 2006
Last sequence update: October 30, 2006
Last modified: March 31, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.