Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transformer-2 protein homolog alpha

Gene

TRA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127191-MONOMER.
ZFISH:ENSG00000164548-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transformer-2 protein homolog alpha
Short name:
TRA-2 alpha
Short name:
TRA2-alpha
Alternative name(s):
Transformer-2 protein homolog A
Gene namesi
Name:TRA2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16645. TRA2A.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • intracellular membrane-bounded organelle Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29896.
OpenTargetsiENSG00000164548.
PharmGKBiPA164726707.

Polymorphism and mutation databases

DMDMi4033480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000819812 – 282Transformer-2 protein homolog alphaAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei24PhosphothreonineCombined sources1
Modified residuei30PhosphoserineBy similarity1
Modified residuei82PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei88PhosphothreonineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Modified residuei100PhosphoserineBy similarity1
Modified residuei202PhosphothreonineCombined sources1
Modified residuei204PhosphothreonineCombined sources1
Modified residuei232Omega-N-methylarginineBy similarity1
Modified residuei236PhosphoserineCombined sources1
Modified residuei255Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei255Dimethylated arginine; alternateBy similarity1
Modified residuei255Omega-N-methylarginine; alternateBy similarity1

Post-translational modificationi

Phosphorylated in the RS domains.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ13595.
PaxDbiQ13595.
PeptideAtlasiQ13595.
PRIDEiQ13595.

PTM databases

iPTMnetiQ13595.
PhosphoSitePlusiQ13595.
SwissPalmiQ13595.

Expressioni

Gene expression databases

BgeeiENSG00000164548.
ExpressionAtlasiQ13595. baseline and differential.
GenevisibleiQ13595. HS.

Organism-specific databases

HPAiHPA054018.

Interactioni

Subunit structurei

Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30.

Protein-protein interaction databases

BioGridi118948. 152 interactors.
IntActiQ13595. 28 interactors.
MINTiMINT-1683046.
STRINGi9606.ENSP00000297071.

Structurei

3D structure databases

ProteinModelPortaliQ13595.
SMRiQ13595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 197RRMPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 225LinkerAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 112Arg/Ser-rich (RS1 domain)Add BLAST83
Compositional biasi226 – 282Arg/Ser-rich (RS2 domain)Add BLAST57

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQWZ. Eukaryota.
ENOG4111HSX. LUCA.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276232.
HOVERGENiHBG102125.
InParanoidiQ13595.
KOiK12897.
OMAiGRPTHGG.
OrthoDBiEOG091G0Y02.
PhylomeDBiQ13595.
TreeFamiTF106265.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q13595-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDVEENNFE GRESRSQSKS PTGTPARVKS ESRSGSRSPS RVSKHSESHS
60 70 80 90 100
RSRSKSRSRS RRHSHRRYTR SRSHSHSHRR RSRSRSYTPE YRRRRSRSHS
110 120 130 140 150
PMSNRRRHTG SRANPDPNTC LGVFGLSLYT TERDLREVFS RYGPLSGVNV
160 170 180 190 200
VYDQRTGRSR GFAFVYFERI DDSKEAMERA NGMELDGRRI RVDYSITKRA
210 220 230 240 250
HTPTPGIYMG RPTHSGGGGG GGGGGGGGGG GRRRDSYYDR GYDRGYDRYE
260 270 280
DYDYRYRRRS PSPYYSRYRS RSRSRSYSPR RY
Length:282
Mass (Da):32,689
Last modified:November 1, 1996 - v1
Checksum:iEDB5ABE7BEA023FD
GO
Isoform Short (identifier: Q13595-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     214-214: H → Q
     215-282: Missing.

Show »
Length:113
Mass (Da):12,952
Checksum:iD7E4DDF02E52CEA0
GO
Isoform 3 (identifier: Q13595-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):20,746
Checksum:i440524DD6FEC3910
GO
Isoform 4 (identifier: Q13595-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     257-257: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,590
Checksum:i792DF54BE964E333
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0058931 – 101Missing in isoform Short, isoform 3 and isoform 4. 2 PublicationsAdd BLAST101
Alternative sequenceiVSP_005894214H → Q in isoform Short. 1 Publication1
Alternative sequenceiVSP_005895215 – 282Missing in isoform Short. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_057405257Missing in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53209 mRNA. Translation: AAC50658.1.
AK298815 mRNA. Translation: BAG60948.1.
AK300565 mRNA. Translation: BAG62271.1.
AK300741 mRNA. Translation: BAG62410.1.
AC023105 Genomic DNA. No translation available.
BC017094 mRNA. Translation: AAH17094.1.
CCDSiCCDS5383.1. [Q13595-1]
CCDS64609.1. [Q13595-3]
CCDS75569.1. [Q13595-4]
RefSeqiNP_001269686.1. NM_001282757.1. [Q13595-3]
NP_001269687.1. NM_001282758.1. [Q13595-3]
NP_001269688.1. NM_001282759.1. [Q13595-4]
NP_037425.1. NM_013293.4. [Q13595-1]
XP_005249782.1. XM_005249725.1. [Q13595-3]
XP_016867578.1. XM_017012089.1. [Q13595-3]
XP_016867579.1. XM_017012090.1. [Q13595-3]
UniGeneiHs.445652.

Genome annotation databases

EnsembliENST00000297071; ENSP00000297071; ENSG00000164548. [Q13595-1]
ENST00000392502; ENSP00000376290; ENSG00000164548. [Q13595-4]
ENST00000538367; ENSP00000441116; ENSG00000164548. [Q13595-3]
ENST00000621813; ENSP00000480822; ENSG00000164548. [Q13595-3]
GeneIDi29896.
KEGGihsa:29896.
UCSCiuc011jzb.4. human.
uc011jzc.5. human. [Q13595-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53209 mRNA. Translation: AAC50658.1.
AK298815 mRNA. Translation: BAG60948.1.
AK300565 mRNA. Translation: BAG62271.1.
AK300741 mRNA. Translation: BAG62410.1.
AC023105 Genomic DNA. No translation available.
BC017094 mRNA. Translation: AAH17094.1.
CCDSiCCDS5383.1. [Q13595-1]
CCDS64609.1. [Q13595-3]
CCDS75569.1. [Q13595-4]
RefSeqiNP_001269686.1. NM_001282757.1. [Q13595-3]
NP_001269687.1. NM_001282758.1. [Q13595-3]
NP_001269688.1. NM_001282759.1. [Q13595-4]
NP_037425.1. NM_013293.4. [Q13595-1]
XP_005249782.1. XM_005249725.1. [Q13595-3]
XP_016867578.1. XM_017012089.1. [Q13595-3]
XP_016867579.1. XM_017012090.1. [Q13595-3]
UniGeneiHs.445652.

3D structure databases

ProteinModelPortaliQ13595.
SMRiQ13595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118948. 152 interactors.
IntActiQ13595. 28 interactors.
MINTiMINT-1683046.
STRINGi9606.ENSP00000297071.

PTM databases

iPTMnetiQ13595.
PhosphoSitePlusiQ13595.
SwissPalmiQ13595.

Polymorphism and mutation databases

DMDMi4033480.

Proteomic databases

EPDiQ13595.
PaxDbiQ13595.
PeptideAtlasiQ13595.
PRIDEiQ13595.

Protocols and materials databases

DNASUi29896.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297071; ENSP00000297071; ENSG00000164548. [Q13595-1]
ENST00000392502; ENSP00000376290; ENSG00000164548. [Q13595-4]
ENST00000538367; ENSP00000441116; ENSG00000164548. [Q13595-3]
ENST00000621813; ENSP00000480822; ENSG00000164548. [Q13595-3]
GeneIDi29896.
KEGGihsa:29896.
UCSCiuc011jzb.4. human.
uc011jzc.5. human. [Q13595-1]

Organism-specific databases

CTDi29896.
DisGeNETi29896.
GeneCardsiTRA2A.
HGNCiHGNC:16645. TRA2A.
HPAiHPA054018.
MIMi602718. gene.
neXtProtiNX_Q13595.
OpenTargetsiENSG00000164548.
PharmGKBiPA164726707.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQWZ. Eukaryota.
ENOG4111HSX. LUCA.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276232.
HOVERGENiHBG102125.
InParanoidiQ13595.
KOiK12897.
OMAiGRPTHGG.
OrthoDBiEOG091G0Y02.
PhylomeDBiQ13595.
TreeFamiTF106265.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127191-MONOMER.
ZFISH:ENSG00000164548-MONOMER.

Miscellaneous databases

ChiTaRSiTRA2A. human.
GeneWikiiTRA2A.
GenomeRNAii29896.
PROiQ13595.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164548.
ExpressionAtlasiQ13595. baseline and differential.
GenevisibleiQ13595. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRA2A_HUMAN
AccessioniPrimary (citable) accession number: Q13595
Secondary accession number(s): B4DQI6, B4DUA9, E9PD75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.