Semaphorin-5A precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q13591 (SEM5A_HUMAN)

Last modified June 16, 2009. Version 89. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Semaphorin-5A
Alternative name(s):
    Semaphorin-F
      Short name=Sema F

Gene names

Name:	SEMA5A
Synonyms:	SEMAF

Organism

Homo sapiens (Human)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1074 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May act as positive axonal guidance cues.
Subunit structure	Binds PLXNB3.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain. Contains 7 TSP type-1 domains.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell adhesion Traceable author statement. Source: ProtInc cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

22

Potential

Chain

1052

Semaphorin-5A

PRO_0000032335

Regions

Topological domain

946

Extracellular Potential

Transmembrane

21

Potential

Topological domain

85

Cytoplasmic Potential

Domain

450

Sema

Domain

54

TSP type-1 1

Domain

57

TSP type-1 2

Domain

50

TSP type-1 3

Domain

59

TSP type-1 4

Domain

56

TSP type-1 5

Domain

56

TSP type-1 6

Domain

48

TSP type-1 7

Amino acid modifications

Modified residue

1

Phosphoserine Ref.5

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Natural variations

Natural variant

1

V → L: dbSNP rs1806079.

VAR_030294

Natural variant

1

S → L: dbSNP rs2290734.

VAR_030295

Experimental info

Sequence conflict

1

V → A in AAC09473. Ref.1

Sequence conflict

1

T → A in AAC09473. Ref.1

Sequence conflict

1

M → V in AAC09473. Ref.1

Sequence conflict

1

S → R in AAC14668. Ref.2

Sequence conflict

1

G → D in AAC09473. Ref.1

Sequence conflict

1

I → T in AAC09473. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q13591-1 [UniParc].

Last modified May 30, 2006. Version 3.
Checksum: AE073413AC974CCC
Show »

1,074

120,615

        10         20         30         40         50         60 
MKGTCVIAWL FSSLGLWRLA HPEAQGTTQC QRTEHPVISY KEIGPWLREF RAKNAVDFSQ 

        70         80         90        100        110        120 
LTFDPGQKEL VVGARNYLFR LQLEDLSLIQ AVEWECDEAT KKACYSKGKS KEECQNYIRV 

       130        140        150        160        170        180 
LLVGGDRLFT CGTNAFTPVC TNRSLSNLTE IHDQISGMAR CPYSPQHNST ALLTAGGELY 

       190        200        210        220        230        240 
AATAMDFPGR DPAIYRSLGI LPPLRTAQYN SKWLNEPNFV SSYDIGNFTY FFFRENAVEH 

       250        260        270        280        290        300 
DCGKTVFSRA ARVCKNDIGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE LQSTFFLPEL 

       310        320        330        340        350        360 
DLIYGIFTTN VNSIAASAVC VFNLSAIAQA FSGPFKYQEN SRSAWLPYPN PNPHFQCGTV 

       370        380        390        400        410        420 
DQGLYVNLTE RNLQDAQKFI LMHEVVQPVT TVPSFMEDNS RFSHVAVDVV QGREALVHII 

       430        440        450        460        470        480 
YLATDYGTIK KVRVPLNQTS SSCLLEEIEL FPERRREPIR SLQILHSQSV LFVGLREHVV 

       490        500        510        520        530        540 
KIPLKRCQFY RTRSTCIGAQ DPYCGWDVVM KKCTSLEESL SMTQWEQSIS ACPTRNLTVD 

       550        560        570        580        590        600 
GHFGVWSPWT PCTHTDGSAV GSCLCRTRSC DSPAPQCGGW QCEGPGMEIA NCSRNGGWTP 

       610        620        630        640        650        660 
WTSWSPCSTT CGIGFQVRQR SCSNPTPRHG GRVCVGQNRE ERYCNEHLLC PPHMFWTGWG 

       670        680        690        700        710        720 
PWERCTAQCG GGIQARRRIC ENGPDCAGCN VEYQSCNTNP CPELKKTTPW TPWTPVNISD 

       730        740        750        760        770        780 
NGGHYEQRFR YTCKARLADP NLLEVGRQRI EMRYCSSDGT SGCSTDGLSG DFLRAGRYSA 

       790        800        810        820        830        840 
HTVNGAWSAW TSWSQCSRDC SRGIRNRKRV CNNPEPKYGG MPCLGPSLEY QECNILPCPV 

       850        860        870        880        890        900 
DGVWSCWSPW TKCSATCGGG HYMRTRSCSN PAPAYGGDIC LGLHTEEALC NTQPCPESWS 

       910        920        930        940        950        960 
EWSDWSECEA SGVQVRARQC ILLFPMGSQC SGNTTESRPC VFDSNFIPEV SVARSSSVEE 

       970        980        990       1000       1010       1020 
KRCGEFNMFH MIAVGLSSSI LGCLLTLLVY TYCQRYQQQS HDATVIHPVS PAPLNTSITN 

      1030       1040       1050       1060       1070 
HINKLDKYDS VEAIKAFNKN NLILEERNKY FNPHLTGKTY SNAYFTDLNN YDEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval." Simmons A.D., Puschel A.W., McPherson J.D., Overhauser J., Lovett M. Biochem. Biophys. Res. Commun. 242:685-691(1998) [PubMed: 9464278] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Plexin-B3 is a functional receptor for semaphorin 5A." Artigiani S., Conrotto P., Fazzari P., Gilestro G.F., Barberis D., Giordano S., Comoglio P.M., Tamagnone L. EMBO Rep. 5:710-714(2004) [PubMed: 15218527] [Abstract] Cited for: INTERACTION WITH PLXNB3.
[5]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, MASS SPECTROMETRY. Tissue: Epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
	U52840 mRNA. Translation: AAC09473.1. AC004615 Genomic DNA. Translation: AAC14668.1. AC022446 Genomic DNA. No translation available. AC027336 Genomic DNA. No translation available. AC091906 Genomic DNA. No translation available. BC115696 mRNA. Translation: AAI15697.1.
IPI	IPI00013880.
PIR	JC5928.
RefSeq	NP_003957.2.
UniGene	Hs.27621
3D structure databases
HSSP	HSSP built from PDB template 1LSL based on UniProtKB P07996.
ModBase	Search...
PTM databases
PhosphoSite	Q13591.
Proteomic databases
PRIDE	Q13591.
Genome annotation databases
Ensembl	ENSG00000112902. Homo sapiens. [Contig view]
GeneID	9037.
KEGG	hsa:9037.
NMPDR	fig\|9606.3.peg.25042.
Organism-specific databases
GeneCards	GC05M009091.
H-InvDB	HIX0032118.
HGNC	HGNC:10736. SEMA5A.
HPA	HPA004632.
MIM	609297. gene.
Orphanet	281. Monosomy 5p.
PharmGKB	PA35658.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q13591.
HOVERGEN	Q13591.
OMA	Q13591. LQDAQKF.
Gene expression databases
ArrayExpress	Q13591.
Bgee	Q13591.
CleanEx	HS_SEMA5A.
GermOnline	ENSG00000112902. Homo sapiens.
Family and domain databases
InterPro	IPR003659. Plexin-like. IPR002165. Plexin_repeat. IPR001627. Semaphorin/CD100_Ag. IPR000884. Thrombospondin_1_rpt. IPR008085. Thrombospondin_1_rpt_sub. IPR015943. WD40/YVTN_repeat-like. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF01437. PSI. 1 hit. PF01403. Sema. 1 hit. PF00090. TSP_1. 5 hits. [Graphical view]
PRINTS	PR01705. TSP1REPEAT.
SMART	SM00423. PSI. 1 hit. SM00630. Sema. 1 hit. SM00209. TSP1. 6 hits. [Graphical view]
PROSITE	PS51004. SEMA. 1 hit. PS50092. TSP1. 6 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33851.
SOURCE	Search...

Entry information

Entry name

SEM5A_HUMAN

Accession

Primary (citable) accession number: Q13591
Secondary accession number(s): O60408, Q1RLL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2006
Last modified:	June 16, 2009
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents