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Protein

GRB2-related adapter protein

Gene

GRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1433557 Signaling by SCF-KIT
SignaLinkiQ13588
SIGNORiQ13588

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-related adapter protein
Gene namesi
Name:GRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000154016.13
HGNCiHGNC:4562 GRAP
MIMi604330 gene
neXtProtiNX_Q13588

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10750
OpenTargetsiENSG00000154016
PharmGKBiPA28958

Polymorphism and mutation databases

BioMutaiGRAP
DMDMi3913785

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000882061 – 217GRB2-related adapter proteinAdd BLAST217

Proteomic databases

MaxQBiQ13588
PaxDbiQ13588
PeptideAtlasiQ13588
PRIDEiQ13588

PTM databases

iPTMnetiQ13588
PhosphoSitePlusiQ13588

Expressioni

Gene expression databases

BgeeiENSG00000154016
CleanExiHS_GRAP
ExpressionAtlasiQ13588 baseline and differential
GenevisibleiQ13588 HS

Organism-specific databases

HPAiHPA046595
HPA066654

Interactioni

Subunit structurei

Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc
  • signaling receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi115973, 8 interactors
IntActiQ13588, 9 interactors
MINTiQ13588
STRINGi9606.ENSP00000284154

Structurei

3D structure databases

ProteinModelPortaliQ13588
SMRiQ13588
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58SH3 1PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 154SH2PROSITE-ProRule annotationAdd BLAST95
Domaini158 – 217SH3 2PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG3601 Eukaryota
ENOG410XR1G LUCA
GeneTreeiENSGT00820000126999
HOGENOMiHOG000251625
HOVERGENiHBG005404
InParanoidiQ13588
OMAiRACFAQA
OrthoDBiEOG091G0HWS
PhylomeDBiQ13588
TreeFamiTF354288

Family and domain databases

CDDicd11948 SH3_GRAP_N, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035645 GRAP_N_SH3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

Q13588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK
60 70 80 90 100
NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN
110 120 130 140 150
YGDQVQHFKV LREASGKYFL WEEKFNSLNE LVDFYRTTTI AKKRQIFLRD
160 170 180 190 200
EEPLLKSPGA CFAQAQFDFS AQDPSQLSFR RGDIIEVLER PDPHWWRGRS
210
CGRVGFFPRS YVQPVHL
Length:217
Mass (Da):25,337
Last modified:November 1, 1996 - v1
Checksum:i09FEC2F3BAC0FAF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52518 mRNA Translation: AAC50541.1
BT019981 mRNA Translation: AAV38784.1
CR541941 mRNA Translation: CAG46739.1
CR541966 mRNA Translation: CAG46764.1
AC003957 Genomic DNA No translation available.
AC007952 Genomic DNA No translation available.
BC035856 mRNA Translation: AAH35856.1
BC063035 mRNA Translation: AAH63035.1
CCDSiCCDS11202.1
RefSeqiNP_001317077.1, NM_001330148.1
NP_006604.1, NM_006613.3
XP_016879518.1, XM_017024029.1
UniGeneiHs.567416

Genome annotation databases

EnsembliENST00000284154; ENSP00000284154; ENSG00000154016
GeneIDi10750
KEGGihsa:10750
UCSCiuc002guy.4 human

Entry informationi

Entry nameiGRAP_HUMAN
AccessioniPrimary (citable) accession number: Q13588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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