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Protein

Melatonin-related receptor

Gene

GPR50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Does not bind melatonin.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • melatonin receptor activity Source: InterPro

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102195-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin-related receptor
Alternative name(s):
G protein-coupled receptor 50
H9
Gene namesi
Name:GPR50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4506. GPR50.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 64CytoplasmicSequence analysisAdd BLAST13
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 103ExtracellularSequence analysisAdd BLAST18
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 188ExtracellularSequence analysisAdd BLAST24
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 239CytoplasmicSequence analysisAdd BLAST30
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 617CytoplasmicSequence analysisAdd BLAST323

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9248.
OpenTargetsiENSG00000102195.
PharmGKBiPA28895.

Chemistry databases

ChEMBLiCHEMBL3341577.

Polymorphism and mutation databases

BioMutaiGPR50.
DMDMi296439298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698781 – 617Melatonin-related receptorAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi101 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ13585.
MaxQBiQ13585.
PaxDbiQ13585.
PeptideAtlasiQ13585.
PRIDEiQ13585.

PTM databases

iPTMnetiQ13585.
PhosphoSitePlusiQ13585.

Expressioni

Tissue specificityi

Hypothalamus and pituitary.

Gene expression databases

BgeeiENSG00000102195.
CleanExiHS_GPR50.
GenevisibleiQ13585. HS.

Organism-specific databases

HPAiHPA049862.

Interactioni

Subunit structurei

Homodimer, and heterodimer with MTNR1A and MTNR1B.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-8550965,EBI-8550965
MT1AP047313EBI-8550965,EBI-8045030
MT2AP027952EBI-8550965,EBI-996616
ZNF572Q7Z3I73EBI-8550965,EBI-10257016

Protein-protein interaction databases

BioGridi114674. 18 interactors.
IntActiQ13585. 4 interactors.
MINTiMINT-2836359.
STRINGi9606.ENSP00000218316.

Structurei

3D structure databases

ProteinModelPortaliQ13585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi315 – 612Pro-richAdd BLAST298

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000133094.
HOVERGENiHBG052529.
InParanoidiQ13585.
KOiK04287.
OMAiPASVHFK.
OrthoDBiEOG091G0GO0.
PhylomeDBiQ13585.
TreeFamiTF331693.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002280. Mel_rcpt_1X.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01151. MELATONIN1XR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI
60 70 80 90 100
LAVTKNKKLR NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ
110 120 130 140 150
CQMVGFITGL SVVGSIFNIV AIAINRYCYI CHSLQYERIF SVRNTCIYLV
160 170 180 190 200
ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF NYLNNPVFTV TIVCIHFVLP
210 220 230 240 250
LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF VIFLLFAVCW
260 270 280 290 300
CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN
310 320 330 340 350
FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD
360 370 380 390 400
RAHACPAVEE TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA
410 420 430 440 450
STHHKSVFSH SKAASGHLKP VSGHSKPASG HPKSATVYPK PASVHFKADS
460 470 480 490 500
VHFKGDSVHF KPDSVHFKPA SSNPKPITGH HVSAGSHSKS AFSAATSHPK
510 520 530 540 550
PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS ASHCPEIPAI
560 570 580 590 600
AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY
610
HDVVVIDVED DPDEMAV
Length:617
Mass (Da):67,369
Last modified:May 18, 2010 - v3
Checksum:iA0B73A7ACE1053BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti320S → P in AAC50614 (PubMed:8647286).Curated1
Sequence conflicti448A → G in AAC50614 (PubMed:8647286).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062254502 – 505Missing Lower fasting circulating triglyceride levels. 3 Publications4
Natural variantiVAR_062255532T → A Higher fasting circulating triglyceride levels. 3 PublicationsCorresponds to variant rs561077dbSNPEnsembl.1
Natural variantiVAR_062256606I → V Higher fasting circulating triglyceride levels. 2 PublicationsCorresponds to variant rs13440581dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52219 mRNA. Translation: AAC50614.1.
EU432118 mRNA. Translation: ABY87917.1.
BC103696 mRNA. Translation: AAI03697.1.
BC105683 mRNA. Translation: AAI05684.1.
BC105684 mRNA. Translation: AAI05685.1.
CCDSiCCDS44012.1.
PIRiS70520.
RefSeqiNP_004215.2. NM_004224.3.
UniGeneiHs.567390.

Genome annotation databases

EnsembliENST00000218316; ENSP00000218316; ENSG00000102195.
GeneIDi9248.
KEGGihsa:9248.
UCSCiuc010ntg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52219 mRNA. Translation: AAC50614.1.
EU432118 mRNA. Translation: ABY87917.1.
BC103696 mRNA. Translation: AAI03697.1.
BC105683 mRNA. Translation: AAI05684.1.
BC105684 mRNA. Translation: AAI05685.1.
CCDSiCCDS44012.1.
PIRiS70520.
RefSeqiNP_004215.2. NM_004224.3.
UniGeneiHs.567390.

3D structure databases

ProteinModelPortaliQ13585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114674. 18 interactors.
IntActiQ13585. 4 interactors.
MINTiMINT-2836359.
STRINGi9606.ENSP00000218316.

Chemistry databases

ChEMBLiCHEMBL3341577.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ13585.
PhosphoSitePlusiQ13585.

Polymorphism and mutation databases

BioMutaiGPR50.
DMDMi296439298.

Proteomic databases

EPDiQ13585.
MaxQBiQ13585.
PaxDbiQ13585.
PeptideAtlasiQ13585.
PRIDEiQ13585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218316; ENSP00000218316; ENSG00000102195.
GeneIDi9248.
KEGGihsa:9248.
UCSCiuc010ntg.3. human.

Organism-specific databases

CTDi9248.
DisGeNETi9248.
GeneCardsiGPR50.
H-InvDBHIX0056463.
HGNCiHGNC:4506. GPR50.
HPAiHPA049862.
MIMi300207. gene.
neXtProtiNX_Q13585.
OpenTargetsiENSG00000102195.
PharmGKBiPA28895.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
GeneTreeiENSGT00440000033318.
HOGENOMiHOG000133094.
HOVERGENiHBG052529.
InParanoidiQ13585.
KOiK04287.
OMAiPASVHFK.
OrthoDBiEOG091G0GO0.
PhylomeDBiQ13585.
TreeFamiTF331693.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102195-MONOMER.

Miscellaneous databases

GeneWikiiGPR50.
GenomeRNAii9248.
PROiQ13585.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102195.
CleanExiHS_GPR50.
GenevisibleiQ13585. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002280. Mel_rcpt_1X.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01151. MELATONIN1XR.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTR1L_HUMAN
AccessioniPrimary (citable) accession number: Q13585
Secondary accession number(s): Q0VGG3, Q3ZAR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.