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Q13585 (MTR1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melatonin-related receptor
Alternative name(s):
G protein-coupled receptor 50
H9
Gene names
Name:GPR50
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Does not bind melatonin.

Subunit structure

Homodimer, and heterodimer with MTNR1A and MTNR1B. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Hypothalamus and pituitary.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617Melatonin-related receptor
PRO_0000069878

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 6413Cytoplasmic Potential
Transmembrane65 – 8521Helical; Name=2; Potential
Topological domain86 – 10318Extracellular Potential
Transmembrane104 – 12421Helical; Name=3; Potential
Topological domain125 – 14319Cytoplasmic Potential
Transmembrane144 – 16421Helical; Name=4; Potential
Topological domain165 – 18824Extracellular Potential
Transmembrane189 – 20921Helical; Name=5; Potential
Topological domain210 – 23930Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 27313Extracellular Potential
Transmembrane274 – 29421Helical; Name=7; Potential
Topological domain295 – 617323Cytoplasmic Potential
Compositional bias315 – 612298Pro-rich

Amino acid modifications

Disulfide bond101 ↔ 178 By similarity

Natural variations

Natural variant502 – 5054Missing Lower fasting circulating triglyceride levels.
VAR_062254
Natural variant5321T → A Higher fasting circulating triglyceride levels. Ref.1 Ref.2 Ref.3
Corresponds to variant rs561077 [ dbSNP | Ensembl ].
VAR_062255
Natural variant6061I → V Higher fasting circulating triglyceride levels. Ref.1 Ref.3
Corresponds to variant rs13440581 [ dbSNP | Ensembl ].
VAR_062256

Experimental info

Sequence conflict3201S → P in AAC50614. Ref.1
Sequence conflict4481A → G in AAC50614. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q13585 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: A0B73A7ACE1053BB

FASTA61767,369
        10         20         30         40         50         60 
MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI LAVTKNKKLR 

        70         80         90        100        110        120 
NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ CQMVGFITGL SVVGSIFNIV 

       130        140        150        160        170        180 
AIAINRYCYI CHSLQYERIF SVRNTCIYLV ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF 

       190        200        210        220        230        240 
NYLNNPVFTV TIVCIHFVLP LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF 

       250        260        270        280        290        300 
VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN 

       310        320        330        340        350        360 
FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD RAHACPAVEE 

       370        380        390        400        410        420 
TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA STHHKSVFSH SKAASGHLKP 

       430        440        450        460        470        480 
VSGHSKPASG HPKSATVYPK PASVHFKADS VHFKGDSVHF KPDSVHFKPA SSNPKPITGH 

       490        500        510        520        530        540 
HVSAGSHSKS AFSAATSHPK PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS 

       550        560        570        580        590        600 
ASHCPEIPAI AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY 

       610 
HDVVVIDVED DPDEMAV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a melatonin-related receptor from human pituitary."
Reppert S.M., Weaver D.R., Ebisawa T., Mahle C.D., Kolakowski L.F. Jr.
FEBS Lett. 386:219-224(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS 502-THR--HIS-505 DEL; ALA-532 AND VAL-606.
Tissue: Pituitary.
[2]Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS 502-THR--HIS-505 DEL AND ALA-532.
Tissue: Pituitary.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS 502-THR--HIS-505 DEL; ALA-532 AND VAL-606.
[4]"The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization."
Levoye A., Dam J., Ayoub M.A., Guillaume J.L., Couturier C., Delagrange P., Jockers R.
EMBO J. 25:3012-3023(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[5]"Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels."
Bhattacharyya S., Luan J., Challis B., Keogh J., Montague C., Brennand J., Morten J., Lowenbeim S., Jenkins S., Farooqi I.S., Wareham N.J., O'Rahilly S.
J. Lipid Res. 47:761-766(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS 502THR--HIS505 DEL; ALA-528 AND ILE-606.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U52219 mRNA. Translation: AAC50614.1.
EU432118 mRNA. Translation: ABY87917.1.
BC103696 mRNA. Translation: AAI03697.1.
BC105683 mRNA. Translation: AAI05684.1.
BC105684 mRNA. Translation: AAI05685.1.
PIRS70520.
RefSeqNP_004215.2. NM_004224.3.
UniGeneHs.567390.

3D structure databases

ProteinModelPortalQ13585.
SMRQ13585. Positions 2-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114674. 5 interactions.
IntActQ13585. 3 interactions.
MINTMINT-2836359.
STRING9606.ENSP00000218316.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ13585.

Polymorphism databases

DMDM296439298.

Proteomic databases

PaxDbQ13585.
PRIDEQ13585.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000218316; ENSP00000218316; ENSG00000102195.
GeneID9248.
KEGGhsa:9248.
UCSCuc010ntg.2. human.

Organism-specific databases

CTD9248.
GeneCardsGC0XP150345.
H-InvDBHIX0056463.
HGNCHGNC:4506. GPR50.
HPAHPA049862.
MIM300207. gene.
neXtProtNX_Q13585.
PharmGKBPA28895.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149107.
HOGENOMHOG000133094.
HOVERGENHBG052529.
InParanoidQ13585.
KOK04287.
OMAPASVHFK.
OrthoDBEOG7MD4Q5.
PhylomeDBQ13585.
TreeFamTF331693.

Gene expression databases

BgeeQ13585.
CleanExHS_GPR50.
GenevestigatorQ13585.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002280. Mel_rcpt_1X.
IPR000025. Melatonin_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01151. MELATONIN1XR.
PR00857. MELATONINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR50.
GenomeRNAi9248.
NextBio34671.
PROQ13585.
SOURCESearch...

Entry information

Entry nameMTR1L_HUMAN
AccessionPrimary (citable) accession number: Q13585
Secondary accession number(s): Q0VGG3, Q3ZAR0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries