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Q13585

- MTR1L_HUMAN

UniProt

Q13585 - MTR1L_HUMAN

Protein

Melatonin-related receptor

Gene

GPR50

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Does not bind melatonin.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. identical protein binding Source: IntAct
    3. melatonin receptor activity Source: InterPro
    4. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melatonin-related receptor
    Alternative name(s):
    G protein-coupled receptor 50
    H9
    Gene namesi
    Name:GPR50
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4506. GPR50.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28895.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 617617Melatonin-related receptorPRO_0000069878Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi101 ↔ 178PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ13585.
    PaxDbiQ13585.
    PRIDEiQ13585.

    PTM databases

    PhosphoSiteiQ13585.

    Expressioni

    Tissue specificityi

    Hypothalamus and pituitary.

    Gene expression databases

    BgeeiQ13585.
    CleanExiHS_GPR50.
    GenevestigatoriQ13585.

    Organism-specific databases

    HPAiHPA049862.

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with MTNR1A and MTNR1B.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-8550965,EBI-8550965
    MT1AP047313EBI-8550965,EBI-8045030
    MT2AP027952EBI-8550965,EBI-996616

    Protein-protein interaction databases

    BioGridi114674. 5 interactions.
    IntActiQ13585. 3 interactions.
    MINTiMINT-2836359.
    STRINGi9606.ENSP00000218316.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13585.
    SMRiQ13585. Positions 15-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini86 – 10318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 18824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 23930CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini295 – 617323CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi315 – 612298Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149107.
    HOGENOMiHOG000133094.
    HOVERGENiHBG052529.
    InParanoidiQ13585.
    KOiK04287.
    OMAiPASVHFK.
    OrthoDBiEOG7MD4Q5.
    PhylomeDBiQ13585.
    TreeFamiTF331693.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002280. Mel_rcpt_1X.
    IPR000025. Melatonin_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01151. MELATONIN1XR.
    PR00857. MELATONINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13585-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI    50
    LAVTKNKKLR NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ 100
    CQMVGFITGL SVVGSIFNIV AIAINRYCYI CHSLQYERIF SVRNTCIYLV 150
    ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF NYLNNPVFTV TIVCIHFVLP 200
    LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF VIFLLFAVCW 250
    CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN 300
    FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD 350
    RAHACPAVEE TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA 400
    STHHKSVFSH SKAASGHLKP VSGHSKPASG HPKSATVYPK PASVHFKADS 450
    VHFKGDSVHF KPDSVHFKPA SSNPKPITGH HVSAGSHSKS AFSAATSHPK 500
    PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS ASHCPEIPAI 550
    AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY 600
    HDVVVIDVED DPDEMAV 617
    Length:617
    Mass (Da):67,369
    Last modified:May 18, 2010 - v3
    Checksum:iA0B73A7ACE1053BB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti320 – 3201S → P in AAC50614. (PubMed:8647286)Curated
    Sequence conflicti448 – 4481A → G in AAC50614. (PubMed:8647286)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti502 – 5054Missing Lower fasting circulating triglyceride levels.
    VAR_062254
    Natural varianti532 – 5321T → A Higher fasting circulating triglyceride levels. 3 Publications
    Corresponds to variant rs561077 [ dbSNP | Ensembl ].
    VAR_062255
    Natural varianti606 – 6061I → V Higher fasting circulating triglyceride levels. 2 Publications
    Corresponds to variant rs13440581 [ dbSNP | Ensembl ].
    VAR_062256

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52219 mRNA. Translation: AAC50614.1.
    EU432118 mRNA. Translation: ABY87917.1.
    BC103696 mRNA. Translation: AAI03697.1.
    BC105683 mRNA. Translation: AAI05684.1.
    BC105684 mRNA. Translation: AAI05685.1.
    CCDSiCCDS44012.1.
    PIRiS70520.
    RefSeqiNP_004215.2. NM_004224.3.
    UniGeneiHs.567390.

    Genome annotation databases

    EnsembliENST00000218316; ENSP00000218316; ENSG00000102195.
    GeneIDi9248.
    KEGGihsa:9248.
    UCSCiuc010ntg.2. human.

    Polymorphism databases

    DMDMi296439298.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52219 mRNA. Translation: AAC50614.1 .
    EU432118 mRNA. Translation: ABY87917.1 .
    BC103696 mRNA. Translation: AAI03697.1 .
    BC105683 mRNA. Translation: AAI05684.1 .
    BC105684 mRNA. Translation: AAI05685.1 .
    CCDSi CCDS44012.1.
    PIRi S70520.
    RefSeqi NP_004215.2. NM_004224.3.
    UniGenei Hs.567390.

    3D structure databases

    ProteinModelPortali Q13585.
    SMRi Q13585. Positions 15-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114674. 5 interactions.
    IntActi Q13585. 3 interactions.
    MINTi MINT-2836359.
    STRINGi 9606.ENSP00000218316.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q13585.

    Polymorphism databases

    DMDMi 296439298.

    Proteomic databases

    MaxQBi Q13585.
    PaxDbi Q13585.
    PRIDEi Q13585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000218316 ; ENSP00000218316 ; ENSG00000102195 .
    GeneIDi 9248.
    KEGGi hsa:9248.
    UCSCi uc010ntg.2. human.

    Organism-specific databases

    CTDi 9248.
    GeneCardsi GC0XP150345.
    H-InvDB HIX0056463.
    HGNCi HGNC:4506. GPR50.
    HPAi HPA049862.
    MIMi 300207. gene.
    neXtProti NX_Q13585.
    PharmGKBi PA28895.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149107.
    HOGENOMi HOG000133094.
    HOVERGENi HBG052529.
    InParanoidi Q13585.
    KOi K04287.
    OMAi PASVHFK.
    OrthoDBi EOG7MD4Q5.
    PhylomeDBi Q13585.
    TreeFami TF331693.

    Miscellaneous databases

    GeneWikii GPR50.
    GenomeRNAii 9248.
    NextBioi 34671.
    PROi Q13585.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13585.
    CleanExi HS_GPR50.
    Genevestigatori Q13585.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002280. Mel_rcpt_1X.
    IPR000025. Melatonin_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01151. MELATONIN1XR.
    PR00857. MELATONINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a melatonin-related receptor from human pituitary."
      Reppert S.M., Weaver D.R., Ebisawa T., Mahle C.D., Kolakowski L.F. Jr.
      FEBS Lett. 386:219-224(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS 502-THR--HIS-505 DEL; ALA-532 AND VAL-606.
      Tissue: Pituitary.
    2. Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS 502-THR--HIS-505 DEL AND ALA-532.
      Tissue: Pituitary.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS 502-THR--HIS-505 DEL; ALA-532 AND VAL-606.
    4. "The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization."
      Levoye A., Dam J., Ayoub M.A., Guillaume J.L., Couturier C., Delagrange P., Jockers R.
      EMBO J. 25:3012-3023(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    5. "Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels."
      Bhattacharyya S., Luan J., Challis B., Keogh J., Montague C., Brennand J., Morten J., Lowenbeim S., Jenkins S., Farooqi I.S., Wareham N.J., O'Rahilly S.
      J. Lipid Res. 47:761-766(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS 502THR--HIS505 DEL; ALA-528 AND ILE-606.

    Entry informationi

    Entry nameiMTR1L_HUMAN
    AccessioniPrimary (citable) accession number: Q13585
    Secondary accession number(s): Q0VGG3, Q3ZAR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 109 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3