Q13576 (IQGA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras GTPase-activating-like protein IQGAP2

Gene names

Name:

IQGAP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1575 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
Tissue specificity	Isoform 2 expression is enhanced in testis.
Sequence similarities	Contains 1 CH (calponin-homology) domain. Contains 3 IQ domains. Contains 1 Ras-GAP domain. Contains 1 WW domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	Calmodulin-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of Ras GTPase activity Inferred from electronic annotation. Source: GOC signal transduction Traceable author statement Ref.1. Source: ProtInc small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	actin cytoskeleton Traceable author statement Ref.1. Source: ProtInc microtubule Inferred from direct assay PubMed 21525035. Source: UniProtKB microvillus Inferred from electronic annotation. Source: Compara
Molecular_function	GTPase inhibitor activity Traceable author statement Ref.1. Source: ProtInc Ras GTPase activator activity Inferred from electronic annotation. Source: InterPro actin binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13576-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13576-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MHSLPG
     642-698: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.5

Chain

2 – 1575

1574

Ras GTPase-activating-like protein IQGAP2

PRO_0000056650

Regions

Domain

41 – 156

116

CH

Domain

594 – 627

34

WW

Domain

690 – 719

30

IQ 1

Domain

720 – 749

30

IQ 2

Domain

750 – 779

30

IQ 3

Domain

917 – 1150

234

Ras-GAP

Compositional bias

263 – 266

4

Poly-Lys

Amino acid modifications

Modified residue

16

1

Phosphoserine Ref.7 Ref.8

Modified residue

1389

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 447

447

Missing in isoform 2.

VSP_010629

Alternative sequence

448 – 453

6

QEENDR → MHSLPG in isoform 2.

VSP_010630

Alternative sequence

642 – 698

57

Missing in isoform 2.

VSP_010631

Natural variant

455

1

V → A.
Corresponds to variant rs7722711 [ dbSNP | Ensembl ].

VAR_055823

Natural variant

479

1

P → R.
Corresponds to variant rs3822530 [ dbSNP | Ensembl ].

VAR_055824

Natural variant

527

1

D → E. Ref.1 Ref.2 Ref.3
Corresponds to variant rs2431352 [ dbSNP | Ensembl ].

VAR_062958

Natural variant

532

1

K → E. Ref.1 Ref.2 Ref.3
Corresponds to variant rs2909888 [ dbSNP | Ensembl ].

VAR_059292

Natural variant

629

1

L → F. Ref.1 Ref.2 Ref.9
Corresponds to variant rs2455230 [ dbSNP | Ensembl ].

VAR_062959

Natural variant

714

1

R → W.
Corresponds to variant rs35366349 [ dbSNP | Ensembl ].

VAR_055825

Natural variant

724

1

I → V. Ref.1 Ref.2
Corresponds to variant rs2431363 [ dbSNP | Ensembl ].

VAR_062960

Natural variant

894

1

T → I.
Corresponds to variant rs34950321 [ dbSNP | Ensembl ].

VAR_055826

Natural variant

1052

1

R → I.
Corresponds to variant rs2287932 [ dbSNP | Ensembl ].

VAR_055827

Natural variant

1184

1

N → S.
Corresponds to variant rs10454915 [ dbSNP | Ensembl ].

VAR_055828

Natural variant

1379

1

R → W.
Corresponds to variant rs17681908 [ dbSNP | Ensembl ].

VAR_055829

Experimental info

Sequence conflict

95

1

V → E in BAF83755. Ref.3

Sequence conflict

778

1

N → S in BAF83755. Ref.3

Sequence conflict

1101

1

G → R in BAF83755. Ref.3

Sequence conflict

1333

1

V → L in BAH13890. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1575

Helix Strand Turn

Details...

Beta strand

1479 – 1482

4

Helix

1483 – 1488

6

Beta strand

1491 – 1495

5

Helix

1500 – 1505

6

Beta strand

1506 – 1512

7

Beta strand

1518 – 1525

8

Beta strand

1528 – 1536

9

Helix

1537 – 1545

9

Beta strand

1550 – 1554

5

Beta strand

1557 – 1560

4

Helix

1561 – 1569

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 23, 2010. Version 4. Checksum: BCC8CED6645CB09B	FASTA	1,575	180,578
	10 20 30 40 50 60 MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEVCLVEELP 70 80 90 100 110 120 PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY KKSGLHFRHT DNTVQWLRAM 130 140 150 160 170 180 ESIGLPKIFY PETTDVYDRK NIPRMIYCIH ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS 190 200 210 220 230 240 NMRKELEKYG IQMPSFSKIG GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP 250 260 270 280 290 300 NAVLTLVDDN LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK 310 320 330 340 350 360 VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN LQKQNTMNYL 370 380 390 400 410 420 AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG LNNLDKAYVE RYANTLLSVK 430 440 450 460 470 480 LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE NDRVVAVGYI NEAIDEGNPL RTLETLLLPT 490 500 510 520 530 540 ANISDVDPAH AQHYQDVLYH AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT 550 560 570 580 590 600 LVVDVNQCLE GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW 610 620 630 640 650 660 LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG YIRENIWSAS 670 680 690 700 710 720 EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF WKGYKQRKEY MHRRQTFIDN 730 740 750 760 770 780 TDSIVKIQSW FRMATARKSY LSRLQYFRDH NNEIVKIQSL LRANKARDDY KTLVGSENPP 790 800 810 820 830 840 LTVIRKFVYL LDQSDLDFQE ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI 850 860 870 880 890 900 TLEDVISHSK KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA 910 920 930 940 950 960 KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK VDQVQDIVTG 970 980 990 1000 1010 1020 NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII NTNPVEVYKA WVNQLETQTG 1030 1040 1050 1060 1070 1080 EASKLPYDVT TEQALTYPEV KNKLEASIEN LRRVTDKVLN SIISSLDLLP YGLRYIAKVL 1090 1100 1110 1120 1130 1140 KNSIHEKFPD ATEDELLKIV GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS 1150 1160 1170 1180 1190 1200 VAKVLQHAAS NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL 1210 1220 1230 1240 1250 1260 VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV ESFLGEGAVD 1270 1280 1290 1300 1310 1320 PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM IKTKKLIIDV IRNQPGNTLT 1330 1340 1350 1360 1370 1380 EILETPATAQ QEVDHATDMV SRAMIDSRTP EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT 1390 1400 1410 1420 1430 1440 LEQTGHVSSE NKYQDILNEI AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN 1450 1460 1470 1480 1490 1500 YYDTYIKTCL DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT 1510 1520 1530 1540 1550 1560 NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV MKMFDKVKVN 1570 VNLLIYLLNK KFYGK
	Isoform 2 [UniParc]. Checksum: 111C704267532C91	FASTA	1,071	122,805
	10 20 30 40 50 60 MHSLPGVVAV GYINEAIDEG NPLRTLETLL LPTANISDVD PAHAQHYQDV LYHAKSQKLG 70 80 90 100 110 120 DSESVSKVLW LDEIQQAVDD ANVDKDRAKQ WVTLVVDVNQ CLEGKKSSDI LSVLKSSTSN 130 140 150 160 170 180 ANDIIPECAD KYYDALVKAK ELKSERVSSD GSWLKLNLHK KYDYYYNTDS KESSWVTPES 190 200 210 220 230 240 CLYKESWLTG KEIEAFWKGY KQRKEYMHRR QTFIDNTDSI VKIQSWFRMA TARKSYLSRL 250 260 270 280 290 300 QYFRDHNNEI VKIQSLLRAN KARDDYKTLV GSENPPLTVI RKFVYLLDQS DLDFQEELEV 310 320 330 340 350 360 ARLREEVVTK IRANQQLEKD LNLMDIKIGL LVKNRITLED VISHSKKLNK KKGGEMEILN 370 380 390 400 410 420 NTDNQGIKSL SKERRKTLET YQQLFYLLQT NPLYLAKLIF QMPQNKSTKF MDTVIFTLYN 430 440 450 460 470 480 YASNQREEYL LLKLFKTALE EEIKSKVDQV QDIVTGNPTV IKMVVSFNRG ARGQNTLRQL 490 500 510 520 530 540 LAPVVKEIID DKSLIINTNP VEVYKAWVNQ LETQTGEASK LPYDVTTEQA LTYPEVKNKL 550 560 570 580 590 600 EASIENLRRV TDKVLNSIIS SLDLLPYGLR YIAKVLKNSI HEKFPDATED ELLKIVGNLL 610 620 630 640 650 660 YYRYMNPAIV APDGFDIIDM TAGGQINSDQ RRNLGSVAKV LQHAASNKLF EGENEHLSSM 670 680 690 700 710 720 NNYLSETYQE FRKYFKEACN VPEPEEKFNM DKYTDLVTVS KPVIYISIEE IISTHSLLLE 730 740 750 760 770 780 HQDAIAPEKN DLLSELLGSL GEVPTVESFL GEGAVDPNDP NKANTLSQLS KTEISLVLTS 790 800 810 820 830 840 KYDIEDGEAI DSRSLMIKTK KLIIDVIRNQ PGNTLTEILE TPATAQQEVD HATDMVSRAM 850 860 870 880 890 900 IDSRTPEEMK HSQSMIEDAQ LPLEQKKRKI QRNLRTLEQT GHVSSENKYQ DILNEIAKDI 910 920 930 940 950 960 RNQRIYRKLR KAELAKLQQT LNALNKKAAF YEEQINYYDT YIKTCLDNLK RKNTRRSIKL 970 980 990 1000 1010 1020 DGKGEPKGAK RAKPVKYTAA KLHEKGVLLD IDDLQTNQFK NVTFDIIATE DVGIFDVRSK 1030 1040 1050 1060 1070 FLGVEMEKVQ LNIQDLLQMQ YEGVAVMKMF DKVKVNVNLL IYLLNKKFYG K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases." Brill S., Li S., Lyman C.W., Church D.M., Wasmuth J.J., Weissbach L., Bernards A., Snijders A.J. Mol. Cell. Biol. 16:4869-4878(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724. Tissue: Liver.
[2]	"Cloning and characterization of a novel isoform of IQGAP2 in human adult testis." Wang H., Huo R., Xu Z.Y., Xu M., Li J.M., Zhou Z.M., Sha J.H. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-527 AND GLU-532. Tissue: Teratocarcinoma and Testis.
[4]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-13. Tissue: Platelet.
[6]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Liver.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-629, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U51903 mRNA. Translation: AAB37765.1.
AY351902 mRNA. Translation: AAQ81291.1.
AK291066 mRNA. Translation: BAF83755.1.
AK303054 mRNA. Translation: BAH13890.1.
AC025188 Genomic DNA. No translation available.
AC026706 Genomic DNA. No translation available.
AC026725 Genomic DNA. No translation available.
AC093251 Genomic DNA. No translation available.
AC112173 Genomic DNA. No translation available.

IPI

IPI00299048.
IPI00871809.

RefSeq

NP_006624.2. NM_006633.2.

UniGene

Hs.291030.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3IEZ	X-ray	1.50	A/B	1476-1571	[»]
4EZA	X-ray	1.50	A/B	1476-1571	[»]

ProteinModelPortal

Q13576.

SMR

Q13576. Positions 23-207, 875-1252, 1477-1571.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-27542N.

IntAct

Q13576. 10 interactions.

MINT

MINT-5004527.

STRING

9606.ENSP00000274364.

PTM databases

PhosphoSite

Q13576.

Polymorphism databases

DMDM

292495090.

2D gel databases

OGP

Q13576.

Proteomic databases

PaxDb

Q13576.

PRIDE

Q13576.

Protocols and materials databases

DNASU

10788.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000274364; ENSP00000274364; ENSG00000145703.
ENST00000396234; ENSP00000379535; ENSG00000145703.

GeneID

10788.

KEGG

hsa:10788.

UCSC

uc003kek.3. human.
uc003kel.3. human.

Organism-specific databases

CTD

10788.

GeneCards

GC05P075699.

HGNC

HGNC:6111. IQGAP2.

HPA

CAB004241.

MIM

605401. gene.

neXtProt

NX_Q13576.

PharmGKB

PA29911.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5261.

HOGENOM

HOG000004842.

HOVERGEN

HBG052143.

InParanoid

Q13576.

KO

K05767.

OMA

PEEMKHS.

OrthoDB

EOG4P8FH6.

PhylomeDB

Q13576.

Gene expression databases

ArrayExpress

Q13576.

Bgee

Q13576.

CleanEx

HS_IQGAP2.

Genevestigator

Q13576.

GermOnline

ENSG00000145703. Homo sapiens.

Family and domain databases

Gene3D

1.10.418.10. 1 hit.
1.10.506.10. 2 hits.

InterPro

IPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]

Pfam

PF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]

SMART

SM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]

SUPFAM

SSF47576. Calponin-homology. 1 hit.
SSF48350. Rho_GAP. 1 hit.
SSF52540. SSF52540. 1 hit.

PROSITE

PS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q13576.

GenomeRNAi

10788.

NextBio

40978.

SOURCE

Search...

Entry information

Entry name

IQGA2_HUMAN

Accession

Primary (citable) accession number: Q13576
Secondary accession number(s): A8K4V1, B7Z8A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	March 23, 2010
Last modified:	May 29, 2013
This is version 128 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.