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Q13576

- IQGA2_HUMAN

UniProt

Q13576 - IQGA2_HUMAN

Protein

Ras GTPase-activating-like protein IQGAP2

Gene

IQGAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 4 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

    GO - Molecular functioni

    1. actin binding Source: ProtInc
    2. GTPase inhibitor activity Source: ProtInc
    3. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
    4. Ras GTPase activator activity Source: InterPro

    GO - Biological processi

    1. negative regulation of catalytic activity Source: GOC
    2. signal transduction Source: ProtInc
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras GTPase-activating-like protein IQGAP2
    Gene namesi
    Name:IQGAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6111. IQGAP2.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: ProtInc
    2. extracellular vesicular exosome Source: UniProt
    3. microtubule Source: UniProtKB
    4. microvillus Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29911.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 15751574Ras GTPase-activating-like protein IQGAP2PRO_0000056650Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ13576.
    PaxDbiQ13576.
    PRIDEiQ13576.

    2D gel databases

    OGPiQ13576.

    PTM databases

    PhosphoSiteiQ13576.

    Expressioni

    Tissue specificityi

    Isoform 2 expression is enhanced in testis.

    Gene expression databases

    ArrayExpressiQ13576.
    BgeeiQ13576.
    CleanExiHS_IQGAP2.
    GenevestigatoriQ13576.

    Organism-specific databases

    HPAiCAB004241.
    HPA037404.

    Interactioni

    Protein-protein interaction databases

    BioGridi116004. 10 interactions.
    DIPiDIP-27542N.
    IntActiQ13576. 15 interactions.
    MINTiMINT-5004527.
    STRINGi9606.ENSP00000274364.

    Structurei

    Secondary structure

    1
    1575
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1479 – 14824
    Helixi1483 – 14886
    Beta strandi1491 – 14955
    Helixi1500 – 15056
    Beta strandi1506 – 15127
    Beta strandi1518 – 15258
    Beta strandi1528 – 15369
    Helixi1537 – 15459
    Beta strandi1550 – 15545
    Beta strandi1557 – 15604
    Helixi1561 – 15699

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IEZX-ray1.50A/B1476-1571[»]
    4EZAX-ray1.50A/B1476-1571[»]
    ProteinModelPortaliQ13576.
    SMRiQ13576. Positions 23-207, 875-1252, 1477-1571.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13576.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 156116CHPROSITE-ProRule annotationAdd
    BLAST
    Domaini594 – 62734WWPROSITE-ProRule annotationAdd
    BLAST
    Domaini690 – 71930IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini720 – 74930IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini750 – 77930IQ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini917 – 1150234Ras-GAPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi263 – 2664Poly-Lys

    Sequence similaritiesi

    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
    Contains 3 IQ domains.PROSITE-ProRule annotation
    Contains 1 Ras-GAP domain.PROSITE-ProRule annotation
    Contains 1 WW domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5261.
    HOGENOMiHOG000004842.
    HOVERGENiHBG052143.
    InParanoidiQ13576.
    KOiK05767.
    OMAiMEKVQLH.
    OrthoDBiEOG7FNC6M.
    PhylomeDBiQ13576.
    TreeFamiTF313078.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    1.10.506.10. 2 hits.
    InterProiIPR001715. CH-domain.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001936. RasGAP.
    IPR000593. RasGAP_C.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00307. CH. 1 hit.
    PF00612. IQ. 2 hits.
    PF00616. RasGAP. 1 hit.
    PF03836. RasGAP_C. 1 hit.
    [Graphical view]
    SMARTiSM00033. CH. 1 hit.
    SM00015. IQ. 3 hits.
    SM00323. RasGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    SSF48350. SSF48350. 2 hits.
    PROSITEiPS50021. CH. 1 hit.
    PS50096. IQ. 3 hits.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13576-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW     50
    MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY 100
    KKSGLHFRHT DNTVQWLRAM ESIGLPKIFY PETTDVYDRK NIPRMIYCIH 150
    ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPSFSKIG 200
    GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP NAVLTLVDDN 250
    LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK 300
    VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN 350
    LQKQNTMNYL AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG 400
    LNNLDKAYVE RYANTLLSVK LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE 450
    NDRVVAVGYI NEAIDEGNPL RTLETLLLPT ANISDVDPAH AQHYQDVLYH 500
    AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT LVVDVNQCLE 550
    GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW 600
    LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG 650
    YIRENIWSAS EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF 700
    WKGYKQRKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH 750
    NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE 800
    ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHSK 850
    KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA 900
    KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK 950
    VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII 1000
    NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN 1050
    LRRVTDKVLN SIISSLDLLP YGLRYIAKVL KNSIHEKFPD ATEDELLKIV 1100
    GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS VAKVLQHAAS 1150
    NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL 1200
    VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV 1250
    ESFLGEGAVD PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM 1300
    IKTKKLIIDV IRNQPGNTLT EILETPATAQ QEVDHATDMV SRAMIDSRTP 1350
    EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT LEQTGHVSSE NKYQDILNEI 1400
    AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN YYDTYIKTCL 1450
    DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT 1500
    NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV 1550
    MKMFDKVKVN VNLLIYLLNK KFYGK 1575
    Length:1,575
    Mass (Da):180,578
    Last modified:March 23, 2010 - v4
    Checksum:iBCC8CED6645CB09B
    GO
    Isoform 2 (identifier: Q13576-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-447: Missing.
         448-453: QEENDR → MHSLPG
         642-698: Missing.

    Show »
    Length:1,071
    Mass (Da):122,805
    Checksum:i111C704267532C91
    GO
    Isoform 3 (identifier: Q13576-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-447: Missing.
         448-453: QEENDR → MGCFKG
         642-698: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,071
    Mass (Da):122,806
    Checksum:i1E59E4F49FB4D334
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951V → E in BAF83755. (PubMed:14702039)Curated
    Sequence conflicti778 – 7781N → S in BAF83755. (PubMed:14702039)Curated
    Sequence conflicti1101 – 11011G → R in BAF83755. (PubMed:14702039)Curated
    Sequence conflicti1333 – 13331V → L in BAH13890. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti455 – 4551V → A.
    Corresponds to variant rs7722711 [ dbSNP | Ensembl ].
    VAR_055823
    Natural varianti479 – 4791P → R.
    Corresponds to variant rs3822530 [ dbSNP | Ensembl ].
    VAR_055824
    Natural varianti527 – 5271D → E.3 Publications
    Corresponds to variant rs2431352 [ dbSNP | Ensembl ].
    VAR_062958
    Natural varianti532 – 5321K → E.3 Publications
    Corresponds to variant rs2909888 [ dbSNP | Ensembl ].
    VAR_059292
    Natural varianti629 – 6291L → F.3 Publications
    Corresponds to variant rs2455230 [ dbSNP | Ensembl ].
    VAR_062959
    Natural varianti714 – 7141R → W.
    Corresponds to variant rs35366349 [ dbSNP | Ensembl ].
    VAR_055825
    Natural varianti724 – 7241I → V.2 Publications
    Corresponds to variant rs2431363 [ dbSNP | Ensembl ].
    VAR_062960
    Natural varianti894 – 8941T → I.
    Corresponds to variant rs34950321 [ dbSNP | Ensembl ].
    VAR_055826
    Natural varianti1052 – 10521R → I.
    Corresponds to variant rs2287932 [ dbSNP | Ensembl ].
    VAR_055827
    Natural varianti1184 – 11841N → S.
    Corresponds to variant rs10454915 [ dbSNP | Ensembl ].
    VAR_055828
    Natural varianti1379 – 13791R → W.
    Corresponds to variant rs17681908 [ dbSNP | Ensembl ].
    VAR_055829
    Natural varianti1445 – 14451Y → C.1 Publication
    VAR_069434
    Natural varianti1530 – 15301M → I.1 Publication
    VAR_069435

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 447447Missing in isoform 2 and isoform 3. 2 PublicationsVSP_010629Add
    BLAST
    Alternative sequencei448 – 4536QEENDR → MHSLPG in isoform 2. 1 PublicationVSP_010630
    Alternative sequencei448 – 4536QEENDR → MGCFKG in isoform 3. 1 PublicationVSP_055149
    Alternative sequencei642 – 69857Missing in isoform 2 and isoform 3. 2 PublicationsVSP_010631Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51903 mRNA. Translation: AAB37765.1.
    AY351902 mRNA. Translation: AAQ81291.1.
    AK291066 mRNA. Translation: BAF83755.1.
    AK303054 mRNA. Translation: BAH13890.1.
    AC025188 Genomic DNA. No translation available.
    AC026706 Genomic DNA. No translation available.
    AC026725 Genomic DNA. No translation available.
    AC093251 Genomic DNA. No translation available.
    AC112173 Genomic DNA. No translation available.
    CCDSiCCDS34188.1. [Q13576-1]
    CCDS68897.1. [Q13576-2]
    CCDS68898.1. [Q13576-3]
    RefSeqiNP_001272389.1. NM_001285460.1.
    NP_001272390.1. NM_001285461.1.
    NP_001272391.1. NM_001285462.1.
    NP_006624.2. NM_006633.3.
    UniGeneiHs.291030.

    Genome annotation databases

    EnsembliENST00000274364; ENSP00000274364; ENSG00000145703. [Q13576-1]
    ENST00000396234; ENSP00000379535; ENSG00000145703. [Q13576-2]
    ENST00000502745; ENSP00000426027; ENSG00000145703. [Q13576-3]
    GeneIDi10788.
    KEGGihsa:10788.
    UCSCiuc003kek.3. human. [Q13576-1]
    uc003kel.3. human. [Q13576-2]

    Polymorphism databases

    DMDMi292495090.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51903 mRNA. Translation: AAB37765.1 .
    AY351902 mRNA. Translation: AAQ81291.1 .
    AK291066 mRNA. Translation: BAF83755.1 .
    AK303054 mRNA. Translation: BAH13890.1 .
    AC025188 Genomic DNA. No translation available.
    AC026706 Genomic DNA. No translation available.
    AC026725 Genomic DNA. No translation available.
    AC093251 Genomic DNA. No translation available.
    AC112173 Genomic DNA. No translation available.
    CCDSi CCDS34188.1. [Q13576-1 ]
    CCDS68897.1. [Q13576-2 ]
    CCDS68898.1. [Q13576-3 ]
    RefSeqi NP_001272389.1. NM_001285460.1.
    NP_001272390.1. NM_001285461.1.
    NP_001272391.1. NM_001285462.1.
    NP_006624.2. NM_006633.3.
    UniGenei Hs.291030.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IEZ X-ray 1.50 A/B 1476-1571 [» ]
    4EZA X-ray 1.50 A/B 1476-1571 [» ]
    ProteinModelPortali Q13576.
    SMRi Q13576. Positions 23-207, 875-1252, 1477-1571.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116004. 10 interactions.
    DIPi DIP-27542N.
    IntActi Q13576. 15 interactions.
    MINTi MINT-5004527.
    STRINGi 9606.ENSP00000274364.

    PTM databases

    PhosphoSitei Q13576.

    Polymorphism databases

    DMDMi 292495090.

    2D gel databases

    OGPi Q13576.

    Proteomic databases

    MaxQBi Q13576.
    PaxDbi Q13576.
    PRIDEi Q13576.

    Protocols and materials databases

    DNASUi 10788.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274364 ; ENSP00000274364 ; ENSG00000145703 . [Q13576-1 ]
    ENST00000396234 ; ENSP00000379535 ; ENSG00000145703 . [Q13576-2 ]
    ENST00000502745 ; ENSP00000426027 ; ENSG00000145703 . [Q13576-3 ]
    GeneIDi 10788.
    KEGGi hsa:10788.
    UCSCi uc003kek.3. human. [Q13576-1 ]
    uc003kel.3. human. [Q13576-2 ]

    Organism-specific databases

    CTDi 10788.
    GeneCardsi GC05P075699.
    HGNCi HGNC:6111. IQGAP2.
    HPAi CAB004241.
    HPA037404.
    MIMi 605401. gene.
    neXtProti NX_Q13576.
    PharmGKBi PA29911.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5261.
    HOGENOMi HOG000004842.
    HOVERGENi HBG052143.
    InParanoidi Q13576.
    KOi K05767.
    OMAi MEKVQLH.
    OrthoDBi EOG7FNC6M.
    PhylomeDBi Q13576.
    TreeFami TF313078.

    Miscellaneous databases

    EvolutionaryTracei Q13576.
    GeneWikii IQGAP2.
    NextBioi 35535510.
    PROi Q13576.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13576.
    Bgeei Q13576.
    CleanExi HS_IQGAP2.
    Genevestigatori Q13576.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    1.10.506.10. 2 hits.
    InterProi IPR001715. CH-domain.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001936. RasGAP.
    IPR000593. RasGAP_C.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00307. CH. 1 hit.
    PF00612. IQ. 2 hits.
    PF00616. RasGAP. 1 hit.
    PF03836. RasGAP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00033. CH. 1 hit.
    SM00015. IQ. 3 hits.
    SM00323. RasGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    SSF48350. SSF48350. 2 hits.
    PROSITEi PS50021. CH. 1 hit.
    PS50096. IQ. 3 hits.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases."
      Brill S., Li S., Lyman C.W., Church D.M., Wasmuth J.J., Weissbach L., Bernards A., Snijders A.J.
      Mol. Cell. Biol. 16:4869-4878(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
      Tissue: Liver.
    2. "Cloning and characterization of a novel isoform of IQGAP2 in human adult testis."
      Wang H., Huo R., Xu Z.Y., Xu M., Li J.M., Zhou Z.M., Sha J.H.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS GLU-527 AND GLU-532.
      Tissue: Teratocarcinoma and Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-13 (ISOFORM 1).
      Tissue: Platelet.
    6. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-629, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: VARIANTS CYS-1445 AND ILE-1530.

    Entry informationi

    Entry nameiIQGA2_HUMAN
    AccessioniPrimary (citable) accession number: Q13576
    Secondary accession number(s): A8K4V1, B7Z8A4, J3KR91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 140 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3