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Protein

Ras GTPase-activating-like protein IQGAP2

Gene

IQGAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

GO - Molecular functioni

  • actin binding Source: ProtInc
  • actin filament binding Source: UniProtKB
  • Arp2/3 complex binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB
  • GTPase inhibitor activity Source: ProtInc
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • Rac GTPase binding Source: UniProtKB
  • Rho GTPase binding Source: UniProtKB

GO - Biological processi

  • Arp2/3 complex-mediated actin nucleation Source: UniProtKB
  • signal transduction Source: ProtInc
  • thrombin-activated receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145703-MONOMER.
ReactomeiR-HSA-5626467. RHO GTPases activate IQGAPs.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating-like protein IQGAP2
Gene namesi
Name:IQGAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6111. IQGAP2.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: ProtInc
  • cell surface Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • filopodium Source: UniProtKB
  • lamellipodium Source: UniProtKB
  • microtubule Source: UniProtKB
  • microvillus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi10788.
OpenTargetsiENSG00000145703.
PharmGKBiPA29911.

Polymorphism and mutation databases

BioMutaiIQGAP2.
DMDMi292495090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566501 – 1575Ras GTPase-activating-like protein IQGAP2Add BLAST1575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei356PhosphothreonineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei716PhosphothreonineCombined sources1
Modified residuei782PhosphothreonineCombined sources1
Modified residuei881PhosphothreonineBy similarity1
Modified residuei1002PhosphothreonineCombined sources1
Modified residuei1269PhosphothreonineCombined sources1
Modified residuei1271PhosphoserineCombined sources1
Modified residuei1279PhosphoserineCombined sources1
Modified residuei1358PhosphoserineCombined sources1
Modified residuei1461PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13576.
MaxQBiQ13576.
PaxDbiQ13576.
PeptideAtlasiQ13576.
PRIDEiQ13576.

2D gel databases

OGPiQ13576.

PTM databases

iPTMnetiQ13576.
PhosphoSitePlusiQ13576.

Expressioni

Tissue specificityi

Isoform 2 expression is enhanced in testis.

Gene expression databases

BgeeiENSG00000145703.
CleanExiHS_IQGAP2.
ExpressionAtlasiQ13576. baseline and differential.
GenevisibleiQ13576. HS.

Organism-specific databases

HPAiCAB004241.
HPA037403.
HPA037404.

Interactioni

GO - Molecular functioni

  • actin binding Source: ProtInc
  • actin filament binding Source: UniProtKB
  • Arp2/3 complex binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB
  • Rac GTPase binding Source: UniProtKB
  • Rho GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116004. 18 interactors.
DIPiDIP-27542N.
IntActiQ13576. 18 interactors.
MINTiMINT-5004527.
STRINGi9606.ENSP00000274364.

Structurei

Secondary structure

11575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi878 – 894Combined sources17
Helixi896 – 905Combined sources10
Helixi908 – 911Combined sources4
Turni912 – 914Combined sources3
Helixi915 – 925Combined sources11
Helixi929 – 950Combined sources22
Beta strandi952 – 955Combined sources4
Helixi956 – 959Combined sources4
Helixi963 – 973Combined sources11
Beta strandi974 – 977Combined sources4
Helixi982 – 994Combined sources13
Helixi1004 – 1010Combined sources7
Helixi1012 – 1015Combined sources4
Helixi1016 – 1018Combined sources3
Helixi1031 – 1034Combined sources4
Helixi1038 – 1064Combined sources27
Helixi1065 – 1068Combined sources4
Helixi1071 – 1087Combined sources17
Helixi1093 – 1104Combined sources12
Helixi1105 – 1109Combined sources5
Helixi1110 – 1114Combined sources5
Turni1116 – 1120Combined sources5
Helixi1132 – 1149Combined sources18
Helixi1159 – 1164Combined sources6
Helixi1165 – 1182Combined sources18
Helixi1188 – 1191Combined sources4
Turni1192 – 1194Combined sources3
Helixi1195 – 1198Combined sources4
Beta strandi1208 – 1214Combined sources7
Helixi1223 – 1225Combined sources3
Helixi1226 – 1229Combined sources4
Helixi1232 – 1243Combined sources12
Beta strandi1479 – 1482Combined sources4
Helixi1483 – 1488Combined sources6
Beta strandi1491 – 1495Combined sources5
Helixi1500 – 1505Combined sources6
Beta strandi1506 – 1512Combined sources7
Beta strandi1518 – 1525Combined sources8
Beta strandi1528 – 1536Combined sources9
Helixi1537 – 1545Combined sources9
Beta strandi1550 – 1554Combined sources5
Beta strandi1557 – 1560Combined sources4
Helixi1561 – 1569Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IEZX-ray1.50A/B1476-1571[»]
4EZAX-ray1.50A/B1476-1571[»]
5CJPX-ray2.60E/F875-1258[»]
ProteinModelPortaliQ13576.
SMRiQ13576.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13576.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 156CHPROSITE-ProRule annotationAdd BLAST116
Domaini594 – 627WWPROSITE-ProRule annotationAdd BLAST34
Domaini690 – 719IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini720 – 749IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini750 – 779IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini917 – 1150Ras-GAPPROSITE-ProRule annotationAdd BLAST234

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi263 – 266Poly-Lys4

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 3 IQ domains.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2128. Eukaryota.
COG5261. LUCA.
GeneTreeiENSGT00600000084379.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiQ13576.
KOiK05767.
OMAiKGGEMQI.
OrthoDBiEOG091G00ET.
PhylomeDBiQ13576.
TreeFamiTF313078.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW
60 70 80 90 100
MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY
110 120 130 140 150
KKSGLHFRHT DNTVQWLRAM ESIGLPKIFY PETTDVYDRK NIPRMIYCIH
160 170 180 190 200
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPSFSKIG
210 220 230 240 250
GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP NAVLTLVDDN
260 270 280 290 300
LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK
310 320 330 340 350
VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN
360 370 380 390 400
LQKQNTMNYL AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG
410 420 430 440 450
LNNLDKAYVE RYANTLLSVK LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE
460 470 480 490 500
NDRVVAVGYI NEAIDEGNPL RTLETLLLPT ANISDVDPAH AQHYQDVLYH
510 520 530 540 550
AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT LVVDVNQCLE
560 570 580 590 600
GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW
610 620 630 640 650
LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG
660 670 680 690 700
YIRENIWSAS EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF
710 720 730 740 750
WKGYKQRKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH
760 770 780 790 800
NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE
810 820 830 840 850
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHSK
860 870 880 890 900
KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA
910 920 930 940 950
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK
960 970 980 990 1000
VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII
1010 1020 1030 1040 1050
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN
1060 1070 1080 1090 1100
LRRVTDKVLN SIISSLDLLP YGLRYIAKVL KNSIHEKFPD ATEDELLKIV
1110 1120 1130 1140 1150
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS VAKVLQHAAS
1160 1170 1180 1190 1200
NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL
1210 1220 1230 1240 1250
VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV
1260 1270 1280 1290 1300
ESFLGEGAVD PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM
1310 1320 1330 1340 1350
IKTKKLIIDV IRNQPGNTLT EILETPATAQ QEVDHATDMV SRAMIDSRTP
1360 1370 1380 1390 1400
EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT LEQTGHVSSE NKYQDILNEI
1410 1420 1430 1440 1450
AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN YYDTYIKTCL
1460 1470 1480 1490 1500
DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT
1510 1520 1530 1540 1550
NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV
1560 1570
MKMFDKVKVN VNLLIYLLNK KFYGK
Length:1,575
Mass (Da):180,578
Last modified:March 23, 2010 - v4
Checksum:iBCC8CED6645CB09B
GO
Isoform 2 (identifier: Q13576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MHSLPG
     642-698: Missing.

Show »
Length:1,071
Mass (Da):122,805
Checksum:i111C704267532C91
GO
Isoform 3 (identifier: Q13576-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MGCFKG
     642-698: Missing.

Note: No experimental confirmation available.
Show »
Length:1,071
Mass (Da):122,806
Checksum:i1E59E4F49FB4D334
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95V → E in BAF83755 (PubMed:14702039).Curated1
Sequence conflicti778N → S in BAF83755 (PubMed:14702039).Curated1
Sequence conflicti1101G → R in BAF83755 (PubMed:14702039).Curated1
Sequence conflicti1333V → L in BAH13890 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055823455V → A.Corresponds to variant rs7722711dbSNPEnsembl.1
Natural variantiVAR_055824479P → R.Corresponds to variant rs3822530dbSNPEnsembl.1
Natural variantiVAR_062958527D → E.3 PublicationsCorresponds to variant rs2431352dbSNPEnsembl.1
Natural variantiVAR_059292532K → E.3 PublicationsCorresponds to variant rs2909888dbSNPEnsembl.1
Natural variantiVAR_062959629L → F.Combined sources2 PublicationsCorresponds to variant rs2455230dbSNPEnsembl.1
Natural variantiVAR_055825714R → W.Corresponds to variant rs35366349dbSNPEnsembl.1
Natural variantiVAR_062960724I → V.2 PublicationsCorresponds to variant rs2431363dbSNPEnsembl.1
Natural variantiVAR_055826894T → I.Corresponds to variant rs34950321dbSNPEnsembl.1
Natural variantiVAR_0558271052R → I.Corresponds to variant rs2287932dbSNPEnsembl.1
Natural variantiVAR_0558281184N → S.Corresponds to variant rs10454915dbSNPEnsembl.1
Natural variantiVAR_0558291379R → W.Corresponds to variant rs17681908dbSNPEnsembl.1
Natural variantiVAR_0694341445Y → C.1 PublicationCorresponds to variant rs369078465dbSNPEnsembl.1
Natural variantiVAR_0694351530M → I.1 PublicationCorresponds to variant rs150409607dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0106291 – 447Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST447
Alternative sequenceiVSP_010630448 – 453QEENDR → MHSLPG in isoform 2. 1 Publication6
Alternative sequenceiVSP_055149448 – 453QEENDR → MGCFKG in isoform 3. 1 Publication6
Alternative sequenceiVSP_010631642 – 698Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51903 mRNA. Translation: AAB37765.1.
AY351902 mRNA. Translation: AAQ81291.1.
AK291066 mRNA. Translation: BAF83755.1.
AK303054 mRNA. Translation: BAH13890.1.
AC025188 Genomic DNA. No translation available.
AC026706 Genomic DNA. No translation available.
AC026725 Genomic DNA. No translation available.
AC093251 Genomic DNA. No translation available.
AC112173 Genomic DNA. No translation available.
CCDSiCCDS34188.1. [Q13576-1]
CCDS68897.1. [Q13576-2]
CCDS68898.1. [Q13576-3]
RefSeqiNP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_001272391.1. NM_001285462.1.
NP_006624.2. NM_006633.3.
UniGeneiHs.291030.

Genome annotation databases

EnsembliENST00000274364; ENSP00000274364; ENSG00000145703. [Q13576-1]
ENST00000396234; ENSP00000379535; ENSG00000145703. [Q13576-2]
ENST00000502745; ENSP00000426027; ENSG00000145703. [Q13576-3]
GeneIDi10788.
KEGGihsa:10788.
UCSCiuc003kek.5. human. [Q13576-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51903 mRNA. Translation: AAB37765.1.
AY351902 mRNA. Translation: AAQ81291.1.
AK291066 mRNA. Translation: BAF83755.1.
AK303054 mRNA. Translation: BAH13890.1.
AC025188 Genomic DNA. No translation available.
AC026706 Genomic DNA. No translation available.
AC026725 Genomic DNA. No translation available.
AC093251 Genomic DNA. No translation available.
AC112173 Genomic DNA. No translation available.
CCDSiCCDS34188.1. [Q13576-1]
CCDS68897.1. [Q13576-2]
CCDS68898.1. [Q13576-3]
RefSeqiNP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_001272391.1. NM_001285462.1.
NP_006624.2. NM_006633.3.
UniGeneiHs.291030.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IEZX-ray1.50A/B1476-1571[»]
4EZAX-ray1.50A/B1476-1571[»]
5CJPX-ray2.60E/F875-1258[»]
ProteinModelPortaliQ13576.
SMRiQ13576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116004. 18 interactors.
DIPiDIP-27542N.
IntActiQ13576. 18 interactors.
MINTiMINT-5004527.
STRINGi9606.ENSP00000274364.

PTM databases

iPTMnetiQ13576.
PhosphoSitePlusiQ13576.

Polymorphism and mutation databases

BioMutaiIQGAP2.
DMDMi292495090.

2D gel databases

OGPiQ13576.

Proteomic databases

EPDiQ13576.
MaxQBiQ13576.
PaxDbiQ13576.
PeptideAtlasiQ13576.
PRIDEiQ13576.

Protocols and materials databases

DNASUi10788.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274364; ENSP00000274364; ENSG00000145703. [Q13576-1]
ENST00000396234; ENSP00000379535; ENSG00000145703. [Q13576-2]
ENST00000502745; ENSP00000426027; ENSG00000145703. [Q13576-3]
GeneIDi10788.
KEGGihsa:10788.
UCSCiuc003kek.5. human. [Q13576-1]

Organism-specific databases

CTDi10788.
DisGeNETi10788.
GeneCardsiIQGAP2.
HGNCiHGNC:6111. IQGAP2.
HPAiCAB004241.
HPA037403.
HPA037404.
MIMi605401. gene.
neXtProtiNX_Q13576.
OpenTargetsiENSG00000145703.
PharmGKBiPA29911.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2128. Eukaryota.
COG5261. LUCA.
GeneTreeiENSGT00600000084379.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiQ13576.
KOiK05767.
OMAiKGGEMQI.
OrthoDBiEOG091G00ET.
PhylomeDBiQ13576.
TreeFamiTF313078.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145703-MONOMER.
ReactomeiR-HSA-5626467. RHO GTPases activate IQGAPs.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiIQGAP2. human.
EvolutionaryTraceiQ13576.
GeneWikiiIQGAP2.
GenomeRNAii10788.
PROiQ13576.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145703.
CleanExiHS_IQGAP2.
ExpressionAtlasiQ13576. baseline and differential.
GenevisibleiQ13576. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIQGA2_HUMAN
AccessioniPrimary (citable) accession number: Q13576
Secondary accession number(s): A8K4V1, B7Z8A4, J3KR91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 23, 2010
Last modified: November 30, 2016
This is version 162 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.