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Q13576

- IQGA2_HUMAN

UniProt

Q13576 - IQGA2_HUMAN

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Protein

Ras GTPase-activating-like protein IQGAP2

Gene

IQGAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

GO - Molecular functioni

  1. actin binding Source: ProtInc
  2. GTPase inhibitor activity Source: ProtInc
  3. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  4. Ras GTPase activator activity Source: InterPro

GO - Biological processi

  1. negative regulation of catalytic activity Source: GOC
  2. signal transduction Source: ProtInc
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating-like protein IQGAP2
Gene namesi
Name:IQGAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6111. IQGAP2.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: ProtInc
  2. extracellular vesicular exosome Source: UniProt
  3. microtubule Source: UniProtKB
  4. microvillus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 15751574Ras GTPase-activating-like protein IQGAP2PRO_0000056650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13576.
PaxDbiQ13576.
PRIDEiQ13576.

2D gel databases

OGPiQ13576.

PTM databases

PhosphoSiteiQ13576.

Expressioni

Tissue specificityi

Isoform 2 expression is enhanced in testis.

Gene expression databases

BgeeiQ13576.
CleanExiHS_IQGAP2.
ExpressionAtlasiQ13576. baseline and differential.
GenevestigatoriQ13576.

Organism-specific databases

HPAiCAB004241.
HPA037404.

Interactioni

Protein-protein interaction databases

BioGridi116004. 15 interactions.
DIPiDIP-27542N.
IntActiQ13576. 15 interactions.
MINTiMINT-5004527.
STRINGi9606.ENSP00000274364.

Structurei

Secondary structure

1
1575
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1479 – 14824Combined sources
Helixi1483 – 14886Combined sources
Beta strandi1491 – 14955Combined sources
Helixi1500 – 15056Combined sources
Beta strandi1506 – 15127Combined sources
Beta strandi1518 – 15258Combined sources
Beta strandi1528 – 15369Combined sources
Helixi1537 – 15459Combined sources
Beta strandi1550 – 15545Combined sources
Beta strandi1557 – 15604Combined sources
Helixi1561 – 15699Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IEZX-ray1.50A/B1476-1571[»]
4EZAX-ray1.50A/B1476-1571[»]
ProteinModelPortaliQ13576.
SMRiQ13576. Positions 23-207, 875-1252, 1477-1571.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13576.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 156116CHPROSITE-ProRule annotationAdd
BLAST
Domaini594 – 62734WWPROSITE-ProRule annotationAdd
BLAST
Domaini690 – 71930IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini720 – 74930IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini750 – 77930IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini917 – 1150234Ras-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi263 – 2664Poly-Lys

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 3 IQ domains.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5261.
GeneTreeiENSGT00600000084379.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiQ13576.
KOiK05767.
OMAiMEKVQLH.
OrthoDBiEOG7FNC6M.
PhylomeDBiQ13576.
TreeFamiTF313078.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13576-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW
60 70 80 90 100
MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY
110 120 130 140 150
KKSGLHFRHT DNTVQWLRAM ESIGLPKIFY PETTDVYDRK NIPRMIYCIH
160 170 180 190 200
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPSFSKIG
210 220 230 240 250
GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP NAVLTLVDDN
260 270 280 290 300
LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK
310 320 330 340 350
VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN
360 370 380 390 400
LQKQNTMNYL AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG
410 420 430 440 450
LNNLDKAYVE RYANTLLSVK LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE
460 470 480 490 500
NDRVVAVGYI NEAIDEGNPL RTLETLLLPT ANISDVDPAH AQHYQDVLYH
510 520 530 540 550
AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT LVVDVNQCLE
560 570 580 590 600
GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW
610 620 630 640 650
LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG
660 670 680 690 700
YIRENIWSAS EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF
710 720 730 740 750
WKGYKQRKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH
760 770 780 790 800
NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE
810 820 830 840 850
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHSK
860 870 880 890 900
KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA
910 920 930 940 950
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK
960 970 980 990 1000
VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII
1010 1020 1030 1040 1050
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN
1060 1070 1080 1090 1100
LRRVTDKVLN SIISSLDLLP YGLRYIAKVL KNSIHEKFPD ATEDELLKIV
1110 1120 1130 1140 1150
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS VAKVLQHAAS
1160 1170 1180 1190 1200
NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL
1210 1220 1230 1240 1250
VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV
1260 1270 1280 1290 1300
ESFLGEGAVD PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM
1310 1320 1330 1340 1350
IKTKKLIIDV IRNQPGNTLT EILETPATAQ QEVDHATDMV SRAMIDSRTP
1360 1370 1380 1390 1400
EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT LEQTGHVSSE NKYQDILNEI
1410 1420 1430 1440 1450
AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN YYDTYIKTCL
1460 1470 1480 1490 1500
DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT
1510 1520 1530 1540 1550
NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV
1560 1570
MKMFDKVKVN VNLLIYLLNK KFYGK
Length:1,575
Mass (Da):180,578
Last modified:March 23, 2010 - v4
Checksum:iBCC8CED6645CB09B
GO
Isoform 2 (identifier: Q13576-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MHSLPG
     642-698: Missing.

Show »
Length:1,071
Mass (Da):122,805
Checksum:i111C704267532C91
GO
Isoform 3 (identifier: Q13576-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MGCFKG
     642-698: Missing.

Note: No experimental confirmation available.

Show »
Length:1,071
Mass (Da):122,806
Checksum:i1E59E4F49FB4D334
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951V → E in BAF83755. (PubMed:14702039)Curated
Sequence conflicti778 – 7781N → S in BAF83755. (PubMed:14702039)Curated
Sequence conflicti1101 – 11011G → R in BAF83755. (PubMed:14702039)Curated
Sequence conflicti1333 – 13331V → L in BAH13890. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti455 – 4551V → A.
Corresponds to variant rs7722711 [ dbSNP | Ensembl ].
VAR_055823
Natural varianti479 – 4791P → R.
Corresponds to variant rs3822530 [ dbSNP | Ensembl ].
VAR_055824
Natural varianti527 – 5271D → E.3 Publications
Corresponds to variant rs2431352 [ dbSNP | Ensembl ].
VAR_062958
Natural varianti532 – 5321K → E.3 Publications
Corresponds to variant rs2909888 [ dbSNP | Ensembl ].
VAR_059292
Natural varianti629 – 6291L → F.3 Publications
Corresponds to variant rs2455230 [ dbSNP | Ensembl ].
VAR_062959
Natural varianti714 – 7141R → W.
Corresponds to variant rs35366349 [ dbSNP | Ensembl ].
VAR_055825
Natural varianti724 – 7241I → V.2 Publications
Corresponds to variant rs2431363 [ dbSNP | Ensembl ].
VAR_062960
Natural varianti894 – 8941T → I.
Corresponds to variant rs34950321 [ dbSNP | Ensembl ].
VAR_055826
Natural varianti1052 – 10521R → I.
Corresponds to variant rs2287932 [ dbSNP | Ensembl ].
VAR_055827
Natural varianti1184 – 11841N → S.
Corresponds to variant rs10454915 [ dbSNP | Ensembl ].
VAR_055828
Natural varianti1379 – 13791R → W.
Corresponds to variant rs17681908 [ dbSNP | Ensembl ].
VAR_055829
Natural varianti1445 – 14451Y → C.1 Publication
VAR_069434
Natural varianti1530 – 15301M → I.1 Publication
VAR_069435

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 447447Missing in isoform 2 and isoform 3. 2 PublicationsVSP_010629Add
BLAST
Alternative sequencei448 – 4536QEENDR → MHSLPG in isoform 2. 1 PublicationVSP_010630
Alternative sequencei448 – 4536QEENDR → MGCFKG in isoform 3. 1 PublicationVSP_055149
Alternative sequencei642 – 69857Missing in isoform 2 and isoform 3. 2 PublicationsVSP_010631Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51903 mRNA. Translation: AAB37765.1.
AY351902 mRNA. Translation: AAQ81291.1.
AK291066 mRNA. Translation: BAF83755.1.
AK303054 mRNA. Translation: BAH13890.1.
AC025188 Genomic DNA. No translation available.
AC026706 Genomic DNA. No translation available.
AC026725 Genomic DNA. No translation available.
AC093251 Genomic DNA. No translation available.
AC112173 Genomic DNA. No translation available.
CCDSiCCDS34188.1. [Q13576-1]
CCDS68897.1. [Q13576-2]
CCDS68898.1. [Q13576-3]
RefSeqiNP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_001272391.1. NM_001285462.1.
NP_006624.2. NM_006633.3.
UniGeneiHs.291030.

Genome annotation databases

EnsembliENST00000274364; ENSP00000274364; ENSG00000145703. [Q13576-1]
ENST00000396234; ENSP00000379535; ENSG00000145703. [Q13576-2]
ENST00000502745; ENSP00000426027; ENSG00000145703. [Q13576-3]
GeneIDi10788.
KEGGihsa:10788.
UCSCiuc003kek.3. human. [Q13576-1]
uc003kel.3. human. [Q13576-2]

Polymorphism databases

DMDMi292495090.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51903 mRNA. Translation: AAB37765.1 .
AY351902 mRNA. Translation: AAQ81291.1 .
AK291066 mRNA. Translation: BAF83755.1 .
AK303054 mRNA. Translation: BAH13890.1 .
AC025188 Genomic DNA. No translation available.
AC026706 Genomic DNA. No translation available.
AC026725 Genomic DNA. No translation available.
AC093251 Genomic DNA. No translation available.
AC112173 Genomic DNA. No translation available.
CCDSi CCDS34188.1. [Q13576-1 ]
CCDS68897.1. [Q13576-2 ]
CCDS68898.1. [Q13576-3 ]
RefSeqi NP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_001272391.1. NM_001285462.1.
NP_006624.2. NM_006633.3.
UniGenei Hs.291030.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IEZ X-ray 1.50 A/B 1476-1571 [» ]
4EZA X-ray 1.50 A/B 1476-1571 [» ]
ProteinModelPortali Q13576.
SMRi Q13576. Positions 23-207, 875-1252, 1477-1571.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116004. 15 interactions.
DIPi DIP-27542N.
IntActi Q13576. 15 interactions.
MINTi MINT-5004527.
STRINGi 9606.ENSP00000274364.

PTM databases

PhosphoSitei Q13576.

Polymorphism databases

DMDMi 292495090.

2D gel databases

OGPi Q13576.

Proteomic databases

MaxQBi Q13576.
PaxDbi Q13576.
PRIDEi Q13576.

Protocols and materials databases

DNASUi 10788.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274364 ; ENSP00000274364 ; ENSG00000145703 . [Q13576-1 ]
ENST00000396234 ; ENSP00000379535 ; ENSG00000145703 . [Q13576-2 ]
ENST00000502745 ; ENSP00000426027 ; ENSG00000145703 . [Q13576-3 ]
GeneIDi 10788.
KEGGi hsa:10788.
UCSCi uc003kek.3. human. [Q13576-1 ]
uc003kel.3. human. [Q13576-2 ]

Organism-specific databases

CTDi 10788.
GeneCardsi GC05P075699.
HGNCi HGNC:6111. IQGAP2.
HPAi CAB004241.
HPA037404.
MIMi 605401. gene.
neXtProti NX_Q13576.
PharmGKBi PA29911.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5261.
GeneTreei ENSGT00600000084379.
HOGENOMi HOG000004842.
HOVERGENi HBG052143.
InParanoidi Q13576.
KOi K05767.
OMAi MEKVQLH.
OrthoDBi EOG7FNC6M.
PhylomeDBi Q13576.
TreeFami TF313078.

Miscellaneous databases

ChiTaRSi IQGAP2. human.
EvolutionaryTracei Q13576.
GeneWikii IQGAP2.
GenomeRNAii 10788.
NextBioi 35535510.
PROi Q13576.
SOURCEi Search...

Gene expression databases

Bgeei Q13576.
CleanExi HS_IQGAP2.
ExpressionAtlasi Q13576. baseline and differential.
Genevestigatori Q13576.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProi IPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view ]
SMARTi SM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEi PS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases."
    Brill S., Li S., Lyman C.W., Church D.M., Wasmuth J.J., Weissbach L., Bernards A., Snijders A.J.
    Mol. Cell. Biol. 16:4869-4878(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
    Tissue: Liver.
  2. "Cloning and characterization of a novel isoform of IQGAP2 in human adult testis."
    Wang H., Huo R., Xu Z.Y., Xu M., Li J.M., Zhou Z.M., Sha J.H.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS GLU-527 AND GLU-532.
    Tissue: Teratocarcinoma and Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-13 (ISOFORM 1).
    Tissue: Platelet.
  6. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-629, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: VARIANTS CYS-1445 AND ILE-1530.

Entry informationi

Entry nameiIQGA2_HUMAN
AccessioniPrimary (citable) accession number: Q13576
Secondary accession number(s): A8K4V1, B7Z8A4, J3KR91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3