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Q13576 (IQGA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras GTPase-activating-like protein IQGAP2
Gene names
Name:IQGAP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1575 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Tissue specificity

Isoform 2 expression is enhanced in testis.

Sequence similarities

Contains 1 CH (calponin-homology) domain.

Contains 3 IQ domains.

Contains 1 Ras-GAP domain.

Contains 1 WW domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q13576-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q13576-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MHSLPG
     642-698: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 15751574Ras GTPase-activating-like protein IQGAP2
PRO_0000056650

Regions

Domain41 – 156116CH
Domain594 – 62734WW
Domain690 – 71930IQ 1
Domain720 – 74930IQ 2
Domain750 – 77930IQ 3
Domain917 – 1150234Ras-GAP
Compositional bias263 – 2664Poly-Lys

Amino acid modifications

Modified residue161Phosphoserine Ref.7 Ref.8

Natural variations

Alternative sequence1 – 447447Missing in isoform 2.
VSP_010629
Alternative sequence448 – 4536QEENDR → MHSLPG in isoform 2.
VSP_010630
Alternative sequence642 – 69857Missing in isoform 2.
VSP_010631
Natural variant4551V → A.
Corresponds to variant rs7722711 [ dbSNP | Ensembl ].
VAR_055823
Natural variant4791P → R.
Corresponds to variant rs3822530 [ dbSNP | Ensembl ].
VAR_055824
Natural variant5271D → E. Ref.1 Ref.2 Ref.3
Corresponds to variant rs2431352 [ dbSNP | Ensembl ].
VAR_062958
Natural variant5321K → E. Ref.1 Ref.2 Ref.3
Corresponds to variant rs2909888 [ dbSNP | Ensembl ].
VAR_059292
Natural variant6291L → F. Ref.1 Ref.2 Ref.9
Corresponds to variant rs2455230 [ dbSNP | Ensembl ].
VAR_062959
Natural variant7141R → W.
Corresponds to variant rs35366349 [ dbSNP | Ensembl ].
VAR_055825
Natural variant7241I → V. Ref.1 Ref.2
Corresponds to variant rs2431363 [ dbSNP | Ensembl ].
VAR_062960
Natural variant8941T → I.
Corresponds to variant rs34950321 [ dbSNP | Ensembl ].
VAR_055826
Natural variant10521R → I.
Corresponds to variant rs2287932 [ dbSNP | Ensembl ].
VAR_055827
Natural variant11841N → S.
Corresponds to variant rs10454915 [ dbSNP | Ensembl ].
VAR_055828
Natural variant13791R → W.
Corresponds to variant rs17681908 [ dbSNP | Ensembl ].
VAR_055829
Natural variant14451Y → C. Ref.10
VAR_069434
Natural variant15301M → I. Ref.10
VAR_069435

Experimental info

Sequence conflict951V → E in BAF83755. Ref.3
Sequence conflict7781N → S in BAF83755. Ref.3
Sequence conflict11011G → R in BAF83755. Ref.3
Sequence conflict13331V → L in BAH13890. Ref.3

Secondary structure

................... 1575
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 23, 2010. Version 4.
Checksum: BCC8CED6645CB09B

FASTA1,575180,578
        10         20         30         40         50         60 
MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEVCLVEELP 

        70         80         90        100        110        120 
PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY KKSGLHFRHT DNTVQWLRAM 

       130        140        150        160        170        180 
ESIGLPKIFY PETTDVYDRK NIPRMIYCIH ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS 

       190        200        210        220        230        240 
NMRKELEKYG IQMPSFSKIG GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP 

       250        260        270        280        290        300 
NAVLTLVDDN LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK 

       310        320        330        340        350        360 
VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN LQKQNTMNYL 

       370        380        390        400        410        420 
AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG LNNLDKAYVE RYANTLLSVK 

       430        440        450        460        470        480 
LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE NDRVVAVGYI NEAIDEGNPL RTLETLLLPT 

       490        500        510        520        530        540 
ANISDVDPAH AQHYQDVLYH AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT 

       550        560        570        580        590        600 
LVVDVNQCLE GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW 

       610        620        630        640        650        660 
LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG YIRENIWSAS 

       670        680        690        700        710        720 
EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF WKGYKQRKEY MHRRQTFIDN 

       730        740        750        760        770        780 
TDSIVKIQSW FRMATARKSY LSRLQYFRDH NNEIVKIQSL LRANKARDDY KTLVGSENPP 

       790        800        810        820        830        840 
LTVIRKFVYL LDQSDLDFQE ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI 

       850        860        870        880        890        900 
TLEDVISHSK KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA 

       910        920        930        940        950        960 
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK VDQVQDIVTG 

       970        980        990       1000       1010       1020 
NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII NTNPVEVYKA WVNQLETQTG 

      1030       1040       1050       1060       1070       1080 
EASKLPYDVT TEQALTYPEV KNKLEASIEN LRRVTDKVLN SIISSLDLLP YGLRYIAKVL 

      1090       1100       1110       1120       1130       1140 
KNSIHEKFPD ATEDELLKIV GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS 

      1150       1160       1170       1180       1190       1200 
VAKVLQHAAS NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL 

      1210       1220       1230       1240       1250       1260 
VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV ESFLGEGAVD 

      1270       1280       1290       1300       1310       1320 
PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM IKTKKLIIDV IRNQPGNTLT 

      1330       1340       1350       1360       1370       1380 
EILETPATAQ QEVDHATDMV SRAMIDSRTP EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT 

      1390       1400       1410       1420       1430       1440 
LEQTGHVSSE NKYQDILNEI AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN 

      1450       1460       1470       1480       1490       1500 
YYDTYIKTCL DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT 

      1510       1520       1530       1540       1550       1560 
NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV MKMFDKVKVN 

      1570 
VNLLIYLLNK KFYGK 

« Hide

Isoform 2 [UniParc].

Checksum: 111C704267532C91
Show »

FASTA1,071122,805

References

« Hide 'large scale' references
[1]"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases."
Brill S., Li S., Lyman C.W., Church D.M., Wasmuth J.J., Weissbach L., Bernards A., Snijders A.J.
Mol. Cell. Biol. 16:4869-4878(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
Tissue: Liver.
[2]"Cloning and characterization of a novel isoform of IQGAP2 in human adult testis."
Wang H., Huo R., Xu Z.Y., Xu M., Li J.M., Zhou Z.M., Sha J.H.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLU-527 AND GLU-532.
Tissue: Teratocarcinoma and Testis.
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-13.
Tissue: Platelet.
[6]"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-629, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Diagnostic exome sequencing in persons with severe intellectual disability."
de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G., Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P., Gilissen C., del Rosario M., Hoischen A., Scheffer H., de Vries B.B., Brunner H.G., Veltman J.A., Vissers L.E.
N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS CYS-1445 AND ILE-1530.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U51903 mRNA. Translation: AAB37765.1.
AY351902 mRNA. Translation: AAQ81291.1.
AK291066 mRNA. Translation: BAF83755.1.
AK303054 mRNA. Translation: BAH13890.1.
AC025188 Genomic DNA. No translation available.
AC026706 Genomic DNA. No translation available.
AC026725 Genomic DNA. No translation available.
AC093251 Genomic DNA. No translation available.
AC112173 Genomic DNA. No translation available.
RefSeqNP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_001272391.1. NM_001285462.1.
NP_006624.2. NM_006633.3.
UniGeneHs.291030.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3IEZX-ray1.50A/B1476-1571[»]
4EZAX-ray1.50A/B1476-1571[»]
ProteinModelPortalQ13576.
SMRQ13576. Positions 23-207, 875-1252, 1477-1571.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116004. 10 interactions.
DIPDIP-27542N.
IntActQ13576. 14 interactions.
MINTMINT-5004527.
STRING9606.ENSP00000274364.

PTM databases

PhosphoSiteQ13576.

Polymorphism databases

DMDM292495090.

2D gel databases

OGPQ13576.

Proteomic databases

PaxDbQ13576.
PRIDEQ13576.

Protocols and materials databases

DNASU10788.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274364; ENSP00000274364; ENSG00000145703. [Q13576-1]
ENST00000396234; ENSP00000379535; ENSG00000145703. [Q13576-2]
GeneID10788.
KEGGhsa:10788.
UCSCuc003kek.3. human. [Q13576-1]
uc003kel.3. human. [Q13576-2]

Organism-specific databases

CTD10788.
GeneCardsGC05P075699.
HGNCHGNC:6111. IQGAP2.
HPACAB004241.
HPA037404.
MIM605401. gene.
neXtProtNX_Q13576.
PharmGKBPA29911.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5261.
HOGENOMHOG000004842.
HOVERGENHBG052143.
InParanoidQ13576.
KOK05767.
OMAMEKVQLH.
OrthoDBEOG7FNC6M.
PhylomeDBQ13576.
TreeFamTF313078.

Gene expression databases

ArrayExpressQ13576.
BgeeQ13576.
CleanExHS_IQGAP2.
GenevestigatorQ13576.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ13576.
GeneWikiIQGAP2.
NextBio40978.
PROQ13576.
SOURCESearch...

Entry information

Entry nameIQGA2_HUMAN
AccessionPrimary (citable) accession number: Q13576
Secondary accession number(s): A8K4V1, B7Z8A4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 23, 2010
Last modified: April 16, 2014
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM