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Q13576

- IQGA2_HUMAN

UniProt

Q13576 - IQGA2_HUMAN

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Protein
Ras GTPase-activating-like protein IQGAP2
Gene
IQGAP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

GO - Molecular functioni

  1. GTPase inhibitor activity Source: ProtInc
  2. Ras GTPase activator activity Source: InterPro
  3. actin binding Source: ProtInc
  4. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. negative regulation of catalytic activity Source: GOC
  2. signal transduction Source: ProtInc
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating-like protein IQGAP2
Gene namesi
Name:IQGAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6111. IQGAP2.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: ProtInc
  2. extracellular vesicular exosome Source: UniProt
  3. intracellular Source: InterPro
  4. microtubule Source: UniProtKB
  5. microvillus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 15751574Ras GTPase-activating-like protein IQGAP2
PRO_0000056650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13576.
PaxDbiQ13576.
PRIDEiQ13576.

2D gel databases

OGPiQ13576.

PTM databases

PhosphoSiteiQ13576.

Expressioni

Tissue specificityi

Isoform 2 expression is enhanced in testis.

Gene expression databases

ArrayExpressiQ13576.
BgeeiQ13576.
CleanExiHS_IQGAP2.
GenevestigatoriQ13576.

Organism-specific databases

HPAiCAB004241.
HPA037404.

Interactioni

Protein-protein interaction databases

BioGridi116004. 10 interactions.
DIPiDIP-27542N.
IntActiQ13576. 14 interactions.
MINTiMINT-5004527.
STRINGi9606.ENSP00000274364.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1479 – 14824
Helixi1483 – 14886
Beta strandi1491 – 14955
Helixi1500 – 15056
Beta strandi1506 – 15127
Beta strandi1518 – 15258
Beta strandi1528 – 15369
Helixi1537 – 15459
Beta strandi1550 – 15545
Beta strandi1557 – 15604
Helixi1561 – 15699

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IEZX-ray1.50A/B1476-1571[»]
4EZAX-ray1.50A/B1476-1571[»]
ProteinModelPortaliQ13576.
SMRiQ13576. Positions 23-207, 875-1252, 1477-1571.

Miscellaneous databases

EvolutionaryTraceiQ13576.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 156116CH
Add
BLAST
Domaini594 – 62734WW
Add
BLAST
Domaini690 – 71930IQ 1
Add
BLAST
Domaini720 – 74930IQ 2
Add
BLAST
Domaini750 – 77930IQ 3
Add
BLAST
Domaini917 – 1150234Ras-GAP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi263 – 2664Poly-Lys

Sequence similaritiesi

Contains 3 IQ domains.
Contains 1 Ras-GAP domain.
Contains 1 WW domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5261.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
InParanoidiQ13576.
KOiK05767.
OMAiMEKVQLH.
OrthoDBiEOG7FNC6M.
PhylomeDBiQ13576.
TreeFamiTF313078.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13576-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW     50
MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY 100
KKSGLHFRHT DNTVQWLRAM ESIGLPKIFY PETTDVYDRK NIPRMIYCIH 150
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPSFSKIG 200
GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP NAVLTLVDDN 250
LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK 300
VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN 350
LQKQNTMNYL AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG 400
LNNLDKAYVE RYANTLLSVK LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE 450
NDRVVAVGYI NEAIDEGNPL RTLETLLLPT ANISDVDPAH AQHYQDVLYH 500
AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT LVVDVNQCLE 550
GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW 600
LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG 650
YIRENIWSAS EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF 700
WKGYKQRKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH 750
NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE 800
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHSK 850
KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA 900
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK 950
VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII 1000
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN 1050
LRRVTDKVLN SIISSLDLLP YGLRYIAKVL KNSIHEKFPD ATEDELLKIV 1100
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS VAKVLQHAAS 1150
NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL 1200
VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV 1250
ESFLGEGAVD PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM 1300
IKTKKLIIDV IRNQPGNTLT EILETPATAQ QEVDHATDMV SRAMIDSRTP 1350
EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT LEQTGHVSSE NKYQDILNEI 1400
AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN YYDTYIKTCL 1450
DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT 1500
NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV 1550
MKMFDKVKVN VNLLIYLLNK KFYGK 1575
Length:1,575
Mass (Da):180,578
Last modified:March 23, 2010 - v4
Checksum:iBCC8CED6645CB09B
GO
Isoform 2 (identifier: Q13576-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MHSLPG
     642-698: Missing.

Show »
Length:1,071
Mass (Da):122,805
Checksum:i111C704267532C91
GO
Isoform 3 (identifier: Q13576-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
     448-453: QEENDR → MGCFKG
     642-698: Missing.

Note: No experimental confirmation available.

Show »
Length:1,071
Mass (Da):122,806
Checksum:i1E59E4F49FB4D334
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti455 – 4551V → A.
Corresponds to variant rs7722711 [ dbSNP | Ensembl ].
VAR_055823
Natural varianti479 – 4791P → R.
Corresponds to variant rs3822530 [ dbSNP | Ensembl ].
VAR_055824
Natural varianti527 – 5271D → E.3 Publications
Corresponds to variant rs2431352 [ dbSNP | Ensembl ].
VAR_062958
Natural varianti532 – 5321K → E.3 Publications
Corresponds to variant rs2909888 [ dbSNP | Ensembl ].
VAR_059292
Natural varianti629 – 6291L → F.3 Publications
Corresponds to variant rs2455230 [ dbSNP | Ensembl ].
VAR_062959
Natural varianti714 – 7141R → W.
Corresponds to variant rs35366349 [ dbSNP | Ensembl ].
VAR_055825
Natural varianti724 – 7241I → V.2 Publications
Corresponds to variant rs2431363 [ dbSNP | Ensembl ].
VAR_062960
Natural varianti894 – 8941T → I.
Corresponds to variant rs34950321 [ dbSNP | Ensembl ].
VAR_055826
Natural varianti1052 – 10521R → I.
Corresponds to variant rs2287932 [ dbSNP | Ensembl ].
VAR_055827
Natural varianti1184 – 11841N → S.
Corresponds to variant rs10454915 [ dbSNP | Ensembl ].
VAR_055828
Natural varianti1379 – 13791R → W.
Corresponds to variant rs17681908 [ dbSNP | Ensembl ].
VAR_055829
Natural varianti1445 – 14451Y → C.1 Publication
VAR_069434
Natural varianti1530 – 15301M → I.1 Publication
VAR_069435

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 447447Missing in isoform 2 and isoform 3.
VSP_010629Add
BLAST
Alternative sequencei448 – 4536QEENDR → MHSLPG in isoform 2.
VSP_010630
Alternative sequencei448 – 4536QEENDR → MGCFKG in isoform 3.
VSP_055149
Alternative sequencei642 – 69857Missing in isoform 2 and isoform 3.
VSP_010631Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951V → E in BAF83755. 1 Publication
Sequence conflicti778 – 7781N → S in BAF83755. 1 Publication
Sequence conflicti1101 – 11011G → R in BAF83755. 1 Publication
Sequence conflicti1333 – 13331V → L in BAH13890. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51903 mRNA. Translation: AAB37765.1.
AY351902 mRNA. Translation: AAQ81291.1.
AK291066 mRNA. Translation: BAF83755.1.
AK303054 mRNA. Translation: BAH13890.1.
AC025188 Genomic DNA. No translation available.
AC026706 Genomic DNA. No translation available.
AC026725 Genomic DNA. No translation available.
AC093251 Genomic DNA. No translation available.
AC112173 Genomic DNA. No translation available.
CCDSiCCDS34188.1. [Q13576-1]
CCDS68897.1. [Q13576-2]
RefSeqiNP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_001272391.1. NM_001285462.1.
NP_006624.2. NM_006633.3.
UniGeneiHs.291030.

Genome annotation databases

EnsembliENST00000274364; ENSP00000274364; ENSG00000145703. [Q13576-1]
ENST00000396234; ENSP00000379535; ENSG00000145703. [Q13576-2]
ENST00000502745; ENSP00000426027; ENSG00000145703.
GeneIDi10788.
KEGGihsa:10788.
UCSCiuc003kek.3. human. [Q13576-1]
uc003kel.3. human. [Q13576-2]

Polymorphism databases

DMDMi292495090.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51903 mRNA. Translation: AAB37765.1 .
AY351902 mRNA. Translation: AAQ81291.1 .
AK291066 mRNA. Translation: BAF83755.1 .
AK303054 mRNA. Translation: BAH13890.1 .
AC025188 Genomic DNA. No translation available.
AC026706 Genomic DNA. No translation available.
AC026725 Genomic DNA. No translation available.
AC093251 Genomic DNA. No translation available.
AC112173 Genomic DNA. No translation available.
CCDSi CCDS34188.1. [Q13576-1 ]
CCDS68897.1. [Q13576-2 ]
RefSeqi NP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_001272391.1. NM_001285462.1.
NP_006624.2. NM_006633.3.
UniGenei Hs.291030.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IEZ X-ray 1.50 A/B 1476-1571 [» ]
4EZA X-ray 1.50 A/B 1476-1571 [» ]
ProteinModelPortali Q13576.
SMRi Q13576. Positions 23-207, 875-1252, 1477-1571.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116004. 10 interactions.
DIPi DIP-27542N.
IntActi Q13576. 14 interactions.
MINTi MINT-5004527.
STRINGi 9606.ENSP00000274364.

PTM databases

PhosphoSitei Q13576.

Polymorphism databases

DMDMi 292495090.

2D gel databases

OGPi Q13576.

Proteomic databases

MaxQBi Q13576.
PaxDbi Q13576.
PRIDEi Q13576.

Protocols and materials databases

DNASUi 10788.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274364 ; ENSP00000274364 ; ENSG00000145703 . [Q13576-1 ]
ENST00000396234 ; ENSP00000379535 ; ENSG00000145703 . [Q13576-2 ]
ENST00000502745 ; ENSP00000426027 ; ENSG00000145703 .
GeneIDi 10788.
KEGGi hsa:10788.
UCSCi uc003kek.3. human. [Q13576-1 ]
uc003kel.3. human. [Q13576-2 ]

Organism-specific databases

CTDi 10788.
GeneCardsi GC05P075699.
HGNCi HGNC:6111. IQGAP2.
HPAi CAB004241.
HPA037404.
MIMi 605401. gene.
neXtProti NX_Q13576.
PharmGKBi PA29911.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5261.
HOGENOMi HOG000004842.
HOVERGENi HBG052143.
InParanoidi Q13576.
KOi K05767.
OMAi MEKVQLH.
OrthoDBi EOG7FNC6M.
PhylomeDBi Q13576.
TreeFami TF313078.

Miscellaneous databases

EvolutionaryTracei Q13576.
GeneWikii IQGAP2.
NextBioi 35535510.
PROi Q13576.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13576.
Bgeei Q13576.
CleanExi HS_IQGAP2.
Genevestigatori Q13576.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProi IPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001936. RasGAP.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view ]
SMARTi SM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEi PS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases."
    Brill S., Li S., Lyman C.W., Church D.M., Wasmuth J.J., Weissbach L., Bernards A., Snijders A.J.
    Mol. Cell. Biol. 16:4869-4878(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
    Tissue: Liver.
  2. "Cloning and characterization of a novel isoform of IQGAP2 in human adult testis."
    Wang H., Huo R., Xu Z.Y., Xu M., Li J.M., Zhou Z.M., Sha J.H.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS GLU-527 AND GLU-532.
    Tissue: Teratocarcinoma and Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-13 (ISOFORM 1).
    Tissue: Platelet.
  6. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-629, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: VARIANTS CYS-1445 AND ILE-1530.

Entry informationi

Entry nameiIQGA2_HUMAN
AccessioniPrimary (citable) accession number: Q13576
Secondary accession number(s): A8K4V1, B7Z8A4, J3KR91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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