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Q13574

- DGKZ_HUMAN

UniProt

Q13574 - DGKZ_HUMAN

Protein

Diacylglycerol kinase zeta

Gene

DGKZ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.1 Publication

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri287 – 34155Phorbol-ester/DAG-type 1Add
    BLAST
    Zinc fingeri361 – 41959Phorbol-ester/DAG-type 2Add
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: ProtInc
    2. diacylglycerol kinase activity Source: UniProtKB
    3. enzyme inhibitor activity Source: Ensembl
    4. lipid kinase activity Source: UniProtKB
    5. metal ion binding Source: UniProtKB-KW
    6. NAD+ kinase activity Source: InterPro
    7. protein binding Source: UniProtKB
    8. protein C-terminus binding Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell migration Source: UniProtKB
    3. intracellular signal transduction Source: InterPro
    4. lipid phosphorylation Source: GOC
    5. mitotic G1 DNA damage checkpoint Source: UniProtKB
    6. negative regulation of mitotic cell cycle Source: UniProtKB
    7. negative regulation of Ras protein signal transduction Source: Ensembl
    8. phosphorylation Source: GOC
    9. platelet activation Source: Reactome
    10. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_2202. Effects of PIP2 hydrolysis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase zeta (EC:2.7.1.107)
    Short name:
    DAG kinase zeta
    Alternative name(s):
    Diglyceride kinase zeta
    Short name:
    DGK-zeta
    Gene namesi
    Name:DGKZ
    Synonyms:DAGK6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:2857. DGKZ.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. lamellipodium Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1115 – 11162TA → NS: Loss of interaction with SNTG1. 1 Publication

    Organism-specific databases

    PharmGKBiPA27318.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11171117Diacylglycerol kinase zetaPRO_0000218468Add
    BLAST

    Post-translational modificationi

    Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ13574.
    PaxDbiQ13574.
    PRIDEiQ13574.

    PTM databases

    PhosphoSiteiQ13574.

    Expressioni

    Tissue specificityi

    Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

    Gene expression databases

    ArrayExpressiQ13574.
    BgeeiQ13574.
    CleanExiHS_DGKZ.
    GenevestigatoriQ13574.

    Organism-specific databases

    HPAiHPA051336.

    Interactioni

    Subunit structurei

    Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RB1P064006EBI-715527,EBI-491274
    RBL1P287492EBI-715527,EBI-971402
    RBL2Q089992EBI-715527,EBI-971439

    Protein-protein interaction databases

    BioGridi114095. 20 interactions.
    IntActiQ13574. 11 interactions.
    MINTiMINT-198176.
    STRINGi9606.ENSP00000320340.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13574.
    SMRiQ13574. Positions 980-1083.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini480 – 614135DAGKcPROSITE-ProRule annotationAdd
    BLAST
    Repeati1011 – 104131ANK 1Add
    BLAST
    Repeati1046 – 107530ANK 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni448 – 46215MARCKS homologyAdd
    BLAST
    Regioni467 – 605139Mediates interaction with RASGRP1Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi550 – 5589Nuclear export signalBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi256 – 2616Poly-Pro
    Compositional biasi448 – 4514Poly-Lys
    Compositional biasi560 – 5634Poly-Pro

    Sequence similaritiesi

    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 DAGKc domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri287 – 34155Phorbol-ester/DAG-type 1Add
    BLAST
    Zinc fingeri361 – 41959Phorbol-ester/DAG-type 2Add
    BLAST

    Keywords - Domaini

    ANK repeat, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG47311.
    HOGENOMiHOG000231472.
    HOVERGENiHBG067303.
    InParanoidiQ13574.
    KOiK00901.
    OMAiQQEPDGA.
    OrthoDBiEOG76HQ0Q.
    PhylomeDBiQ13574.
    TreeFamiTF312817.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view]
    PfamiPF00023. Ank. 2 hits.
    PF00130. C1_1. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.
    SSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS50146. DAGK. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13574-1) [UniParc]FASTAAdd to Basket

    Also known as: Long, zeta2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METFFRRHFR GKVPGPGEGQ QRPSSVGLPT GKARRRSPAG QASSSLAQRR     50
    RSSAQLQGCL LSCGVRAQGS SRRRSSTVPP SCNPRFIVDK VLTPQPTTVG 100
    AQLLGAPLLL TGLVGMNEEE GVQEDVVAEA SSAIQPGTKT PGPPPPRGAQ 150
    PLLPLPRYLR RASSHLLPAD AVYDHALWGL HGYYRRLSQR RPSGQHPGPG 200
    GRRASGTTAG TMLPTRVRPL SRRRQVALRR KAAGPQAWSA LLAKAITKSG 250
    LQHLAPPPPT PGAPCSESER QIRSTVDWSE SATYGEHIWF ETNVSGDFCY 300
    VGEQYCVARM LKSVSRRKCA ACKIVVHTPC IEQLEKINFR CKPSFRESGS 350
    RNVREPTFVR HHWVHRRRQD GKCRHCGKGF QQKFTFHSKE IVAISCSWCK 400
    QAYHSKVSCF MLQQIEEPCS LGVHAAVVIP PTWILRARRP QNTLKASKKK 450
    KRASFKRKSS KKGPEEGRWR PFIIRPTPSP LMKPLLVFVN PKSGGNQGAK 500
    IIQSFLWYLN PRQVFDLSQG GPKEALEMYR KVHNLRILAC GGDGTVGWIL 550
    STLDQLRLKP PPPVAILPLG TGNDLARTLN WGGGYTDEPV SKILSHVEEG 600
    NVVQLDRWDL HAEPNPEAGP EDRDEGATDR LPLDVFNNYF SLGFDAHVTL 650
    EFHESREANP EKFNSRFRNK MFYAGTAFSD FLMGSSKDLA KHIRVVCDGM 700
    DLTPKIQDLK PQCVVFLNIP RYCAGTMPWG HPGEHHDFEP QRHDDGYLEV 750
    IGFTMTSLAA LQVGGHGERL TQCREVVLTT SKAIPVQVDG EPCKLAASRI 800
    RIALRNQATM VQKAKRRSAA PLHSDQQPVP EQLRIQVSRV SMHDYEALHY 850
    DKEQLKEASV PLGTVVVPGD SDLELCRAHI ERLQQEPDGA GAKSPTCQKL 900
    SPKWCFLDAT TASRFYRIDR AQEHLNYVTE IAQDEIYILD PELLGASARP 950
    DLPTPTSPLP TSPCSPTPRS LQGDAAPPQG EELIEAAKRN DFCKLQELHR 1000
    AGGDLMHRDE QSRTLLHHAV STGSKDVVRY LLDHAPPEIL DAVEENGETC 1050
    LHQAAALGQR TICHYIVEAG ASLMKTDQQG DTPRQRAEKA QDTELAAYLE 1100
    NRQHYQMIQR EDQETAV 1117

    Note: Minor isoform.

    Length:1,117
    Mass (Da):124,128
    Last modified:November 25, 2008 - v3
    Checksum:iF3A7C2382ECF549B
    GO
    Isoform 2 (identifier: Q13574-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR

    Note: Major isoform.

    Show »
    Length:928
    Mass (Da):103,981
    Checksum:i7936A979CB3D35AA
    GO
    Isoform 3 (identifier: Q13574-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-71: METFFRRHFR...SCGVRAQGSS → MAEGQGGGGQ...LHLRKQVSYR
         72-243: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:945
    Mass (Da):106,030
    Checksum:i6EF612B9FE91F7E7
    GO
    Isoform 4 (identifier: Q13574-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
         311-311: L → LQ

    Note: No experimental confirmation available.

    Show »
    Length:929
    Mass (Da):104,109
    Checksum:i362346DD9046B323
    GO
    Isoform 5 (identifier: Q13574-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
         311-311: L → LQ
         1046-1046: N → NPCSPS

    Note: No experimental confirmation available.

    Show »
    Length:934
    Mass (Da):104,581
    Checksum:i3B9CEB5C58B865F7
    GO
    Isoform 6 (identifier: Q13574-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
         311-311: L → LQ
         356-378: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:906
    Mass (Da):101,230
    Checksum:i99789AD08DCCB5BD
    GO
    Isoform 7 (identifier: Q13574-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-243: METFFRRHFR...GPQAWSALLA → MSAPGAGHSA...QIPSEAPQTQ
         280-280: Missing.
         311-311: L → LQ

    Note: No experimental confirmation available.

    Show »
    Length:933
    Mass (Da):104,296
    Checksum:i57D46241E25FC58C
    GO

    Sequence cautioni

    The sequence AAB60859.1 differs from that shown. Reason: Frameshift at positions 166 and 167.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591L → V in AAB60859. (PubMed:9159104)Curated
    Sequence conflicti494 – 4941G → W in BAH11915. (PubMed:14702039)Curated
    Sequence conflicti783 – 7831A → S in BAH11915. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211Q → R.1 Publication
    Corresponds to variant rs1317826 [ dbSNP | Ensembl ].
    VAR_047371
    Natural varianti69 – 691G → C.
    Corresponds to variant rs901998 [ dbSNP | Ensembl ].
    VAR_061131
    Natural varianti712 – 7121Q → K.1 Publication
    Corresponds to variant rs17854149 [ dbSNP | Ensembl ].
    VAR_069059

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 243243METFF…SALLA → MEPRDGSPEARSSDSESASA SSSGSERDAGPEPDKAPRRL NKRRFPGLRLFGHR in isoform 2, isoform 4, isoform 5 and isoform 6. 4 PublicationsVSP_001268Add
    BLAST
    Alternative sequencei1 – 243243METFF…SALLA → MSAPGAGHSAGGSCNESSAL GPVEALGTEEGERPGSLRQM WRYRSWDVPQIPSEAPQTQ in isoform 7. CuratedVSP_055147Add
    BLAST
    Alternative sequencei1 – 7171METFF…AQGSS → MAEGQGGGGQRWDWAGGGRA AEEEVVRRRCRRGEEAQVAQ PWPEGSRGTAAGPPVEERFR QLHLRKQVSYR in isoform 3. 1 PublicationVSP_043163Add
    BLAST
    Alternative sequencei72 – 243172Missing in isoform 3. 1 PublicationVSP_043164Add
    BLAST
    Alternative sequencei280 – 2801Missing in isoform 7. CuratedVSP_055148
    Alternative sequencei311 – 3111L → LQ in isoform 4, isoform 5, isoform 6 and isoform 7. 3 PublicationsVSP_045628
    Alternative sequencei356 – 37823Missing in isoform 6. 1 PublicationVSP_046919Add
    BLAST
    Alternative sequencei1046 – 10461N → NPCSPS in isoform 5. 1 PublicationVSP_046920

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51477 mRNA. Translation: AAC50478.1.
    U94905 mRNA. Translation: AAB60859.1. Frameshift.
    AK124594 mRNA. Translation: BAC85894.1.
    AK294888 mRNA. Translation: BAH11915.1.
    AK300577 mRNA. Translation: BAH13309.1.
    AK225774 mRNA. No translation available.
    AC116021 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68008.1.
    BC041770 mRNA. Translation: AAH41770.1.
    CCDSiCCDS41640.1. [Q13574-1]
    CCDS44579.2. [Q13574-7]
    CCDS44580.1. [Q13574-4]
    CCDS55757.1. [Q13574-5]
    CCDS55758.1. [Q13574-6]
    CCDS55759.1. [Q13574-2]
    CCDS7918.1. [Q13574-3]
    RefSeqiNP_001099010.1. NM_001105540.1. [Q13574-1]
    NP_001186195.1. NM_001199266.1. [Q13574-5]
    NP_001186196.1. NM_001199267.1. [Q13574-2]
    NP_001186197.1. NM_001199268.1. [Q13574-6]
    NP_003637.2. NM_003646.3. [Q13574-4]
    NP_963290.1. NM_201532.2. [Q13574-3]
    NP_963291.2. NM_201533.3.
    UniGeneiHs.502461.

    Genome annotation databases

    EnsembliENST00000318201; ENSP00000320340; ENSG00000149091. [Q13574-6]
    ENST00000343674; ENSP00000343065; ENSG00000149091. [Q13574-3]
    ENST00000421244; ENSP00000391021; ENSG00000149091. [Q13574-4]
    ENST00000454345; ENSP00000412178; ENSG00000149091. [Q13574-1]
    ENST00000456247; ENSP00000395684; ENSG00000149091. [Q13574-2]
    ENST00000527911; ENSP00000436291; ENSG00000149091. [Q13574-5]
    ENST00000532868; ENSP00000436273; ENSG00000149091. [Q13574-7]
    GeneIDi8525.
    KEGGihsa:8525.
    UCSCiuc001nch.2. human. [Q13574-3]
    uc001nck.2. human. [Q13574-1]
    uc001ncl.2. human.
    uc001ncm.2. human. [Q13574-2]

    Polymorphism databases

    DMDMi215274170.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51477 mRNA. Translation: AAC50478.1 .
    U94905 mRNA. Translation: AAB60859.1 . Frameshift.
    AK124594 mRNA. Translation: BAC85894.1 .
    AK294888 mRNA. Translation: BAH11915.1 .
    AK300577 mRNA. Translation: BAH13309.1 .
    AK225774 mRNA. No translation available.
    AC116021 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68008.1 .
    BC041770 mRNA. Translation: AAH41770.1 .
    CCDSi CCDS41640.1. [Q13574-1 ]
    CCDS44579.2. [Q13574-7 ]
    CCDS44580.1. [Q13574-4 ]
    CCDS55757.1. [Q13574-5 ]
    CCDS55758.1. [Q13574-6 ]
    CCDS55759.1. [Q13574-2 ]
    CCDS7918.1. [Q13574-3 ]
    RefSeqi NP_001099010.1. NM_001105540.1. [Q13574-1 ]
    NP_001186195.1. NM_001199266.1. [Q13574-5 ]
    NP_001186196.1. NM_001199267.1. [Q13574-2 ]
    NP_001186197.1. NM_001199268.1. [Q13574-6 ]
    NP_003637.2. NM_003646.3. [Q13574-4 ]
    NP_963290.1. NM_201532.2. [Q13574-3 ]
    NP_963291.2. NM_201533.3.
    UniGenei Hs.502461.

    3D structure databases

    ProteinModelPortali Q13574.
    SMRi Q13574. Positions 980-1083.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114095. 20 interactions.
    IntActi Q13574. 11 interactions.
    MINTi MINT-198176.
    STRINGi 9606.ENSP00000320340.

    PTM databases

    PhosphoSitei Q13574.

    Polymorphism databases

    DMDMi 215274170.

    Proteomic databases

    MaxQBi Q13574.
    PaxDbi Q13574.
    PRIDEi Q13574.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318201 ; ENSP00000320340 ; ENSG00000149091 . [Q13574-6 ]
    ENST00000343674 ; ENSP00000343065 ; ENSG00000149091 . [Q13574-3 ]
    ENST00000421244 ; ENSP00000391021 ; ENSG00000149091 . [Q13574-4 ]
    ENST00000454345 ; ENSP00000412178 ; ENSG00000149091 . [Q13574-1 ]
    ENST00000456247 ; ENSP00000395684 ; ENSG00000149091 . [Q13574-2 ]
    ENST00000527911 ; ENSP00000436291 ; ENSG00000149091 . [Q13574-5 ]
    ENST00000532868 ; ENSP00000436273 ; ENSG00000149091 . [Q13574-7 ]
    GeneIDi 8525.
    KEGGi hsa:8525.
    UCSCi uc001nch.2. human. [Q13574-3 ]
    uc001nck.2. human. [Q13574-1 ]
    uc001ncl.2. human.
    uc001ncm.2. human. [Q13574-2 ]

    Organism-specific databases

    CTDi 8525.
    GeneCardsi GC11P046311.
    H-InvDB HIX0009600.
    HIX0037561.
    HGNCi HGNC:2857. DGKZ.
    HPAi HPA051336.
    MIMi 601441. gene.
    neXtProti NX_Q13574.
    PharmGKBi PA27318.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47311.
    HOGENOMi HOG000231472.
    HOVERGENi HBG067303.
    InParanoidi Q13574.
    KOi K00901.
    OMAi QQEPDGA.
    OrthoDBi EOG76HQ0Q.
    PhylomeDBi Q13574.
    TreeFami TF312817.

    Enzyme and pathway databases

    Reactomei REACT_2202. Effects of PIP2 hydrolysis.

    Miscellaneous databases

    ChiTaRSi DGKZ. human.
    GeneWikii DGKZ.
    GenomeRNAii 8525.
    NextBioi 31916.
    PROi Q13574.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13574.
    Bgeei Q13574.
    CleanExi HS_DGKZ.
    Genevestigatori Q13574.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view ]
    Pfami PF00023. Ank. 2 hits.
    PF00130. C1_1. 1 hit.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS50146. DAGK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta."
      Bunting M., Tang W., Zimmerman G.A., McIntyre T.M., Prescott S.M.
      J. Biol. Chem. 271:10230-10236(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Endothelial cell.
    2. "Alternative splicing of the human diacylglycerol kinase zeta gene in muscle."
      Ding L., Bunting M., Topham M.K., McIntyre T.M., Zimmerman G.A., Prescott S.M.
      Proc. Natl. Acad. Sci. U.S.A. 94:5519-5524(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-21.
      Tissue: Skeletal muscle.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 6), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
      Tissue: Brain and Cerebellum.
    4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT LYS-712.
      Tissue: Brain.
    8. "Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta."
      Topham M.K., Bunting M., Zimmerman G.A., McIntyre T.M., Blackshear P.J., Prescott S.M.
      Nature 394:697-700(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
    9. "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions."
      Hogan A., Shepherd L., Chabot J., Quenneville S., Prescott S.M., Topham M.K., Gee S.H.
      J. Biol. Chem. 276:26526-26533(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNTG1, MUTAGENESIS OF 1115-THR-ALA-1116.
    10. "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism."
      Topham M.K., Prescott S.M.
      J. Cell Biol. 152:1135-1143(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A RASGRP1 REGULATOR, IDENTIFICATION IN A COMPLEX WITH RASGRP1 AND HRAS, SUBCELLULAR LOCATION.
    11. "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling."
      Rincon E., Santos T., Avila-Flores A., Albar J.P., Lalioti V., Lei C., Hong W., Merida I.
      Mol. Cell. Proteomics 6:1073-1087(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNX27.

    Entry informationi

    Entry nameiDGKZ_HUMAN
    AccessioniPrimary (citable) accession number: Q13574
    Secondary accession number(s): B7Z2M9
    , B7Z6M3, E9PPW4, F6UCU9, G3V0F6, J3KNJ6, O00542, Q6ZVG7, Q8IVW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 149 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3