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Q13574

- DGKZ_HUMAN

UniProt

Q13574 - DGKZ_HUMAN

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Protein
Diacylglycerol kinase zeta
Gene
DGKZ, DAGK6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.1 Publication

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri287 – 34155Phorbol-ester/DAG-type 1
Add
BLAST
Zinc fingeri361 – 41959Phorbol-ester/DAG-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: InterPro
  3. diacylglycerol kinase activity Source: UniProtKB-EC
  4. enzyme inhibitor activity Source: Ensembl
  5. lipid kinase activity Source: UniProtKB
  6. metal ion binding Source: UniProtKB-KW
  7. protein C-terminus binding Source: UniProtKB
  8. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. cell migration Source: UniProtKB
  3. intracellular signal transduction Source: InterPro
  4. lipid phosphorylation Source: GOC
  5. mitotic G1 DNA damage checkpoint Source: UniProtKB
  6. negative regulation of Ras protein signal transduction Source: Ensembl
  7. negative regulation of mitotic cell cycle Source: UniProtKB
  8. phosphorylation Source: GOC
  9. platelet activation Source: Reactome
  10. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_2202. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase zeta (EC:2.7.1.107)
Short name:
DAG kinase zeta
Alternative name(s):
Diglyceride kinase zeta
Short name:
DGK-zeta
Gene namesi
Name:DGKZ
Synonyms:DAGK6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:2857. DGKZ.

Subcellular locationi

Cytoplasm. Nucleus. Cell membrane 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. lamellipodium Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1115 – 11162TA → NS: Loss of interaction with SNTG1. 1 Publication

Organism-specific databases

PharmGKBiPA27318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11171117Diacylglycerol kinase zeta
PRO_0000218468Add
BLAST

Post-translational modificationi

Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13574.
PaxDbiQ13574.
PRIDEiQ13574.

PTM databases

PhosphoSiteiQ13574.

Expressioni

Tissue specificityi

Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

Gene expression databases

ArrayExpressiQ13574.
BgeeiQ13574.
CleanExiHS_DGKZ.
GenevestigatoriQ13574.

Organism-specific databases

HPAiHPA051336.

Interactioni

Subunit structurei

Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RB1P064006EBI-715527,EBI-491274
RBL1P287492EBI-715527,EBI-971402
RBL2Q089992EBI-715527,EBI-971439

Protein-protein interaction databases

BioGridi114095. 19 interactions.
IntActiQ13574. 11 interactions.
MINTiMINT-198176.
STRINGi9606.ENSP00000320340.

Structurei

3D structure databases

ProteinModelPortaliQ13574.
SMRiQ13574. Positions 980-1083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini480 – 614135DAGKc
Add
BLAST
Repeati1011 – 104131ANK 1
Add
BLAST
Repeati1046 – 107530ANK 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni448 – 46215MARCKS homology
Add
BLAST
Regioni467 – 605139Mediates interaction with RASGRP1
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi550 – 5589Nuclear export signal By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi256 – 2616Poly-Pro
Compositional biasi448 – 4514Poly-Lys
Compositional biasi560 – 5634Poly-Pro

Sequence similaritiesi

Contains 2 ANK repeats.
Contains 1 DAGKc domain.

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG47311.
HOGENOMiHOG000231472.
HOVERGENiHBG067303.
InParanoidiQ13574.
KOiK00901.
OMAiQQEPDGA.
OrthoDBiEOG76HQ0Q.
PhylomeDBiQ13574.
TreeFamiTF312817.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13574-1) [UniParc]FASTAAdd to Basket

Also known as: Long, zeta2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

METFFRRHFR GKVPGPGEGQ QRPSSVGLPT GKARRRSPAG QASSSLAQRR     50
RSSAQLQGCL LSCGVRAQGS SRRRSSTVPP SCNPRFIVDK VLTPQPTTVG 100
AQLLGAPLLL TGLVGMNEEE GVQEDVVAEA SSAIQPGTKT PGPPPPRGAQ 150
PLLPLPRYLR RASSHLLPAD AVYDHALWGL HGYYRRLSQR RPSGQHPGPG 200
GRRASGTTAG TMLPTRVRPL SRRRQVALRR KAAGPQAWSA LLAKAITKSG 250
LQHLAPPPPT PGAPCSESER QIRSTVDWSE SATYGEHIWF ETNVSGDFCY 300
VGEQYCVARM LKSVSRRKCA ACKIVVHTPC IEQLEKINFR CKPSFRESGS 350
RNVREPTFVR HHWVHRRRQD GKCRHCGKGF QQKFTFHSKE IVAISCSWCK 400
QAYHSKVSCF MLQQIEEPCS LGVHAAVVIP PTWILRARRP QNTLKASKKK 450
KRASFKRKSS KKGPEEGRWR PFIIRPTPSP LMKPLLVFVN PKSGGNQGAK 500
IIQSFLWYLN PRQVFDLSQG GPKEALEMYR KVHNLRILAC GGDGTVGWIL 550
STLDQLRLKP PPPVAILPLG TGNDLARTLN WGGGYTDEPV SKILSHVEEG 600
NVVQLDRWDL HAEPNPEAGP EDRDEGATDR LPLDVFNNYF SLGFDAHVTL 650
EFHESREANP EKFNSRFRNK MFYAGTAFSD FLMGSSKDLA KHIRVVCDGM 700
DLTPKIQDLK PQCVVFLNIP RYCAGTMPWG HPGEHHDFEP QRHDDGYLEV 750
IGFTMTSLAA LQVGGHGERL TQCREVVLTT SKAIPVQVDG EPCKLAASRI 800
RIALRNQATM VQKAKRRSAA PLHSDQQPVP EQLRIQVSRV SMHDYEALHY 850
DKEQLKEASV PLGTVVVPGD SDLELCRAHI ERLQQEPDGA GAKSPTCQKL 900
SPKWCFLDAT TASRFYRIDR AQEHLNYVTE IAQDEIYILD PELLGASARP 950
DLPTPTSPLP TSPCSPTPRS LQGDAAPPQG EELIEAAKRN DFCKLQELHR 1000
AGGDLMHRDE QSRTLLHHAV STGSKDVVRY LLDHAPPEIL DAVEENGETC 1050
LHQAAALGQR TICHYIVEAG ASLMKTDQQG DTPRQRAEKA QDTELAAYLE 1100
NRQHYQMIQR EDQETAV 1117

Note: Minor isoform.

Length:1,117
Mass (Da):124,128
Last modified:November 25, 2008 - v3
Checksum:iF3A7C2382ECF549B
GO
Isoform 2 (identifier: Q13574-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR

Note: Major isoform.

Show »
Length:928
Mass (Da):103,981
Checksum:i7936A979CB3D35AA
GO
Isoform 3 (identifier: Q13574-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: METFFRRHFR...SCGVRAQGSS → MAEGQGGGGQ...LHLRKQVSYR
     72-243: Missing.

Note: No experimental confirmation available.

Show »
Length:945
Mass (Da):106,030
Checksum:i6EF612B9FE91F7E7
GO
Isoform 4 (identifier: Q13574-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ

Note: No experimental confirmation available.

Show »
Length:929
Mass (Da):104,109
Checksum:i362346DD9046B323
GO
Isoform 5 (identifier: Q13574-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     1046-1046: N → NPCSPS

Note: No experimental confirmation available.

Show »
Length:934
Mass (Da):104,581
Checksum:i3B9CEB5C58B865F7
GO
Isoform 6 (identifier: Q13574-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     356-378: Missing.

Note: No experimental confirmation available.

Show »
Length:906
Mass (Da):101,230
Checksum:i99789AD08DCCB5BD
GO
Isoform 7 (identifier: Q13574-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MSAPGAGHSA...QIPSEAPQTQ
     280-280: Missing.
     311-311: L → LQ

Note: No experimental confirmation available.

Show »
Length:933
Mass (Da):104,296
Checksum:i57D46241E25FC58C
GO

Sequence cautioni

The sequence AAB60859.1 differs from that shown. Reason: Frameshift at positions 166 and 167.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211Q → R.1 Publication
Corresponds to variant rs1317826 [ dbSNP | Ensembl ].
VAR_047371
Natural varianti69 – 691G → C.
Corresponds to variant rs901998 [ dbSNP | Ensembl ].
VAR_061131
Natural varianti712 – 7121Q → K.1 Publication
Corresponds to variant rs17854149 [ dbSNP | Ensembl ].
VAR_069059

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 243243METFF…SALLA → MEPRDGSPEARSSDSESASA SSSGSERDAGPEPDKAPRRL NKRRFPGLRLFGHR in isoform 2, isoform 4, isoform 5 and isoform 6.
VSP_001268Add
BLAST
Alternative sequencei1 – 243243METFF…SALLA → MSAPGAGHSAGGSCNESSAL GPVEALGTEEGERPGSLRQM WRYRSWDVPQIPSEAPQTQ in isoform 7.
VSP_055147Add
BLAST
Alternative sequencei1 – 7171METFF…AQGSS → MAEGQGGGGQRWDWAGGGRA AEEEVVRRRCRRGEEAQVAQ PWPEGSRGTAAGPPVEERFR QLHLRKQVSYR in isoform 3.
VSP_043163Add
BLAST
Alternative sequencei72 – 243172Missing in isoform 3.
VSP_043164Add
BLAST
Alternative sequencei280 – 2801Missing in isoform 7.
VSP_055148
Alternative sequencei311 – 3111L → LQ in isoform 4, isoform 5, isoform 6 and isoform 7.
VSP_045628
Alternative sequencei356 – 37823Missing in isoform 6.
VSP_046919Add
BLAST
Alternative sequencei1046 – 10461N → NPCSPS in isoform 5.
VSP_046920

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591L → V in AAB60859. 1 Publication
Sequence conflicti494 – 4941G → W in BAH11915. 1 Publication
Sequence conflicti783 – 7831A → S in BAH11915. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51477 mRNA. Translation: AAC50478.1.
U94905 mRNA. Translation: AAB60859.1. Frameshift.
AK124594 mRNA. Translation: BAC85894.1.
AK294888 mRNA. Translation: BAH11915.1.
AK300577 mRNA. Translation: BAH13309.1.
AK225774 mRNA. No translation available.
AC116021 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68008.1.
BC041770 mRNA. Translation: AAH41770.1.
CCDSiCCDS41640.1. [Q13574-1]
CCDS44580.1. [Q13574-4]
CCDS55757.1. [Q13574-5]
CCDS55758.1. [Q13574-6]
CCDS55759.1. [Q13574-2]
CCDS7918.1. [Q13574-3]
RefSeqiNP_001099010.1. NM_001105540.1. [Q13574-1]
NP_001186195.1. NM_001199266.1. [Q13574-5]
NP_001186196.1. NM_001199267.1. [Q13574-2]
NP_001186197.1. NM_001199268.1. [Q13574-6]
NP_003637.2. NM_003646.3. [Q13574-4]
NP_963290.1. NM_201532.2. [Q13574-3]
NP_963291.2. NM_201533.3.
UniGeneiHs.502461.

Genome annotation databases

EnsembliENST00000318201; ENSP00000320340; ENSG00000149091. [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091. [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091. [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091. [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091. [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091. [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091.
GeneIDi8525.
KEGGihsa:8525.
UCSCiuc001nch.2. human. [Q13574-3]
uc001nck.2. human. [Q13574-1]
uc001ncl.2. human.
uc001ncm.2. human. [Q13574-2]

Polymorphism databases

DMDMi215274170.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51477 mRNA. Translation: AAC50478.1 .
U94905 mRNA. Translation: AAB60859.1 . Frameshift.
AK124594 mRNA. Translation: BAC85894.1 .
AK294888 mRNA. Translation: BAH11915.1 .
AK300577 mRNA. Translation: BAH13309.1 .
AK225774 mRNA. No translation available.
AC116021 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68008.1 .
BC041770 mRNA. Translation: AAH41770.1 .
CCDSi CCDS41640.1. [Q13574-1 ]
CCDS44580.1. [Q13574-4 ]
CCDS55757.1. [Q13574-5 ]
CCDS55758.1. [Q13574-6 ]
CCDS55759.1. [Q13574-2 ]
CCDS7918.1. [Q13574-3 ]
RefSeqi NP_001099010.1. NM_001105540.1. [Q13574-1 ]
NP_001186195.1. NM_001199266.1. [Q13574-5 ]
NP_001186196.1. NM_001199267.1. [Q13574-2 ]
NP_001186197.1. NM_001199268.1. [Q13574-6 ]
NP_003637.2. NM_003646.3. [Q13574-4 ]
NP_963290.1. NM_201532.2. [Q13574-3 ]
NP_963291.2. NM_201533.3.
UniGenei Hs.502461.

3D structure databases

ProteinModelPortali Q13574.
SMRi Q13574. Positions 980-1083.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114095. 19 interactions.
IntActi Q13574. 11 interactions.
MINTi MINT-198176.
STRINGi 9606.ENSP00000320340.

PTM databases

PhosphoSitei Q13574.

Polymorphism databases

DMDMi 215274170.

Proteomic databases

MaxQBi Q13574.
PaxDbi Q13574.
PRIDEi Q13574.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318201 ; ENSP00000320340 ; ENSG00000149091 . [Q13574-6 ]
ENST00000343674 ; ENSP00000343065 ; ENSG00000149091 . [Q13574-3 ]
ENST00000421244 ; ENSP00000391021 ; ENSG00000149091 . [Q13574-4 ]
ENST00000454345 ; ENSP00000412178 ; ENSG00000149091 . [Q13574-1 ]
ENST00000456247 ; ENSP00000395684 ; ENSG00000149091 . [Q13574-2 ]
ENST00000527911 ; ENSP00000436291 ; ENSG00000149091 . [Q13574-5 ]
ENST00000532868 ; ENSP00000436273 ; ENSG00000149091 .
GeneIDi 8525.
KEGGi hsa:8525.
UCSCi uc001nch.2. human. [Q13574-3 ]
uc001nck.2. human. [Q13574-1 ]
uc001ncl.2. human.
uc001ncm.2. human. [Q13574-2 ]

Organism-specific databases

CTDi 8525.
GeneCardsi GC11P046311.
H-InvDB HIX0009600.
HIX0037561.
HGNCi HGNC:2857. DGKZ.
HPAi HPA051336.
MIMi 601441. gene.
neXtProti NX_Q13574.
PharmGKBi PA27318.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47311.
HOGENOMi HOG000231472.
HOVERGENi HBG067303.
InParanoidi Q13574.
KOi K00901.
OMAi QQEPDGA.
OrthoDBi EOG76HQ0Q.
PhylomeDBi Q13574.
TreeFami TF312817.

Enzyme and pathway databases

Reactomei REACT_2202. Effects of PIP2 hydrolysis.

Miscellaneous databases

ChiTaRSi DGKZ. human.
GeneWikii DGKZ.
GenomeRNAii 8525.
NextBioi 31916.
PROi Q13574.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13574.
Bgeei Q13574.
CleanExi HS_DGKZ.
Genevestigatori Q13574.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta."
    Bunting M., Tang W., Zimmerman G.A., McIntyre T.M., Prescott S.M.
    J. Biol. Chem. 271:10230-10236(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Endothelial cell.
  2. "Alternative splicing of the human diacylglycerol kinase zeta gene in muscle."
    Ding L., Bunting M., Topham M.K., McIntyre T.M., Zimmerman G.A., Prescott S.M.
    Proc. Natl. Acad. Sci. U.S.A. 94:5519-5524(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-21.
    Tissue: Skeletal muscle.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 6), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
    Tissue: Brain and Cerebellum.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT LYS-712.
    Tissue: Brain.
  8. "Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta."
    Topham M.K., Bunting M., Zimmerman G.A., McIntyre T.M., Blackshear P.J., Prescott S.M.
    Nature 394:697-700(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
  9. "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions."
    Hogan A., Shepherd L., Chabot J., Quenneville S., Prescott S.M., Topham M.K., Gee S.H.
    J. Biol. Chem. 276:26526-26533(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNTG1, MUTAGENESIS OF 1115-THR-ALA-1116.
  10. "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism."
    Topham M.K., Prescott S.M.
    J. Cell Biol. 152:1135-1143(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A RASGRP1 REGULATOR, IDENTIFICATION IN A COMPLEX WITH RASGRP1 AND HRAS, SUBCELLULAR LOCATION.
  11. "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling."
    Rincon E., Santos T., Avila-Flores A., Albar J.P., Lalioti V., Lei C., Hong W., Merida I.
    Mol. Cell. Proteomics 6:1073-1087(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNX27.

Entry informationi

Entry nameiDGKZ_HUMAN
AccessioniPrimary (citable) accession number: Q13574
Secondary accession number(s): B7Z2M9
, B7Z6M3, E9PPW4, F6UCU9, G3V0F6, J3KNJ6, O00542, Q6ZVG7, Q8IVW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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