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Protein

Diacylglycerol kinase zeta

Gene

DGKZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.1 Publication

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri287 – 341Phorbol-ester/DAG-type 1Add BLAST55
Zinc fingeri361 – 419Phorbol-ester/DAG-type 2Add BLAST59

GO - Molecular functioni

  • ATP binding Source: ProtInc
  • diacylglycerol kinase activity Source: BHF-UCL
  • kinase activity Source: BHF-UCL
  • lipid kinase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

  • cell migration Source: UniProtKB
  • diacylglycerol metabolic process Source: BHF-UCL
  • glycerolipid metabolic process Source: BHF-UCL
  • intracellular signal transduction Source: InterPro
  • lipid phosphorylation Source: BHF-UCL
  • mitotic G1 DNA damage checkpoint Source: UniProtKB
  • negative regulation of mitotic cell cycle Source: UniProtKB
  • platelet activation Source: Reactome
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS07583-MONOMER.
BRENDAi2.7.1.107. 2681.
ReactomeiR-HSA-114508. Effects of PIP2 hydrolysis.
SIGNORiQ13574.

Chemistry databases

SwissLipidsiSLP:000000547.
SLP:000000921. [Q13574-1]
SLP:000000922. [Q13574-2]

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase zeta (EC:2.7.1.107)
Short name:
DAG kinase zeta
Alternative name(s):
Diglyceride kinase zeta
Short name:
DGK-zeta
Gene namesi
Name:DGKZ
Synonyms:DAGK6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:2857. DGKZ.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • lamellipodium Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1115 – 1116TA → NS: Loss of interaction with SNTG1. 1 Publication2

Organism-specific databases

DisGeNETi8525.
OpenTargetsiENSG00000149091.
PharmGKBiPA27318.

Polymorphism and mutation databases

BioMutaiDGKZ.
DMDMi215274170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002184681 – 1117Diacylglycerol kinase zetaAdd BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei894PhosphoserineCombined sources1
Modified residuei970PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13574.
MaxQBiQ13574.
PaxDbiQ13574.
PeptideAtlasiQ13574.
PRIDEiQ13574.

PTM databases

iPTMnetiQ13574.
PhosphoSitePlusiQ13574.

Expressioni

Tissue specificityi

Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

Gene expression databases

BgeeiENSG00000149091.
CleanExiHS_DGKZ.
ExpressionAtlasiQ13574. baseline and differential.
GenevisibleiQ13574. HS.

Organism-specific databases

HPAiHPA051336.
HPA056920.

Interactioni

Subunit structurei

Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RB1P064006EBI-715527,EBI-491274
RBL1P287492EBI-715527,EBI-971402
RBL2Q089992EBI-715527,EBI-971439

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114095. 20 interactors.
IntActiQ13574. 12 interactors.
MINTiMINT-198176.
STRINGi9606.ENSP00000412178.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ELQX-ray1.10C/P1110-1117[»]
ProteinModelPortaliQ13574.
SMRiQ13574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini480 – 614DAGKcPROSITE-ProRule annotationAdd BLAST135
Repeati1011 – 1041ANK 1Add BLAST31
Repeati1046 – 1075ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni448 – 462MARCKS homologyAdd BLAST15
Regioni467 – 605Mediates interaction with RASGRP1Add BLAST139

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi550 – 558Nuclear export signalBy similarity9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi256 – 261Poly-Pro6
Compositional biasi448 – 451Poly-Lys4
Compositional biasi560 – 563Poly-Pro4

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 DAGKc domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri287 – 341Phorbol-ester/DAG-type 1Add BLAST55
Zinc fingeri361 – 419Phorbol-ester/DAG-type 2Add BLAST59

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0782. Eukaryota.
ENOG410XSCB. LUCA.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000231472.
HOVERGENiHBG067303.
InParanoidiQ13574.
KOiK00901.
OMAiAGGDLMH.
OrthoDBiEOG091G13Z8.
PhylomeDBiQ13574.
TreeFamiTF312817.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13574-1) [UniParc]FASTAAdd to basket
Also known as: Long, zeta2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METFFRRHFR GKVPGPGEGQ QRPSSVGLPT GKARRRSPAG QASSSLAQRR
60 70 80 90 100
RSSAQLQGCL LSCGVRAQGS SRRRSSTVPP SCNPRFIVDK VLTPQPTTVG
110 120 130 140 150
AQLLGAPLLL TGLVGMNEEE GVQEDVVAEA SSAIQPGTKT PGPPPPRGAQ
160 170 180 190 200
PLLPLPRYLR RASSHLLPAD AVYDHALWGL HGYYRRLSQR RPSGQHPGPG
210 220 230 240 250
GRRASGTTAG TMLPTRVRPL SRRRQVALRR KAAGPQAWSA LLAKAITKSG
260 270 280 290 300
LQHLAPPPPT PGAPCSESER QIRSTVDWSE SATYGEHIWF ETNVSGDFCY
310 320 330 340 350
VGEQYCVARM LKSVSRRKCA ACKIVVHTPC IEQLEKINFR CKPSFRESGS
360 370 380 390 400
RNVREPTFVR HHWVHRRRQD GKCRHCGKGF QQKFTFHSKE IVAISCSWCK
410 420 430 440 450
QAYHSKVSCF MLQQIEEPCS LGVHAAVVIP PTWILRARRP QNTLKASKKK
460 470 480 490 500
KRASFKRKSS KKGPEEGRWR PFIIRPTPSP LMKPLLVFVN PKSGGNQGAK
510 520 530 540 550
IIQSFLWYLN PRQVFDLSQG GPKEALEMYR KVHNLRILAC GGDGTVGWIL
560 570 580 590 600
STLDQLRLKP PPPVAILPLG TGNDLARTLN WGGGYTDEPV SKILSHVEEG
610 620 630 640 650
NVVQLDRWDL HAEPNPEAGP EDRDEGATDR LPLDVFNNYF SLGFDAHVTL
660 670 680 690 700
EFHESREANP EKFNSRFRNK MFYAGTAFSD FLMGSSKDLA KHIRVVCDGM
710 720 730 740 750
DLTPKIQDLK PQCVVFLNIP RYCAGTMPWG HPGEHHDFEP QRHDDGYLEV
760 770 780 790 800
IGFTMTSLAA LQVGGHGERL TQCREVVLTT SKAIPVQVDG EPCKLAASRI
810 820 830 840 850
RIALRNQATM VQKAKRRSAA PLHSDQQPVP EQLRIQVSRV SMHDYEALHY
860 870 880 890 900
DKEQLKEASV PLGTVVVPGD SDLELCRAHI ERLQQEPDGA GAKSPTCQKL
910 920 930 940 950
SPKWCFLDAT TASRFYRIDR AQEHLNYVTE IAQDEIYILD PELLGASARP
960 970 980 990 1000
DLPTPTSPLP TSPCSPTPRS LQGDAAPPQG EELIEAAKRN DFCKLQELHR
1010 1020 1030 1040 1050
AGGDLMHRDE QSRTLLHHAV STGSKDVVRY LLDHAPPEIL DAVEENGETC
1060 1070 1080 1090 1100
LHQAAALGQR TICHYIVEAG ASLMKTDQQG DTPRQRAEKA QDTELAAYLE
1110
NRQHYQMIQR EDQETAV
Note: Minor isoform.
Length:1,117
Mass (Da):124,128
Last modified:November 25, 2008 - v3
Checksum:iF3A7C2382ECF549B
GO
Isoform 2 (identifier: Q13574-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR

Note: Major isoform.
Show »
Length:928
Mass (Da):103,981
Checksum:i7936A979CB3D35AA
GO
Isoform 3 (identifier: Q13574-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: METFFRRHFR...SCGVRAQGSS → MAEGQGGGGQ...LHLRKQVSYR
     72-243: Missing.

Note: No experimental confirmation available.
Show »
Length:945
Mass (Da):106,030
Checksum:i6EF612B9FE91F7E7
GO
Isoform 4 (identifier: Q13574-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ

Note: No experimental confirmation available.
Show »
Length:929
Mass (Da):104,109
Checksum:i362346DD9046B323
GO
Isoform 5 (identifier: Q13574-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     1046-1046: N → NPCSPS

Note: No experimental confirmation available.
Show »
Length:934
Mass (Da):104,581
Checksum:i3B9CEB5C58B865F7
GO
Isoform 6 (identifier: Q13574-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MEPRDGSPEA...FPGLRLFGHR
     311-311: L → LQ
     356-378: Missing.

Note: No experimental confirmation available.
Show »
Length:906
Mass (Da):101,230
Checksum:i99789AD08DCCB5BD
GO
Isoform 7 (identifier: Q13574-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: METFFRRHFR...GPQAWSALLA → MSAPGAGHSA...QIPSEAPQTQ
     280-280: Missing.
     311-311: L → LQ

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):104,296
Checksum:i57D46241E25FC58C
GO

Sequence cautioni

The sequence AAB60859 differs from that shown. Reason: Frameshift at positions 166 and 167.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159L → V in AAB60859 (PubMed:9159104).Curated1
Sequence conflicti494G → W in BAH11915 (PubMed:14702039).Curated1
Sequence conflicti783A → S in BAH11915 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04737121Q → R.1 PublicationCorresponds to variant rs1317826dbSNPEnsembl.1
Natural variantiVAR_06113169G → C.Corresponds to variant rs901998dbSNPEnsembl.1
Natural variantiVAR_069059712Q → K.1 PublicationCorresponds to variant rs17854149dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0012681 – 243METFF…SALLA → MEPRDGSPEARSSDSESASA SSSGSERDAGPEPDKAPRRL NKRRFPGLRLFGHR in isoform 2, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST243
Alternative sequenceiVSP_0551471 – 243METFF…SALLA → MSAPGAGHSAGGSCNESSAL GPVEALGTEEGERPGSLRQM WRYRSWDVPQIPSEAPQTQ in isoform 7. CuratedAdd BLAST243
Alternative sequenceiVSP_0431631 – 71METFF…AQGSS → MAEGQGGGGQRWDWAGGGRA AEEEVVRRRCRRGEEAQVAQ PWPEGSRGTAAGPPVEERFR QLHLRKQVSYR in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_04316472 – 243Missing in isoform 3. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_055148280Missing in isoform 7. Curated1
Alternative sequenceiVSP_045628311L → LQ in isoform 4, isoform 5, isoform 6 and isoform 7. 3 Publications1
Alternative sequenceiVSP_046919356 – 378Missing in isoform 6. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0469201046N → NPCSPS in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51477 mRNA. Translation: AAC50478.1.
U94905 mRNA. Translation: AAB60859.1. Frameshift.
AK124594 mRNA. Translation: BAC85894.1.
AK294888 mRNA. Translation: BAH11915.1.
AK300577 mRNA. Translation: BAH13309.1.
AK225774 mRNA. No translation available.
AC116021 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68008.1.
BC041770 mRNA. Translation: AAH41770.1.
CCDSiCCDS41640.1. [Q13574-1]
CCDS44579.2. [Q13574-7]
CCDS44580.1. [Q13574-4]
CCDS55757.1. [Q13574-5]
CCDS55758.1. [Q13574-6]
CCDS55759.1. [Q13574-2]
CCDS7918.1. [Q13574-3]
RefSeqiNP_001099010.1. NM_001105540.1. [Q13574-1]
NP_001186195.1. NM_001199266.1. [Q13574-5]
NP_001186196.1. NM_001199267.1. [Q13574-2]
NP_001186197.1. NM_001199268.1. [Q13574-6]
NP_003637.2. NM_003646.3. [Q13574-4]
NP_963290.1. NM_201532.2. [Q13574-3]
NP_963291.2. NM_201533.3. [Q13574-7]
UniGeneiHs.502461.

Genome annotation databases

EnsembliENST00000318201; ENSP00000320340; ENSG00000149091. [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091. [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091. [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091. [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091. [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091. [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091. [Q13574-7]
GeneIDi8525.
KEGGihsa:8525.
UCSCiuc001nch.2. human. [Q13574-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51477 mRNA. Translation: AAC50478.1.
U94905 mRNA. Translation: AAB60859.1. Frameshift.
AK124594 mRNA. Translation: BAC85894.1.
AK294888 mRNA. Translation: BAH11915.1.
AK300577 mRNA. Translation: BAH13309.1.
AK225774 mRNA. No translation available.
AC116021 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68008.1.
BC041770 mRNA. Translation: AAH41770.1.
CCDSiCCDS41640.1. [Q13574-1]
CCDS44579.2. [Q13574-7]
CCDS44580.1. [Q13574-4]
CCDS55757.1. [Q13574-5]
CCDS55758.1. [Q13574-6]
CCDS55759.1. [Q13574-2]
CCDS7918.1. [Q13574-3]
RefSeqiNP_001099010.1. NM_001105540.1. [Q13574-1]
NP_001186195.1. NM_001199266.1. [Q13574-5]
NP_001186196.1. NM_001199267.1. [Q13574-2]
NP_001186197.1. NM_001199268.1. [Q13574-6]
NP_003637.2. NM_003646.3. [Q13574-4]
NP_963290.1. NM_201532.2. [Q13574-3]
NP_963291.2. NM_201533.3. [Q13574-7]
UniGeneiHs.502461.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ELQX-ray1.10C/P1110-1117[»]
ProteinModelPortaliQ13574.
SMRiQ13574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114095. 20 interactors.
IntActiQ13574. 12 interactors.
MINTiMINT-198176.
STRINGi9606.ENSP00000412178.

Chemistry databases

SwissLipidsiSLP:000000547.
SLP:000000921. [Q13574-1]
SLP:000000922. [Q13574-2]

PTM databases

iPTMnetiQ13574.
PhosphoSitePlusiQ13574.

Polymorphism and mutation databases

BioMutaiDGKZ.
DMDMi215274170.

Proteomic databases

EPDiQ13574.
MaxQBiQ13574.
PaxDbiQ13574.
PeptideAtlasiQ13574.
PRIDEiQ13574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318201; ENSP00000320340; ENSG00000149091. [Q13574-6]
ENST00000343674; ENSP00000343065; ENSG00000149091. [Q13574-3]
ENST00000421244; ENSP00000391021; ENSG00000149091. [Q13574-4]
ENST00000454345; ENSP00000412178; ENSG00000149091. [Q13574-1]
ENST00000456247; ENSP00000395684; ENSG00000149091. [Q13574-2]
ENST00000527911; ENSP00000436291; ENSG00000149091. [Q13574-5]
ENST00000532868; ENSP00000436273; ENSG00000149091. [Q13574-7]
GeneIDi8525.
KEGGihsa:8525.
UCSCiuc001nch.2. human. [Q13574-1]

Organism-specific databases

CTDi8525.
DisGeNETi8525.
GeneCardsiDGKZ.
H-InvDBHIX0009600.
HIX0037561.
HGNCiHGNC:2857. DGKZ.
HPAiHPA051336.
HPA056920.
MIMi601441. gene.
neXtProtiNX_Q13574.
OpenTargetsiENSG00000149091.
PharmGKBiPA27318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0782. Eukaryota.
ENOG410XSCB. LUCA.
GeneTreeiENSGT00760000119050.
HOGENOMiHOG000231472.
HOVERGENiHBG067303.
InParanoidiQ13574.
KOiK00901.
OMAiAGGDLMH.
OrthoDBiEOG091G13Z8.
PhylomeDBiQ13574.
TreeFamiTF312817.

Enzyme and pathway databases

BioCyciZFISH:HS07583-MONOMER.
BRENDAi2.7.1.107. 2681.
ReactomeiR-HSA-114508. Effects of PIP2 hydrolysis.
SIGNORiQ13574.

Miscellaneous databases

ChiTaRSiDGKZ. human.
GeneWikiiDGKZ.
GenomeRNAii8525.
PROiQ13574.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149091.
CleanExiHS_DGKZ.
ExpressionAtlasiQ13574. baseline and differential.
GenevisibleiQ13574. HS.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00130. C1_1. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGKZ_HUMAN
AccessioniPrimary (citable) accession number: Q13574
Secondary accession number(s): B7Z2M9
, B7Z6M3, E9PPW4, F6UCU9, G3V0F6, J3KNJ6, O00542, Q6ZVG7, Q8IVW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.