ID   LAPM5_HUMAN             Reviewed;         262 AA.
AC   Q13571; Q13240; Q14698; Q3KP54;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 170.
DE   RecName: Full=Lysosomal-associated transmembrane protein 5;
DE   AltName: Full=Lysosomal-associated multitransmembrane protein 5;
DE   AltName: Full=Retinoic acid-inducible E3 protein;
GN   Name=LAPTM5; Synonyms=KIAA0085;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Spleen;
RX   PubMed=8661146; DOI=10.1006/geno.1996.0364;
RA   Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H.,
RA   Horiuchi T., Lelias J.-M., Rowley J.D., Lim B.;
RT   "LAPTM5: a novel lysosomal-associated multispanning membrane protein
RT   preferentially expressed in hematopoietic cells.";
RL   Genomics 35:328-337(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Scott L.M., Collins S.J.;
RL   Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7788527; DOI=10.1093/dnares/2.1.37;
RA   Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S.,
RA   Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. III. The
RT   coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of
RT   cDNA clones from human cell line KG-1.";
RL   DNA Res. 2:37-43(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-226.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May have a special functional role during embryogenesis and
CC       in adult hematopoietic cells. {ECO:0000269|PubMed:8661146}.
CC   -!- SUBUNIT: Binds to ubiquitin.
CC   -!- INTERACTION:
CC       Q13571; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-2865663, EBI-11957045;
CC       Q13571; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-2865663, EBI-12003442;
CC       Q13571; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-2865663, EBI-12256978;
CC       Q13571; P00387: CYB5R3; NbExp=3; IntAct=EBI-2865663, EBI-1046040;
CC       Q13571; Q96F81: DISP1; NbExp=3; IntAct=EBI-2865663, EBI-10230179;
CC       Q13571; P02724: GYPA; NbExp=3; IntAct=EBI-2865663, EBI-702665;
CC       Q13571; P30519: HMOX2; NbExp=3; IntAct=EBI-2865663, EBI-712096;
CC       Q13571; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-2865663, EBI-8503746;
CC       Q13571; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-2865663, EBI-17272405;
CC       Q13571; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-2865663, EBI-10173166;
CC       Q13571; Q9H0U6: MRPL18; NbExp=3; IntAct=EBI-2865663, EBI-2560240;
CC       Q13571; Q9NS64: RPRM; NbExp=3; IntAct=EBI-2865663, EBI-1052363;
CC       Q13571; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-2865663, EBI-10244780;
CC       Q13571; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-2865663, EBI-988826;
CC       Q13571; P23763-3: VAMP1; NbExp=3; IntAct=EBI-2865663, EBI-12097582;
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:8661146};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:8661146}.
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in adult hematopoietic
CC       tissues. High levels in lymphoid and myeloid tissues. Highly expressed
CC       in peripheral blood leukocytes, thymus, spleen and lung, followed by
CC       placenta, liver and kidney. {ECO:0000269|PubMed:8661146}.
CC   -!- INDUCTION: By retinoic acid.
CC   -!- SIMILARITY: Belongs to the LAPTM4/LAPTM5 transporter family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA07643.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U51240; AAB08975.1; -; mRNA.
DR   EMBL; U30498; AAA74018.1; -; mRNA.
DR   EMBL; D42042; BAA07643.1; ALT_INIT; mRNA.
DR   EMBL; BC106896; AAI06897.1; -; mRNA.
DR   CCDS; CCDS337.1; -.
DR   PIR; G02476; G02476.
DR   RefSeq; NP_006753.1; NM_006762.2.
DR   AlphaFoldDB; Q13571; -.
DR   BioGRID; 113580; 57.
DR   IntAct; Q13571; 34.
DR   MINT; Q13571; -.
DR   STRING; 9606.ENSP00000294507; -.
DR   TCDB; 2.A.74.1.4; the 4 tms multidrug endosomal transporter (met) family.
DR   iPTMnet; Q13571; -.
DR   PhosphoSitePlus; Q13571; -.
DR   SwissPalm; Q13571; -.
DR   BioMuta; LAPTM5; -.
DR   EPD; Q13571; -.
DR   jPOST; Q13571; -.
DR   MassIVE; Q13571; -.
DR   PaxDb; 9606-ENSP00000294507; -.
DR   PeptideAtlas; Q13571; -.
DR   ProteomicsDB; 59574; -.
DR   Pumba; Q13571; -.
DR   Antibodypedia; 54047; 113 antibodies from 18 providers.
DR   DNASU; 7805; -.
DR   Ensembl; ENST00000294507.4; ENSP00000294507.3; ENSG00000162511.8.
DR   GeneID; 7805; -.
DR   KEGG; hsa:7805; -.
DR   MANE-Select; ENST00000294507.4; ENSP00000294507.3; NM_006762.3; NP_006753.1.
DR   AGR; HGNC:29612; -.
DR   CTD; 7805; -.
DR   DisGeNET; 7805; -.
DR   GeneCards; LAPTM5; -.
DR   HGNC; HGNC:29612; LAPTM5.
DR   HPA; ENSG00000162511; Tissue enhanced (bone marrow, lymphoid tissue).
DR   MIM; 601476; gene.
DR   neXtProt; NX_Q13571; -.
DR   OpenTargets; ENSG00000162511; -.
DR   PharmGKB; PA134953439; -.
DR   VEuPathDB; HostDB:ENSG00000162511; -.
DR   eggNOG; ENOG502RY9P; Eukaryota.
DR   GeneTree; ENSGT00940000153446; -.
DR   HOGENOM; CLU_1065422_0_0_1; -.
DR   InParanoid; Q13571; -.
DR   OMA; QICCCFN; -.
DR   OrthoDB; 5322047at2759; -.
DR   PhylomeDB; Q13571; -.
DR   TreeFam; TF330843; -.
DR   PathwayCommons; Q13571; -.
DR   SignaLink; Q13571; -.
DR   SIGNOR; Q13571; -.
DR   BioGRID-ORCS; 7805; 18 hits in 1154 CRISPR screens.
DR   ChiTaRS; LAPTM5; human.
DR   GenomeRNAi; 7805; -.
DR   Pharos; Q13571; Tbio.
DR   PRO; PR:Q13571; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q13571; Protein.
DR   Bgee; ENSG00000162511; Expressed in blood and 202 other cell types or tissues.
DR   ExpressionAtlas; Q13571; baseline and differential.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IDA:ARUK-UCL.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005765; C:lysosomal membrane; IDA:ARUK-UCL.
DR   GO; GO:0005764; C:lysosome; IDA:ARUK-UCL.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IMP:ARUK-UCL.
DR   GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR   GO; GO:0032991; C:protein-containing complex; IDA:ARUK-UCL.
DR   GO; GO:0030133; C:transport vesicle; IDA:ARUK-UCL.
DR   GO; GO:0140311; F:protein sequestering activity; ISS:ARUK-UCL.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:ARUK-UCL.
DR   GO; GO:0140036; F:ubiquitin-dependent protein binding; IMP:ARUK-UCL.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:ARUK-UCL.
DR   GO; GO:0002357; P:defense response to tumor cell; IDA:ARUK-UCL.
DR   GO; GO:0090160; P:Golgi to lysosome transport; ISS:ARUK-UCL.
DR   GO; GO:0012502; P:induction of programmed cell death; IDA:ARUK-UCL.
DR   GO; GO:0006886; P:intracellular protein transport; ISS:ARUK-UCL.
DR   GO; GO:1904093; P:negative regulation of autophagic cell death; IDA:ARUK-UCL.
DR   GO; GO:0050869; P:negative regulation of B cell activation; ISS:ARUK-UCL.
DR   GO; GO:0032703; P:negative regulation of interleukin-2 production; ISS:ARUK-UCL.
DR   GO; GO:0050868; P:negative regulation of T cell activation; ISS:ARUK-UCL.
DR   GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; ISS:ARUK-UCL.
DR   GO; GO:0032689; P:negative regulation of type II interferon production; ISS:ARUK-UCL.
DR   GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; ISS:ARUK-UCL.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; ISS:ARUK-UCL.
DR   GO; GO:0097214; P:positive regulation of lysosomal membrane permeability; IDA:ARUK-UCL.
DR   GO; GO:0060907; P:positive regulation of macrophage cytokine production; ISS:ARUK-UCL.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:ARUK-UCL.
DR   GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; ISS:ARUK-UCL.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:ARUK-UCL.
DR   GO; GO:2000646; P:positive regulation of receptor catabolic process; ISS:ARUK-UCL.
DR   GO; GO:1903265; P:positive regulation of tumor necrosis factor-mediated signaling pathway; ISS:ARUK-UCL.
DR   GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; ISS:ARUK-UCL.
DR   GO; GO:0006622; P:protein targeting to lysosome; ISS:ARUK-UCL.
DR   InterPro; IPR004687; LAPTM4/5.
DR   InterPro; IPR018396; LAPTM_4A/5.
DR   NCBIfam; TIGR00799; mtp; 1.
DR   PANTHER; PTHR12479; LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR12479:SF2; LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN 5; 1.
DR   Pfam; PF03821; Mtp; 1.
DR   Genevisible; Q13571; HS.
PE   1: Evidence at protein level;
KW   Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..262
FT                   /note="Lysosomal-associated transmembrane protein 5"
FT                   /id="PRO_0000084357"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         259
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q61168"
FT   VARIANT         226
FT                   /note="R -> K (in dbSNP:rs35351292)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_053653"
FT   CONFLICT        249
FT                   /note="T -> D (in Ref. 2; AAA74018)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   262 AA;  29937 MW;  64A9B3F09C14FCE7 CRC64;
     MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI
     ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI MDYLLCLLTL LGSYIELPAY
     LKLASRSRAS SSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP
     HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE
     EALSLPSKTP EGGPAPPPYS EV
//