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Protein

Lysosomal-associated transmembrane protein 5

Gene

LAPTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a special functional role during embryogenesis and in adult hematopoietic cells.1 Publication

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.74.1.4. the 4 tms multidrug endosomal transporter (met) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 5
Alternative name(s):
Lysosomal-associated multitransmembrane protein 5
Retinoic acid-inducible E3 protein
Gene namesi
Name:LAPTM5
Synonyms:KIAA0085
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29612. LAPTM5.

Subcellular locationi

Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. lysosomal membrane Source: UniProtKB-SubCell
  3. lysosome Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Lysosomal-associated transmembrane protein 5PRO_0000084357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei259 – 2591PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13571.
PaxDbiQ13571.
PRIDEiQ13571.

PTM databases

PhosphoSiteiQ13571.

Expressioni

Tissue specificityi

Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and kidney.1 Publication

Inductioni

By retinoic acid.

Gene expression databases

BgeeiQ13571.
CleanExiHS_LAPTM5.
ExpressionAtlasiQ13571. baseline and differential.
GenevestigatoriQ13571.

Organism-specific databases

HPAiHPA051293.

Interactioni

Subunit structurei

Binds to ubiquitin.

Protein-protein interaction databases

BioGridi113580. 23 interactions.
IntActiQ13571. 18 interactions.
MINTiMINT-1179617.
STRINGi9606.ENSP00000294507.

Structurei

3D structure databases

ProteinModelPortaliQ13571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 25813Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44671.
HOGENOMiHOG000113282.
HOVERGENiHBG052307.
InParanoidiQ13571.
KOiK12387.
OMAiCVWRCYK.
OrthoDBiEOG7K9K3R.
PhylomeDBiQ13571.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF2. PTHR12479:SF2. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC
60 70 80 90 100
KLSQMGYLRI ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI
110 120 130 140 150
MDYLLCLLTL LGSYIELPAY LKLASRSRAS SSKFPLMTLQ LLDFCLSILT
160 170 180 190 200
LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP HNQFIKMMII FSIAFITVLI
210 220 230 240 250
FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE EALSLPSKTP
260
EGGPAPPPYS EV
Length:262
Mass (Da):29,937
Last modified:November 1, 1996 - v1
Checksum:i64A9B3F09C14FCE7
GO

Sequence cautioni

The sequence BAA07643.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491T → D in AAA74018 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261R → K.1 Publication
Corresponds to variant rs35351292 [ dbSNP | Ensembl ].
VAR_053653

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51240 mRNA. Translation: AAB08975.1.
U30498 mRNA. Translation: AAA74018.1.
D42042 mRNA. Translation: BAA07643.1. Different initiation.
BC106896 mRNA. Translation: AAI06897.1.
CCDSiCCDS337.1.
PIRiG02476.
RefSeqiNP_006753.1. NM_006762.2.
UniGeneiHs.371021.

Genome annotation databases

EnsembliENST00000294507; ENSP00000294507; ENSG00000162511.
GeneIDi7805.
KEGGihsa:7805.
UCSCiuc001bsc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51240 mRNA. Translation: AAB08975.1.
U30498 mRNA. Translation: AAA74018.1.
D42042 mRNA. Translation: BAA07643.1. Different initiation.
BC106896 mRNA. Translation: AAI06897.1.
CCDSiCCDS337.1.
PIRiG02476.
RefSeqiNP_006753.1. NM_006762.2.
UniGeneiHs.371021.

3D structure databases

ProteinModelPortaliQ13571.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113580. 23 interactions.
IntActiQ13571. 18 interactions.
MINTiMINT-1179617.
STRINGi9606.ENSP00000294507.

Protein family/group databases

TCDBi2.A.74.1.4. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

PhosphoSiteiQ13571.

Proteomic databases

MaxQBiQ13571.
PaxDbiQ13571.
PRIDEiQ13571.

Protocols and materials databases

DNASUi7805.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294507; ENSP00000294507; ENSG00000162511.
GeneIDi7805.
KEGGihsa:7805.
UCSCiuc001bsc.2. human.

Organism-specific databases

CTDi7805.
GeneCardsiGC01M031205.
HGNCiHGNC:29612. LAPTM5.
HPAiHPA051293.
MIMi601476. gene.
neXtProtiNX_Q13571.
PharmGKBiPA134953439.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44671.
HOGENOMiHOG000113282.
HOVERGENiHBG052307.
InParanoidiQ13571.
KOiK12387.
OMAiCVWRCYK.
OrthoDBiEOG7K9K3R.
PhylomeDBiQ13571.
TreeFamiTF330843.

Miscellaneous databases

ChiTaRSiLAPTM5. human.
GenomeRNAii7805.
NextBioi30198.
PROiQ13571.
SOURCEiSearch...

Gene expression databases

BgeeiQ13571.
CleanExiHS_LAPTM5.
ExpressionAtlasiQ13571. baseline and differential.
GenevestigatoriQ13571.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF2. PTHR12479:SF2. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells."
    Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H., Horiuchi T., Lelias J.-M., Rowley J.D., Lim B.
    Genomics 35:328-337(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Spleen.
  2. Scott L.M., Collins S.J.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-226.

Entry informationi

Entry nameiLAPM5_HUMAN
AccessioniPrimary (citable) accession number: Q13571
Secondary accession number(s): Q13240, Q14698, Q3KP54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.