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Q13571 (LAPM5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosomal-associated transmembrane protein 5
Alternative name(s):
Lysosomal-associated multitransmembrane protein 5
Retinoic acid-inducible E3 protein
Gene names
Name:LAPTM5
Synonyms:KIAA0085
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have a special functional role during embryogenesis and in adult hematopoietic cells. Ref.1

Subunit structure

Binds to ubiquitin. Ref.1

Subcellular location

Lysosome membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and kidney. Ref.1

Induction

By retinoic acid.

Sequence similarities

Belongs to the LAPTM4/LAPTM5 transporter family.

Sequence caution

The sequence BAA07643.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentLysosome
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

lysosomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

lysosome

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Lysosomal-associated transmembrane protein 5
PRO_0000084357

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane64 – 8421Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane184 – 20421Helical; Potential
Compositional bias246 – 25813Pro-rich

Amino acid modifications

Modified residue2591Phosphotyrosine By similarity

Natural variations

Natural variant2261R → K. Ref.4
Corresponds to variant rs35351292 [ dbSNP | Ensembl ].
VAR_053653

Experimental info

Sequence conflict2491T → D in AAA74018. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q13571 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 64A9B3F09C14FCE7

FASTA26229,937
        10         20         30         40         50         60 
MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI 

        70         80         90        100        110        120 
ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI MDYLLCLLTL LGSYIELPAY 

       130        140        150        160        170        180 
LKLASRSRAS SSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP 

       190        200        210        220        230        240 
HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE 

       250        260 
EALSLPSKTP EGGPAPPPYS EV 

« Hide

References

« Hide 'large scale' references
[1]"LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells."
Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H., Horiuchi T., Lelias J.-M., Rowley J.D., Lim B.
Genomics 35:328-337(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Spleen.
[2]Scott L.M., Collins S.J.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-226.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U51240 mRNA. Translation: AAB08975.1.
U30498 mRNA. Translation: AAA74018.1.
D42042 mRNA. Translation: BAA07643.1. Different initiation.
BC106896 mRNA. Translation: AAI06897.1.
PIRG02476.
RefSeqNP_006753.1. NM_006762.2.
UniGeneHs.371021.

3D structure databases

ProteinModelPortalQ13571.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113580. 21 interactions.
IntActQ13571. 18 interactions.
MINTMINT-1179617.
STRING9606.ENSP00000294507.

Protein family/group databases

TCDB2.A.74.1.4. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

PhosphoSiteQ13571.

Polymorphism databases

DMDM3183068.

Proteomic databases

PaxDbQ13571.
PRIDEQ13571.

Protocols and materials databases

DNASU7805.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294507; ENSP00000294507; ENSG00000162511.
GeneID7805.
KEGGhsa:7805.
UCSCuc001bsc.2. human.

Organism-specific databases

CTD7805.
GeneCardsGC01M031205.
HGNCHGNC:29612. LAPTM5.
HPAHPA051293.
MIM601476. gene.
neXtProtNX_Q13571.
PharmGKBPA134953439.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44671.
HOGENOMHOG000113282.
HOVERGENHBG052307.
InParanoidQ13571.
KOK12387.
OMAPAYLKFA.
OrthoDBEOG7K9K3R.
PhylomeDBQ13571.
TreeFamTF330843.

Gene expression databases

ArrayExpressQ13571.
BgeeQ13571.
CleanExHS_LAPTM5.
GenevestigatorQ13571.

Family and domain databases

InterProIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view]
PANTHERPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF2. PTHR12479:SF2. 1 hit.
PfamPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsTIGR00799. mtp. 1 hit.
ProtoNetSearch...

Other

ChiTaRSLAPTM5. human.
GenomeRNAi7805.
NextBio30198.
PROQ13571.
SOURCESearch...

Entry information

Entry nameLAPM5_HUMAN
AccessionPrimary (citable) accession number: Q13571
Secondary accession number(s): Q13240, Q14698, Q3KP54
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM