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Q13571

- LAPM5_HUMAN

UniProt

Q13571 - LAPM5_HUMAN

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Protein

Lysosomal-associated transmembrane protein 5

Gene

LAPTM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May have a special functional role during embryogenesis and in adult hematopoietic cells.1 Publication

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.74.1.4. the 4 tms multidrug endosomal transporter (met) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 5
Alternative name(s):
Lysosomal-associated multitransmembrane protein 5
Retinoic acid-inducible E3 protein
Gene namesi
Name:LAPTM5
Synonyms:KIAA0085
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29612. LAPTM5.

Subcellular locationi

Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. lysosomal membrane Source: InterPro
  3. lysosome Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Lysosomal-associated transmembrane protein 5PRO_0000084357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei259 – 2591PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13571.
PaxDbiQ13571.
PRIDEiQ13571.

PTM databases

PhosphoSiteiQ13571.

Expressioni

Tissue specificityi

Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and kidney.1 Publication

Inductioni

By retinoic acid.

Gene expression databases

BgeeiQ13571.
CleanExiHS_LAPTM5.
ExpressionAtlasiQ13571. baseline and differential.
GenevestigatoriQ13571.

Organism-specific databases

HPAiHPA051293.

Interactioni

Subunit structurei

Binds to ubiquitin.

Protein-protein interaction databases

BioGridi113580. 21 interactions.
IntActiQ13571. 18 interactions.
MINTiMINT-1179617.
STRINGi9606.ENSP00000294507.

Structurei

3D structure databases

ProteinModelPortaliQ13571.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 25813Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44671.
HOGENOMiHOG000113282.
HOVERGENiHBG052307.
InParanoidiQ13571.
KOiK12387.
OMAiCVWRCYK.
OrthoDBiEOG7K9K3R.
PhylomeDBiQ13571.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF2. PTHR12479:SF2. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13571-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC
60 70 80 90 100
KLSQMGYLRI ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI
110 120 130 140 150
MDYLLCLLTL LGSYIELPAY LKLASRSRAS SSKFPLMTLQ LLDFCLSILT
160 170 180 190 200
LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP HNQFIKMMII FSIAFITVLI
210 220 230 240 250
FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE EALSLPSKTP
260
EGGPAPPPYS EV
Length:262
Mass (Da):29,937
Last modified:November 1, 1996 - v1
Checksum:i64A9B3F09C14FCE7
GO

Sequence cautioni

The sequence BAA07643.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491T → D in AAA74018. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti226 – 2261R → K.1 Publication
Corresponds to variant rs35351292 [ dbSNP | Ensembl ].
VAR_053653

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51240 mRNA. Translation: AAB08975.1.
U30498 mRNA. Translation: AAA74018.1.
D42042 mRNA. Translation: BAA07643.1. Different initiation.
BC106896 mRNA. Translation: AAI06897.1.
CCDSiCCDS337.1.
PIRiG02476.
RefSeqiNP_006753.1. NM_006762.2.
UniGeneiHs.371021.

Genome annotation databases

EnsembliENST00000294507; ENSP00000294507; ENSG00000162511.
GeneIDi7805.
KEGGihsa:7805.
UCSCiuc001bsc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51240 mRNA. Translation: AAB08975.1 .
U30498 mRNA. Translation: AAA74018.1 .
D42042 mRNA. Translation: BAA07643.1 . Different initiation.
BC106896 mRNA. Translation: AAI06897.1 .
CCDSi CCDS337.1.
PIRi G02476.
RefSeqi NP_006753.1. NM_006762.2.
UniGenei Hs.371021.

3D structure databases

ProteinModelPortali Q13571.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113580. 21 interactions.
IntActi Q13571. 18 interactions.
MINTi MINT-1179617.
STRINGi 9606.ENSP00000294507.

Protein family/group databases

TCDBi 2.A.74.1.4. the 4 tms multidrug endosomal transporter (met) family.

PTM databases

PhosphoSitei Q13571.

Proteomic databases

MaxQBi Q13571.
PaxDbi Q13571.
PRIDEi Q13571.

Protocols and materials databases

DNASUi 7805.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294507 ; ENSP00000294507 ; ENSG00000162511 .
GeneIDi 7805.
KEGGi hsa:7805.
UCSCi uc001bsc.2. human.

Organism-specific databases

CTDi 7805.
GeneCardsi GC01M031205.
HGNCi HGNC:29612. LAPTM5.
HPAi HPA051293.
MIMi 601476. gene.
neXtProti NX_Q13571.
PharmGKBi PA134953439.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44671.
HOGENOMi HOG000113282.
HOVERGENi HBG052307.
InParanoidi Q13571.
KOi K12387.
OMAi CVWRCYK.
OrthoDBi EOG7K9K3R.
PhylomeDBi Q13571.
TreeFami TF330843.

Miscellaneous databases

ChiTaRSi LAPTM5. human.
GenomeRNAii 7805.
NextBioi 30198.
PROi Q13571.
SOURCEi Search...

Gene expression databases

Bgeei Q13571.
CleanExi HS_LAPTM5.
ExpressionAtlasi Q13571. baseline and differential.
Genevestigatori Q13571.

Family and domain databases

InterProi IPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view ]
PANTHERi PTHR12479. PTHR12479. 1 hit.
PTHR12479:SF2. PTHR12479:SF2. 1 hit.
Pfami PF03821. Mtp. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00799. mtp. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells."
    Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H., Horiuchi T., Lelias J.-M., Rowley J.D., Lim B.
    Genomics 35:328-337(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Spleen.
  2. Scott L.M., Collins S.J.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-226.

Entry informationi

Entry nameiLAPM5_HUMAN
AccessioniPrimary (citable) accession number: Q13571
Secondary accession number(s): Q13240, Q14698, Q3KP54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3