Q13571 (LAPM5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysosomal-associated transmembrane protein 5

Alternative name(s):
Lysosomal-associated multitransmembrane protein 5
Retinoic acid-inducible E3 protein

Gene names

Name:	LAPTM5
Synonyms:	KIAA0085

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a special functional role during embryogenesis and in adult hematopoietic cells. Ref.1
Subunit structure	Binds to ubiquitin. Ref.1
Subcellular location	Lysosome membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and kidney. Ref.1
Induction	By retinoic acid.
Sequence similarities	Belongs to the LAPTM4/LAPTM5 transporter family.
Sequence caution	The sequence BAA07643.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Lysosome Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc lysosomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell lysosome Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Lysosomal-associated transmembrane protein 5		PRO_0000084357
Regions
	Transmembrane	19 – 39	21	Helical; Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Compositional bias	246 – 258	13	Pro-rich
Amino acid modifications
	Modified residue	259	1	Phosphotyrosine By similarity
Natural variations
	Natural variant	226	1	R → K. Ref.4 Corresponds to variant rs35351292 [ dbSNP | Ensembl ].		VAR_053653
Experimental info
	Sequence conflict	249	1	T → D in AAA74018. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q13571 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 64A9B3F09C14FCE7	FASTA	262	29,937
	10 20 30 40 50 60 MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI 70 80 90 100 110 120 ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI MDYLLCLLTL LGSYIELPAY 130 140 150 160 170 180 LKLASRSRAS SSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP 190 200 210 220 230 240 HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE 250 260 EALSLPSKTP EGGPAPPPYS EV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells." Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H., Horiuchi T., Lelias J.-M., Rowley J.D., Lim B. Genomics 35:328-337(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Spleen.
[2]	Scott L.M., Collins S.J. Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N. DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-226.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U51240 mRNA. Translation: AAB08975.1. U30498 mRNA. Translation: AAA74018.1. D42042 mRNA. Translation: BAA07643.1. Different initiation. BC106896 mRNA. Translation: AAI06897.1.
IPI	IPI00013827.
PIR	G02476.
RefSeq	NP_006753.1. NM_006762.2.
UniGene	Hs.371021.
3D structure databases
ProteinModelPortal	Q13571.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13571. 2 interactions.
MINT	MINT-1179617.
STRING	9606.ENSP00000294507.
PTM databases
PhosphoSite	Q13571.
Polymorphism databases
DMDM	3183068.
Proteomic databases
PaxDb	Q13571.
PRIDE	Q13571.
Protocols and materials databases
DNASU	7805.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294507; ENSP00000294507; ENSG00000162511.
GeneID	7805.
KEGG	hsa:7805.
UCSC	uc001bsc.2. human.
Organism-specific databases
CTD	7805.
GeneCards	GC01M031205.
HGNC	HGNC:29612. LAPTM5.
HPA	HPA051293.
MIM	601476. gene.
neXtProt	NX_Q13571.
PharmGKB	PA134953439.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44671.
HOGENOM	HOG000113282.
HOVERGEN	HBG052307.
InParanoid	Q13571.
KO	K12387.
OrthoDB	EOG4BRWMH.
PhylomeDB	Q13571.
Gene expression databases
ArrayExpress	Q13571.
Bgee	Q13571.
CleanEx	HS_LAPTM5.
Genevestigator	Q13571.
GermOnline	ENSG00000162511. Homo sapiens.
Family and domain databases
InterPro	IPR004687. LAPTM4/5. IPR018396. LAPTM_4A/5. IPR018397. Lysosomal-assoc_TM_prot5. [Graphical view]
PANTHER	PTHR12479. PTHR12479. 1 hit. PTHR12479:SF2. PTHR12479:SF2. 1 hit.
Pfam	PF03821. Mtp. 1 hit. [Graphical view]
TIGRFAMs	TIGR00799. mtp. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	LAPTM5. human.
GenomeRNAi	7805.
NextBio	30198.
SOURCE	Search...

Entry information

Entry name

LAPM5_HUMAN

Accession

Primary (citable) accession number: Q13571
Secondary accession number(s): Q13240, Q14698, Q3KP54

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.