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Q13571

- LAPM5_HUMAN

UniProt

Q13571 - LAPM5_HUMAN

Protein

Lysosomal-associated transmembrane protein 5

Gene

LAPTM5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May have a special functional role during embryogenesis and in adult hematopoietic cells.1 Publication

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.74.1.4. the 4 tms multidrug endosomal transporter (met) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal-associated transmembrane protein 5
    Alternative name(s):
    Lysosomal-associated multitransmembrane protein 5
    Retinoic acid-inducible E3 protein
    Gene namesi
    Name:LAPTM5
    Synonyms:KIAA0085
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29612. LAPTM5.

    Subcellular locationi

    Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. lysosomal membrane Source: UniProtKB-SubCell
    3. lysosome Source: ProtInc

    Keywords - Cellular componenti

    Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134953439.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Lysosomal-associated transmembrane protein 5PRO_0000084357Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei259 – 2591PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ13571.
    PaxDbiQ13571.
    PRIDEiQ13571.

    PTM databases

    PhosphoSiteiQ13571.

    Expressioni

    Tissue specificityi

    Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and kidney.1 Publication

    Inductioni

    By retinoic acid.

    Gene expression databases

    ArrayExpressiQ13571.
    BgeeiQ13571.
    CleanExiHS_LAPTM5.
    GenevestigatoriQ13571.

    Organism-specific databases

    HPAiHPA051293.

    Interactioni

    Subunit structurei

    Binds to ubiquitin.

    Protein-protein interaction databases

    BioGridi113580. 21 interactions.
    IntActiQ13571. 18 interactions.
    MINTiMINT-1179617.
    STRINGi9606.ENSP00000294507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13571.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi246 – 25813Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LAPTM4/LAPTM5 transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44671.
    HOGENOMiHOG000113282.
    HOVERGENiHBG052307.
    InParanoidiQ13571.
    KOiK12387.
    OMAiCVWRCYK.
    OrthoDBiEOG7K9K3R.
    PhylomeDBiQ13571.
    TreeFamiTF330843.

    Family and domain databases

    InterProiIPR004687. LAPTM4/5.
    IPR018396. LAPTM_4A/5.
    IPR018397. Lysosomal-assoc_TM_prot5.
    [Graphical view]
    PANTHERiPTHR12479. PTHR12479. 1 hit.
    PTHR12479:SF2. PTHR12479:SF2. 1 hit.
    PfamiPF03821. Mtp. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00799. mtp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q13571-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC    50
    KLSQMGYLRI ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI 100
    MDYLLCLLTL LGSYIELPAY LKLASRSRAS SSKFPLMTLQ LLDFCLSILT 150
    LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP HNQFIKMMII FSIAFITVLI 200
    FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE EALSLPSKTP 250
    EGGPAPPPYS EV 262
    Length:262
    Mass (Da):29,937
    Last modified:November 1, 1996 - v1
    Checksum:i64A9B3F09C14FCE7
    GO

    Sequence cautioni

    The sequence BAA07643.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti249 – 2491T → D in AAA74018. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti226 – 2261R → K.1 Publication
    Corresponds to variant rs35351292 [ dbSNP | Ensembl ].
    VAR_053653

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51240 mRNA. Translation: AAB08975.1.
    U30498 mRNA. Translation: AAA74018.1.
    D42042 mRNA. Translation: BAA07643.1. Different initiation.
    BC106896 mRNA. Translation: AAI06897.1.
    CCDSiCCDS337.1.
    PIRiG02476.
    RefSeqiNP_006753.1. NM_006762.2.
    UniGeneiHs.371021.

    Genome annotation databases

    EnsembliENST00000294507; ENSP00000294507; ENSG00000162511.
    GeneIDi7805.
    KEGGihsa:7805.
    UCSCiuc001bsc.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51240 mRNA. Translation: AAB08975.1 .
    U30498 mRNA. Translation: AAA74018.1 .
    D42042 mRNA. Translation: BAA07643.1 . Different initiation.
    BC106896 mRNA. Translation: AAI06897.1 .
    CCDSi CCDS337.1.
    PIRi G02476.
    RefSeqi NP_006753.1. NM_006762.2.
    UniGenei Hs.371021.

    3D structure databases

    ProteinModelPortali Q13571.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113580. 21 interactions.
    IntActi Q13571. 18 interactions.
    MINTi MINT-1179617.
    STRINGi 9606.ENSP00000294507.

    Protein family/group databases

    TCDBi 2.A.74.1.4. the 4 tms multidrug endosomal transporter (met) family.

    PTM databases

    PhosphoSitei Q13571.

    Proteomic databases

    MaxQBi Q13571.
    PaxDbi Q13571.
    PRIDEi Q13571.

    Protocols and materials databases

    DNASUi 7805.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294507 ; ENSP00000294507 ; ENSG00000162511 .
    GeneIDi 7805.
    KEGGi hsa:7805.
    UCSCi uc001bsc.2. human.

    Organism-specific databases

    CTDi 7805.
    GeneCardsi GC01M031205.
    HGNCi HGNC:29612. LAPTM5.
    HPAi HPA051293.
    MIMi 601476. gene.
    neXtProti NX_Q13571.
    PharmGKBi PA134953439.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44671.
    HOGENOMi HOG000113282.
    HOVERGENi HBG052307.
    InParanoidi Q13571.
    KOi K12387.
    OMAi CVWRCYK.
    OrthoDBi EOG7K9K3R.
    PhylomeDBi Q13571.
    TreeFami TF330843.

    Miscellaneous databases

    ChiTaRSi LAPTM5. human.
    GenomeRNAii 7805.
    NextBioi 30198.
    PROi Q13571.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13571.
    Bgeei Q13571.
    CleanExi HS_LAPTM5.
    Genevestigatori Q13571.

    Family and domain databases

    InterProi IPR004687. LAPTM4/5.
    IPR018396. LAPTM_4A/5.
    IPR018397. Lysosomal-assoc_TM_prot5.
    [Graphical view ]
    PANTHERi PTHR12479. PTHR12479. 1 hit.
    PTHR12479:SF2. PTHR12479:SF2. 1 hit.
    Pfami PF03821. Mtp. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00799. mtp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells."
      Adra C.N., Zhu S., Ko J.-L., Guillemot J.-C., Cuervo A.M., Kobayashi H., Horiuchi T., Lelias J.-M., Rowley J.D., Lim B.
      Genomics 35:328-337(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH UBIQUITIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Spleen.
    2. Scott L.M., Collins S.J.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
      DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-226.

    Entry informationi

    Entry nameiLAPM5_HUMAN
    AccessioniPrimary (citable) accession number: Q13571
    Secondary accession number(s): Q13240, Q14698, Q3KP54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3