Q13568 (IRF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon regulatory factor 5
Short name=IRF-5

Gene names

Name:

IRF5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Ref.1 Ref.2
Subunit structure	Homodimer, when phosphorylated. Ref.19
Subcellular location	Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Ref.12 Ref.14 Ref.18
Post-translational modification	Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription. 'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.
Involvement in disease	Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.16 Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.13 Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarities	Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Ontologies

Keywords
Biological process	Antiviral defense Immunity Innate immunity Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Disease	Systemic lupus erythematosus
Ligand	DNA-binding
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to virus Inferred from electronic annotation. Source: UniProtKB-KW interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome positive regulation of apoptotic process Inferred from mutant phenotype Ref.18. Source: BHF-UCL positive regulation of interferon-alpha production Inferred by curator Ref.18. Source: BHF-UCL positive regulation of interferon-beta production Inferred by curator Ref.18. Source: BHF-UCL positive regulation of interleukin-12 production Inferred by curator Ref.18. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.18. Source: BHF-UCL response to muramyl dipeptide Inferred from direct assay Ref.18. Source: BHF-UCL response to peptidoglycan Inferred from direct assay Ref.18. Source: BHF-UCL transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome nucleus Inferred from direct assay Ref.18. Source: BHF-UCL
Molecular_function	regulatory region DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAVS	Q7Z434	2	EBI-3931258,EBI-995373
SGTA	O43765	3	EBI-3931258,EBI-347996

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13568-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13568-2)

The sequence of this isoform differs from the canonical sequence as follows:
     160-160: T → TDAVQSGPHMTPYSLLK

Isoform 3 (identifier: Q13568-3)

The sequence of this isoform differs from the canonical sequence as follows:
     161-175: EDVKWPPTLQPPTLR → DAVQSGPHMTPYSLLKEDVKW

Isoform 4 (identifier: Q13568-4)

The sequence of this isoform differs from the canonical sequence as follows:
     166-175: Missing.

Isoform 5 (identifier: Q13568-5)

The sequence of this isoform differs from the canonical sequence as follows:
     161-247: EDVKWPPTLQ...LLISPHMLPL → V

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 498

498

Interferon regulatory factor 5

PRO_0000154558

Regions

DNA binding

14 – 122

109

IRF tryptophan pentad repeat

Motif

12 – 18

7

Nuclear localization signal Ref.12

Motif

150 – 160

11

Nuclear export signal

Compositional bias

142 – 149

8

Poly-Glu

Amino acid modifications

Modified residue

10

1

Phosphothreonine Ref.18

Modified residue

158

1

Phosphoserine; by TBK1 Ref.18

Modified residue

293

1

Phosphoserine; by TBK1 Ref.18

Modified residue

301

1

Phosphoserine Ref.18

Modified residue

435

1

Phosphoserine Ref.18 Ref.19

Modified residue

437

1

Phosphoserine Ref.19

Modified residue

440

1

Phosphoserine Ref.19

Modified residue

446

1

Phosphoserine Ref.18 Ref.19

Cross-link

411

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.17

Cross-link

412

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.17

Natural variations

Alternative sequence

160

1

T → TDAVQSGPHMTPYSLLK in isoform 2.

VSP_041375

Alternative sequence

161 – 247

87

EDVKW…HMLPL → V in isoform 5.

VSP_044822

Alternative sequence

161 – 175

15

EDVKW…PPTLR → DAVQSGPHMTPYSLLKEDVK W in isoform 3.

VSP_043924

Alternative sequence

166 – 175

10

Missing in isoform 4.

VSP_043925

Experimental info

Sequence conflict

253

1

K → KK in AAU12880. Ref.3

Secondary structure

1

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498

Helix Strand Turn

Details...

Helix

235 – 239

5

Turn

242 – 244

3

Beta strand

250 – 256

7

Beta strand

262 – 266

5

Beta strand

272 – 275

4

Helix

283 – 285

3

Helix

286 – 289

4

Beta strand

294 – 298

5

Helix

308 – 318

11

Beta strand

325 – 330

6

Beta strand

333 – 338

6

Beta strand

340 – 342

3

Beta strand

344 – 348

5

Beta strand

367 – 371

5

Helix

372 – 383

12

Beta strand

395 – 401

7

Helix

409 – 411

3

Beta strand

413 – 420

8

Helix

421 – 431

11

Helix

450 – 465

16

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 16, 2002. Version 2. Checksum: 01B2ED95C28384E8	FASTA	498	56,044
	10 20 30 40 50 60 MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 70 80 90 100 110 120 NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV 130 140 150 160 170 180 CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ 190 200 210 220 230 240 PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI 250 260 270 280 290 300 SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP 310 320 330 340 350 360 SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP 370 380 390 400 410 420 IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP 430 440 450 460 470 480 VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG 490 AGLGVGQGPW PMHPAGMQ
	Isoform 2 [UniParc]. Checksum: D554D121D9E35893	FASTA	514	57,770
	10 20 30 40 50 60 MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 70 80 90 100 110 120 NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV 130 140 150 160 170 180 CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT DAVQSGPHMT PYSLLKEDVK 190 200 210 220 230 240 WPPTLQPPTL RPPTLQPPTL QPPVVLGPPA PDPSPLAPPP GNPAGFRELL SEVLEPGPLP 250 260 270 280 290 300 ASLPPAGEQL LPDLLISPHM LPLTDLEIKF QYRGRPPRAL TISNPHGCRL FYSQLEATQE 310 320 330 340 350 360 QVELFGPISL EQVRFPSPED IPSDKQRFYT NQLLDVLDRG LILQLQGQDL YAIRLCQCKV 370 380 390 400 410 420 FWSGPCASAH DSCPNPIQRE VKTKLFSLEH FLNELILFQK GQTNTPPPFE IFFCFGEEWP 430 440 450 460 470 480 DRKPREKKLI TVQVVPVAAR LLLEMFSGEL SWSADSIRLQ ISNPDLKDRM VEQFKELHHI 490 500 510 WQSQQRLQPV AQAPPGAGLG VGQGPWPMHP AGMQ
	Isoform 3 [UniParc]. Checksum: A99FD4C058EC49C5	FASTA	504	56,669
	10 20 30 40 50 60 MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 70 80 90 100 110 120 NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV 130 140 150 160 170 180 CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT DAVQSGPHMT PYSLLKEDVK 190 200 210 220 230 240 WPPTLQPPTL QPPVVLGPPA PDPSPLAPPP GNPAGFRELL SEVLEPGPLP ASLPPAGEQL 250 260 270 280 290 300 LPDLLISPHM LPLTDLEIKF QYRGRPPRAL TISNPHGCRL FYSQLEATQE QVELFGPISL 310 320 330 340 350 360 EQVRFPSPED IPSDKQRFYT NQLLDVLDRG LILQLQGQDL YAIRLCQCKV FWSGPCASAH 370 380 390 400 410 420 DSCPNPIQRE VKTKLFSLEH FLNELILFQK GQTNTPPPFE IFFCFGEEWP DRKPREKKLI 430 440 450 460 470 480 TVQVVPVAAR LLLEMFSGEL SWSADSIRLQ ISNPDLKDRM VEQFKELHHI WQSQQRLQPV 490 500 AQAPPGAGLG VGQGPWPMHP AGMQ
	Isoform 4 [UniParc]. Checksum: 4E43B54EE74A7E37	FASTA	488	54,943
	10 20 30 40 50 60 MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 70 80 90 100 110 120 NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV 130 140 150 160 170 180 CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLQPPVVL 190 200 210 220 230 240 GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL 250 260 270 280 290 300 EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP SPEDIPSDKQ 310 320 330 340 350 360 RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP IQREVKTKLF 370 380 390 400 410 420 SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP VAARLLLEMF 430 440 450 460 470 480 SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQ
	Isoform 5 [UniParc]. Checksum: 3519DC06A3230949	FASTA	412	47,035
	10 20 30 40 50 60 MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 70 80 90 100 110 120 NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV 130 140 150 160 170 180 CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT VTDLEIKFQY RGRPPRALTI 190 200 210 220 230 240 SNPHGCRLFY SQLEATQEQV ELFGPISLEQ VRFPSPEDIP SDKQRFYTNQ LLDVLDRGLI 250 260 270 280 290 300 LQLQGQDLYA IRLCQCKVFW SGPCASAHDS CPNPIQREVK TKLFSLEHFL NELILFQKGQ 310 320 330 340 350 360 TNTPPPFEIF FCFGEEWPDR KPREKKLITV QVVPVAARLL LEMFSGELSW SADSIRLQIS 370 380 390 400 410 NPDLKDRMVE QFKELHHIWQ SQQRLQPVAQ APPGAGLGVG QGPWPMHPAG MQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes." Barnes B.J., Moore P.A., Pitha P.M. J. Biol. Chem. 276:23382-23390(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION.
[2]	"The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling." Schoenemeyer A., Barnes B.J., Mancl M.E., Latz E., Goutagny N., Pitha P.M., Fitzgerald K.A., Golenbock D.T. J. Biol. Chem. 280:17005-17012(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION.
[3]	"Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function." Mancl M.E., Hu G., Sangster-Guity N., Olshalsky S.L., Hoops K., Fitzgerald-Bocarsly P., Pitha P.M., Pinder K., Barnes B.J. J. Biol. Chem. 280:21078-21090(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 5), ALTERNATIVE SPLICING.
[4]	"A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus." Graham R.R., Kozyrev S.V., Baechler E.C., Reddy M.V., Plenge R.M., Bauer J.W., Ortmann W.A., Koeuth T., Escribano M.F., Collaborative Groups T.A., Pons-Estel B., Petri M., Daly M., Gregersen P.K., Martin J., Altshuler D., Behrens T.W., Alarcon-Riquelme M.E. Nat. Genet. 38:550-555(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[5]	Grossman A., Mittrucker H.W., Lantonio L., Mak T.W. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[6]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[11]	"Structural indel variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in SLE." Kozyrev S.V., Lewen S., Linga-Reddy P.M.V., Alarcon-Riquelme M.E. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-253 (ISOFORMS 2 AND 3).
[12]	"Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes." Barnes B.J., Kellum M.J., Field A.E., Pitha P.M. Mol. Cell. Biol. 22:5721-5740(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
[13]	"Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus." Sigurdsson S., Nordmark G., Goering H.H.H., Lindroos K., Wiman A.-C., Sturfelt G., Joensen A., Rantapaeae-Dahlqvist S., Moeller B., Kere J., Koskenmies S., Widen E., Eloranta M.-L., Julkunen H., Kristjansdottir H., Steinsson K., Alm G., Roennblom L., Syvaenen A.-C. Am. J. Hum. Genet. 76:528-537(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLEB10.
[14]	"A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization." Lin R., Yang L., Arguello M., Penafuerte C., Hiscott J. J. Biol. Chem. 280:3088-3095(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
[15]	"Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis." Sigurdsson S., Padyukov L., Kurreeman F.A., Liljedahl U., Wiman A.C., Alfredsson L., Toes R., Ronnelid J., Klareskog L., Huizinga T.W., Alm G., Syvanen A.C., Ronnblom L. Arthritis Rheum. 56:2202-2210(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS.
[16]	"An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases." Dideberg V., Kristjansdottir G., Milani L., Libioulle C., Sigurdsson S., Louis E., Wiman A.-C., Vermeire S., Rutgeerts P., Belaiche J., Franchimont D., Van Gossum A., Bours V., Syvaenen A.-C. Hum. Mol. Genet. 16:3008-3016(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IBD14.
[17]	"Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination." Balkhi M.Y., Fitzgerald K.A., Pitha P.M. Mol. Cell. Biol. 28:7296-7308(2008) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION AT LYS-411 AND LYS-412 BY TRAF6.
[18]	"Activation of interferon regulatory factor 5 by site specific phosphorylation." Chang Foreman H.C., Van Scoy S., Cheng T.F., Reich N.C. PLoS ONE 7:E33098-E33098(2012) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT THR-10; SER-158; SER-293; SER-301; SER-435 AND SER-446, SUBCELLULAR LOCATION.
[19]	"Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5." Chen W., Lam S.S., Srinath H., Jiang Z., Correia J.J., Schiffer C.A., Fitzgerald K.A., Lin K., Royer W.E. Jr. Nat. Struct. Mol. Biol. 15:1213-1220(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 232-477 OF MUTANT ASP-440, SUBUNIT, PHOSPHORYLATION AT SER-435; SER-437; SER-440 AND SER-446.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY504947 mRNA. Translation: AAR90326.1.
AY504946 mRNA. Translation: AAR90325.1.
AY693665 mRNA. Translation: AAU12877.1.
AY693666 mRNA. Translation: AAU12878.1.
AY693668 mRNA. Translation: AAU12880.1.
DQ277633 mRNA. Translation: ABB88960.1.
U51127 mRNA. Translation: AAA96056.1.
EF064718 Genomic DNA. Translation: ABK41901.1.
AC025594 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24107.1.
CH236950 Genomic DNA. Translation: EAL24108.1.
CH471070 Genomic DNA. Translation: EAW83703.1.
CH471070 Genomic DNA. Translation: EAW83705.1.
BC004201 mRNA. Translation: AAH04201.1.
BC004139 mRNA. Translation: AAH04139.1.
DQ995495 Genomic DNA. Translation: ABL96293.1.
DQ995496 Genomic DNA. Translation: ABL96294.1.

IPI

IPI00220220.
IPI00396061.
IPI00746140.
IPI00940314.

PIR

G02474.

RefSeq

NP_001092097.2. NM_001098627.2.
NP_001092099.1. NM_001098629.1.
NP_001092100.1. NM_001098630.1.
NP_001229381.1. NM_001242452.1.
NP_116032.1. NM_032643.3.

UniGene

Hs.521181.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DSH	X-ray	2.00	A	232-477	[»]

ProteinModelPortal

Q13568.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-46348N.

IntAct

Q13568. 11 interactions.

STRING

9606.ENSP00000349770.

PTM databases

PhosphoSite

Q13568.

Polymorphism databases

DMDM

20178305.

Proteomic databases

PaxDb

Q13568.

PRIDE

Q13568.

Protocols and materials databases

DNASU

3663.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000249375; ENSP00000249375; ENSG00000128604.
ENST00000357234; ENSP00000349770; ENSG00000128604.
ENST00000402030; ENSP00000385352; ENSG00000128604.
ENST00000473745; ENSP00000419149; ENSG00000128604.
ENST00000477535; ENSP00000419950; ENSG00000128604.

GeneID

3663.

KEGG

hsa:3663.

UCSC

uc003vog.3. human.
uc003voh.3. human.
uc010llt.3. human.

Organism-specific databases

CTD

3663.

GeneCards

GC07P128577.

HGNC

HGNC:6120. IRF5.

HPA

HPA046700.

MIM

180300. phenotype.
607218. gene.
612245. phenotype.
612251. phenotype.

neXtProt

NX_Q13568.

Orphanet

206. Crohn disease.
186. Primary biliary cirrhosis.
536. Systemic lupus erythematosus.
771. Ulcerative colitis.

PharmGKB

PA29919.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG45024.

HOGENOM

HOG000037433.

HOVERGEN

HBG105715.

KO

K09446.

OMA

EDVKWPP.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q13568.

Bgee

Q13568.

CleanEx

HS_IRF5.

Genevestigator

Q13568.

GermOnline

ENSG00000128604. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.10. 1 hit.
2.60.200.10. 1 hit.

InterPro

IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
[Graphical view]

PRINTS

PR00267. INTFRNREGFCT.

SMART

SM00348. IRF. 1 hit.
[Graphical view]

SUPFAM

SSF49879. SMAD_FHA. 1 hit.

PROSITE

PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q13568.

GenomeRNAi

3663.

NextBio

14327.

SOURCE

Search...

Entry information

Entry name

IRF5_HUMAN

Accession

Primary (citable) accession number: Q13568
Secondary accession number(s): A4D1J8 , A8DUA8, A8DUA9, E7EQ16, E7EW54, Q64GA9, Q64GB1, Q64GB2, Q6RCM8, Q9BQF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 16, 2002
Last modified:	May 29, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.