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Protein

Interferon regulatory factor 5

Gene

IRF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi14 – 122109IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. regulatory region DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Reactome
  2. defense response to virus Source: UniProtKB-KW
  3. interferon-gamma-mediated signaling pathway Source: Reactome
  4. positive regulation of apoptotic process Source: BHF-UCL
  5. positive regulation of interferon-alpha production Source: BHF-UCL
  6. positive regulation of interferon-beta production Source: BHF-UCL
  7. positive regulation of interleukin-12 production Source: BHF-UCL
  8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  9. response to muramyl dipeptide Source: BHF-UCL
  10. response to peptidoglycan Source: BHF-UCL
  11. transcription, DNA-templated Source: UniProtKB-KW
  12. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 5
Short name:
IRF-5
Gene namesi
Name:IRF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6120. IRF5.

Subcellular locationi

  1. Cytoplasm
  2. Nucleus

  3. Note: Shuttles between the nucleus and the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytosol Source: Reactome
  3. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Inflammatory bowel disease 14 (IBD14)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

See also OMIM:612245
Systemic lupus erythematosus 10 (SLEB10)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

See also OMIM:612251
Rheumatoid arthritis (RA)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionAn inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

See also OMIM:180300

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

MIMi180300. phenotype.
612245. phenotype.
612251. phenotype.
Orphaneti206. Crohn disease.
220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
186. Primary biliary cirrhosis.
536. Systemic lupus erythematosus.
771. Ulcerative colitis.
PharmGKBiPA29919.

Polymorphism and mutation databases

BioMutaiIRF5.
DMDMi20178305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Interferon regulatory factor 5PRO_0000154558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphothreonine1 Publication
Modified residuei158 – 1581Phosphoserine; by TBK11 Publication
Modified residuei293 – 2931Phosphoserine; by TBK11 Publication
Modified residuei301 – 3011Phosphoserine1 Publication
Cross-linki411 – 411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki412 – 412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei435 – 4351Phosphoserine2 Publications
Modified residuei437 – 4371Phosphoserine1 Publication
Modified residuei440 – 4401Phosphoserine1 Publication
Modified residuei446 – 4461Phosphoserine2 Publications

Post-translational modificationi

Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.2 Publications
'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ13568.
PaxDbiQ13568.
PRIDEiQ13568.

PTM databases

PhosphoSiteiQ13568.

Expressioni

Gene expression databases

BgeeiQ13568.
CleanExiHS_IRF5.
ExpressionAtlasiQ13568. baseline and differential.
GenevestigatoriQ13568.

Organism-specific databases

HPAiHPA046700.

Interactioni

Subunit structurei

Homodimer, when phosphorylated.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MAVSQ7Z4342EBI-3931258,EBI-995373
RELAQ042064EBI-3931258,EBI-73886
SGTAO437653EBI-3931258,EBI-347996

Protein-protein interaction databases

BioGridi109871. 34 interactions.
DIPiDIP-46348N.
IntActiQ13568. 12 interactions.
STRINGi9606.ENSP00000349770.

Structurei

Secondary structure

1
498
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi235 – 2395Combined sources
Turni242 – 2443Combined sources
Beta strandi250 – 2567Combined sources
Beta strandi262 – 2665Combined sources
Beta strandi272 – 2754Combined sources
Helixi283 – 2853Combined sources
Helixi286 – 2894Combined sources
Beta strandi294 – 2985Combined sources
Helixi308 – 31811Combined sources
Beta strandi325 – 3306Combined sources
Beta strandi333 – 3386Combined sources
Beta strandi340 – 3423Combined sources
Beta strandi344 – 3485Combined sources
Beta strandi367 – 3715Combined sources
Helixi372 – 38312Combined sources
Beta strandi395 – 4017Combined sources
Helixi409 – 4113Combined sources
Beta strandi413 – 4208Combined sources
Helixi421 – 43111Combined sources
Helixi450 – 46516Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DSHX-ray2.00A232-477[»]
ProteinModelPortaliQ13568.
SMRiQ13568. Positions 19-119, 232-467.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13568.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 187Nuclear localization signal1 Publication
Motifi150 – 16011Nuclear export signalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 1498Poly-Glu

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG45024.
GeneTreeiENSGT00760000119093.
HOGENOMiHOG000037433.
HOVERGENiHBG105715.
InParanoidiQ13568.
KOiK09446.
OMAiYDGPRDM.
PhylomeDBiQ13568.
TreeFamiTF328512.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProiIPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR029838. IRF5.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11949:SF10. PTHR11949:SF10. 1 hit.
PfamiPF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
[Graphical view]
PRINTSiPR00267. INTFRNREGFCT.
SMARTiSM00348. IRF. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13568-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA
60 70 80 90 100
TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF
110 120 130 140 150
RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL
160 170 180 190 200
QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL
210 220 230 240 250
APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL
260 270 280 290 300
EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP
310 320 330 340 350
SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC
360 370 380 390 400
ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG
410 420 430 440 450
EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL
460 470 480 490
KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQ
Length:498
Mass (Da):56,044
Last modified:April 16, 2002 - v2
Checksum:i01B2ED95C28384E8
GO
Isoform 2 (identifier: Q13568-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-160: T → TDAVQSGPHMTPYSLLK

Show »
Length:514
Mass (Da):57,770
Checksum:iD554D121D9E35893
GO
Isoform 3 (identifier: Q13568-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-175: EDVKWPPTLQPPTLR → DAVQSGPHMTPYSLLKEDVKW

Show »
Length:504
Mass (Da):56,669
Checksum:iA99FD4C058EC49C5
GO
Isoform 4 (identifier: Q13568-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-175: Missing.

Show »
Length:488
Mass (Da):54,943
Checksum:i4E43B54EE74A7E37
GO
Isoform 5 (identifier: Q13568-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-247: EDVKWPPTLQ...LLISPHMLPL → V

Show »
Length:412
Mass (Da):47,035
Checksum:i3519DC06A3230949
GO
Isoform 6 (identifier: Q13568-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-147: VCSNGPAPTDSQPPEDYSFGAGEEEEEE → TPSPLRITLLVQERRRKKRKSCRGCCQA
     148-498: Missing.

Show »
Length:147
Mass (Da):17,020
Checksum:iFEBD2F74E9F8AA38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti253 – 2531K → KK in AAU12880 (PubMed:15805103).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei120 – 14728VCSNG…EEEEE → TPSPLRITLLVQERRRKKRK SCRGCCQA in isoform 6. 1 PublicationVSP_053330Add
BLAST
Alternative sequencei148 – 498351Missing in isoform 6. 1 PublicationVSP_053331Add
BLAST
Alternative sequencei160 – 1601T → TDAVQSGPHMTPYSLLK in isoform 2. 2 PublicationsVSP_041375
Alternative sequencei161 – 24787EDVKW…HMLPL → V in isoform 5. 1 PublicationVSP_044822Add
BLAST
Alternative sequencei161 – 17515EDVKW…PPTLR → DAVQSGPHMTPYSLLKEDVK W in isoform 3. 2 PublicationsVSP_043924Add
BLAST
Alternative sequencei166 – 17510Missing in isoform 4. 3 PublicationsVSP_043925

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504947 mRNA. Translation: AAR90326.1.
AY504946 mRNA. Translation: AAR90325.1.
AY693665 mRNA. Translation: AAU12877.1.
AY693666 mRNA. Translation: AAU12878.1.
AY693668 mRNA. Translation: AAU12880.1.
DQ277633 mRNA. Translation: ABB88960.1.
DQ277634 mRNA. Translation: ABB88961.1.
U51127 mRNA. Translation: AAA96056.1.
EF064718 Genomic DNA. Translation: ABK41901.1.
AC025594 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24107.1.
CH236950 Genomic DNA. Translation: EAL24108.1.
CH471070 Genomic DNA. Translation: EAW83703.1.
CH471070 Genomic DNA. Translation: EAW83705.1.
BC004201 mRNA. Translation: AAH04201.1.
BC004139 mRNA. Translation: AAH04139.1.
DQ995495 Genomic DNA. Translation: ABL96293.1.
DQ995496 Genomic DNA. Translation: ABL96294.1.
CCDSiCCDS43645.1. [Q13568-2]
CCDS56512.1. [Q13568-5]
CCDS5808.1. [Q13568-1]
PIRiG02474.
RefSeqiNP_001092097.2. NM_001098627.3. [Q13568-1]
NP_001092099.1. NM_001098629.2. [Q13568-2]
NP_001092100.1. NM_001098630.2. [Q13568-1]
NP_001229381.1. NM_001242452.2. [Q13568-5]
NP_116032.1. NM_032643.4. [Q13568-1]
XP_005250374.1. XM_005250317.2. [Q13568-2]
XP_006716037.1. XM_006715974.2. [Q13568-2]
UniGeneiHs.521181.

Genome annotation databases

EnsembliENST00000249375; ENSP00000249375; ENSG00000128604. [Q13568-1]
ENST00000357234; ENSP00000349770; ENSG00000128604. [Q13568-2]
ENST00000402030; ENSP00000385352; ENSG00000128604. [Q13568-1]
ENST00000465603; ENSP00000418534; ENSG00000128604. [Q13568-6]
ENST00000473745; ENSP00000419149; ENSG00000128604. [Q13568-1]
ENST00000477535; ENSP00000419950; ENSG00000128604. [Q13568-5]
ENST00000619830; ENSP00000483292; ENSG00000128604. [Q13568-6]
GeneIDi3663.
KEGGihsa:3663.
UCSCiuc003vog.3. human. [Q13568-2]
uc003voh.3. human. [Q13568-1]

Polymorphism and mutation databases

BioMutaiIRF5.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY504947 mRNA. Translation: AAR90326.1.
AY504946 mRNA. Translation: AAR90325.1.
AY693665 mRNA. Translation: AAU12877.1.
AY693666 mRNA. Translation: AAU12878.1.
AY693668 mRNA. Translation: AAU12880.1.
DQ277633 mRNA. Translation: ABB88960.1.
DQ277634 mRNA. Translation: ABB88961.1.
U51127 mRNA. Translation: AAA96056.1.
EF064718 Genomic DNA. Translation: ABK41901.1.
AC025594 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24107.1.
CH236950 Genomic DNA. Translation: EAL24108.1.
CH471070 Genomic DNA. Translation: EAW83703.1.
CH471070 Genomic DNA. Translation: EAW83705.1.
BC004201 mRNA. Translation: AAH04201.1.
BC004139 mRNA. Translation: AAH04139.1.
DQ995495 Genomic DNA. Translation: ABL96293.1.
DQ995496 Genomic DNA. Translation: ABL96294.1.
CCDSiCCDS43645.1. [Q13568-2]
CCDS56512.1. [Q13568-5]
CCDS5808.1. [Q13568-1]
PIRiG02474.
RefSeqiNP_001092097.2. NM_001098627.3. [Q13568-1]
NP_001092099.1. NM_001098629.2. [Q13568-2]
NP_001092100.1. NM_001098630.2. [Q13568-1]
NP_001229381.1. NM_001242452.2. [Q13568-5]
NP_116032.1. NM_032643.4. [Q13568-1]
XP_005250374.1. XM_005250317.2. [Q13568-2]
XP_006716037.1. XM_006715974.2. [Q13568-2]
UniGeneiHs.521181.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DSHX-ray2.00A232-477[»]
ProteinModelPortaliQ13568.
SMRiQ13568. Positions 19-119, 232-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109871. 34 interactions.
DIPiDIP-46348N.
IntActiQ13568. 12 interactions.
STRINGi9606.ENSP00000349770.

PTM databases

PhosphoSiteiQ13568.

Polymorphism and mutation databases

BioMutaiIRF5.
DMDMi20178305.

Proteomic databases

MaxQBiQ13568.
PaxDbiQ13568.
PRIDEiQ13568.

Protocols and materials databases

DNASUi3663.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249375; ENSP00000249375; ENSG00000128604. [Q13568-1]
ENST00000357234; ENSP00000349770; ENSG00000128604. [Q13568-2]
ENST00000402030; ENSP00000385352; ENSG00000128604. [Q13568-1]
ENST00000465603; ENSP00000418534; ENSG00000128604. [Q13568-6]
ENST00000473745; ENSP00000419149; ENSG00000128604. [Q13568-1]
ENST00000477535; ENSP00000419950; ENSG00000128604. [Q13568-5]
ENST00000619830; ENSP00000483292; ENSG00000128604. [Q13568-6]
GeneIDi3663.
KEGGihsa:3663.
UCSCiuc003vog.3. human. [Q13568-2]
uc003voh.3. human. [Q13568-1]

Organism-specific databases

CTDi3663.
GeneCardsiGC07P128577.
HGNCiHGNC:6120. IRF5.
HPAiHPA046700.
MIMi180300. phenotype.
607218. gene.
612245. phenotype.
612251. phenotype.
neXtProtiNX_Q13568.
Orphaneti206. Crohn disease.
220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
186. Primary biliary cirrhosis.
536. Systemic lupus erythematosus.
771. Ulcerative colitis.
PharmGKBiPA29919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45024.
GeneTreeiENSGT00760000119093.
HOGENOMiHOG000037433.
HOVERGENiHBG105715.
InParanoidiQ13568.
KOiK09446.
OMAiYDGPRDM.
PhylomeDBiQ13568.
TreeFamiTF328512.

Enzyme and pathway databases

ReactomeiREACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.

Miscellaneous databases

EvolutionaryTraceiQ13568.
GeneWikiiIRF5.
GenomeRNAii3663.
NextBioi14327.
PROiQ13568.
SOURCEiSearch...

Gene expression databases

BgeeiQ13568.
CleanExiHS_IRF5.
ExpressionAtlasiQ13568. baseline and differential.
GenevestigatoriQ13568.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProiIPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR029838. IRF5.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11949:SF10. PTHR11949:SF10. 1 hit.
PfamiPF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
[Graphical view]
PRINTSiPR00267. INTFRNREGFCT.
SMARTiSM00348. IRF. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes."
    Barnes B.J., Moore P.A., Pitha P.M.
    J. Biol. Chem. 276:23382-23390(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION.
  2. "The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling."
    Schoenemeyer A., Barnes B.J., Mancl M.E., Latz E., Goutagny N., Pitha P.M., Fitzgerald K.A., Golenbock D.T.
    J. Biol. Chem. 280:17005-17012(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION.
  3. "Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function."
    Mancl M.E., Hu G., Sangster-Guity N., Olshalsky S.L., Hoops K., Fitzgerald-Bocarsly P., Pitha P.M., Pinder K., Barnes B.J.
    J. Biol. Chem. 280:21078-21090(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 5), ALTERNATIVE SPLICING.
  4. "A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus."
    Graham R.R., Kozyrev S.V., Baechler E.C., Reddy M.V., Plenge R.M., Bauer J.W., Ortmann W.A., Koeuth T., Escribano M.F., Collaborative Groups T.A., Pons-Estel B., Petri M., Daly M., Gregersen P.K., Martin J., Altshuler D., Behrens T.W., Alarcon-Riquelme M.E.
    Nat. Genet. 38:550-555(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 6).
  5. Grossman A., Mittrucker H.W., Lantonio L., Mak T.W.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  11. "Structural indel variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in SLE."
    Kozyrev S.V., Lewen S., Linga-Reddy P.M.V., Alarcon-Riquelme M.E.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-253 (ISOFORMS 2 AND 3).
  12. "Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes."
    Barnes B.J., Kellum M.J., Field A.E., Pitha P.M.
    Mol. Cell. Biol. 22:5721-5740(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
  13. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLEB10.
  14. "A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization."
    Lin R., Yang L., Arguello M., Penafuerte C., Hiscott J.
    J. Biol. Chem. 280:3088-3095(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
  15. "Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis."
    Sigurdsson S., Padyukov L., Kurreeman F.A., Liljedahl U., Wiman A.C., Alfredsson L., Toes R., Ronnelid J., Klareskog L., Huizinga T.W., Alm G., Syvanen A.C., Ronnblom L.
    Arthritis Rheum. 56:2202-2210(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS.
  16. "An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases."
    Dideberg V., Kristjansdottir G., Milani L., Libioulle C., Sigurdsson S., Louis E., Wiman A.-C., Vermeire S., Rutgeerts P., Belaiche J., Franchimont D., Van Gossum A., Bours V., Syvaenen A.-C.
    Hum. Mol. Genet. 16:3008-3016(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IBD14.
  17. "Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination."
    Balkhi M.Y., Fitzgerald K.A., Pitha P.M.
    Mol. Cell. Biol. 28:7296-7308(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-411 AND LYS-412 BY TRAF6.
  18. "Activation of interferon regulatory factor 5 by site specific phosphorylation."
    Chang Foreman H.C., Van Scoy S., Cheng T.F., Reich N.C.
    PLoS ONE 7:E33098-E33098(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-10; SER-158; SER-293; SER-301; SER-435 AND SER-446, SUBCELLULAR LOCATION.
  19. "Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5."
    Chen W., Lam S.S., Srinath H., Jiang Z., Correia J.J., Schiffer C.A., Fitzgerald K.A., Lin K., Royer W.E. Jr.
    Nat. Struct. Mol. Biol. 15:1213-1220(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 232-477 OF MUTANT ASP-440, SUBUNIT, PHOSPHORYLATION AT SER-435; SER-437; SER-440 AND SER-446.

Entry informationi

Entry nameiIRF5_HUMAN
AccessioniPrimary (citable) accession number: Q13568
Secondary accession number(s): A4D1J8
, A8DUA8, A8DUA9, E7EQ16, E7EW54, Q1A7B4, Q64GA9, Q64GB1, Q64GB2, Q6RCM8, Q9BQF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: April 29, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.