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Q13568 (IRF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon regulatory factor 5

Short name=IRF-5
Gene names
Name:IRF5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Ref.1 Ref.2

Subunit structure

Homodimer, when phosphorylated. Ref.19

Subcellular location

Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Ref.12 Ref.14 Ref.18

Post-translational modification

Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.

'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.

Involvement in disease

Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.16

Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.13

Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Sequence similarities

Belongs to the IRF family.

Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Ontologies

Keywords
   Biological processAntiviral defense
Immunity
Innate immunity
Transcription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   DiseaseSystemic lupus erythematosus
   LigandDNA-binding
   PTMIsopeptide bond
Phosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of apoptotic process

Inferred from mutant phenotype Ref.18. Source: BHF-UCL

positive regulation of interferon-alpha production

Inferred by curator Ref.18. Source: BHF-UCL

positive regulation of interferon-beta production

Inferred by curator Ref.18. Source: BHF-UCL

positive regulation of interleukin-12 production

Inferred by curator Ref.18. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.18. Source: BHF-UCL

response to muramyl dipeptide

Inferred from direct assay Ref.18. Source: BHF-UCL

response to peptidoglycan

Inferred from direct assay Ref.18. Source: BHF-UCL

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

type I interferon signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay Ref.18. Source: BHF-UCL

cytosol

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay Ref.18. Source: BHF-UCL

   Molecular_functionregulatory region DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q13568-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q13568-2)

The sequence of this isoform differs from the canonical sequence as follows:
     160-160: T → TDAVQSGPHMTPYSLLK
Isoform 3 (identifier: Q13568-3)

The sequence of this isoform differs from the canonical sequence as follows:
     161-175: EDVKWPPTLQPPTLR → DAVQSGPHMTPYSLLKEDVKW
Isoform 4 (identifier: Q13568-4)

The sequence of this isoform differs from the canonical sequence as follows:
     166-175: Missing.
Isoform 5 (identifier: Q13568-5)

The sequence of this isoform differs from the canonical sequence as follows:
     161-247: EDVKWPPTLQ...LLISPHMLPL → V
Isoform 6 (identifier: Q13568-6)

The sequence of this isoform differs from the canonical sequence as follows:
     120-147: VCSNGPAPTDSQPPEDYSFGAGEEEEEE → TPSPLRITLLVQERRRKKRKSCRGCCQA
     148-498: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Interferon regulatory factor 5
PRO_0000154558

Regions

DNA binding14 – 122109IRF tryptophan pentad repeat
Motif12 – 187Nuclear localization signal Ref.12
Motif150 – 16011Nuclear export signal
Compositional bias142 – 1498Poly-Glu

Amino acid modifications

Modified residue101Phosphothreonine Ref.18
Modified residue1581Phosphoserine; by TBK1 Ref.18
Modified residue2931Phosphoserine; by TBK1 Ref.18
Modified residue3011Phosphoserine Ref.18
Modified residue4351Phosphoserine Ref.18 Ref.19
Modified residue4371Phosphoserine Ref.19
Modified residue4401Phosphoserine Ref.19
Modified residue4461Phosphoserine Ref.18 Ref.19
Cross-link411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.17
Cross-link412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.17

Natural variations

Alternative sequence120 – 14728VCSNG…EEEEE → TPSPLRITLLVQERRRKKRK SCRGCCQA in isoform 6.
VSP_053330
Alternative sequence148 – 498351Missing in isoform 6.
VSP_053331
Alternative sequence1601T → TDAVQSGPHMTPYSLLK in isoform 2.
VSP_041375
Alternative sequence161 – 24787EDVKW…HMLPL → V in isoform 5.
VSP_044822
Alternative sequence161 – 17515EDVKW…PPTLR → DAVQSGPHMTPYSLLKEDVK W in isoform 3.
VSP_043924
Alternative sequence166 – 17510Missing in isoform 4.
VSP_043925

Experimental info

Sequence conflict2531K → KK in AAU12880. Ref.3

Secondary structure

...................................... 498
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 16, 2002. Version 2.
Checksum: 01B2ED95C28384E8

FASTA49856,044
        10         20         30         40         50         60 
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD 

        70         80         90        100        110        120 
NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV 

       130        140        150        160        170        180 
CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ 

       190        200        210        220        230        240 
PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI 

       250        260        270        280        290        300 
SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP 

       310        320        330        340        350        360 
SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP 

       370        380        390        400        410        420 
IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP 

       430        440        450        460        470        480 
VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG 

       490 
AGLGVGQGPW PMHPAGMQ 

« Hide

Isoform 2 [UniParc].

Checksum: D554D121D9E35893
Show »

FASTA51457,770
Isoform 3 [UniParc].

Checksum: A99FD4C058EC49C5
Show »

FASTA50456,669
Isoform 4 [UniParc].

Checksum: 4E43B54EE74A7E37
Show »

FASTA48854,943
Isoform 5 [UniParc].

Checksum: 3519DC06A3230949
Show »

FASTA41247,035
Isoform 6 [UniParc].

Checksum: FEBD2F74E9F8AA38
Show »

FASTA14717,020

References

« Hide 'large scale' references
[1]"Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes."
Barnes B.J., Moore P.A., Pitha P.M.
J. Biol. Chem. 276:23382-23390(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION.
[2]"The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling."
Schoenemeyer A., Barnes B.J., Mancl M.E., Latz E., Goutagny N., Pitha P.M., Fitzgerald K.A., Golenbock D.T.
J. Biol. Chem. 280:17005-17012(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION.
[3]"Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function."
Mancl M.E., Hu G., Sangster-Guity N., Olshalsky S.L., Hoops K., Fitzgerald-Bocarsly P., Pitha P.M., Pinder K., Barnes B.J.
J. Biol. Chem. 280:21078-21090(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 5), ALTERNATIVE SPLICING.
[4]"A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus."
Graham R.R., Kozyrev S.V., Baechler E.C., Reddy M.V., Plenge R.M., Bauer J.W., Ortmann W.A., Koeuth T., Escribano M.F., Collaborative Groups T.A., Pons-Estel B., Petri M., Daly M., Gregersen P.K., Martin J., Altshuler D., Behrens T.W., Alarcon-Riquelme M.E.
Nat. Genet. 38:550-555(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 6).
[5]Grossman A., Mittrucker H.W., Lantonio L., Mak T.W.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[6]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[11]"Structural indel variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in SLE."
Kozyrev S.V., Lewen S., Linga-Reddy P.M.V., Alarcon-Riquelme M.E.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-253 (ISOFORMS 2 AND 3).
[12]"Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes."
Barnes B.J., Kellum M.J., Field A.E., Pitha P.M.
Mol. Cell. Biol. 22:5721-5740(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
[13]"Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus."
Sigurdsson S., Nordmark G., Goering H.H.H., Lindroos K., Wiman A.-C., Sturfelt G., Joensen A., Rantapaeae-Dahlqvist S., Moeller B., Kere J., Koskenmies S., Widen E., Eloranta M.-L., Julkunen H., Kristjansdottir H., Steinsson K., Alm G., Roennblom L., Syvaenen A.-C.
Am. J. Hum. Genet. 76:528-537(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLEB10.
[14]"A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization."
Lin R., Yang L., Arguello M., Penafuerte C., Hiscott J.
J. Biol. Chem. 280:3088-3095(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
[15]"Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis."
Sigurdsson S., Padyukov L., Kurreeman F.A., Liljedahl U., Wiman A.C., Alfredsson L., Toes R., Ronnelid J., Klareskog L., Huizinga T.W., Alm G., Syvanen A.C., Ronnblom L.
Arthritis Rheum. 56:2202-2210(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS.
[16]"An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases."
Dideberg V., Kristjansdottir G., Milani L., Libioulle C., Sigurdsson S., Louis E., Wiman A.-C., Vermeire S., Rutgeerts P., Belaiche J., Franchimont D., Van Gossum A., Bours V., Syvaenen A.-C.
Hum. Mol. Genet. 16:3008-3016(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IBD14.
[17]"Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination."
Balkhi M.Y., Fitzgerald K.A., Pitha P.M.
Mol. Cell. Biol. 28:7296-7308(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION AT LYS-411 AND LYS-412 BY TRAF6.
[18]"Activation of interferon regulatory factor 5 by site specific phosphorylation."
Chang Foreman H.C., Van Scoy S., Cheng T.F., Reich N.C.
PLoS ONE 7:E33098-E33098(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-10; SER-158; SER-293; SER-301; SER-435 AND SER-446, SUBCELLULAR LOCATION.
[19]"Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5."
Chen W., Lam S.S., Srinath H., Jiang Z., Correia J.J., Schiffer C.A., Fitzgerald K.A., Lin K., Royer W.E. Jr.
Nat. Struct. Mol. Biol. 15:1213-1220(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 232-477 OF MUTANT ASP-440, SUBUNIT, PHOSPHORYLATION AT SER-435; SER-437; SER-440 AND SER-446.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY504947 mRNA. Translation: AAR90326.1.
AY504946 mRNA. Translation: AAR90325.1.
AY693665 mRNA. Translation: AAU12877.1.
AY693666 mRNA. Translation: AAU12878.1.
AY693668 mRNA. Translation: AAU12880.1.
DQ277633 mRNA. Translation: ABB88960.1.
DQ277634 mRNA. Translation: ABB88961.1.
U51127 mRNA. Translation: AAA96056.1.
EF064718 Genomic DNA. Translation: ABK41901.1.
AC025594 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24107.1.
CH236950 Genomic DNA. Translation: EAL24108.1.
CH471070 Genomic DNA. Translation: EAW83703.1.
CH471070 Genomic DNA. Translation: EAW83705.1.
BC004201 mRNA. Translation: AAH04201.1.
BC004139 mRNA. Translation: AAH04139.1.
DQ995495 Genomic DNA. Translation: ABL96293.1.
DQ995496 Genomic DNA. Translation: ABL96294.1.
PIRG02474.
RefSeqNP_001092097.2. NM_001098627.2.
NP_001092099.1. NM_001098629.1.
NP_001092100.1. NM_001098630.1.
NP_001229381.1. NM_001242452.1.
NP_116032.1. NM_032643.3.
XP_005250374.1. XM_005250317.1.
UniGeneHs.521181.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DSHX-ray2.00A232-477[»]
ProteinModelPortalQ13568.
SMRQ13568. Positions 16-119, 232-467.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109871. 34 interactions.
DIPDIP-46348N.
IntActQ13568. 11 interactions.
STRING9606.ENSP00000349770.

PTM databases

PhosphoSiteQ13568.

Polymorphism databases

DMDM20178305.

Proteomic databases

PaxDbQ13568.
PRIDEQ13568.

Protocols and materials databases

DNASU3663.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249375; ENSP00000249375; ENSG00000128604. [Q13568-1]
ENST00000357234; ENSP00000349770; ENSG00000128604. [Q13568-2]
ENST00000402030; ENSP00000385352; ENSG00000128604. [Q13568-1]
ENST00000465603; ENSP00000418534; ENSG00000128604. [Q13568-6]
ENST00000473745; ENSP00000419149; ENSG00000128604. [Q13568-1]
ENST00000477535; ENSP00000419950; ENSG00000128604. [Q13568-5]
GeneID3663.
KEGGhsa:3663.
UCSCuc003vog.3. human. [Q13568-2]
uc003voh.3. human. [Q13568-1]

Organism-specific databases

CTD3663.
GeneCardsGC07P128577.
HGNCHGNC:6120. IRF5.
HPAHPA046700.
MIM180300. phenotype.
607218. gene.
612245. phenotype.
612251. phenotype.
neXtProtNX_Q13568.
Orphanet206. Crohn disease.
220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
186. Primary biliary cirrhosis.
536. Systemic lupus erythematosus.
771. Ulcerative colitis.
PharmGKBPA29919.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45024.
HOGENOMHOG000037433.
HOVERGENHBG105715.
KOK09446.
OMAYDGPRDM.
PhylomeDBQ13568.
TreeFamTF328512.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ13568.
BgeeQ13568.
CleanExHS_IRF5.
GenevestigatorQ13568.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProIPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
[Graphical view]
PRINTSPR00267. INTFRNREGFCT.
SMARTSM00348. IRF. 1 hit.
[Graphical view]
SUPFAMSSF49879. SSF49879. 1 hit.
PROSITEPS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ13568.
GeneWikiIRF5.
GenomeRNAi3663.
NextBio14327.
PROQ13568.
SOURCESearch...

Entry information

Entry nameIRF5_HUMAN
AccessionPrimary (citable) accession number: Q13568
Secondary accession number(s): A4D1J8 expand/collapse secondary AC list , A8DUA8, A8DUA9, E7EQ16, E7EW54, Q1A7B4, Q64GA9, Q64GB1, Q64GB2, Q6RCM8, Q9BQF0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: April 16, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM