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Q13568

- IRF5_HUMAN

UniProt

Q13568 - IRF5_HUMAN

Protein

Interferon regulatory factor 5

Gene

IRF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (16 Apr 2002)
      Previous versions | rss
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    Functioni

    Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi14 – 122109IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. regulatory region DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: Reactome
    2. defense response to virus Source: UniProtKB-KW
    3. interferon-gamma-mediated signaling pathway Source: Reactome
    4. positive regulation of apoptotic process Source: BHF-UCL
    5. positive regulation of interferon-alpha production Source: BHF-UCL
    6. positive regulation of interferon-beta production Source: BHF-UCL
    7. positive regulation of interleukin-12 production Source: BHF-UCL
    8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    9. response to muramyl dipeptide Source: BHF-UCL
    10. response to peptidoglycan Source: BHF-UCL
    11. transcription, DNA-templated Source: UniProtKB-KW
    12. type I interferon signaling pathway Source: Reactome

    Keywords - Biological processi

    Antiviral defense, Immunity, Innate immunity, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon regulatory factor 5
    Short name:
    IRF-5
    Gene namesi
    Name:IRF5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:6120. IRF5.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Shuttles between the nucleus and the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytosol Source: Reactome
    3. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Systemic lupus erythematosus

    Organism-specific databases

    MIMi180300. phenotype.
    612245. phenotype.
    612251. phenotype.
    Orphaneti206. Crohn disease.
    220393. Diffuse cutaneous systemic sclerosis.
    220402. Limited cutaneous systemic sclerosis.
    186. Primary biliary cirrhosis.
    536. Systemic lupus erythematosus.
    771. Ulcerative colitis.
    PharmGKBiPA29919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Interferon regulatory factor 5PRO_0000154558Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101Phosphothreonine1 Publication
    Modified residuei158 – 1581Phosphoserine; by TBK11 Publication
    Modified residuei293 – 2931Phosphoserine; by TBK11 Publication
    Modified residuei301 – 3011Phosphoserine1 Publication
    Cross-linki411 – 411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki412 – 412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei435 – 4351Phosphoserine2 Publications
    Modified residuei437 – 4371Phosphoserine1 Publication
    Modified residuei440 – 4401Phosphoserine1 Publication
    Modified residuei446 – 4461Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.2 Publications
    'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ13568.
    PaxDbiQ13568.
    PRIDEiQ13568.

    PTM databases

    PhosphoSiteiQ13568.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13568.
    BgeeiQ13568.
    CleanExiHS_IRF5.
    GenevestigatoriQ13568.

    Organism-specific databases

    HPAiHPA046700.

    Interactioni

    Subunit structurei

    Homodimer, when phosphorylated.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAVSQ7Z4342EBI-3931258,EBI-995373
    SGTAO437653EBI-3931258,EBI-347996

    Protein-protein interaction databases

    BioGridi109871. 34 interactions.
    DIPiDIP-46348N.
    IntActiQ13568. 11 interactions.
    STRINGi9606.ENSP00000349770.

    Structurei

    Secondary structure

    1
    498
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi235 – 2395
    Turni242 – 2443
    Beta strandi250 – 2567
    Beta strandi262 – 2665
    Beta strandi272 – 2754
    Helixi283 – 2853
    Helixi286 – 2894
    Beta strandi294 – 2985
    Helixi308 – 31811
    Beta strandi325 – 3306
    Beta strandi333 – 3386
    Beta strandi340 – 3423
    Beta strandi344 – 3485
    Beta strandi367 – 3715
    Helixi372 – 38312
    Beta strandi395 – 4017
    Helixi409 – 4113
    Beta strandi413 – 4208
    Helixi421 – 43111
    Helixi450 – 46516

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3DSHX-ray2.00A232-477[»]
    ProteinModelPortaliQ13568.
    SMRiQ13568. Positions 19-119, 232-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13568.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 187Nuclear localization signal1 Publication
    Motifi150 – 16011Nuclear export signalAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi142 – 1498Poly-Glu

    Sequence similaritiesi

    Belongs to the IRF family.PROSITE-ProRule annotation
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG45024.
    HOGENOMiHOG000037433.
    HOVERGENiHBG105715.
    KOiK09446.
    OMAiYDGPRDM.
    PhylomeDBiQ13568.
    TreeFamiTF328512.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.200.10. 1 hit.
    InterProiIPR019817. Interferon_reg_fac_CS.
    IPR001346. Interferon_reg_fact_DNA-bd_dom.
    IPR019471. Interferon_reg_factor-3.
    IPR017855. SMAD_dom-like.
    IPR008984. SMAD_FHA_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00605. IRF. 1 hit.
    PF10401. IRF-3. 1 hit.
    [Graphical view]
    PRINTSiPR00267. INTFRNREGFCT.
    SMARTiSM00348. IRF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    PROSITEiPS00601. IRF_1. 1 hit.
    PS51507. IRF_2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13568-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA    50
    TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF 100
    RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL 150
    QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL 200
    APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL 250
    EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP 300
    SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC 350
    ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG 400
    EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL 450
    KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQ 498
    Length:498
    Mass (Da):56,044
    Last modified:April 16, 2002 - v2
    Checksum:i01B2ED95C28384E8
    GO
    Isoform 2 (identifier: Q13568-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         160-160: T → TDAVQSGPHMTPYSLLK

    Show »
    Length:514
    Mass (Da):57,770
    Checksum:iD554D121D9E35893
    GO
    Isoform 3 (identifier: Q13568-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         161-175: EDVKWPPTLQPPTLR → DAVQSGPHMTPYSLLKEDVKW

    Show »
    Length:504
    Mass (Da):56,669
    Checksum:iA99FD4C058EC49C5
    GO
    Isoform 4 (identifier: Q13568-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         166-175: Missing.

    Show »
    Length:488
    Mass (Da):54,943
    Checksum:i4E43B54EE74A7E37
    GO
    Isoform 5 (identifier: Q13568-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         161-247: EDVKWPPTLQ...LLISPHMLPL → V

    Show »
    Length:412
    Mass (Da):47,035
    Checksum:i3519DC06A3230949
    GO
    Isoform 6 (identifier: Q13568-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         120-147: VCSNGPAPTDSQPPEDYSFGAGEEEEEE → TPSPLRITLLVQERRRKKRKSCRGCCQA
         148-498: Missing.

    Show »
    Length:147
    Mass (Da):17,020
    Checksum:iFEBD2F74E9F8AA38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti253 – 2531K → KK in AAU12880. (PubMed:15805103)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei120 – 14728VCSNG…EEEEE → TPSPLRITLLVQERRRKKRK SCRGCCQA in isoform 6. 1 PublicationVSP_053330Add
    BLAST
    Alternative sequencei148 – 498351Missing in isoform 6. 1 PublicationVSP_053331Add
    BLAST
    Alternative sequencei160 – 1601T → TDAVQSGPHMTPYSLLK in isoform 2. 2 PublicationsVSP_041375
    Alternative sequencei161 – 24787EDVKW…HMLPL → V in isoform 5. 1 PublicationVSP_044822Add
    BLAST
    Alternative sequencei161 – 17515EDVKW…PPTLR → DAVQSGPHMTPYSLLKEDVK W in isoform 3. 2 PublicationsVSP_043924Add
    BLAST
    Alternative sequencei166 – 17510Missing in isoform 4. 3 PublicationsVSP_043925

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY504947 mRNA. Translation: AAR90326.1.
    AY504946 mRNA. Translation: AAR90325.1.
    AY693665 mRNA. Translation: AAU12877.1.
    AY693666 mRNA. Translation: AAU12878.1.
    AY693668 mRNA. Translation: AAU12880.1.
    DQ277633 mRNA. Translation: ABB88960.1.
    DQ277634 mRNA. Translation: ABB88961.1.
    U51127 mRNA. Translation: AAA96056.1.
    EF064718 Genomic DNA. Translation: ABK41901.1.
    AC025594 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24107.1.
    CH236950 Genomic DNA. Translation: EAL24108.1.
    CH471070 Genomic DNA. Translation: EAW83703.1.
    CH471070 Genomic DNA. Translation: EAW83705.1.
    BC004201 mRNA. Translation: AAH04201.1.
    BC004139 mRNA. Translation: AAH04139.1.
    DQ995495 Genomic DNA. Translation: ABL96293.1.
    DQ995496 Genomic DNA. Translation: ABL96294.1.
    CCDSiCCDS43645.1. [Q13568-2]
    CCDS56512.1. [Q13568-5]
    CCDS5808.1. [Q13568-1]
    PIRiG02474.
    RefSeqiNP_001092097.2. NM_001098627.3. [Q13568-1]
    NP_001092099.1. NM_001098629.2. [Q13568-2]
    NP_001092100.1. NM_001098630.2. [Q13568-1]
    NP_001229381.1. NM_001242452.2. [Q13568-5]
    NP_116032.1. NM_032643.4. [Q13568-1]
    XP_005250374.1. XM_005250317.1. [Q13568-2]
    XP_006716037.1. XM_006715974.1. [Q13568-2]
    UniGeneiHs.521181.

    Genome annotation databases

    EnsembliENST00000249375; ENSP00000249375; ENSG00000128604. [Q13568-1]
    ENST00000357234; ENSP00000349770; ENSG00000128604. [Q13568-2]
    ENST00000402030; ENSP00000385352; ENSG00000128604. [Q13568-1]
    ENST00000465603; ENSP00000418534; ENSG00000128604. [Q13568-6]
    ENST00000473745; ENSP00000419149; ENSG00000128604. [Q13568-1]
    ENST00000477535; ENSP00000419950; ENSG00000128604. [Q13568-5]
    GeneIDi3663.
    KEGGihsa:3663.
    UCSCiuc003vog.3. human. [Q13568-2]
    uc003voh.3. human. [Q13568-1]

    Polymorphism databases

    DMDMi20178305.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY504947 mRNA. Translation: AAR90326.1 .
    AY504946 mRNA. Translation: AAR90325.1 .
    AY693665 mRNA. Translation: AAU12877.1 .
    AY693666 mRNA. Translation: AAU12878.1 .
    AY693668 mRNA. Translation: AAU12880.1 .
    DQ277633 mRNA. Translation: ABB88960.1 .
    DQ277634 mRNA. Translation: ABB88961.1 .
    U51127 mRNA. Translation: AAA96056.1 .
    EF064718 Genomic DNA. Translation: ABK41901.1 .
    AC025594 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24107.1 .
    CH236950 Genomic DNA. Translation: EAL24108.1 .
    CH471070 Genomic DNA. Translation: EAW83703.1 .
    CH471070 Genomic DNA. Translation: EAW83705.1 .
    BC004201 mRNA. Translation: AAH04201.1 .
    BC004139 mRNA. Translation: AAH04139.1 .
    DQ995495 Genomic DNA. Translation: ABL96293.1 .
    DQ995496 Genomic DNA. Translation: ABL96294.1 .
    CCDSi CCDS43645.1. [Q13568-2 ]
    CCDS56512.1. [Q13568-5 ]
    CCDS5808.1. [Q13568-1 ]
    PIRi G02474.
    RefSeqi NP_001092097.2. NM_001098627.3. [Q13568-1 ]
    NP_001092099.1. NM_001098629.2. [Q13568-2 ]
    NP_001092100.1. NM_001098630.2. [Q13568-1 ]
    NP_001229381.1. NM_001242452.2. [Q13568-5 ]
    NP_116032.1. NM_032643.4. [Q13568-1 ]
    XP_005250374.1. XM_005250317.1. [Q13568-2 ]
    XP_006716037.1. XM_006715974.1. [Q13568-2 ]
    UniGenei Hs.521181.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3DSH X-ray 2.00 A 232-477 [» ]
    ProteinModelPortali Q13568.
    SMRi Q13568. Positions 19-119, 232-467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109871. 34 interactions.
    DIPi DIP-46348N.
    IntActi Q13568. 11 interactions.
    STRINGi 9606.ENSP00000349770.

    PTM databases

    PhosphoSitei Q13568.

    Polymorphism databases

    DMDMi 20178305.

    Proteomic databases

    MaxQBi Q13568.
    PaxDbi Q13568.
    PRIDEi Q13568.

    Protocols and materials databases

    DNASUi 3663.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249375 ; ENSP00000249375 ; ENSG00000128604 . [Q13568-1 ]
    ENST00000357234 ; ENSP00000349770 ; ENSG00000128604 . [Q13568-2 ]
    ENST00000402030 ; ENSP00000385352 ; ENSG00000128604 . [Q13568-1 ]
    ENST00000465603 ; ENSP00000418534 ; ENSG00000128604 . [Q13568-6 ]
    ENST00000473745 ; ENSP00000419149 ; ENSG00000128604 . [Q13568-1 ]
    ENST00000477535 ; ENSP00000419950 ; ENSG00000128604 . [Q13568-5 ]
    GeneIDi 3663.
    KEGGi hsa:3663.
    UCSCi uc003vog.3. human. [Q13568-2 ]
    uc003voh.3. human. [Q13568-1 ]

    Organism-specific databases

    CTDi 3663.
    GeneCardsi GC07P128577.
    HGNCi HGNC:6120. IRF5.
    HPAi HPA046700.
    MIMi 180300. phenotype.
    607218. gene.
    612245. phenotype.
    612251. phenotype.
    neXtProti NX_Q13568.
    Orphaneti 206. Crohn disease.
    220393. Diffuse cutaneous systemic sclerosis.
    220402. Limited cutaneous systemic sclerosis.
    186. Primary biliary cirrhosis.
    536. Systemic lupus erythematosus.
    771. Ulcerative colitis.
    PharmGKBi PA29919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45024.
    HOGENOMi HOG000037433.
    HOVERGENi HBG105715.
    KOi K09446.
    OMAi YDGPRDM.
    PhylomeDBi Q13568.
    TreeFami TF328512.

    Enzyme and pathway databases

    Reactomei REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.

    Miscellaneous databases

    EvolutionaryTracei Q13568.
    GeneWikii IRF5.
    GenomeRNAii 3663.
    NextBioi 14327.
    PROi Q13568.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13568.
    Bgeei Q13568.
    CleanExi HS_IRF5.
    Genevestigatori Q13568.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.200.10. 1 hit.
    InterProi IPR019817. Interferon_reg_fac_CS.
    IPR001346. Interferon_reg_fact_DNA-bd_dom.
    IPR019471. Interferon_reg_factor-3.
    IPR017855. SMAD_dom-like.
    IPR008984. SMAD_FHA_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00605. IRF. 1 hit.
    PF10401. IRF-3. 1 hit.
    [Graphical view ]
    PRINTSi PR00267. INTFRNREGFCT.
    SMARTi SM00348. IRF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    PROSITEi PS00601. IRF_1. 1 hit.
    PS51507. IRF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes."
      Barnes B.J., Moore P.A., Pitha P.M.
      J. Biol. Chem. 276:23382-23390(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION.
    2. "The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling."
      Schoenemeyer A., Barnes B.J., Mancl M.E., Latz E., Goutagny N., Pitha P.M., Fitzgerald K.A., Golenbock D.T.
      J. Biol. Chem. 280:17005-17012(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION.
    3. "Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function."
      Mancl M.E., Hu G., Sangster-Guity N., Olshalsky S.L., Hoops K., Fitzgerald-Bocarsly P., Pitha P.M., Pinder K., Barnes B.J.
      J. Biol. Chem. 280:21078-21090(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 5), ALTERNATIVE SPLICING.
    4. "A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus."
      Graham R.R., Kozyrev S.V., Baechler E.C., Reddy M.V., Plenge R.M., Bauer J.W., Ortmann W.A., Koeuth T., Escribano M.F., Collaborative Groups T.A., Pons-Estel B., Petri M., Daly M., Gregersen P.K., Martin J., Altshuler D., Behrens T.W., Alarcon-Riquelme M.E.
      Nat. Genet. 38:550-555(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 6).
    5. Grossman A., Mittrucker H.W., Lantonio L., Mak T.W.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    11. "Structural indel variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in SLE."
      Kozyrev S.V., Lewen S., Linga-Reddy P.M.V., Alarcon-Riquelme M.E.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-253 (ISOFORMS 2 AND 3).
    12. "Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes."
      Barnes B.J., Kellum M.J., Field A.E., Pitha P.M.
      Mol. Cell. Biol. 22:5721-5740(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL.
    13. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SLEB10.
    14. "A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization."
      Lin R., Yang L., Arguello M., Penafuerte C., Hiscott J.
      J. Biol. Chem. 280:3088-3095(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL.
    15. "Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis."
      Sigurdsson S., Padyukov L., Kurreeman F.A., Liljedahl U., Wiman A.C., Alfredsson L., Toes R., Ronnelid J., Klareskog L., Huizinga T.W., Alm G., Syvanen A.C., Ronnblom L.
      Arthritis Rheum. 56:2202-2210(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS.
    16. "An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases."
      Dideberg V., Kristjansdottir G., Milani L., Libioulle C., Sigurdsson S., Louis E., Wiman A.-C., Vermeire S., Rutgeerts P., Belaiche J., Franchimont D., Van Gossum A., Bours V., Syvaenen A.-C.
      Hum. Mol. Genet. 16:3008-3016(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IBD14.
    17. "Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination."
      Balkhi M.Y., Fitzgerald K.A., Pitha P.M.
      Mol. Cell. Biol. 28:7296-7308(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION AT LYS-411 AND LYS-412 BY TRAF6.
    18. "Activation of interferon regulatory factor 5 by site specific phosphorylation."
      Chang Foreman H.C., Van Scoy S., Cheng T.F., Reich N.C.
      PLoS ONE 7:E33098-E33098(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-10; SER-158; SER-293; SER-301; SER-435 AND SER-446, SUBCELLULAR LOCATION.
    19. "Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5."
      Chen W., Lam S.S., Srinath H., Jiang Z., Correia J.J., Schiffer C.A., Fitzgerald K.A., Lin K., Royer W.E. Jr.
      Nat. Struct. Mol. Biol. 15:1213-1220(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 232-477 OF MUTANT ASP-440, SUBUNIT, PHOSPHORYLATION AT SER-435; SER-437; SER-440 AND SER-446.

    Entry informationi

    Entry nameiIRF5_HUMAN
    AccessioniPrimary (citable) accession number: Q13568
    Secondary accession number(s): A4D1J8
    , A8DUA8, A8DUA9, E7EQ16, E7EW54, Q1A7B4, Q64GA9, Q64GB1, Q64GB2, Q6RCM8, Q9BQF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3