Q13562 (NDF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurogenic differentiation factor 1
Short name=NeuroD
Short name=NeuroD1

Alternative name(s):
Class A basic helix-loop-helix protein 3
Short name=bHLHa3

Gene names

Name:	NEUROD1
Synonyms:	BHLHA3, NEUROD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.
Subunit structure	Interacts (via helix-loop-helix motif domain) with EP300 (via C-terminus) By similarity. Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Efficient DNA-binding requires dimerization with another bHLH protein. Interacts with RREB1. Interacts with EP300; the interaction is inhibited by NR0B2. Interacts with TCF3; the interaction is inhibited by ID2. Ref.15 Ref.16
Subcellular location	Cytoplasm By similarity. Nucleus. Note: In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation By similarity. Colocalizes with NR0B2 in the nucleus. Ref.16
Post-translational modification	Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth. Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells By similarity.
Involvement in disease	Maturity-onset diabetes of the young 6 (MODY6) [MIM:606394]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Disease	Diabetes mellitus Disease mutation
Ligand	DNA-binding
Molecular function	Activator Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	amacrine cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara cellular response to glucose stimulus Inferred from electronic annotation. Source: Compara cerebellum development Inferred from sequence or structural similarity. Source: UniProtKB dentate gyrus development Inferred from sequence or structural similarity. Source: UniProtKB embryonic organ morphogenesis Inferred from sequence or structural similarity PubMed 9308961. Source: BHF-UCL endocrine pancreas development Inferred from sequence or structural similarity. Source: UniProtKB enteroendocrine cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB glucose homeostasis Inferred from sequence or structural similarity PubMed 9308961. Source: BHF-UCL inner ear development Inferred from sequence or structural similarity. Source: UniProtKB insulin secretion Inferred from direct assay PubMed 17941991. Source: BHF-UCL negative regulation of JAK-STAT cascade Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from sequence or structural similarity PubMed 9308961. Source: BHF-UCL nitric oxide mediated signal transduction Inferred from direct assay PubMed 17941991. Source: BHF-UCL nucleocytoplasmic transport Inferred from electronic annotation. Source: Compara pancreatic A cell fate commitment Inferred from electronic annotation. Source: Compara pancreatic PP cell fate commitment Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.16. Source: UniProtKB positive regulation of transcription regulatory region DNA binding Inferred from direct assay PubMed 19619559. Source: BHF-UCL regulation of cell cycle arrest Inferred from sequence or structural similarity. Source: UniProtKB regulation of insulin secretion Inferred by curator Ref.17. Source: BHF-UCL regulation of intestinal epithelial structure maintenance Inferred from sequence or structural similarity. Source: UniProtKB response to drug Inferred from electronic annotation. Source: Compara response to glucose stimulus Inferred from mutant phenotype Ref.17. Source: BHF-UCL signal transduction involved in regulation of gene expression Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	E-box binding Inferred from direct assay Ref.16. Source: UniProtKB RNA polymerase II transcription coactivator activity Inferred from direct assay PubMed 19619559. Source: BHF-UCL chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB double-stranded DNA binding Inferred from electronic annotation. Source: Compara protein heterodimerization activity Inferred from direct assay Ref.16. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.17. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Neurogenic differentiation factor 1		PRO_0000127381
Regions
	Domain	101 – 153	53	bHLH
	Motif	87 – 93	7	Nuclear localization signal Potential
	Compositional bias	58 – 77	20	Glu-rich (acidic)
	Compositional bias	67 – 75	9	Poly-Glu
	Compositional bias	87 – 90	4	Poly-Lys
Amino acid modifications
	Modified residue	162	1	Phosphoserine By similarity
	Modified residue	259	1	Phosphoserine By similarity
	Modified residue	266	1	Phosphoserine By similarity
	Modified residue	274	1	Phosphoserine By similarity
	Modified residue	335	1	Phosphoserine; by CaMK2 By similarity
Natural variations
	Natural variant	45	1	T → A. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Ref.9 Ref.11 Ref.12 Corresponds to variant rs1801262 [ dbSNP | Ensembl ].		VAR_014820
	Natural variant	111	1	R → L in MODY6. Ref.17		VAR_012487
	Natural variant	197	1	P → H. Corresponds to variant rs8192556 [ dbSNP | Ensembl ].		VAR_031260
Experimental info
	Sequence conflict	157	1	L → S in AAA93480. Ref.1
	Sequence conflict	185	1	A → G in BAA11558. Ref.2
	Sequence conflict	185	1	A → G in BAA87605. Ref.5
	Sequence conflict	232	1	G → D in BAA36519. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q13562 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: B78075D1CF66E943	FASTA	356	39,920
	10 20 30 40 50 60 MTKSYSESGL MGEPQPQGPP SWTDECLSSQ DEEHEADKKE DDLETMNAEE DSLRNGGEEE 70 80 90 100 110 120 DEDEDLEEEE EEEEEDDDQK PKRRGPKKKK MTKARLERFK LRRMKANARE RNRMHGLNAA 130 140 150 160 170 180 LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG KSPDLVSFVQ TLCKGLSQPT 190 200 210 220 230 240 TNLVAGCLQL NPRTFLPEQN QDMPPHLPTA SASFPVHPYS YQSPGLPSPP YGTMDSSHVF 250 260 270 280 290 300 HVKPPPHAYS AALEPFFESP LTDCTSPSFD GPLSPPLSIN GNFSFKHEPS AEFEKNYAFT 310 320 330 340 350 MHYPAATLAG AQSHGSIFSG TAAPRCEIPI DNIMSFDSHS HHERVMSAQL NAIFHD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2." Tamimi R., Steingrimsson E., Copeland N.G., Dyer-Montgomery K., Lee J.E., Hernandez R., Jenkins N.A., Tapscott S.J. Genomics 34:418-421(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-45.
[2]	"Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum." Yokoyama M., Nishi Y., Miyamoto Y., Nakamura M., Akiyama K., Matsubara K., Okubo K. Brain Res. Mol. Brain Res. 42:135-139(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-45.
[3]	Furuta H., Horikawa Y., Iwasaki N., Hara M., Sussel L., le Beau M.M., Davis E.M., Ogata M., Iwamoto Y., German M.S., Bell G.I. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-45.
[4]	"Structure and regulation of the human NeuroD (BETA2/BHF1) gene." Miyachi T., Maruyama H., Kitamura T., Nakamura S., Kawakami H. Brain Res. Mol. Brain Res. 69:223-231(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-45.
[5]	Noma T. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-45.
[6]	"Ala45Thr mutation of the human BETA2 gene." Kuroe A., Yamada Y., Kubota A., Someya Y., Iwakura T., Watanabe R., Inada A., Miyawaki K., Ban N., Ihara Y., Seino Y. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-45.
[7]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-45. Tissue: Cerebellum.
[9]	"Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method." Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S. Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-45.
[10]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-45.
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-45. Tissue: Eye.
[13]	"cDNA cloning and expression analysis of NeuroD mRNA in human retina." Acharya H.R., Dooley C.M., Thoreson W.B., Ahmad I. Biochem. Biophys. Res. Commun. 233:459-463(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 88-200. Tissue: Retina.
[14]	Shum C.H., Triche T.J. Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 147-198. Tissue: Rhabdomyosarcoma.
[15]	"Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1." Ray S.K., Nishitani J., Petry M.W., Fessing M.Y., Leiter A.B. Mol. Cell. Biol. 23:259-271(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RREB1.
[16]	"Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD." Kim J.Y., Chu K., Kim H.J., Seong H.A., Park K.C., Sanyal S., Takeda J., Ha H., Shong M., Tsai M.J., Choi H.S. Mol. Endocrinol. 18:776-790(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NR0B2; EP300 AND TCF3, HETERODIMERIZATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[17]	"Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus." Malecki M.T., Jhala U.S., Antonellis A., Fields L., Doria A., Orban T., Saad M., Warram J.H., Montminy M., Krolewski A.S. Nat. Genet. 23:323-328(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MODY6 LEU-111.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	U50822 Genomic DNA. Translation: AAA93480.1. D82347 mRNA. Translation: BAA11558.1. AF045152 Genomic DNA. Translation: AAC83145.1. AB018693 Genomic DNA. Translation: BAA76603.1. AB009997 Genomic DNA. Translation: BAA87605.1. AB016079 Genomic DNA. Translation: BAA36519.1. BT019731 mRNA. Translation: AAV38536.1. AK313799 mRNA. Translation: BAG36535.1. AB593068 mRNA. Translation: BAJ84015.1. AB593069 mRNA. Translation: BAJ84016.1. AB593070 mRNA. Translation: BAJ84017.1. AB593071 mRNA. Translation: BAJ84018.1. AC013733 Genomic DNA. Translation: AAY24267.1. CH471058 Genomic DNA. Translation: EAX10983.1. BC009046 mRNA. Translation: AAH09046.1. U80578 mRNA. Translation: AAC51318.1. U36472 mRNA. Translation: AAA79702.1.
IPI	IPI00299039.
RefSeq	NP_002491.2. NM_002500.4.
UniGene	Hs.574626. Hs.709709.
3D structure databases
ProteinModelPortal	Q13562.
SMR	Q13562. Positions 102-159.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13562. 1 interaction.
STRING	9606.ENSP00000295108.
PTM databases
PhosphoSite	Q13562.
Polymorphism databases
DMDM	311033428.
Proteomic databases
PaxDb	Q13562.
PRIDE	Q13562.
Protocols and materials databases
DNASU	4760.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295108; ENSP00000295108; ENSG00000162992.
GeneID	4760.
KEGG	hsa:4760.
UCSC	uc002uof.3. human. uc021vtn.1. human.
Organism-specific databases
CTD	4760.
GeneCards	GC02M182505.
HGNC	HGNC:7762. NEUROD1.
HPA	CAB022450. HPA003278.
MIM	125853. phenotype. 601724. gene. 606391. phenotype. 606394. phenotype.
neXtProt	NX_Q13562.
Orphanet	552. MODY syndrome.
PharmGKB	PA31564.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG287211.
HOVERGEN	HBG000250.
InParanoid	Q13562.
KO	K08033.
OMA	DEEHETD.
OrthoDB	EOG44F69G.
PhylomeDB	Q13562.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
Bgee	Q13562.
CleanEx	HS_NEUROD1.
Genevestigator	Q13562.
GermOnline	ENSG00000162992. Homo sapiens.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. IPR022575. Neurogenic_DUF. IPR016637. TF_bHLH_NeuroD. [Graphical view]
Pfam	PF00010. HLH. 1 hit. PF12533. Neuro_bHLH. 1 hit. [Graphical view]
PIRSF	PIRSF015618. bHLH_NeuroD. 1 hit.
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4760.
NextBio	18336.
SOURCE	Search...

Entry information

Entry name

NDF1_HUMAN

Accession

Primary (citable) accession number: Q13562
Secondary accession number(s): B2R9I8 , F1T0E1, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 2, 2010
Last modified:	May 29, 2013
This is version 135 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.