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Q13561

- DCTN2_HUMAN

UniProt

Q13561 - DCTN2_HUMAN

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Protein
Dynactin subunit 2
Gene
DCTN2, DCTN50
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

GO - Molecular functioni

  1. motor activity Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. spectrin binding Source: MGI

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  3. cell proliferation Source: UniProtKB
  4. mitotic cell cycle Source: Reactome
  5. mitotic nuclear division Source: UniProtKB
  6. mitotic spindle organization Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
SignaLinkiQ13561.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 2
Alternative name(s):
50 kDa dynein-associated polypeptide
Dynactin complex 50 kDa subunit
Short name:
DCTN-50
p50 dynamitin
Gene namesi
Name:DCTN2
Synonyms:DCTN50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:2712. DCTN2.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: HPA
  3. cytosol Source: Reactome
  4. dynactin complex Source: UniProtKB
  5. dynein complex Source: UniProtKB-KW
  6. extracellular vesicular exosome Source: UniProt
  7. growth cone Source: Ensembl
  8. kinetochore Source: UniProtKB
  9. membrane Source: UniProtKB-SubCell
  10. microtubule Source: UniProtKB-KW
  11. vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 401400Dynactin subunit 2
PRO_0000079821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei6 – 61Phosphotyrosine1 Publication
Modified residuei83 – 831Phosphoserine1 Publication
Modified residuei86 – 861Phosphotyrosine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ13561.
PaxDbiQ13561.
PRIDEiQ13561.

2D gel databases

REPRODUCTION-2DPAGEIPI00220503.

PTM databases

PhosphoSiteiQ13561.

Miscellaneous databases

PMAP-CutDBQ13561.

Expressioni

Gene expression databases

ArrayExpressiQ13561.
BgeeiQ13561.
CleanExiHS_DCTN2.
GenevestigatoriQ13561.

Organism-specific databases

HPAiHPA039715.
HPA040040.

Interactioni

Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 By similarity. Interacts with DYNAP, ECM29 and MAPRE1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI53EBI-715074,EBI-529989
HTTP428586EBI-715074,EBI-466029

Protein-protein interaction databases

BioGridi115794. 52 interactions.
IntActiQ13561. 24 interactions.
MINTiMINT-206219.
STRINGi9606.ENSP00000408910.

Structurei

3D structure databases

ProteinModelPortaliQ13561.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili99 – 13234 Reviewed prediction
Add
BLAST
Coiled coili214 – 24431 Reviewed prediction
Add
BLAST
Coiled coili379 – 39921 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39555.
HOVERGENiHBG051323.
InParanoidiQ13561.
KOiK10424.
OMAiTQQMIAN.
OrthoDBiEOG7JT6WG.
PhylomeDBiQ13561.
TreeFamiTF105247.

Family and domain databases

InterProiIPR028133. Dynamitin.
[Graphical view]
PANTHERiPTHR15346:SF0. PTHR15346:SF0. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13561-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELTS TSVEHIIVNP    50
NAAYDKFKDK RVGTKGLDFS DRIGKTKRTG YESGEYEMLG EGLGVKETPQ 100
QKYQRLLHEV QELTTEVEKI KTTVKESATE EKLTPVLLAK QLAALKQQLV 150
ASHLEKLLGP DAAINLTDPD GALAKRLLLQ LEATKNSKGG SGGKTTGTPP 200
DSSLVTYELH SRPEQDKFSQ AAKVAELEKR LTELETAVRC DQDAQNPLSA 250
GLQGACLMET VELLQAKVSA LDLAVLDQVE ARLQSVLGKV NEIAKHKASV 300
EDADTQSKVH QLYETIQRWS PIASTLPELV QRLVTIKQLH EQAMQFGQLL 350
THLDTTQQMI ANSLKDNTTL LTQVQTTMRE NLATVEGNFA SIDERMKKLG 400
K 401
Length:401
Mass (Da):44,231
Last modified:January 23, 2007 - v4
Checksum:iC2FF01A9739337B2
GO
Isoform 2 (identifier: Q13561-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: A → AFAQEL

Show »
Length:406
Mass (Da):44,820
Checksum:i1166997A6D07479D
GO
Isoform 3 (identifier: Q13561-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: A → AEL

Show »
Length:403
Mass (Da):44,473
Checksum:i864FD68AF5433E22
GO

Sequence cautioni

The sequence AAO34395.1 differs from that shown. Reason: Frameshift at position 381.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei35 – 351A → AFAQEL in isoform 2.
VSP_040485
Alternative sequencei35 – 351A → AEL in isoform 3.
VSP_040486

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U50733 mRNA. Translation: AAC50423.1.
AK314705 mRNA. Translation: BAG37252.1.
AC022366 Genomic DNA. No translation available.
AC022506 Genomic DNA. No translation available.
BC000718 mRNA. Translation: AAH00718.1.
BC009468 mRNA. Translation: AAH09468.1.
BC014083 mRNA. Translation: AAH14083.1.
AY189155 mRNA. Translation: AAO34395.1. Frameshift.
CCDSiCCDS44930.1. [Q13561-2]
CCDS58245.1. [Q13561-1]
RefSeqiNP_001248341.1. NM_001261412.1. [Q13561-3]
NP_001248342.1. NM_001261413.1. [Q13561-1]
NP_006391.1. NM_006400.4. [Q13561-2]
UniGeneiHs.289123.

Genome annotation databases

EnsembliENST00000434715; ENSP00000408910; ENSG00000175203. [Q13561-2]
ENST00000548249; ENSP00000447824; ENSG00000175203. [Q13561-1]
GeneIDi10540.
KEGGihsa:10540.
UCSCiuc001som.2. human. [Q13561-2]
uc009zpv.2. human. [Q13561-1]

Polymorphism databases

DMDMi22096346.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U50733 mRNA. Translation: AAC50423.1 .
AK314705 mRNA. Translation: BAG37252.1 .
AC022366 Genomic DNA. No translation available.
AC022506 Genomic DNA. No translation available.
BC000718 mRNA. Translation: AAH00718.1 .
BC009468 mRNA. Translation: AAH09468.1 .
BC014083 mRNA. Translation: AAH14083.1 .
AY189155 mRNA. Translation: AAO34395.1 . Frameshift.
CCDSi CCDS44930.1. [Q13561-2 ]
CCDS58245.1. [Q13561-1 ]
RefSeqi NP_001248341.1. NM_001261412.1. [Q13561-3 ]
NP_001248342.1. NM_001261413.1. [Q13561-1 ]
NP_006391.1. NM_006400.4. [Q13561-2 ]
UniGenei Hs.289123.

3D structure databases

ProteinModelPortali Q13561.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115794. 52 interactions.
IntActi Q13561. 24 interactions.
MINTi MINT-206219.
STRINGi 9606.ENSP00000408910.

PTM databases

PhosphoSitei Q13561.

Polymorphism databases

DMDMi 22096346.

2D gel databases

REPRODUCTION-2DPAGE IPI00220503.

Proteomic databases

MaxQBi Q13561.
PaxDbi Q13561.
PRIDEi Q13561.

Protocols and materials databases

DNASUi 10540.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000434715 ; ENSP00000408910 ; ENSG00000175203 . [Q13561-2 ]
ENST00000548249 ; ENSP00000447824 ; ENSG00000175203 . [Q13561-1 ]
GeneIDi 10540.
KEGGi hsa:10540.
UCSCi uc001som.2. human. [Q13561-2 ]
uc009zpv.2. human. [Q13561-1 ]

Organism-specific databases

CTDi 10540.
GeneCardsi GC12M057924.
H-InvDB HIX0010763.
HGNCi HGNC:2712. DCTN2.
HPAi HPA039715.
HPA040040.
MIMi 607376. gene.
neXtProti NX_Q13561.
PharmGKBi PA27181.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39555.
HOVERGENi HBG051323.
InParanoidi Q13561.
KOi K10424.
OMAi TQQMIAN.
OrthoDBi EOG7JT6WG.
PhylomeDBi Q13561.
TreeFami TF105247.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
SignaLinki Q13561.

Miscellaneous databases

ChiTaRSi DCTN2. human.
GeneWikii DCTN2.
GenomeRNAii 10540.
NextBioi 39989.
PMAP-CutDB Q13561.
PROi Q13561.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13561.
Bgeei Q13561.
CleanExi HS_DCTN2.
Genevestigatori Q13561.

Family and domain databases

InterProi IPR028133. Dynamitin.
[Graphical view ]
PANTHERi PTHR15346:SF0. PTHR15346:SF0. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis."
    Echeverri C.J., Paschal B.M., Vaughan K.T., Vallee R.B.
    J. Cell Biol. 132:617-633(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta, Skin and Uterus.
  5. "Human 50 kD dynactin subunit, p50 dynamitin, isolated from HeLa cells."
    Aumais J.P., Yu-Lee L.-Y.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-385 (ISOFORM 3).
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-14.
    Tissue: Platelet.
  7. Bienvenut W.V., Ramsay A., Leung H.Y.
    Submitted (FEB-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-14, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic kidney.
  8. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 6-14; 79-96; 106-119; 157-185; 231-282 AND 366-395, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  9. "The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain."
    Berrueta L., Tirnauer J.S., Schuyler S.C., Pellman D., Bierer B.E.
    Curr. Biol. 9:425-428(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAPRE1.
  10. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."
    Gorbea C., Pratt G., Ustrell V., Bell R., Sahasrabudhe S., Hughes R.E., Rechsteiner M.
    J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ECM29.
  14. "A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells."
    Kunoh T., Noda T., Koseki K., Sekigawa M., Takagi M., Shin-ya K., Goshima N., Iemura S., Natsume T., Wada S., Mukai Y., Ohta S., Sasaki R., Mizukami T.
    Mol. Cancer Ther. 9:2934-2942(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYNAP.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCTN2_HUMAN
AccessioniPrimary (citable) accession number: Q13561
Secondary accession number(s): B2RBK5, Q86YN2, Q9BW17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi