Calcium/calmodulin-dependent protein kinase type II subunit delta

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit delta
      Short name=CaM kinase II subunit delta
      Short name=CaMK-II subunit delta
    EC=2.7.11.17

Gene names

Name:	CAMK2D
Synonyms:	CAMKD

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.
Subunit structure	CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with RRAD By similarity.
Tissue specificity	Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle. Ref.1
Miscellaneous	Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.

Hide | Top

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	regulation of cell growth Ref.6 Non-traceable author statement. Source: UniProtKB
Cellular component	calcium- and calmodulin-dependent protein kinase complex Traceable author statement. Source: UniProtKB cytosol Inferred from Experiment. Source: Reactome endocytic vesicle membrane Inferred from Experiment. Source: Reactome nucleoplasm Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Non-traceable author statement. Source: UniProtKB calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Hide | Top

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CAMK2A	Q9UQM7	1	EBI-351018,EBI-1383687

Hide | Top

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform Delta 2 (identifier: Q13557-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Delta 3 (identifier: Q13557-3) The sequence of this isoform differs from the canonical sequence as follows: 328-328: K → KKRKSSSSVQMM

Isoform Delta 4 (identifier: Q13557-4) The sequence of this isoform differs from the canonical sequence as follows: 328-328: K → KINNKANVVTSPKENIPTPAL

Isoform Delta 6 (identifier: Q13557-8) The sequence of this isoform differs from the canonical sequence as follows: 479-499: Missing.

Isoform Delta 7 (identifier: Q13557-9) The sequence of this isoform differs from the canonical sequence as follows: 328-328: K → KKRKSSSSVQMM 479-499: Missing.

Isoform Delta 8 (identifier: Q13557-5) The sequence of this isoform differs from the canonical sequence as follows: 328-328: K → KINNKANVVTSPKENIPTPAL 479-499: Missing.

Isoform Delta 9 (identifier: Q13557-6) The sequence of this isoform differs from the canonical sequence as follows: 329-329: E → EPQTTVIHNPDGNKE

Isoform Delta 10 (identifier: Q13557-10) The sequence of this isoform differs from the canonical sequence as follows: 329-329: E → EPQTTVIHNPDGNKE 479-499: Missing.

Isoform Delta 11 (identifier: Q13557-11) The sequence of this isoform differs from the canonical sequence as follows: 328-328: K → KKRKSSSSVQMMEPQTTVIHNPDGNK

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed

Chain

2 – 499

498

Calcium/calmodulin-dependent protein kinase type II subunit delta

PRO_0000086099

Regions

Domain

14 – 272

259

Protein kinase

Nucleotide binding

20 – 28

9

ATP By similarity

Region

291 – 301

11

Calmodulin-binding By similarity

Sites

Active site

136

1

Proton acceptor By similarity

Binding site

43

1

ATP By similarity

Amino acid modifications

Modified residue

2

1

N-acetylalanine Ref.12

Modified residue

3

1

Phosphoserine Ref.9

Modified residue

231

1

Phosphotyrosine By similarity

Modified residue

287

1

Phosphothreonine

Modified residue

306

1

Phosphothreonine

Modified residue

307

1

Phosphothreonine

Modified residue

315

1

Phosphoserine Ref.9 Ref.8

Modified residue

319

1

Phosphoserine Ref.9 Ref.8

Modified residue

330

1

Phosphoserine Ref.10

Modified residue

331

1

Phosphothreonine Ref.9 Ref.10

Modified residue

333

1

Phosphoserine Ref.12 Ref.10

Modified residue

334

1

Phosphoserine

Modified residue

336

1

Phosphothreonine

Modified residue

337

1

Phosphothreonine Ref.8 Ref.10 Ref.7

Modified residue

404

1

Phosphoserine

Modified residue

441

1

Phosphoserine

Modified residue

470

1

Phosphoserine

Modified residue

472

1

Phosphoserine Ref.9

Modified residue

490

1

Phosphoserine

Natural variations

Alternative sequence

328

1

K → KKRKSSSSVQMMEPQTTVIH NPDGNK in isoform Delta 11.

VSP_023095

Alternative sequence

328

1

K → KKRKSSSSVQMM in isoform Delta 3 and isoform Delta 7.

VSP_023096

Alternative sequence

328

1

K → KINNKANVVTSPKENIPTPA L in isoform Delta 4 and isoform Delta 8.

VSP_023097

Alternative sequence

329

1

E → EPQTTVIHNPDGNKE in isoform Delta 9 and isoform Delta 10.

VSP_023098

Alternative sequence

479 – 499

21

Missing in isoform Delta 6, isoform Delta 7, isoform Delta 8 and isoform Delta 10.

VSP_023099

Natural variant

167

1

D → E: dbSNP rs35367671. Ref.14

VAR_040602

Natural variant

463

1

Q → E: dbSNP rs1053668.

VAR_028196

Natural variant

493

1

T → I: dbSNP rs35765784. Ref.14

VAR_040603

Experimental info

Sequence conflict

39

1

E → G in AAD20442. Ref.1

Sequence conflict

272

1

I → T in AAX88806. Ref.3

Secondary structure

1

.

499

Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence		Length	Mass (Da)
Isoform Delta 2 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 62999FBAB98120CE Show »	FASTA	499	56,369
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI IKVTEQLIEA 370 380 390 400 410 420 INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH 430 440 450 460 470 480 LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIKPP 490 CIPNGKENFS GGTSLWQNI « Hide
Isoform Delta 3. Checksum: 0F312AC0E5938A07 Show »	FASTA	510	57,620
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKKR KSSSSVQMME STESSNTTIE DEDVKARKQE 370 380 390 400 410 420 IIKVTEQLIE AINNGDFEAY TKICDPGLTA FEPEALGNLV EGMDFHRFYF ENALSKSNKP 430 440 450 460 470 480 IHTIILNPHV HLVGDDAACI AYIRLTQYMD GSGMPKTMQS EETRVWHRRD GKWQNVHFHR 490 500 510 SGSPTVPIKP PCIPNGKENF SGGTSLWQNI « Hide
Isoform Delta 4. Checksum: 184D4250A261D923 Show »	FASTA	519	58,472
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKIN NKANVVTSPK ENIPTPALES TESSNTTIED 370 380 390 400 410 420 EDVKARKQEI IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE 430 440 450 460 470 480 NALSKSNKPI HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG 490 500 510 KWQNVHFHRS GSPTVPIKPP CIPNGKENFS GGTSLWQNI « Hide
Isoform Delta 6. Checksum: 571DA27C914E4F7E Show »	FASTA	478	54,128
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI IKVTEQLIEA 370 380 390 400 410 420 INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH 430 440 450 460 470 LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIK « Hide
Isoform Delta 7. Checksum: A45841A7EBFBFA5E Show »	FASTA	489	55,378
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKKR KSSSSVQMME STESSNTTIE DEDVKARKQE 370 380 390 400 410 420 IIKVTEQLIE AINNGDFEAY TKICDPGLTA FEPEALGNLV EGMDFHRFYF ENALSKSNKP 430 440 450 460 470 480 IHTIILNPHV HLVGDDAACI AYIRLTQYMD GSGMPKTMQS EETRVWHRRD GKWQNVHFHR SGSPTVPIK « Hide
Isoform Delta 8. Checksum: 3EE4353E136343BB Show »	FASTA	498	56,230
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKIN NKANVVTSPK ENIPTPALES TESSNTTIED 370 380 390 400 410 420 EDVKARKQEI IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE 430 440 450 460 470 480 NALSKSNKPI HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG 490 KWQNVHFHRS GSPTVPIK « Hide
Isoform Delta 9. Checksum: 79B81366F7E1C69B Show »	FASTA	513	57,901
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKEP QTTVIHNPDG NKESTESSNT TIEDEDVKAR 370 380 390 400 410 420 KQEIIKVTEQ LIEAINNGDF EAYTKICDPG LTAFEPEALG NLVEGMDFHR FYFENALSKS 430 440 450 460 470 480 NKPIHTIILN PHVHLVGDDA ACIAYIRLTQ YMDGSGMPKT MQSEETRVWH RRDGKWQNVH 490 500 510 FHRSGSPTVP IKPPCIPNGK ENFSGGTSLW QNI « Hide
Isoform Delta 10. Checksum: E78D0E736590F908 Show »	FASTA	492	55,660
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKEP QTTVIHNPDG NKESTESSNT TIEDEDVKAR 370 380 390 400 410 420 KQEIIKVTEQ LIEAINNGDF EAYTKICDPG LTAFEPEALG NLVEGMDFHR FYFENALSKS 430 440 450 460 470 480 NKPIHTIILN PHVHLVGDDA ACIAYIRLTQ YMDGSGMPKT MQSEETRVWH RRDGKWQNVH 490 FHRSGSPTVP IK « Hide
Isoform Delta 11. Checksum: 3BFC4B5CAF9B3B88 Show »	FASTA	524	59,152
10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKKR KSSSSVQMME PQTTVIHNPD GNKESTESSN 370 380 390 400 410 420 TTIEDEDVKA RKQEIIKVTE QLIEAINNGD FEAYTKICDP GLTAFEPEAL GNLVEGMDFH 430 440 450 460 470 480 RFYFENALSK SNKPIHTIIL NPHVHLVGDD AACIAYIRLT QYMDGSGMPK TMQSEETRVW 490 500 510 520 HRRDGKWQNV HFHRSGSPTV PIKPPCIPNG KENFSGGTSL WQNI « Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium." Hoch B., Meyer R., Hetzer R., Krause E.-G., Karczewski P. Circ. Res. 84:713-721(1999) [PubMed: 10189359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Myocardium.
[2]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA 10). Tissue: Brain.
[3]	Zhou G., Nong W., Li H., Ke R., Li M., Zheng Z., Zhong G., Shen C., Liang M., Lin L., Yang S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA 7).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA 6).
[5]	"Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells." Rochlitz H., Voigt A., Lankat-Buttgereit B., Goeke B., Heimberg H., Nauck M.A., Schiemann U., Schatz H., Pfeiffer A.F. Diabetologia 43:465-473(2000) [PubMed: 10819240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-243, ALTERNATIVE SPLICING. Tissue: Insulinoma.
[6]	"Identification of novel human tumor cell-specific CaMK-II variants." Tombes R.M., Krystal G.W. Biochim. Biophys. Acta 1355:281-292(1997) [PubMed: 9060999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-417, ALTERNATIVE SPLICING.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-337, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R., Keri G., Wehland J., Daub H. Mol. Cell. Proteomics 6:537-547(2007) [PubMed: 17192257] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; SER-319 AND THR-337, MASS SPECTROMETRY.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-315; SER-319; THR-331 AND SER-472, MASS SPECTROMETRY.
[10]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330; THR-331; SER-333 AND THR-337, MASS SPECTROMETRY. Tissue: Liver.
[11]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[12]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, MASS SPECTROMETRY.
[13]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; THR-287; THR-306; THR-307; SER-315; SER-319; SER-330; THR-331; SER-333; SER-334; THR-336; THR-337; SER-404; SER-441; SER-470; SER-472 AND SER-490, MASS SPECTROMETRY.
[14]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-167 AND ILE-493.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF071569 mRNA. Translation: AAD20442.1.
AB209288 mRNA. Translation: BAD92525.1. Different initiation.
AY987011 mRNA. Translation: AAX88806.1.
BC032784 mRNA. Translation: AAH32784.1.
AJ252239 mRNA. Translation: CAB65123.1.
U50361 mRNA. Translation: AAB16866.1.

IPI

IPI00172636.
IPI00430291.
IPI00654569.
IPI00827573.
IPI00827606.
IPI00827625.
IPI00827717.
IPI00828139.
IPI00828178.

RefSeq

NP_001212.2.
NP_742112.1.
NP_742113.1.
NP_742125.1.
NP_742126.1.
NP_742127.1.

UniGene

Hs.144114

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VN9	X-ray	2.30	A/B	11-309	[»]
2W2C	X-ray	2.70	A/B/C/D/E/F/G/H/I/J/K/L/M/N	334-475	[»]
2WEL	X-ray	1.90	A	11-335	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13557. 11 interactions.

STRING

Q13557.

PTM databases

PhosphoSite

Q13557.

Proteomic databases

PRIDE

Q13557.

Genome annotation databases

Ensembl

ENST00000342666; ENSP00000339740; ENSG00000145349; Homo sapiens. [Genome view]

GeneID

817.

KEGG

hsa:817.

UCSC

uc003ibi.1. human.
uc003ibk.1. human.
uc003ibm.1. human.
uc003ibn.1. human.

Organism-specific databases

CTD

817.

GeneCards

GC04M114655.

HGNC

HGNC:1462. CAMK2D.

HPA

HPA026281.

MIM

607708. gene.

PharmGKB

PA92.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG15150.

HOGENOM

HBG755340.

HOVERGEN

Q13557.

InParanoid

Q13557.

PhylomeDB

Q13557.

Enzyme and pathway databases

BRENDA

2.7.11.17. 247.

Pathway_Interaction_DB

ifngpathway. IFN-gamma pathway.

Reactome

REACT_13685. Synaptic Transmission.

Gene expression databases

ArrayExpress

Q13557.

Bgee

Q13557.

CleanEx

HS_CAMK2D.

Genevestigator

Q13557.

GermOnline

ENSG00000145349. Homo sapiens.

Family and domain databases

InterPro

IPR020636. Ca/CaM-dep_prot_kinase-like.
IPR015742. Ca/CaM-dep_prot_kinase_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]

PANTHER

PTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit.
PTHR22982:SF64. CaMKII. 1 hit.

Pfam

PF00069. Pkinase. 1 hit.
[Graphical view]

SMART

SM00220. S_TKc. 1 hit.
[Graphical view]

PROSITE

PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

3330.

SOURCE

Search...

Hide | Top

Entry information

Entry name

KCC2D_HUMAN

Accession

Primary (citable) accession number: Q13557
Secondary accession number(s): Q52PK4

Q9UQE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 17, 2006
Last modified:	February 9, 2010
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents