Reviewed, UniProtKB/Swiss-Prot Q13557 (KCC2D_HUMAN)

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent protein kinase type II delta chain
      Short name=CaM-kinase II delta chain
      Short name=CaM kinase II subunit delta
      Short name=CaMK-II subunit delta
    EC=2.7.11.17

Gene names

Name:	CAMK2D
Synonyms:	CAMKD

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.
Subunit structure	CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.
Tissue specificity	Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle. Ref.1
Miscellaneous	Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	regulation of cell growth Ref.6 Non-traceable author statement. Source: UniProtKB
Cellular component	calcium- and calmodulin-dependent protein kinase complex Traceable author statement. Source: UniProtKB
Molecular function	ATP binding Non-traceable author statement. Source: UniProtKB calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CAMK2A	Q9UQM7	1	EBI-351018,EBI-1383687

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform Delta 2 (identifier: Q13557-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Delta 3 (identifier: Q13557-3)

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: K → KRKSSSSVQMM

Isoform Delta 4 (identifier: Q13557-4)

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: K → INNKANVVTSPKENIPTPAL

Isoform Delta 6 (identifier: Q13557-8)

The sequence of this isoform differs from the canonical sequence as follows:
     479-499: Missing.

Isoform Delta 7 (identifier: Q13557-9)

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: K → KRKSSSSVQMM
     479-499: Missing.

Isoform Delta 8 (identifier: Q13557-5)

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: K → INNKANVVTSPKENIPTPAL
     479-499: Missing.

Isoform Delta 9 (identifier: Q13557-6)

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: K → EPQTTVIHNPDGNK

Isoform Delta 10 (identifier: Q13557-10)

The sequence of this isoform differs from the canonical sequence as follows:
     328-328: K → EPQTTVIHNPDGNK
     479-499: Missing.

Isoform Delta 11 (identifier: Q13557-11)

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	Calcium/calmodulin-dependent protein kinase type II delta chain		PRO_0000086099
Regions
	Domain	14 – 272	259	Protein kinase
	Nucleotide binding	20 – 28	9	ATP By similarity
	Region	291 – 301	11	Calmodulin-binding By similarity
Sites
	Active site	136	1	Proton acceptor By similarity
	Binding site	43	1	ATP By similarity
Amino acid modifications
	Modified residue	3	1	Phosphoserine Ref.9
	Modified residue	231	1	Phosphotyrosine By similarity
	Modified residue	287	1	Phosphothreonine By similarity
	Modified residue	315	1	Phosphoserine Ref.9 Ref.8
	Modified residue	319	1	Phosphoserine Ref.9 Ref.8
	Modified residue	330	1	Phosphoserine Ref.10
	Modified residue	331	1	Phosphothreonine Ref.9 Ref.10
	Modified residue	333	1	Phosphoserine Ref.10
	Modified residue	337	1	Phosphothreonine Ref.8 Ref.10 Ref.7
	Modified residue	472	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	316	1	Missing in isoform Delta 11.		VSP_023095
	Alternative sequence	328	1	K → KRKSSSSVQMM in isoform Delta 3 and isoform Delta 7.		VSP_023096
	Alternative sequence	328	1	K → INNKANVVTSPKENIPTPAL in isoform Delta 4 and isoform Delta 8.		VSP_023097
	Alternative sequence	328	1	K → EPQTTVIHNPDGNK in isoform Delta 9 and isoform Delta 10.		VSP_023098
	Alternative sequence	479 – 499	21	Missing in isoform Delta 6, isoform Delta 7, isoform Delta 8 and isoform Delta 10.		VSP_023099
	Natural variant	167	1	D → E Ref.12		VAR_040602
	Natural variant	463	1	Q → E: dbSNP rs1053668.		VAR_028196
	Natural variant	493	1	T → I: dbSNP rs35765784. Ref.12		VAR_040603
Experimental info
	Sequence conflict	39	1	E → G in AAD20442. Ref.1
	Sequence conflict	272	1	I → T in AAX88806. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform Delta 2 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: 62999FBAB98120CE	FASTA	499	56,369
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI IKVTEQLIEA 370 380 390 400 410 420 INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH 430 440 450 460 470 480 LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIKPP 490 CIPNGKENFS GGTSLWQNI
	Isoform Delta 3. Checksum: 425C1B8126CCBA0B	FASTA	509	57,492
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKRK SSSSVQMMES TESSNTTIED EDVKARKQEI 370 380 390 400 410 420 IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI 430 440 450 460 470 480 HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS 490 500 GSPTVPIKPP CIPNGKENFS GGTSLWQNI
	Isoform Delta 4. Checksum: 1717E28C7F67779E	FASTA	518	58,344
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVINN KANVVTSPKE NIPTPALEST ESSNTTIEDE 370 380 390 400 410 420 DVKARKQEII KVTEQLIEAI NNGDFEAYTK ICDPGLTAFE PEALGNLVEG MDFHRFYFEN 430 440 450 460 470 480 ALSKSNKPIH TIILNPHVHL VGDDAACIAY IRLTQYMDGS GMPKTMQSEE TRVWHRRDGK 490 500 510 WQNVHFHRSG SPTVPIKPPC IPNGKENFSG GTSLWQNI
	Isoform Delta 6. Checksum: 571DA27C914E4F7E	FASTA	478	54,128
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI IKVTEQLIEA 370 380 390 400 410 420 INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH 430 440 450 460 470 LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIK
	Isoform Delta 7. Checksum: 452259A6C192377F	FASTA	488	55,250
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVKRK SSSSVQMMES TESSNTTIED EDVKARKQEI 370 380 390 400 410 420 IKVTEQLIEA INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI 430 440 450 460 470 480 HTIILNPHVH LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIK
	Isoform Delta 8. Checksum: 8E82CAC892EBF535	FASTA	497	56,102
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVINN KANVVTSPKE NIPTPALEST ESSNTTIEDE 370 380 390 400 410 420 DVKARKQEII KVTEQLIEAI NNGDFEAYTK ICDPGLTAFE PEALGNLVEG MDFHRFYFEN 430 440 450 460 470 480 ALSKSNKPIH TIILNPHVHL VGDDAACIAY IRLTQYMDGS GMPKTMQSEE TRVWHRRDGK 490 WQNVHFHRSG SPTVPIK
	Isoform Delta 9. Checksum: 0705186B9AD08758	FASTA	512	57,773
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVEPQ TTVIHNPDGN KESTESSNTT IEDEDVKARK 370 380 390 400 410 420 QEIIKVTEQL IEAINNGDFE AYTKICDPGL TAFEPEALGN LVEGMDFHRF YFENALSKSN 430 440 450 460 470 480 KPIHTIILNP HVHLVGDDAA CIAYIRLTQY MDGSGMPKTM QSEETRVWHR RDGKWQNVHF 490 500 510 HRSGSPTVPI KPPCIPNGKE NFSGGTSLWQ NI
	Isoform Delta 10. Checksum: B103C9221F88F822	FASTA	491	55,531
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LKKPDGVEPQ TTVIHNPDGN KESTESSNTT IEDEDVKARK 370 380 390 400 410 420 QEIIKVTEQL IEAINNGDFE AYTKICDPGL TAFEPEALGN LVEGMDFHRF YFENALSKSN 430 440 450 460 470 480 KPIHTIILNP HVHLVGDDAA CIAYIRLTQY MDGSGMPKTM QSEETRVWHR RDGKWQNVHF 490 HRSGSPTVPI K
	Isoform Delta 11. Checksum: 671917C787E95FDD	FASTA	498	56,298
	10 20 30 40 50 60 MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAKSLL KKPDGVKEST ESSNTTIEDE DVKARKQEII KVTEQLIEAI 370 380 390 400 410 420 NNGDFEAYTK ICDPGLTAFE PEALGNLVEG MDFHRFYFEN ALSKSNKPIH TIILNPHVHL 430 440 450 460 470 480 VGDDAACIAY IRLTQYMDGS GMPKTMQSEE TRVWHRRDGK WQNVHFHRSG SPTVPIKPPC 490 IPNGKENFSG GTSLWQNI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium." Hoch B., Meyer R., Hetzer R., Krause E.-G., Karczewski P. Circ. Res. 84:713-721(1999) [PubMed: 10189359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Myocardium.
[2]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA 10). Tissue: Brain.
[3]	Zhou G., Nong W., Li H., Ke R., Li M., Zheng Z., Zhong G., Shen C., Liang M., Lin L., Yang S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA 7).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA 6). Tissue: Brain.
[5]	"Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells." Rochlitz H., Voigt A., Lankat-Buttgereit B., Goeke B., Heimberg H., Nauck M.A., Schiemann U., Schatz H., Pfeiffer A.F. Diabetologia 43:465-473(2000) [PubMed: 10819240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-243, ALTERNATIVE SPLICING. Tissue: Insulinoma.
[6]	"Identification of novel human tumor cell-specific CaMK-II variants." Tombes R.M., Krystal G.W. Biochim. Biophys. Acta 1355:281-292(1997) [PubMed: 9060999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-417, ALTERNATIVE SPLICING.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-337, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R., Keri G., Wehland J., Daub H. Mol. Cell. Proteomics 6:537-547(2007) [PubMed: 17192257] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; SER-319 AND THR-337, MASS SPECTROMETRY.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-315; SER-319; THR-331 AND SER-472, MASS SPECTROMETRY.
[10]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330; THR-331; SER-333 AND THR-337, MASS SPECTROMETRY. Tissue: Liver.
[11]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[12]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-167 AND ILE-493.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF071569 mRNA. Translation: AAD20442.1.
AB209288 mRNA. Translation: BAD92525.1. Different initiation.
AY987011 mRNA. Translation: AAX88806.1.
BC032784 mRNA. Translation: AAH32784.1.
AJ252239 mRNA. Translation: CAB65123.1.
U50361 mRNA. Translation: AAB16866.1.

IPI

IPI00172636.
IPI00430291.
IPI00827573.
IPI00827606.
IPI00827625.
IPI00827717.
IPI00828081.
IPI00828139.
IPI00828178.

RefSeq

NP_001212.2.
NP_742112.1.
NP_742113.1.
NP_742125.1.
NP_742126.1.
NP_742127.1.

UniGene

Hs.144114

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VN9	X-ray	2.30	A/B	11-309	[»]
2W2C	X-ray	2.70	A/B/C/D/E/F/G/H/I/J/K/L/M/N	334-475	[»]
2WEL	X-ray	1.90	A	11-335	[»]

SMR

Q13557. Positions 336-474.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13557. 11 interactions.

PTM databases

PhosphoSite

Q13557.

Proteomic databases

PRIDE

Q13557.

Genome annotation databases

Ensembl

ENSG00000145349. Homo sapiens. [Contig view]

GeneID

817.

KEGG

hsa:817.

UCSC

uc003ibi.1. human.
uc003ibk.1. human.
uc003ibm.1. human.
uc003ibn.1. human.

Organism-specific databases

GeneCards

GC04M114655.

HGNC

HGNC:1462. CAMK2D.

MIM

607708. gene.

PharmGKB

PA92.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q13557.

HOVERGEN

Q13557.

OMA

Q13557. QYMDGGG.

Enzyme and pathway databases

BRENDA

2.7.11.17. 247.

Pathway_Interaction_DB

ifngpathway. IFN-gamma pathway.

Gene expression databases

ArrayExpress

Q13557.

Bgee

Q13557.

CleanEx

HS_CAMK2D.

GermOnline

ENSG00000145349. Homo sapiens.

Family and domain databases

InterPro

IPR015742. Ca/calmodulin-dep_kinase.
IPR013543. Ca/calmodulin-dep_kinase-assoc.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]

PANTHER

PTHR22982:SF64. CaMKII. 1 hit.

Pfam

PF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]

ProDom

PD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00220. S_TKc. 1 hit.
[Graphical view]

PROSITE

PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

3330.

SOURCE

Search...

Entry information

Entry name

KCC2D_HUMAN

Accession

Primary (citable) accession number: Q13557
Secondary accession number(s): Q52PK4 , Q59G21, Q8N553, Q9UGH6, Q9UQE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 17, 2006
Last modified:	July 7, 2009
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)