Reviewed, UniProtKB/Swiss-Prot Q13555 (KCC2G_HUMAN)

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit gamma
      Short name=CaM kinase II subunit gamma
      Short name=CaMK-II subunit gamma
    EC=2.7.11.17

Gene names

Name:	CAMK2G
Synonyms:	CAMKG

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.
Subunit structure	CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	insulin secretion Ref.4 Non-traceable author statement. Source: UniProtKB protein amino acid phosphorylation Non-traceable author statement. Source: UniProtKB
Cellular component	calcium- and calmodulin-dependent protein kinase complex Traceable author statement. Source: UniProtKB cytosol Inferred from Experiment. Source: Reactome endocytic vesicle membrane Inferred from Experiment. Source: Reactome nucleoplasm Inferred from Experiment. Source: Reactome plasma membrane Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Non-traceable author statement. Source: UniProtKB calcium-dependent protein serine/threonine phosphatase activity Ref.6 Non-traceable author statement. Source: UniProtKB calmodulin binding Ref.6 Non-traceable author statement. Source: UniProtKB calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13555-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13555-2)

The sequence of this isoform differs from the canonical sequence as follows:
     331-341: Missing.

Isoform 3 (identifier: Q13555-3)

The sequence of this isoform differs from the canonical sequence as follows:
     331-364: Missing.

Isoform 4 (identifier: Q13555-4)

The sequence of this isoform differs from the canonical sequence as follows:
     396-425: ARSPEGRSSRDRTAPSAGMQPQPSLCSSAM → V

Isoform 5 (identifier: Q13555-5)

The sequence of this isoform differs from the canonical sequence as follows:
     315-315: S → SVGRQSSAPASPAASAAGLAGQ
     341-363: Missing.
     396-425: ARSPEGRSSRDRTAPSAGMQPQPSLCSSAM → V

Isoform 6 (identifier: Q13555-6)

The sequence of this isoform differs from the canonical sequence as follows:
     315-315: S → SVGRQSSAPASPAASAAGLAGQ
     397-398: RS → APLRTGNGSSV

Isoform 7 (identifier: Q13555-7)

Also known as: gamma F;

The sequence of this isoform differs from the canonical sequence as follows:
     331-364: Missing.
     397-398: RS → APLRTGNGSSV

Isoform 8 (identifier: Q13555-8)

Also known as: gamma E;

The sequence of this isoform differs from the canonical sequence as follows:
     331-341: Missing.
     397-398: RS → APLRTGNGSSV

Isoform 9 (identifier: Q13555-9)

Also known as: gamma D;

The sequence of this isoform differs from the canonical sequence as follows:
     331-341: Missing.
     351-364: Missing.
     397-398: RS → APLRTGNGSSV

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 558

558

Calcium/calmodulin-dependent protein kinase type II subunit gamma

PRO_0000086101

Regions

Domain

14 – 272

259

Protein kinase

Nucleotide binding

20 – 28

9

ATP By similarity

Region

291 – 301

11

Calmodulin-binding By similarity

Sites

Active site

136

1

Proton acceptor By similarity

Binding site

43

1

ATP By similarity

Amino acid modifications

Modified residue

235

1

Phosphoserine By similarity

Modified residue

287

1

Phosphothreonine Ref.8 Ref.11

Modified residue

307

1

Phosphothreonine

Modified residue

311

1

Phosphoserine

Modified residue

315

1

Phosphoserine Ref.9

Modified residue

319

1

Phosphoserine Ref.9

Modified residue

325

1

Phosphoserine Ref.10

Modified residue

349

1

Phosphoserine Ref.10

Modified residue

352

1

Phosphoserine

Modified residue

375

1

Phosphothreonine

Modified residue

381

1

Phosphoserine

Modified residue

382

1

Phosphothreonine

Modified residue

384

1

Phosphoserine

Modified residue

387

1

Phosphothreonine

Modified residue

388

1

Phosphothreonine

Modified residue

419

1

Phosphoserine

Natural variations

Alternative sequence

315

1

S → SVGRQSSAPASPAASAAGLA GQ in isoform 5 and isoform 6.

VSP_032699

Alternative sequence

331 – 364

34

Missing in isoform 3 and isoform 7.

VSP_013350

Alternative sequence

331 – 341

11

Missing in isoform 2, isoform 8 and isoform 9.

VSP_013349

Alternative sequence

341 – 363

23

Missing in isoform 5.

VSP_032700

Alternative sequence

351 – 364

14

Missing in isoform 9.

VSP_036027

Alternative sequence

396 – 425

30

ARSPE…CSSAM → V in isoform 4 and isoform 5.

VSP_004778

Alternative sequence

397 – 398

2

RS → APLRTGNGSSV in isoform 6, isoform 7, isoform 8 and isoform 9.

VSP_035456

Natural variant

36

1

S → P: dbSNP rs17853266. Ref.2 Ref.3

VAR_042430

Secondary structure

1

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558

Helix Strand Turn

Details...

Helix

9 – 13

5

Beta strand

14 – 19

6

Beta strand

26 – 33

8

Turn

34 – 37

4

Beta strand

38 – 45

8

Helix

52 – 67

16

Beta strand

76 – 81

6

Beta strand

86 – 91

6

Helix

98 – 103

6

Helix

110 – 129

20

Helix

139 – 141

3

Beta strand

142 – 145

4

Beta strand

153 – 155

3

Helix

183 – 187

5

Helix

194 – 199

6

Helix

203 – 208

6

Helix

219 – 227

9

Helix

237 – 240

4

Helix

243 – 252

10

Turn

257 – 259

3

Helix

263 – 266

4

Helix

270 – 273

4

Helix

275 – 278

4

Helix

285 – 300

16

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 12, 2005. Version 3. Checksum: 38D4112C2FDBD44C	FASTA	558	62,609
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSAAKSL LNKKSDGGVK KRKSSSSVHL MPQSNNKNSL VSPAQEPAPL 370 380 390 400 410 420 QTAMEPQTTV VHNATDGIKG STESCNTTTE DEDLKARSPE GRSSRDRTAP SAGMQPQPSL 430 440 450 460 470 480 CSSAMRKQEI IKITEQLIEA INNGDFEAYT KICDPGLTSF EPEALGNLVE GMDFHKFYFE 490 500 510 520 530 540 NLLSKNSKPI HTTILNPHVH VIGEDAACIA YIRLTQYIDG QGRPRTSQSE ETRVWHRRDG 550 KWLNVHYHCS GAPAAPLQ
	Isoform 2. Checksum: 1A1B6D508CF3D210	FASTA	547	61,368
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSAAKSL LNKKSDGGVK PQSNNKNSLV SPAQEPAPLQ TAMEPQTTVV 370 380 390 400 410 420 HNATDGIKGS TESCNTTTED EDLKARSPEG RSSRDRTAPS AGMQPQPSLC SSAMRKQEII 430 440 450 460 470 480 KITEQLIEAI NNGDFEAYTK ICDPGLTSFE PEALGNLVEG MDFHKFYFEN LLSKNSKPIH 490 500 510 520 530 540 TTILNPHVHV IGEDAACIAY IRLTQYIDGQ GRPRTSQSEE TRVWHRRDGK WLNVHYHCSG APAAPLQ
	Isoform 3. Checksum: 75E1E7B03A01C061	FASTA	524	58,963
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSAAKSL LNKKSDGGVK EPQTTVVHNA TDGIKGSTES CNTTTEDEDL 370 380 390 400 410 420 KARSPEGRSS RDRTAPSAGM QPQPSLCSSA MRKQEIIKIT EQLIEAINNG DFEAYTKICD 430 440 450 460 470 480 PGLTSFEPEA LGNLVEGMDF HKFYFENLLS KNSKPIHTTI LNPHVHVIGE DAACIAYIRL 490 500 510 520 TQYIDGQGRP RTSQSEETRV WHRRDGKWLN VHYHCSGAPA APLQ
	Isoform 4. Checksum: EE1D127BBA178544	FASTA	529	59,607
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSAAKSL LNKKSDGGVK KRKSSSSVHL MPQSNNKNSL VSPAQEPAPL 370 380 390 400 410 420 QTAMEPQTTV VHNATDGIKG STESCNTTTE DEDLKVRKQE IIKITEQLIE AINNGDFEAY 430 440 450 460 470 480 TKICDPGLTS FEPEALGNLV EGMDFHKFYF ENLLSKNSKP IHTTILNPHV HVIGEDAACI 490 500 510 520 AYIRLTQYID GQGRPRTSQS EETRVWHRRD GKWLNVHYHC SGAPAAPLQ
	Isoform 5. Checksum: 58DBF1B72F64FA31	FASTA	527	59,038
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSVGRQS SAPASPAASA AGLAGQAAKS LLNKKSDGGV KKRKSSSSVH 370 380 390 400 410 420 LMEPQTTVVH NATDGIKGST ESCNTTTEDE DLKVRKQEII KITEQLIEAI NNGDFEAYTK 430 440 450 460 470 480 ICDPGLTSFE PEALGNLVEG MDFHKFYFEN LLSKNSKPIH TTILNPHVHV IGEDAACIAY 490 500 510 520 IRLTQYIDGQ GRPRTSQSEE TRVWHRRDGK WLNVHYHCSG APAAPLQ
	Isoform 6. Checksum: 2B608F45E8FD3F86	FASTA	588	65,242
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSVGRQS SAPASPAASA AGLAGQAAKS LLNKKSDGGV KKRKSSSSVH 370 380 390 400 410 420 LMPQSNNKNS LVSPAQEPAP LQTAMEPQTT VVHNATDGIK GSTESCNTTT EDEDLKAAPL 430 440 450 460 470 480 RTGNGSSVPE GRSSRDRTAP SAGMQPQPSL CSSAMRKQEI IKITEQLIEA INNGDFEAYT 490 500 510 520 530 540 KICDPGLTSF EPEALGNLVE GMDFHKFYFE NLLSKNSKPI HTTILNPHVH VIGEDAACIA 550 560 570 580 YIRLTQYIDG QGRPRTSQSE ETRVWHRRDG KWLNVHYHCS GAPAAPLQ
	Isoform 7 (gamma F). Checksum: 864E8CCF92872FB3	FASTA	533	59,760
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSAAKSL LNKKSDGGVK EPQTTVVHNA TDGIKGSTES CNTTTEDEDL 370 380 390 400 410 420 KAAPLRTGNG SSVPEGRSSR DRTAPSAGMQ PQPSLCSSAM RKQEIIKITE QLIEAINNGD 430 440 450 460 470 480 FEAYTKICDP GLTSFEPEAL GNLVEGMDFH KFYFENLLSK NSKPIHTTIL NPHVHVIGED 490 500 510 520 530 AACIAYIRLT QYIDGQGRPR TSQSEETRVW HRRDGKWLNV HYHCSGAPAA PLQ
	Isoform 8 (gamma E). Checksum: B0E88BF9F07715CB	FASTA	556	62,165
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSAAKSL LNKKSDGGVK PQSNNKNSLV SPAQEPAPLQ TAMEPQTTVV 370 380 390 400 410 420 HNATDGIKGS TESCNTTTED EDLKAAPLRT GNGSSVPEGR SSRDRTAPSA GMQPQPSLCS 430 440 450 460 470 480 SAMRKQEIIK ITEQLIEAIN NGDFEAYTKI CDPGLTSFEP EALGNLVEGM DFHKFYFENL 490 500 510 520 530 540 LSKNSKPIHT TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW 550 LNVHYHCSGA PAAPLQ
	Isoform 9 (gamma D). Checksum: 99F906D2A0BBCA36	FASTA	542	60,743
	10 20 30 40 50 60 MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI 130 140 150 160 170 180 LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL 310 320 330 340 350 360 KGAILTTMLV SRNFSAAKSL LNKKSDGGVK PQSNNKNSLE PQTTVVHNAT DGIKGSTESC 370 380 390 400 410 420 NTTTEDEDLK AAPLRTGNGS SVPEGRSSRD RTAPSAGMQP QPSLCSSAMR KQEIIKITEQ 430 440 450 460 470 480 LIEAINNGDF EAYTKICDPG LTSFEPEALG NLVEGMDFHK FYFENLLSKN SKPIHTTILN 490 500 510 520 530 540 PHVHVIGEDA ACIAYIRLTQ YIDGQGRPRT SQSEETRVWH RRDGKWLNVH YHCSGAPAAP LQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-36.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT PRO-36. Tissue: Brain.
[4]	"Human islets of Langerhans express multiple isoforms of calcium/calmodulin-dependent protein kinase II." Breen M.A., Ashcroft S.J. Biochem. Biophys. Res. Commun. 236:473-478(1997) [PubMed: 9240463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-315.
[5]	"Human calcium/calmodulin-dependent protein kinase II gamma: cloning, genomic structure and detection of variants in subjects with type ii diabetes." Gloyn A.L., Desai M., Clark A., Levy J.C., Holman R.R., Frayling T.M., Hattersley A.T., Ashcroft S.J. Diabetologia 45:580-583(2002) [PubMed: 12032636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-558, ALTERNATIVE SPLICING (ISOFORM 6).
[6]	"Identification of novel human tumor cell-specific CaMK-II variants." Tombes R.M., Krystal G.W. Biochim. Biophys. Acta 1355:281-292(1997) [PubMed: 9060999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-497 (ISOFORMS 2 AND 4).
[7]	"Human biliary epithelial cell line Mz-ChA-1 expresses new isoforms of calmodulin-dependent protein kinase II." Kwiatkowski A.P., McGill J.M. Gastroenterology 109:1316-1323(1995) [PubMed: 7557101] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 326-432 (ISOFORMS 7; 8 AND 9).
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R., Keri G., Wehland J., Daub H. Mol. Cell. Proteomics 6:537-547(2007) [PubMed: 17192257] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315 AND SER-319, MASS SPECTROMETRY.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325 AND SER-349, MASS SPECTROMETRY.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287, MASS SPECTROMETRY.
[12]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287; THR-307; SER-311; SER-315; SER-319; SER-325; SER-349; SER-352; THR-375; SER-381; THR-382; SER-384; THR-387; THR-388 AND SER-419, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL713896, AC022400, AL596247 Genomic DNA. Translation: CAI13790.1.
AL713896, AC022400, AL596247 Genomic DNA. Translation: CAI13791.1.
AL596247, AC022400, AL713896 Genomic DNA. Translation: CAI13965.1.
AL596247, AC022400, AL713896 Genomic DNA. Translation: CAI13968.1.
CH471083 Genomic DNA. Translation: EAW54532.1.
BC034044 mRNA. Translation: AAH34044.1.
U66064 mRNA. Translation: AAB80848.1.
AF415197 , AF415177, AF415178, AF415179, AF415180, AF415181, AF415182, AF415183, AF415184, AF415185, AF415186, AF415187, AF415188, AF415189, AF415190, AF415191, AF415192, AF415193, AF415194, AF415195, AF415196 Genomic DNA. Translation: AAM33514.1.
U50359 mRNA. Translation: AAB16864.1.
U50360 mRNA. Translation: AAB16865.1.
U32472 mRNA. Translation: AAA75201.1.
U32473 mRNA. Translation: AAA75202.1.
U32509 mRNA. Translation: AAA75203.1.

IPI

IPI00172450.
IPI00296678.
IPI00334344.
IPI00556423.
IPI00908444.
IPI00915309.
IPI00915327.
IPI00915383.
IPI00915393.

PIR

G01975.
G01978.

RefSeq

NP_001213.2.
NP_751909.1.
NP_751911.1.
NP_751913.1.

UniGene

Hs.523045

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2UX0	X-ray	2.46	A/B/C/D/E/F	426-556	[»]
2V7O	X-ray	2.25	A	5-315	[»]

SMR

Q13555. Positions 3-302.

ModBase

Search...

Protein-protein interaction databases

STRING

Q13555.

PTM databases

PhosphoSite

Q13555.

Proteomic databases

PRIDE

Q13555.

Genome annotation databases

Ensembl

ENST00000394763; ENSP00000378244; ENSG00000148660; Homo sapiens. [Genome view]

GeneID

818.

KEGG

hsa:818.

UCSC

uc001jvo.1. human.
uc001jvs.1. human.
uc001jvv.1. human.

Organism-specific databases

CTD

818.

GeneCards

GC10M075242.

HGNC

HGNC:1463. CAMK2G.

MIM

602123. gene.

PharmGKB

PA93.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q13555.

InParanoid

Q13555.

OMA

XPQSNNK.

OrthoDB

EOG9T1M5P.

PhylomeDB

Q13555.

Enzyme and pathway databases

BRENDA

2.7.11.17. 247.

Pathway_Interaction_DB

bcr_5pathway. BCR signaling pathway.
ifngpathway. IFN-gamma pathway.

Reactome

REACT_13685. Synaptic Transmission.

Gene expression databases

ArrayExpress

Q13555.

Bgee

Q13555.

Genevestigator

Q13555.

GermOnline

ENSG00000148660. Homo sapiens.

Family and domain databases

InterPro

IPR020636. Ca/CaM-dep_prot_kinase-like.
IPR015742. Ca/CaM-dep_prot_kinase_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]

PANTHER

PTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit.
PTHR22982:SF64. CaMKII. 1 hit.

Pfam

PF00069. Pkinase. 1 hit.
[Graphical view]

SMART

SM00220. S_TKc. 1 hit.
[Graphical view]

PROSITE

PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

3340.

SOURCE

Search...

Entry information

Entry name

KCC2G_HUMAN

Accession

Primary (citable) accession number: Q13555
Secondary accession number(s): O15378 , Q13279, Q13282, Q13556, Q5SQZ3, Q5SQZ4, Q7KYX5, Q8N4I3, Q8NIA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 12, 2005
Last modified:	February 9, 2010
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.