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Protein

Calcium/calmodulin-dependent protein kinase type II subunit beta

Gene

CAMK2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by Ca2+/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca2+-independent activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431ATPPROSITE-ProRule annotation
Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cell projection morphogenesis Source: Ensembl
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • MAPK cascade Source: Reactome
  • positive regulation of dendritic spine morphogenesis Source: UniProtKB
  • positive regulation of neuron projection development Source: UniProtKB
  • positive regulation of phospholipase A2 activity Source: Ensembl
  • positive regulation of synapse maturation Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: ProtInc
  • regulation of calcium ion transport Source: UniProtKB
  • regulation of cellular response to heat Source: Reactome
  • regulation of dendritic spine development Source: UniProtKB
  • regulation of long-term neuronal synaptic plasticity Source: UniProtKB
  • regulation of skeletal muscle adaptation Source: UniProtKB
  • regulation of synapse structural plasticity Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.17. 2681.
ReactomeiR-HSA-3371571. HSF1-dependent transactivation.
R-HSA-399719. Trafficking of AMPA receptors.
R-HSA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-HSA-442729. CREB phosphorylation through the activation of CaMKII.
R-HSA-442742. CREB phosphorylation through the activation of Ras.
R-HSA-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-HSA-5576892. Phase 0 - rapid depolarisation.
R-HSA-5578775. Ion homeostasis.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-877300. Interferon gamma signaling.
R-HSA-936837. Ion transport by P-type ATPases.
SignaLinkiQ13554.
SIGNORiQ13554.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II subunit beta (EC:2.7.11.17)
Short name:
CaM kinase II subunit beta
Short name:
CaMK-II subunit beta
Gene namesi
Name:CAMK2B
Synonyms:CAM2, CAMK2, CAMKB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:1461. CAMK2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA91.

Chemistry

ChEMBLiCHEMBL2097164.
GuidetoPHARMACOLOGYi1556.

Polymorphism and mutation databases

BioMutaiCAMK2B.
DMDMi334302890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Calcium/calmodulin-dependent protein kinase type II subunit betaPRO_0000086096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphotyrosineBy similarity
Modified residuei287 – 2871Phosphothreonine; by autocatalysis1 Publication
Modified residuei306 – 3061Phosphothreonine; by autocatalysisBy similarity
Modified residuei307 – 3071Phosphothreonine; by autocatalysisBy similarity
Modified residuei367 – 3671PhosphoserineBy similarity
Modified residuei394 – 3941PhosphoserineBy similarity
Modified residuei397 – 3971PhosphoserineBy similarity
Modified residuei400 – 4001PhosphothreonineBy similarity
Modified residuei401 – 4011PhosphothreonineCombined sources

Post-translational modificationi

Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13554.
PaxDbiQ13554.
PeptideAtlasiQ13554.
PRIDEiQ13554.

PTM databases

iPTMnetiQ13554.
PhosphoSiteiQ13554.

Expressioni

Tissue specificityi

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.1 Publication

Inductioni

Activity is induced in skeletal muscle during exercise.1 Publication

Gene expression databases

BgeeiENSG00000058404.
ExpressionAtlasiQ13554. baseline and differential.
GenevisibleiQ13554. HS.

Organism-specific databases

HPAiCAB006849.
HPA026307.
HPA051783.
HPA051785.
HPA053973.

Interactioni

Subunit structurei

CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083, Ref. 19). Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ (PubMed:15312654). Interacts with FOXO3 (By similarity).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B3KWQ73EBI-1058722,EBI-10175974
ACOT7O001543EBI-1058722,EBI-948905
AP5B1Q2VPB73EBI-1058722,EBI-5917279
FAM171A2Q8N0U13EBI-1058722,EBI-10264767
KRTAP10-11P604123EBI-1058722,EBI-10217483
KRTAP19-5Q3LI723EBI-1058722,EBI-1048945
KRTAP19-7Q3SYF93EBI-1058722,EBI-10241353
MAD2L2Q9UI953EBI-1058722,EBI-77889
MED18Q9BUE03EBI-1058722,EBI-394640
MORF4L1Q9UBU83EBI-1058722,EBI-399246
MORF4L1Q9UBU8-23EBI-1058722,EBI-10288852
MRPL11Q9Y3B73EBI-1058722,EBI-5453723
PHKBQ931003EBI-1058722,EBI-740559
POP5Q969H63EBI-1058722,EBI-366525
RAP2BP612253EBI-1058722,EBI-750871
RBFOX2O432513EBI-1058722,EBI-746056
RBPMSQ930623EBI-1058722,EBI-740322
RPL11P629133EBI-1058722,EBI-354380
SEMA4GQ9NTN9-33EBI-1058722,EBI-9089805
SPRYD7Q5W1113EBI-1058722,EBI-10248098
TTC5Q8N0Z63EBI-1058722,EBI-9526213

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi107266. 46 interactions.
DIPiDIP-39770N.
IntActiQ13554. 26 interactions.
STRINGi9606.ENSP00000379098.

Chemistry

BindingDBiQ13554.

Structurei

Secondary structure

1
666
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 196Combined sources
Beta strandi27 – 337Combined sources
Turni34 – 363Combined sources
Beta strandi39 – 468Combined sources
Helixi52 – 6716Combined sources
Beta strandi76 – 816Combined sources
Beta strandi83 – 919Combined sources
Beta strandi95 – 973Combined sources
Helixi98 – 1025Combined sources
Helixi110 – 12920Combined sources
Helixi139 – 1413Combined sources
Beta strandi142 – 1454Combined sources
Beta strandi153 – 1553Combined sources
Helixi178 – 1803Combined sources
Helixi183 – 1864Combined sources
Helixi194 – 20916Combined sources
Helixi219 – 22810Combined sources
Turni235 – 2384Combined sources
Beta strandi239 – 2413Combined sources
Helixi243 – 25210Combined sources
Turni257 – 2593Combined sources
Helixi263 – 2664Combined sources
Helixi270 – 2734Combined sources
Helixi275 – 2784Combined sources
Helixi285 – 29814Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BHHX-ray2.40A/B/C/D11-303[»]
ProteinModelPortaliQ13554.
SMRiQ13554. Positions 10-396, 534-660.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13554.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 272259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni283 – 29210Autoinhibitory domainBy similarity
Regioni291 – 30111Calmodulin-bindingAdd
BLAST

Domaini

The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0033. Eukaryota.
ENOG410XNRX. LUCA.
GeneTreeiENSGT00760000118944.
HOVERGENiHBG108055.
InParanoidiQ13554.
KOiK04515.
OMAiVGPPPCL.
OrthoDBiEOG091G0SCS.
PhylomeDBiQ13554.
TreeFamiTF315229.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543. Ca/CaM-dep_prot_kinase-assoc.
IPR011009. Kinase-like_dom.
IPR032710. NTF2-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 3 hits.
PfamiPF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms.
Isoform 4 (identifier: Q13554-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL
60 70 80 90 100
SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE
110 120 130 140 150
DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG
160 170 180 190 200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC
210 220 230 240 250
GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN
260 270 280 290 300
QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL
310 320 330 340 350
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD
360 370 380 390 400
GVKPQTNSTK NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT
410 420 430 440 450
TIEDEDAKAP RVPDILSSVR RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI
460 470 480 490 500
SDILNSVRRG SGTPEAEGPL SAGPPPCLSP ALLGPLSSPS PRISDILNSV
510 520 530 540 550
RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK TTEQLIEAVN
560 570 580 590 600
NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT
610 620 630 640 650
TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW
660
QNVHFHCSGA PVAPLQ
Length:666
Mass (Da):72,678
Last modified:May 31, 2011 - v3
Checksum:i8CACFC3E392C3857
GO
Isoform 1 (identifier: Q13554-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     410-533: Missing.

Show »
Length:542
Mass (Da):60,387
Checksum:i1F7AF874A78C9D26
GO
Isoform 2 (identifier: Q13554-3) [UniParc]FASTAAdd to basket
Also known as: Beta1, Beta'E

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     379-393: Missing.
     410-533: Missing.

Show »
Length:503
Mass (Da):56,379
Checksum:i4389A566D66A9FE1
GO
Isoform 3 (identifier: Q13554-4) [UniParc]FASTAAdd to basket
Also known as: Beta2

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     354-392: Missing.
     410-533: Missing.

Show »
Length:479
Mass (Da):54,074
Checksum:iE8A4B57BD6AA98AC
GO
Isoform 5 (identifier: Q13554-5) [UniParc]FASTAAdd to basket
Also known as: Beta4, BetaE

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     410-533: Missing.

Show »
Length:518
Mass (Da):58,009
Checksum:i5853A731579E86D8
GO
Isoform 6 (identifier: Q13554-6) [UniParc]FASTAAdd to basket
Also known as: Beta6

The sequence of this isoform differs from the canonical sequence as follows:
     354-377: Missing.
     410-533: Missing.
     559-584: Missing.

Show »
Length:492
Mass (Da):55,223
Checksum:i1102B7F9B979E307
GO
Isoform 7 (identifier: Q13554-7) [UniParc]FASTAAdd to basket
Also known as: Beta7

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-533: Missing.

Show »
Length:449
Mass (Da):50,955
Checksum:i6EB6617646B54829
GO
Isoform 8 (identifier: Q13554-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-340: Missing.
     410-533: Missing.

Show »
Length:517
Mass (Da):57,938
Checksum:i1F4A8797FB7458A4
GO

Sequence cautioni

The sequence AAC99802 differs from that shown. Reason: Frameshift at positions 426, 433, 511 and 516. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681L → V in AAD03744 (Ref. 3) Curated
Sequence conflicti68 – 681L → V in AAD03743 (Ref. 3) Curated
Sequence conflicti535 – 5351K → N in AAB16863 (PubMed:9060999).Curated
Isoform 2 (identifier: Q13554-3)
Sequence conflicti316 – 3161A → V in AAD42036 (PubMed:10858498).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti489 – 4891P → L in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
Corresponds to variant rs555460132 [ dbSNP | Ensembl ].
VAR_045581
Natural varianti510 – 5101E → K.1 Publication
Corresponds to variant rs35452727 [ dbSNP | Ensembl ].
VAR_045582

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei316 – 34025Missing in isoform 8. CuratedVSP_041219Add
BLAST
Alternative sequencei316 – 3161V → A in isoform 2, isoform 3, isoform 5 and isoform 7. 6 PublicationsVSP_004770
Alternative sequencei317 – 533217Missing in isoform 7. 1 PublicationVSP_004772Add
BLAST
Alternative sequencei317 – 34024Missing in isoform 2, isoform 3 and isoform 5. 6 PublicationsVSP_004771Add
BLAST
Alternative sequencei354 – 39239Missing in isoform 3. 1 PublicationVSP_004774Add
BLAST
Alternative sequencei354 – 37724Missing in isoform 6. 1 PublicationVSP_004773Add
BLAST
Alternative sequencei379 – 39315Missing in isoform 2. 5 PublicationsVSP_004775Add
BLAST
Alternative sequencei410 – 533124Missing in isoform 1, isoform 2, isoform 3, isoform 5, isoform 6 and isoform 8. 6 PublicationsVSP_004776Add
BLAST
Alternative sequencei559 – 58426Missing in isoform 6. 1 PublicationVSP_004777Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078803 mRNA. Translation: AAD42035.1.
AF081572 mRNA. Translation: AAD42036.1.
AF081924 mRNA. Translation: AAD42037.1.
AF083419 mRNA. Translation: AAD42038.1.
AF140350 mRNA. Translation: AAD42070.1.
U23460 mRNA. Translation: AAC99802.1. Frameshift.
AF112472 mRNA. Translation: AAD03744.1.
AF112471 mRNA. Translation: AAD03743.1.
AJ252236 mRNA. Translation: CAB65120.1.
AJ252237 mRNA. Translation: CAB65121.1.
AJ252238 mRNA. Translation: CAB65122.1.
AK290148 mRNA. Translation: BAF82837.1.
AK315663 mRNA. Translation: BAG38029.1.
CH236960 Genomic DNA. Translation: EAL23756.1.
CH236960 Genomic DNA. Translation: EAL23757.1.
CH236960 Genomic DNA. Translation: EAL23758.1.
CH236960 Genomic DNA. Translation: EAL23759.1.
CH236960 Genomic DNA. Translation: EAL23760.1.
CH236960 Genomic DNA. Translation: EAL23761.1.
CH236960 Genomic DNA. Translation: EAL23762.1.
BC019070 mRNA. Translation: AAH19070.1.
U50358 mRNA. Translation: AAB16863.1.
CCDSiCCDS43573.1. [Q13554-8]
CCDS5483.1. [Q13554-1]
CCDS5484.1. [Q13554-2]
CCDS5485.1. [Q13554-5]
CCDS5486.1. [Q13554-3]
CCDS5487.1. [Q13554-6]
CCDS5488.1. [Q13554-4]
CCDS5489.1. [Q13554-7]
RefSeqiNP_001211.3. NM_001220.4. [Q13554-1]
NP_001280099.1. NM_001293170.1. [Q13554-2]
NP_742075.1. NM_172078.2. [Q13554-2]
NP_742076.1. NM_172079.2. [Q13554-5]
NP_742077.1. NM_172080.2. [Q13554-8]
NP_742078.1. NM_172081.2. [Q13554-3]
NP_742079.1. NM_172082.2. [Q13554-6]
NP_742080.1. NM_172083.2. [Q13554-4]
NP_742081.1. NM_172084.2. [Q13554-7]
UniGeneiHs.351887.

Genome annotation databases

EnsembliENST00000258682; ENSP00000258682; ENSG00000058404. [Q13554-8]
ENST00000346990; ENSP00000326518; ENSG00000058404. [Q13554-7]
ENST00000347193; ENSP00000326544; ENSG00000058404. [Q13554-6]
ENST00000350811; ENSP00000326375; ENSG00000058404. [Q13554-2]
ENST00000353625; ENSP00000326427; ENSG00000058404. [Q13554-4]
ENST00000358707; ENSP00000351542; ENSG00000058404. [Q13554-3]
ENST00000395747; ENSP00000379096; ENSG00000058404. [Q13554-5]
ENST00000395749; ENSP00000379098; ENSG00000058404. [Q13554-1]
ENST00000440254; ENSP00000397937; ENSG00000058404. [Q13554-2]
ENST00000457475; ENSP00000390292; ENSG00000058404. [Q13554-5]
GeneIDi816.
KEGGihsa:816.
UCSCiuc003tkp.3. human. [Q13554-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078803 mRNA. Translation: AAD42035.1.
AF081572 mRNA. Translation: AAD42036.1.
AF081924 mRNA. Translation: AAD42037.1.
AF083419 mRNA. Translation: AAD42038.1.
AF140350 mRNA. Translation: AAD42070.1.
U23460 mRNA. Translation: AAC99802.1. Frameshift.
AF112472 mRNA. Translation: AAD03744.1.
AF112471 mRNA. Translation: AAD03743.1.
AJ252236 mRNA. Translation: CAB65120.1.
AJ252237 mRNA. Translation: CAB65121.1.
AJ252238 mRNA. Translation: CAB65122.1.
AK290148 mRNA. Translation: BAF82837.1.
AK315663 mRNA. Translation: BAG38029.1.
CH236960 Genomic DNA. Translation: EAL23756.1.
CH236960 Genomic DNA. Translation: EAL23757.1.
CH236960 Genomic DNA. Translation: EAL23758.1.
CH236960 Genomic DNA. Translation: EAL23759.1.
CH236960 Genomic DNA. Translation: EAL23760.1.
CH236960 Genomic DNA. Translation: EAL23761.1.
CH236960 Genomic DNA. Translation: EAL23762.1.
BC019070 mRNA. Translation: AAH19070.1.
U50358 mRNA. Translation: AAB16863.1.
CCDSiCCDS43573.1. [Q13554-8]
CCDS5483.1. [Q13554-1]
CCDS5484.1. [Q13554-2]
CCDS5485.1. [Q13554-5]
CCDS5486.1. [Q13554-3]
CCDS5487.1. [Q13554-6]
CCDS5488.1. [Q13554-4]
CCDS5489.1. [Q13554-7]
RefSeqiNP_001211.3. NM_001220.4. [Q13554-1]
NP_001280099.1. NM_001293170.1. [Q13554-2]
NP_742075.1. NM_172078.2. [Q13554-2]
NP_742076.1. NM_172079.2. [Q13554-5]
NP_742077.1. NM_172080.2. [Q13554-8]
NP_742078.1. NM_172081.2. [Q13554-3]
NP_742079.1. NM_172082.2. [Q13554-6]
NP_742080.1. NM_172083.2. [Q13554-4]
NP_742081.1. NM_172084.2. [Q13554-7]
UniGeneiHs.351887.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BHHX-ray2.40A/B/C/D11-303[»]
ProteinModelPortaliQ13554.
SMRiQ13554. Positions 10-396, 534-660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107266. 46 interactions.
DIPiDIP-39770N.
IntActiQ13554. 26 interactions.
STRINGi9606.ENSP00000379098.

Chemistry

BindingDBiQ13554.
ChEMBLiCHEMBL2097164.
GuidetoPHARMACOLOGYi1556.

PTM databases

iPTMnetiQ13554.
PhosphoSiteiQ13554.

Polymorphism and mutation databases

BioMutaiCAMK2B.
DMDMi334302890.

Proteomic databases

MaxQBiQ13554.
PaxDbiQ13554.
PeptideAtlasiQ13554.
PRIDEiQ13554.

Protocols and materials databases

DNASUi816.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258682; ENSP00000258682; ENSG00000058404. [Q13554-8]
ENST00000346990; ENSP00000326518; ENSG00000058404. [Q13554-7]
ENST00000347193; ENSP00000326544; ENSG00000058404. [Q13554-6]
ENST00000350811; ENSP00000326375; ENSG00000058404. [Q13554-2]
ENST00000353625; ENSP00000326427; ENSG00000058404. [Q13554-4]
ENST00000358707; ENSP00000351542; ENSG00000058404. [Q13554-3]
ENST00000395747; ENSP00000379096; ENSG00000058404. [Q13554-5]
ENST00000395749; ENSP00000379098; ENSG00000058404. [Q13554-1]
ENST00000440254; ENSP00000397937; ENSG00000058404. [Q13554-2]
ENST00000457475; ENSP00000390292; ENSG00000058404. [Q13554-5]
GeneIDi816.
KEGGihsa:816.
UCSCiuc003tkp.3. human. [Q13554-1]

Organism-specific databases

CTDi816.
GeneCardsiCAMK2B.
HGNCiHGNC:1461. CAMK2B.
HPAiCAB006849.
HPA026307.
HPA051783.
HPA051785.
HPA053973.
MIMi607707. gene.
neXtProtiNX_Q13554.
PharmGKBiPA91.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0033. Eukaryota.
ENOG410XNRX. LUCA.
GeneTreeiENSGT00760000118944.
HOVERGENiHBG108055.
InParanoidiQ13554.
KOiK04515.
OMAiVGPPPCL.
OrthoDBiEOG091G0SCS.
PhylomeDBiQ13554.
TreeFamiTF315229.

Enzyme and pathway databases

BRENDAi2.7.11.17. 2681.
ReactomeiR-HSA-3371571. HSF1-dependent transactivation.
R-HSA-399719. Trafficking of AMPA receptors.
R-HSA-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-HSA-442729. CREB phosphorylation through the activation of CaMKII.
R-HSA-442742. CREB phosphorylation through the activation of Ras.
R-HSA-442982. Ras activation uopn Ca2+ infux through NMDA receptor.
R-HSA-5576892. Phase 0 - rapid depolarisation.
R-HSA-5578775. Ion homeostasis.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-877300. Interferon gamma signaling.
R-HSA-936837. Ion transport by P-type ATPases.
SignaLinkiQ13554.
SIGNORiQ13554.

Miscellaneous databases

EvolutionaryTraceiQ13554.
GeneWikiiCAMK2B.
GenomeRNAii816.
PROiQ13554.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000058404.
ExpressionAtlasiQ13554. baseline and differential.
GenevisibleiQ13554. HS.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543. Ca/CaM-dep_prot_kinase-assoc.
IPR011009. Kinase-like_dom.
IPR032710. NTF2-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 3 hits.
PfamiPF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCC2B_HUMAN
AccessioniPrimary (citable) accession number: Q13554
Secondary accession number(s): A4D2K0
, A4D2K1, A4D2K2, A4D2K3, A4D2K4, A4D2K5, A4D2K6, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 31, 2011
Last modified: September 7, 2016
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.