Reviewed, UniProtKB/Swiss-Prot Q13554 (KCC2B_HUMAN)

Names and origin

Protein names

Recommended name:
    Calcium/calmodulin-dependent protein kinase type II beta chain
      Short name=CaM-kinase II beta chain
      Short name=CaM kinase II subunit beta
      Short name=CaMK-II subunit beta
    EC=2.7.11.17

Gene names

Name:	CAMK2B
Synonyms:	CAM2, CAMKB

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	664 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.
Subunit structure	CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 By similarity. Interacts with MPDZ.
Tissue specificity	Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Ref.8 Traceable author statement. Source: ProtInc signal transduction Ref.8 Traceable author statement. Source: ProtInc
Cellular component	endocytic vesicle membrane Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms.

Isoform 4 (identifier: Q13554-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q13554-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     410-531: Missing.

Isoform 2 (identifier: Q13554-3)

Also known as: Beta1; Beta'E;

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     379-393: Missing.
     410-531: Missing.

Isoform 3 (identifier: Q13554-4)

Also known as: Beta2;

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     354-392: Missing.
     410-531: Missing.

Isoform 5 (identifier: Q13554-5)

Also known as: Beta4; BetaE;

The sequence of this isoform differs from the canonical sequence as follows:
     316-316: V → A
     317-340: Missing.
     410-531: Missing.

Isoform 6 (identifier: Q13554-6)

Also known as: Beta6;

The sequence of this isoform differs from the canonical sequence as follows:
     354-377: Missing.
     410-531: Missing.
     557-582: Missing.

Isoform 7 (identifier: Q13554-7)

Also known as: Beta7;

The sequence of this isoform differs from the canonical sequence as follows:
     316-408: Missing.
     410-531: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 664	664	Calcium/calmodulin-dependent protein kinase type II beta chain		PRO_0000086096
Regions
	Domain	14 – 272	259	Protein kinase
	Nucleotide binding	20 – 28	9	ATP By similarity
	Region	291 – 301	11	Calmodulin-binding
Sites
	Active site	136	1	Proton acceptor By similarity
	Binding site	43	1	ATP By similarity
Amino acid modifications
	Modified residue	17	1	Phosphotyrosine By similarity
	Modified residue	287	1	Phosphothreonine By similarity
	Modified residue	315	1	Phosphoserine By similarity
	Modified residue	367	1	Phosphoserine By similarity
	Modified residue	397	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	316 – 408	93	Missing in isoform 7.		VSP_004772
	Alternative sequence	316	1	V → A in isoform 2, isoform 3 and isoform 5.		VSP_004770
	Alternative sequence	317 – 340	24	Missing in isoform 2, isoform 3 and isoform 5.		VSP_004771
	Alternative sequence	354 – 392	39	Missing in isoform 3.		VSP_004774
	Alternative sequence	354 – 377	24	Missing in isoform 6.		VSP_004773
	Alternative sequence	379 – 393	15	Missing in isoform 2.		VSP_004775
	Alternative sequence	410 – 531	122	Missing in isoform 1, isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7.		VSP_004776
	Alternative sequence	557 – 582	26	Missing in isoform 6.		VSP_004777
	Natural variant	488	1	P → L in a colorectal adenocarcinoma sample; somatic mutation. Ref.11		VAR_045581
	Natural variant	509	1	E → K		VAR_045582
Experimental info
	Sequence conflict	68	1	L → V in AAD03744. Ref.3
	Sequence conflict	68	1	L → V in AAD03743. Ref.3
	Sequence conflict	533	1	K → N in AAB16863. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 [UniParc]. Last modified January 24, 2001. Version 2. Checksum: 9E8C82918D986814	FASTA	664	72,727
	10 20 30 40 50 60 MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK 370 380 390 400 410 420 NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT TIEDEDAKAP RVPDILSSVR 430 440 450 460 470 480 RGSGARSRGA PACPSPAPFS PLPAPSPRIS DILNSVRRGS GTPEAEGPLS AGPPPCLSPA 490 500 510 520 530 540 LLGPLSSPSP RISDILNSVR RGSGTPEAEA PRQWPPPCPS PTIPGPLPTP SRKQEIIKTT 550 560 570 580 590 600 EQLIEAVNNG DFEAYAKICD PGLTSFEPEA LGNLVEGMDF HRFYFENLLA KNSKPIHTTI 610 620 630 640 650 660 LNPHVHVIGE DAACIAYIRL TQYIDGQGRP RTSQSEETRV WHRRDGKWQN VHFHCSGAPV APLQ
	Isoform 1 (Beta). Checksum: 1F7AF874A78C9D26	FASTA	542	60,387
	10 20 30 40 50 60 MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK 370 380 390 400 410 420 NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT TIEDEDAKAR KQEIIKTTEQ 430 440 450 460 470 480 LIEAVNNGDF EAYAKICDPG LTSFEPEALG NLVEGMDFHR FYFENLLAKN SKPIHTTILN 490 500 510 520 530 540 PHVHVIGEDA ACIAYIRLTQ YIDGQGRPRT SQSEETRVWH RRDGKWQNVH FHCSGAPVAP LQ
	Isoform 2 (Beta1) (Beta'E). Checksum: 4389A566D66A9FE1	FASTA	503	56,379
	10 20 30 40 50 60 MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LNKKADGVKP QTNSTKNSAA ATSPKGTLPP AALESSDSAN 370 380 390 400 410 420 TTIEDEDAKA RKQEIIKTTE QLIEAVNNGD FEAYAKICDP GLTSFEPEAL GNLVEGMDFH 430 440 450 460 470 480 RFYFENLLAK NSKPIHTTIL NPHVHVIGED AACIAYIRLT QYIDGQGRPR TSQSEETRVW 490 500 HRRDGKWQNV HFHCSGAPVA PLQ
	Isoform 3 (Beta2). Checksum: E8A4B57BD6AA98AC	FASTA	479	54,074
	10 20 30 40 50 60 MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LNKKADGVKE SSDSANTTIE DEDAKARKQE IIKTTEQLIE 370 380 390 400 410 420 AVNNGDFEAY AKICDPGLTS FEPEALGNLV EGMDFHRFYF ENLLAKNSKP IHTTILNPHV 430 440 450 460 470 HVIGEDAACI AYIRLTQYID GQGRPRTSQS EETRVWHRRD GKWQNVHFHC SGAPVAPLQ
	Isoform 5 (Beta4) (BetaE). Checksum: 5853A731579E86D8	FASTA	518	58,009
	10 20 30 40 50 60 MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSAAKSL LNKKADGVKP QTNSTKNSAA ATSPKGTLPP AALEPQTTVI 370 380 390 400 410 420 HNPVDGIKES SDSANTTIED EDAKARKQEI IKTTEQLIEA VNNGDFEAYA KICDPGLTSF 430 440 450 460 470 480 EPEALGNLVE GMDFHRFYFE NLLAKNSKPI HTTILNPHVH VIGEDAACIA YIRLTQYIDG 490 500 510 QGRPRTSQSE ETRVWHRRDG KWQNVHFHCS GAPVAPLQ
	Isoform 6 (Beta6). Checksum: 1102B7F9B979E307	FASTA	492	55,223
	10 20 30 40 50 60 MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKEPQTTVI 370 380 390 400 410 420 HNPVDGIKES SDSANTTIED EDAKARKQEI IKTTEQLIEA VNNGDFEAYA FYFENLLAKN 430 440 450 460 470 480 SKPIHTTILN PHVHVIGEDA ACIAYIRLTQ YIDGQGRPRT SQSEETRVWH RRDGKWQNVH 490 FHCSGAPVAP LQ
	Isoform 7 (Beta7). Checksum: 6EB6617646B54829	FASTA	449	50,955
	10 20 30 40 50 60 MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 70 80 90 100 110 120 EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 130 140 150 160 170 180 LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 190 200 210 220 230 240 LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 250 260 270 280 290 300 VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 310 320 330 340 350 360 KGAILTTMLA TRNFSARKQE IIKTTEQLIE AVNNGDFEAY AKICDPGLTS FEPEALGNLV 370 380 390 400 410 420 EGMDFHRFYF ENLLAKNSKP IHTTILNPHV HVIGEDAACI AYIRLTQYID GQGRPRTSQS 430 440 EETRVWHRRD GKWQNVHFHC SGAPVAPLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities." Wang P., Wu Y., Zhou T.H., Sun Y., Pei G. FEBS Lett. 475:107-110(2000) [PubMed: 10858498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 5; 6 AND 7). Tissue: Brain.
[2]	Leddy J.J., Salih M., Tuana B.S. Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Skeletal muscle.
[3]	"Molecular cloning and sequencing of human calcium/calmodulin dependent protein kinase II beta subunit." Li G.Y., Cooper N.G.F. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5). Tissue: Brain.
[4]	"Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells." Rochlitz H., Voigt A., Lankat-Buttgereit B., Goeke B., Heimberg H., Nauck M.A., Schiemann U., Schatz H., Pfeiffer A.F. Diabetologia 43:465-473(2000) [PubMed: 10819240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 5). Tissue: Insulinoma.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[6]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung.
[8]	"Identification of novel human tumor cell-specific CaMK-II variants." Tombes R.M., Krystal G.W. Biochim. Biophys. Acta 1355:281-292(1997) [PubMed: 9060999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-603 (ISOFORM 2).
[9]	"SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation." Krapivinsky G., Medina I., Krapivinsky L., Gapon S., Clapham D.E. Neuron 43:563-574(2004) [PubMed: 15312654] [Abstract] Cited for: INTERACTION WITH MPDZ.
[10]	"Crystal structure of human calcium/calmodulin-dependent protein kinase IIb isoform 1 (CAMK2B)." Structural genomics consortium (SGC) Submitted (DEC-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 11-303.
[11]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-488 AND LYS-509.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF078803 mRNA. Translation: AAD42035.1.
AF081572 mRNA. Translation: AAD42036.1.
AF083419 mRNA. Translation: AAD42038.1.
AF081924 mRNA. Translation: AAD42037.1.
AK315663 mRNA. Translation: BAG38029.1.
AF140350 mRNA. Translation: AAD42070.1.
U23460 mRNA. Translation: AAC99802.1.
AF112472 mRNA. Translation: AAD03744.1.
AF112471 mRNA. Translation: AAD03743.1.
AJ252236 mRNA. Translation: CAB65120.1.
AJ252237 mRNA. Translation: CAB65121.1.
AJ252238 mRNA. Translation: CAB65122.1.
CH236960 Genomic DNA. Translation: EAL23757.1.
CH236960 Genomic DNA. Translation: EAL23758.1.
CH236960 Genomic DNA. Translation: EAL23759.1.
CH236960 Genomic DNA. Translation: EAL23760.1.
CH236960 Genomic DNA. Translation: EAL23762.1.
BC019070 mRNA. Translation: AAH19070.1.
U50358 mRNA. Translation: AAB16863.1.

IPI

IPI00182944.
IPI00183066.
IPI00219165.
IPI00219166.
IPI00221305.
IPI00298090.
IPI00334271.

RefSeq

NP_001211.3.
NP_742075.1.
NP_742076.1.
NP_742077.1.
NP_742078.1.
NP_742079.1.
NP_742080.1.
NP_742081.1.

UniGene

Hs.351887

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BHH	X-ray	2.40	A/B/C/D	11-303	[»]

SMR

Q13554. Positions 8-315, 532-658.

ModBase

Search...

Protein-protein interaction databases

STRING

Q13554.

PTM databases

PhosphoSite

Q13554.

Proteomic databases

PRIDE

Q13554.

Genome annotation databases

Ensembl

ENST00000258682; ENSP00000258682; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000346990; ENSP00000326518; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000347193; ENSP00000326544; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000350811; ENSP00000326375; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000353185; ENSP00000326600; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000353625; ENSP00000326427; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000358707; ENSP00000351542; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000395747; ENSP00000379096; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000395749; ENSP00000379098; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000398374; ENSP00000381411; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000415369; ENSP00000390419; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000421607; ENSP00000388445; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000424197; ENSP00000400387; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000425809; ENSP00000410445; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000427209; ENSP00000394799; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000433930; ENSP00000388951; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000440254; ENSP00000397937; ENSG00000058404; Homo sapiens. [Genome view]
ENST00000457475; ENSP00000390292; ENSG00000058404; Homo sapiens. [Genome view]

GeneID

816.

KEGG

hsa:816.

UCSC

uc003tkp.1. human.
uc003tkr.1. human.
uc003tkt.1. human.
uc003tku.1. human.
uc003tkv.1. human.
uc003tkw.1. human.

Organism-specific databases

CTD

816.

GeneCards

GC07M044225.

H-InvDB

HIX0006648.

HGNC

HGNC:1461. CAMK2B.

HPA

CAB006849.
HPA026307.

MIM

607707. gene.

PharmGKB

PA91.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q13554.

Enzyme and pathway databases

BRENDA

2.7.11.17. 247.

Pathway_Interaction_DB

ifngpathway. IFN-gamma pathway.
p38_mkk3_6pathway. p38 MAPK signaling pathway.

Reactome

REACT_13685. Synaptic Transmission.

Gene expression databases

ArrayExpress

Q13554.

Bgee

Q13554.

Genevestigator

Q13554.

GermOnline

ENSG00000058404. Homo sapiens.

Family and domain databases

InterPro

IPR015742. Ca/calmodulin-dep_kinase.
IPR013543. Ca/calmodulin-dep_kinase-assoc.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]

PANTHER

PTHR22982:SF64. CaMKII. 1 hit.

Pfam

PF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]

ProDom

PD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00220. S_TKc. 1 hit.
[Graphical view]

PROSITE

PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

3310.

SOURCE

Search...

Entry information

Entry name

KCC2B_HUMAN

Accession

Primary (citable) accession number: Q13554
Secondary accession number(s): A4D2K1 , A4D2K2, A4D2K3, A4D2K4, A4D2K6, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 24, 2001
Last modified:	October 13, 2009
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.