Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein CROC-4

Gene

C1orf61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CROC-4
Alternative name(s):
Contingent replication of cDNA 4
Gene namesi
Name:C1orf61
Synonyms:CROC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30780. C1orf61.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Associates within the nuclear transcriptional apparatus during proliferation and differentiation.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672511.

Polymorphism and mutation databases

BioMutaiC1orf61.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Protein CROC-4PRO_0000333952Add
BLAST

Proteomic databases

PaxDbiQ13536.
PRIDEiQ13536.

Expressioni

Tissue specificityi

Expressed throughout the brain in the thalamus, subthalamic nucleus, corpus callosum, hippocampus, substantia nigra, caudate nucleus, and amygdala.1 Publication

Gene expression databases

BgeeiQ13536.
CleanExiHS_C1orf61.
ExpressionAtlasiQ13536. baseline and differential.
GenevisibleiQ13536. HS.

Organism-specific databases

HPAiHPA027989.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357226.

Structurei

3D structure databases

ProteinModelPortaliQ13536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J4DY. Eukaryota.
ENOG4111BGU. LUCA.
GeneTreeiENSGT00390000005493.
HOGENOMiHOG000111975.
InParanoidiQ13536.
PhylomeDBiQ13536.
TreeFamiTF342418.

Sequencei

Sequence statusi: Complete.

Q13536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTEDLITF NLRNFLLFQL WESSFSPGAG GFCTTLPPSF LRVDDRATSS
60 70 80 90 100
TTDSSRAPSS PRPPGSTSHC GISTRCTERC LCVLPLRTSQ VPDVMAPQHD
110 120 130 140 150
QEKFHDLAYS CLGKSFSMSN QDLYGYSTSS LALGLAWLSW ETKKKNVLHL

VGLDSL
Length:156
Mass (Da):17,231
Last modified:November 1, 1996 - v1
Checksum:i939C3E7168FE35CE
GO

Sequence cautioni

The sequence CAI12173.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12175.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49857 mRNA. Translation: AAA93029.1.
AL139130 Genomic DNA. Translation: CAI12172.1.
AL139130 Genomic DNA. Translation: CAI12173.1. Sequence problems.
AL139130 Genomic DNA. Translation: CAI12175.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW52956.1.
CCDSiCCDS1142.1.
RefSeqiNP_006356.1. NM_006365.2.
XP_006711182.1. XM_006711119.1.
XP_011507371.1. XM_011509069.1.
XP_011507372.1. XM_011509070.1.
XP_011507373.1. XM_011509071.1.
XP_011507374.1. XM_011509072.1.
UniGeneiHs.380027.

Genome annotation databases

EnsembliENST00000368243; ENSP00000357226; ENSG00000125462.
ENST00000615748; ENSP00000479346; ENSG00000125462.
GeneIDi10485.
KEGGihsa:10485.
UCSCiuc001fou.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49857 mRNA. Translation: AAA93029.1.
AL139130 Genomic DNA. Translation: CAI12172.1.
AL139130 Genomic DNA. Translation: CAI12173.1. Sequence problems.
AL139130 Genomic DNA. Translation: CAI12175.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW52956.1.
CCDSiCCDS1142.1.
RefSeqiNP_006356.1. NM_006365.2.
XP_006711182.1. XM_006711119.1.
XP_011507371.1. XM_011509069.1.
XP_011507372.1. XM_011509070.1.
XP_011507373.1. XM_011509071.1.
XP_011507374.1. XM_011509072.1.
UniGeneiHs.380027.

3D structure databases

ProteinModelPortaliQ13536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357226.

Polymorphism and mutation databases

BioMutaiC1orf61.

Proteomic databases

PaxDbiQ13536.
PRIDEiQ13536.

Protocols and materials databases

DNASUi10485.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368243; ENSP00000357226; ENSG00000125462.
ENST00000615748; ENSP00000479346; ENSG00000125462.
GeneIDi10485.
KEGGihsa:10485.
UCSCiuc001fou.2. human.

Organism-specific databases

CTDi10485.
GeneCardsiC1orf61.
HGNCiHGNC:30780. C1orf61.
HPAiHPA027989.
neXtProtiNX_Q13536.
PharmGKBiPA142672511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4DY. Eukaryota.
ENOG4111BGU. LUCA.
GeneTreeiENSGT00390000005493.
HOGENOMiHOG000111975.
InParanoidiQ13536.
PhylomeDBiQ13536.
TreeFamiTF342418.

Miscellaneous databases

ChiTaRSiC1orf61. human.
GenomeRNAii10485.
NextBioi39784.
PROiQ13536.

Gene expression databases

BgeeiQ13536.
CleanExiHS_C1orf61.
ExpressionAtlasiQ13536. baseline and differential.
GenevisibleiQ13536. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CROC-4: a novel brain specific transcriptional activator of c-fos expressed from proliferation through to maturation of multiple neuronal cell types."
    Jeffrey P.L., Capes-Davis A., Dunn J.M., Tolhurst O., Seeto G., Hannan A.J., Lin S.L.
    Mol. Cell. Neurosci. 16:185-196(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCROC4_HUMAN
AccessioniPrimary (citable) accession number: Q13536
Secondary accession number(s): B1ALL5, B1ALL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.