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Protein

Protein CROC-4

Gene

C1orf61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in FOS signaling pathways involved in development and remodeling of neurons. Promotes transcription of the FOS promoter.1 Publication

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CROC-4
Alternative name(s):
Contingent replication of cDNA 4
Gene namesi
Name:C1orf61
Synonyms:CROC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000125462.16
HGNCiHGNC:30780 C1orf61
neXtProtiNX_Q13536

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10485
OpenTargetsiENSG00000125462
PharmGKBiPA142672511

Polymorphism and mutation databases

BioMutaiC1orf61

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003339521 – 156Protein CROC-4Add BLAST156

Proteomic databases

PaxDbiQ13536
PRIDEiQ13536

Expressioni

Tissue specificityi

Expressed throughout the brain in the thalamus, subthalamic nucleus, corpus callosum, hippocampus, substantia nigra, caudate nucleus, and amygdala.1 Publication

Gene expression databases

BgeeiENSG00000125462
CleanExiHS_C1orf61
ExpressionAtlasiQ13536 baseline and differential
GenevisibleiQ13536 HS

Structurei

3D structure databases

ProteinModelPortaliQ13536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J4DY Eukaryota
ENOG4111BGU LUCA
GeneTreeiENSGT00390000005493
HOGENOMiHOG000111975
InParanoidiQ13536
PhylomeDBiQ13536
TreeFamiTF342418

Sequencei

Sequence statusi: Complete.

Q13536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTEDLITF NLRNFLLFQL WESSFSPGAG GFCTTLPPSF LRVDDRATSS
60 70 80 90 100
TTDSSRAPSS PRPPGSTSHC GISTRCTERC LCVLPLRTSQ VPDVMAPQHD
110 120 130 140 150
QEKFHDLAYS CLGKSFSMSN QDLYGYSTSS LALGLAWLSW ETKKKNVLHL

VGLDSL
Length:156
Mass (Da):17,231
Last modified:November 1, 1996 - v1
Checksum:i939C3E7168FE35CE
GO

Sequence cautioni

The sequence CAI12173 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12175 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49857 mRNA Translation: AAA93029.1
AL139130 Genomic DNA Translation: CAI12172.1
AL139130 Genomic DNA Translation: CAI12173.1 Sequence problems.
AL139130 Genomic DNA Translation: CAI12175.1 Sequence problems.
CH471121 Genomic DNA Translation: EAW52956.1
CCDSiCCDS1142.1
RefSeqiNP_006356.1, NM_006365.2
XP_011507372.1, XM_011509070.1
XP_011507373.1, XM_011509071.2
XP_011507374.1, XM_011509072.1
XP_016855551.1, XM_017000062.1
XP_016855552.1, XM_017000063.1
UniGeneiHs.380027

Genome annotation databases

EnsembliENST00000368243; ENSP00000357226; ENSG00000125462
ENST00000615748; ENSP00000479346; ENSG00000125462
GeneIDi10485
KEGGihsa:10485
UCSCiuc001fou.2 human

Similar proteinsi

Entry informationi

Entry nameiCROC4_HUMAN
AccessioniPrimary (citable) accession number: Q13536
Secondary accession number(s): B1ALL5, B1ALL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

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