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Protein

Serine incorporator 3

Gene

SERINC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in cellular transformation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 3
Alternative name(s):
Tumor differentially expressed protein 1
Gene namesi
Name:SERINC3
Synonyms:DIFF33, TDE1
ORF Names:SBBI99
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11699. SERINC3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9696ExtracellularSequence AnalysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Topological domaini118 – 13215CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Topological domaini154 – 1596ExtracellularSequence Analysis
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Topological domaini181 – 20323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Topological domaini225 – 23915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST
Topological domaini261 – 32969CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence AnalysisAdd
BLAST
Topological domaini351 – 40656ExtracellularSequence AnalysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST
Topological domaini428 – 44619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST
Topological domaini468 – 4736ExtracellularSequence Analysis

GO - Cellular componenti

  • Golgi apparatus Source: Ensembl
  • integral component of membrane Source: ProtInc
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36418.

Polymorphism and mutation databases

BioMutaiSERINC3.
DMDMi25453293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Serine incorporator 3PRO_0000218970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ13530.
PaxDbiQ13530.
PRIDEiQ13530.

PTM databases

PhosphoSiteiQ13530.

Expressioni

Tissue specificityi

Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

Gene expression databases

BgeeiQ13530.
CleanExiHS_SERINC3.
ExpressionAtlasiQ13530. baseline and differential.
GenevisibleiQ13530. HS.

Organism-specific databases

HPAiHPA043993.
HPA048116.

Interactioni

Protein-protein interaction databases

BioGridi116155. 11 interactions.
IntActiQ13530. 2 interactions.
STRINGi9606.ENSP00000255175.

Structurei

3D structure databases

ProteinModelPortaliQ13530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308011.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ13530.
OMAiRKEMETY.
PhylomeDBiQ13530.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029557. Serinc3.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF13. PTHR10383:SF13. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13530-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST
60 70 80 90 100
VVSYIMQRKE METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR
110 120 130 140 150
ISFAMAIFFF VFSLLMFKVK TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY
160 170 180 190 200
IPGGYFSSVW FVVGMIGAAL FILIQLVLLV DFAHSWNESW VNRMEEGNPR
210 220 230 240 250
LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF ISINLILCVV
260 270 280 290 300
ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM
310 320 330 340 350
SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY
360 370 380 390 400
SSIRTSTNSQ VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG
410 420 430 440 450
VQYSYSLFHL MLCLASLYIM MTLTSWYSPD AKFQSMTSKW PAVWVKISSS
460 470
WVCLLLYVWT LVAPLVLTSR DFS
Length:473
Mass (Da):52,580
Last modified:November 25, 2002 - v2
Checksum:i9DCB04B2A0AB1132
GO
Isoform 2 (identifier: Q13530-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):46,821
Checksum:i6EB1F9F980ECFB6F
GO

Sequence cautioni

The sequence AAB48858.1 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459. Curated
The sequence AAD34641.1 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti437 – 4371T → A.1 Publication
VAR_014315

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5555Missing in isoform 2. 1 PublicationVSP_056833Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112227 mRNA. Translation: AAD22448.1.
U49188 mRNA. Translation: AAB48858.1. Frameshift.
AF153979 mRNA. Translation: AAD34641.1. Frameshift.
AK300618 mRNA. Translation: BAG62311.1.
Z97053 Genomic DNA. Translation: CAB09783.1.
BC006088 mRNA. Translation: AAH06088.1.
CCDSiCCDS13333.1. [Q13530-1]
RefSeqiNP_006802.1. NM_006811.2. [Q13530-1]
NP_945179.1. NM_198941.1. [Q13530-1]
UniGeneiHs.272168.

Genome annotation databases

EnsembliENST00000255175; ENSP00000255175; ENSG00000132824. [Q13530-1]
ENST00000342374; ENSP00000340243; ENSG00000132824. [Q13530-1]
GeneIDi10955.
KEGGihsa:10955.
UCSCiuc002xme.3. human. [Q13530-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112227 mRNA. Translation: AAD22448.1.
U49188 mRNA. Translation: AAB48858.1. Frameshift.
AF153979 mRNA. Translation: AAD34641.1. Frameshift.
AK300618 mRNA. Translation: BAG62311.1.
Z97053 Genomic DNA. Translation: CAB09783.1.
BC006088 mRNA. Translation: AAH06088.1.
CCDSiCCDS13333.1. [Q13530-1]
RefSeqiNP_006802.1. NM_006811.2. [Q13530-1]
NP_945179.1. NM_198941.1. [Q13530-1]
UniGeneiHs.272168.

3D structure databases

ProteinModelPortaliQ13530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116155. 11 interactions.
IntActiQ13530. 2 interactions.
STRINGi9606.ENSP00000255175.

PTM databases

PhosphoSiteiQ13530.

Polymorphism and mutation databases

BioMutaiSERINC3.
DMDMi25453293.

Proteomic databases

MaxQBiQ13530.
PaxDbiQ13530.
PRIDEiQ13530.

Protocols and materials databases

DNASUi10955.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255175; ENSP00000255175; ENSG00000132824. [Q13530-1]
ENST00000342374; ENSP00000340243; ENSG00000132824. [Q13530-1]
GeneIDi10955.
KEGGihsa:10955.
UCSCiuc002xme.3. human. [Q13530-1]

Organism-specific databases

CTDi10955.
GeneCardsiGC20M043124.
HGNCiHGNC:11699. SERINC3.
HPAiHPA043993.
HPA048116.
MIMi607165. gene.
neXtProtiNX_Q13530.
PharmGKBiPA36418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG308011.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ13530.
OMAiRKEMETY.
PhylomeDBiQ13530.
TreeFamiTF312881.

Miscellaneous databases

ChiTaRSiSERINC3. human.
GeneWikiiSERINC3.
GenomeRNAii10955.
NextBioi35475169.
PROiQ13530.
SOURCEiSearch...

Gene expression databases

BgeeiQ13530.
CleanExiHS_SERINC3.
ExpressionAtlasiQ13530. baseline and differential.
GenevisibleiQ13530. HS.

Family and domain databases

InterProiIPR029557. Serinc3.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF13. PTHR10383:SF13. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue."
    Bossolasco M., Lebel M., Lemieux N., Mes-Masson A.-M.
    Mol. Carcinog. 26:189-200(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-437.
    Tissue: Placenta.
  2. Dakuor J., Li H., Morrish D.W.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Hypothetical human protein SBBI99."
    Zhang W., Wan T., Cao X.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.

Entry informationi

Entry nameiSERC3_HUMAN
AccessioniPrimary (citable) accession number: Q13530
Secondary accession number(s): B4DUE9, O43717, Q9BR33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: June 24, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.