Q13530 (SERC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine incorporator 3

Alternative name(s):
Tumor differentially expressed protein 1

Gene names

Name:	SERINC3
Synonyms:	DIFF33, TDE1
ORF Names:	SBBI99

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in cellular transformation.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.
Post-translational modification	N-glycosylated By similarity.
Sequence similarities	Belongs to the TDE1 family.
Sequence caution	The sequence AAB48858.1 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459. The sequence AAD34641.1 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	induction of apoptosis Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara integral to membrane Traceable author statement Ref.1. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Serine incorporator 3		PRO_0000218970
Regions
	Topological domain	1 – 96	96	Extracellular Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Topological domain	118 – 132	15	Cytoplasmic Potential
	Transmembrane	133 – 153	21	Helical; Potential
	Topological domain	154 – 159	6	Extracellular Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Topological domain	181 – 203	23	Cytoplasmic Potential
	Transmembrane	204 – 224	21	Helical; Potential
	Topological domain	225 – 239	15	Extracellular Potential
	Transmembrane	240 – 260	21	Helical; Potential
	Topological domain	261 – 329	69	Cytoplasmic Potential
	Transmembrane	330 – 350	21	Helical; Potential
	Topological domain	351 – 406	56	Extracellular Potential
	Transmembrane	407 – 427	21	Helical; Potential
	Topological domain	428 – 446	19	Cytoplasmic Potential
	Transmembrane	447 – 467	21	Helical; Potential
	Topological domain	468 – 473	6	Extracellular Potential
Amino acid modifications
	Modified residue	371	1	Phosphoserine By similarity
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	437	1	T → A. Ref.1		VAR_014315

Sequences

	Sequence		Length	Mass (Da)
	Q13530 [UniParc]. Last modified November 25, 2002. Version 2. Checksum: 9DCB04B2A0AB1132	FASTA	473	52,580
	10 20 30 40 50 60 MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST VVSYIMQRKE 70 80 90 100 110 120 METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR ISFAMAIFFF VFSLLMFKVK 130 140 150 160 170 180 TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY IPGGYFSSVW FVVGMIGAAL FILIQLVLLV 190 200 210 220 230 240 DFAHSWNESW VNRMEEGNPR LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF 250 260 270 280 290 300 ISINLILCVV ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM 310 320 330 340 350 360 SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY SSIRTSTNSQ 370 380 390 400 410 420 VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG VQYSYSLFHL MLCLASLYIM 430 440 450 460 470 MTLTSWYSPD AKFQSMTSKW PAVWVKISSS WVCLLLYVWT LVAPLVLTSR DFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue." Bossolasco M., Lebel M., Lemieux N., Mes-Masson A.-M. Mol. Carcinog. 26:189-200(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-437. Tissue: Placenta.
[2]	Dakuor J., Li H., Morrish D.W. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"Hypothetical human protein SBBI99." Zhang W., Wan T., Cao X. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF112227 mRNA. Translation: AAD22448.1. U49188 mRNA. Translation: AAB48858.1. Frameshift. AF153979 mRNA. Translation: AAD34641.1. Frameshift. Z97053 Genomic DNA. Translation: CAB09783.1. BC006088 mRNA. Translation: AAH06088.1.
IPI	IPI00013746.
RefSeq	NP_006802.1. NM_006811.2. NP_945179.1. NM_198941.1.
UniGene	Hs.272168. Hs.696043.
3D structure databases
ProteinModelPortal	Q13530.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13530. 2 interactions.
PTM databases
PhosphoSite	Q13530.
Polymorphism databases
DMDM	25453293.
Proteomic databases
PaxDb	Q13530.
PRIDE	Q13530.
Protocols and materials databases
DNASU	10955.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255175; ENSP00000255175; ENSG00000132824. ENST00000342374; ENSP00000340243; ENSG00000132824.
GeneID	10955.
KEGG	hsa:10955.
UCSC	uc002xme.3. human.
Organism-specific databases
CTD	10955.
GeneCards	GC20M043124.
HGNC	HGNC:11699. SERINC3.
HPA	HPA043993. HPA048116.
MIM	607165. gene.
neXtProt	NX_Q13530.
PharmGKB	PA36418.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG308011.
HOGENOM	HOG000165463.
HOVERGEN	HBG025699.
InParanoid	Q13530.
OMA	CCPNSKN.
PhylomeDB	Q13530.
Gene expression databases
ArrayExpress	Q13530.
Bgee	Q13530.
CleanEx	HS_SERINC3.
Genevestigator	Q13530.
GermOnline	ENSG00000132824. Homo sapiens.
Family and domain databases
InterPro	IPR005016. TMS_TDE. [Graphical view]
PANTHER	PTHR10383. PTHR10383. 1 hit.
Pfam	PF03348. Serinc. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SERINC3. human.
GenomeRNAi	10955.
NextBio	41625.
SOURCE	Search...

Entry information

Entry name

SERC3_HUMAN

Accession

Primary (citable) accession number: Q13530
Secondary accession number(s): O43717, Q9BR33

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	November 25, 2002
Last modified:	April 3, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.