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Q13530

- SERC3_HUMAN

UniProt

Q13530 - SERC3_HUMAN

Protein

Serine incorporator 3

Gene

SERINC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (25 Nov 2002)
      Previous versions | rss
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    Functioni

    May be involved in cellular transformation.

    GO - Biological processi

    1. positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine incorporator 3
    Alternative name(s):
    Tumor differentially expressed protein 1
    Gene namesi
    Name:SERINC3
    Synonyms:DIFF33, TDE1
    ORF Names:SBBI99
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11699. SERINC3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. integral component of membrane Source: ProtInc
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36418.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Serine incorporator 3PRO_0000218970Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ13530.
    PaxDbiQ13530.
    PRIDEiQ13530.

    PTM databases

    PhosphoSiteiQ13530.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

    Gene expression databases

    ArrayExpressiQ13530.
    BgeeiQ13530.
    CleanExiHS_SERINC3.
    GenevestigatoriQ13530.

    Organism-specific databases

    HPAiHPA043993.
    HPA048116.

    Interactioni

    Protein-protein interaction databases

    BioGridi116155. 11 interactions.
    IntActiQ13530. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13530.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9696ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 13215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini154 – 1596ExtracellularSequence Analysis
    Topological domaini181 – 20323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini225 – 23915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini261 – 32969CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 40656ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini428 – 44619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini468 – 4736ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei447 – 46721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TDE1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308011.
    HOGENOMiHOG000165463.
    HOVERGENiHBG025699.
    InParanoidiQ13530.
    OMAiADKDCDV.
    PhylomeDBiQ13530.
    TreeFamiTF312881.

    Family and domain databases

    InterProiIPR029557. Serinc3.
    IPR005016. TDE1/TMS.
    [Graphical view]
    PANTHERiPTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF13. PTHR10383:SF13. 1 hit.
    PfamiPF03348. Serinc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13530-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST    50
    VVSYIMQRKE METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR 100
    ISFAMAIFFF VFSLLMFKVK TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY 150
    IPGGYFSSVW FVVGMIGAAL FILIQLVLLV DFAHSWNESW VNRMEEGNPR 200
    LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF ISINLILCVV 250
    ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM 300
    SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY 350
    SSIRTSTNSQ VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG 400
    VQYSYSLFHL MLCLASLYIM MTLTSWYSPD AKFQSMTSKW PAVWVKISSS 450
    WVCLLLYVWT LVAPLVLTSR DFS 473
    Length:473
    Mass (Da):52,580
    Last modified:November 25, 2002 - v2
    Checksum:i9DCB04B2A0AB1132
    GO

    Sequence cautioni

    The sequence AAB48858.1 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.
    The sequence AAD34641.1 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti437 – 4371T → A.1 Publication
    VAR_014315

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112227 mRNA. Translation: AAD22448.1.
    U49188 mRNA. Translation: AAB48858.1. Frameshift.
    AF153979 mRNA. Translation: AAD34641.1. Frameshift.
    Z97053 Genomic DNA. Translation: CAB09783.1.
    BC006088 mRNA. Translation: AAH06088.1.
    CCDSiCCDS13333.1.
    RefSeqiNP_006802.1. NM_006811.2.
    NP_945179.1. NM_198941.1.
    UniGeneiHs.272168.

    Genome annotation databases

    EnsembliENST00000255175; ENSP00000255175; ENSG00000132824.
    ENST00000342374; ENSP00000340243; ENSG00000132824.
    GeneIDi10955.
    KEGGihsa:10955.
    UCSCiuc002xme.3. human.

    Polymorphism databases

    DMDMi25453293.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112227 mRNA. Translation: AAD22448.1 .
    U49188 mRNA. Translation: AAB48858.1 . Frameshift.
    AF153979 mRNA. Translation: AAD34641.1 . Frameshift.
    Z97053 Genomic DNA. Translation: CAB09783.1 .
    BC006088 mRNA. Translation: AAH06088.1 .
    CCDSi CCDS13333.1.
    RefSeqi NP_006802.1. NM_006811.2.
    NP_945179.1. NM_198941.1.
    UniGenei Hs.272168.

    3D structure databases

    ProteinModelPortali Q13530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116155. 11 interactions.
    IntActi Q13530. 2 interactions.

    PTM databases

    PhosphoSitei Q13530.

    Polymorphism databases

    DMDMi 25453293.

    Proteomic databases

    MaxQBi Q13530.
    PaxDbi Q13530.
    PRIDEi Q13530.

    Protocols and materials databases

    DNASUi 10955.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255175 ; ENSP00000255175 ; ENSG00000132824 .
    ENST00000342374 ; ENSP00000340243 ; ENSG00000132824 .
    GeneIDi 10955.
    KEGGi hsa:10955.
    UCSCi uc002xme.3. human.

    Organism-specific databases

    CTDi 10955.
    GeneCardsi GC20M043124.
    HGNCi HGNC:11699. SERINC3.
    HPAi HPA043993.
    HPA048116.
    MIMi 607165. gene.
    neXtProti NX_Q13530.
    PharmGKBi PA36418.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308011.
    HOGENOMi HOG000165463.
    HOVERGENi HBG025699.
    InParanoidi Q13530.
    OMAi ADKDCDV.
    PhylomeDBi Q13530.
    TreeFami TF312881.

    Miscellaneous databases

    ChiTaRSi SERINC3. human.
    GeneWikii SERINC3.
    GenomeRNAii 10955.
    NextBioi 41625.
    PROi Q13530.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13530.
    Bgeei Q13530.
    CleanExi HS_SERINC3.
    Genevestigatori Q13530.

    Family and domain databases

    InterProi IPR029557. Serinc3.
    IPR005016. TDE1/TMS.
    [Graphical view ]
    PANTHERi PTHR10383. PTHR10383. 1 hit.
    PTHR10383:SF13. PTHR10383:SF13. 1 hit.
    Pfami PF03348. Serinc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue."
      Bossolasco M., Lebel M., Lemieux N., Mes-Masson A.-M.
      Mol. Carcinog. 26:189-200(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-437.
      Tissue: Placenta.
    2. Dakuor J., Li H., Morrish D.W.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Hypothetical human protein SBBI99."
      Zhang W., Wan T., Cao X.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiSERC3_HUMAN
    AccessioniPrimary (citable) accession number: Q13530
    Secondary accession number(s): O43717, Q9BR33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: November 25, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3