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Q13530 (SERC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine incorporator 3
Alternative name(s):
Tumor differentially expressed protein 1
Gene names
Name:SERINC3
Synonyms:DIFF33, TDE1
ORF Names:SBBI99
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in cellular transformation.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the TDE1 family.

Sequence caution

The sequence AAB48858.1 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.

The sequence AAD34641.1 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Serine incorporator 3
PRO_0000218970

Regions

Topological domain1 – 9696Extracellular Potential
Transmembrane97 – 11721Helical; Potential
Topological domain118 – 13215Cytoplasmic Potential
Transmembrane133 – 15321Helical; Potential
Topological domain154 – 1596Extracellular Potential
Transmembrane160 – 18021Helical; Potential
Topological domain181 – 20323Cytoplasmic Potential
Transmembrane204 – 22421Helical; Potential
Topological domain225 – 23915Extracellular Potential
Transmembrane240 – 26021Helical; Potential
Topological domain261 – 32969Cytoplasmic Potential
Transmembrane330 – 35021Helical; Potential
Topological domain351 – 40656Extracellular Potential
Transmembrane407 – 42721Helical; Potential
Topological domain428 – 44619Cytoplasmic Potential
Transmembrane447 – 46721Helical; Potential
Topological domain468 – 4736Extracellular Potential

Amino acid modifications

Glycosylation341N-linked (GlcNAc...) Potential

Natural variations

Natural variant4371T → A. Ref.1
VAR_014315

Sequences

Sequence LengthMass (Da)Tools
Q13530 [UniParc].

Last modified November 25, 2002. Version 2.
Checksum: 9DCB04B2A0AB1132

FASTA47352,580
        10         20         30         40         50         60 
MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST VVSYIMQRKE 

        70         80         90        100        110        120 
METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR ISFAMAIFFF VFSLLMFKVK 

       130        140        150        160        170        180 
TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY IPGGYFSSVW FVVGMIGAAL FILIQLVLLV 

       190        200        210        220        230        240 
DFAHSWNESW VNRMEEGNPR LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF 

       250        260        270        280        290        300 
ISINLILCVV ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM 

       310        320        330        340        350        360 
SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY SSIRTSTNSQ 

       370        380        390        400        410        420 
VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG VQYSYSLFHL MLCLASLYIM 

       430        440        450        460        470 
MTLTSWYSPD AKFQSMTSKW PAVWVKISSS WVCLLLYVWT LVAPLVLTSR DFS 

« Hide

References

« Hide 'large scale' references
[1]"The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue."
Bossolasco M., Lebel M., Lemieux N., Mes-Masson A.-M.
Mol. Carcinog. 26:189-200(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-437.
Tissue: Placenta.
[2]Dakuor J., Li H., Morrish D.W.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]"Hypothetical human protein SBBI99."
Zhang W., Wan T., Cao X.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF112227 mRNA. Translation: AAD22448.1.
U49188 mRNA. Translation: AAB48858.1. Frameshift.
AF153979 mRNA. Translation: AAD34641.1. Frameshift.
Z97053 Genomic DNA. Translation: CAB09783.1.
BC006088 mRNA. Translation: AAH06088.1.
RefSeqNP_006802.1. NM_006811.2.
NP_945179.1. NM_198941.1.
UniGeneHs.272168.

3D structure databases

ProteinModelPortalQ13530.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116155. 11 interactions.
IntActQ13530. 2 interactions.

PTM databases

PhosphoSiteQ13530.

Polymorphism databases

DMDM25453293.

Proteomic databases

PaxDbQ13530.
PRIDEQ13530.

Protocols and materials databases

DNASU10955.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255175; ENSP00000255175; ENSG00000132824.
ENST00000342374; ENSP00000340243; ENSG00000132824.
GeneID10955.
KEGGhsa:10955.
UCSCuc002xme.3. human.

Organism-specific databases

CTD10955.
GeneCardsGC20M043124.
HGNCHGNC:11699. SERINC3.
HPAHPA043993.
HPA048116.
MIM607165. gene.
neXtProtNX_Q13530.
PharmGKBPA36418.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG308011.
HOGENOMHOG000165463.
HOVERGENHBG025699.
InParanoidQ13530.
OMAADKDCDV.
PhylomeDBQ13530.
TreeFamTF312881.

Gene expression databases

ArrayExpressQ13530.
BgeeQ13530.
CleanExHS_SERINC3.
GenevestigatorQ13530.

Family and domain databases

InterProIPR005016. TMS_TDE.
[Graphical view]
PANTHERPTHR10383. PTHR10383. 1 hit.
PfamPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSERINC3. human.
GeneWikiSERINC3.
GenomeRNAi10955.
NextBio41625.
PROQ13530.
SOURCESearch...

Entry information

Entry nameSERC3_HUMAN
AccessionPrimary (citable) accession number: Q13530
Secondary accession number(s): O43717, Q9BR33
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: February 19, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM