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Protein

Serine incorporator 3

Gene

SERINC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132824-MONOMER.
ReactomeiR-HSA-977347. Serine biosynthesis.

Protein family/group databases

TCDBi9.A.29.3.4. the lantibiotic immunity protein/serine connector (lip/sip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine incorporator 3
Alternative name(s):
Tumor differentially expressed protein 11 Publication
Gene namesi
Name:SERINC3
Synonyms:DIFF33, TDE11 Publication
ORF Names:SBBI991 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11699. SERINC3.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 96ExtracellularSequence analysisAdd BLAST96
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 132CytoplasmicSequence analysisAdd BLAST15
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 159ExtracellularSequence analysis6
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 203CytoplasmicSequence analysisAdd BLAST23
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 239ExtracellularSequence analysisAdd BLAST15
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 329CytoplasmicSequence analysisAdd BLAST69
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 406ExtracellularSequence analysisAdd BLAST56
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 446CytoplasmicSequence analysisAdd BLAST19
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 473ExtracellularSequence analysis6

GO - Cellular componenti

  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: ProtInc
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10955.
OpenTargetsiENSG00000132824.
PharmGKBiPA36418.

Polymorphism and mutation databases

BioMutaiSERINC3.
DMDMi25453293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189701 – 473Serine incorporator 3Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ13530.
PaxDbiQ13530.
PeptideAtlasiQ13530.
PRIDEiQ13530.

PTM databases

iPTMnetiQ13530.
PhosphoSitePlusiQ13530.
SwissPalmiQ13530.

Expressioni

Tissue specificityi

Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues.1 Publication

Gene expression databases

BgeeiENSG00000132824.
CleanExiHS_SERINC3.
ExpressionAtlasiQ13530. baseline and differential.
GenevisibleiQ13530. HS.

Organism-specific databases

HPAiHPA043993.
HPA048116.

Interactioni

Protein-protein interaction databases

BioGridi116155. 12 interactors.
IntActiQ13530. 3 interactors.
STRINGi9606.ENSP00000255175.

Structurei

3D structure databases

ProteinModelPortaliQ13530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDE1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ13530.
OMAiEPERNCN.
OrthoDBiEOG091G07WS.
PhylomeDBiQ13530.
TreeFamiTF312881.

Family and domain databases

InterProiIPR029557. Serinc3.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF27. PTHR10383:SF27. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13530-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST
60 70 80 90 100
VVSYIMQRKE METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR
110 120 130 140 150
ISFAMAIFFF VFSLLMFKVK TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY
160 170 180 190 200
IPGGYFSSVW FVVGMIGAAL FILIQLVLLV DFAHSWNESW VNRMEEGNPR
210 220 230 240 250
LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF ISINLILCVV
260 270 280 290 300
ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM
310 320 330 340 350
SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY
360 370 380 390 400
SSIRTSTNSQ VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG
410 420 430 440 450
VQYSYSLFHL MLCLASLYIM MTLTSWYSPD AKFQSMTSKW PAVWVKISSS
460 470
WVCLLLYVWT LVAPLVLTSR DFS
Length:473
Mass (Da):52,580
Last modified:November 25, 2002 - v2
Checksum:i9DCB04B2A0AB1132
GO
Isoform 2 (identifier: Q13530-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):46,821
Checksum:i6EB1F9F980ECFB6F
GO

Sequence cautioni

The sequence AAB48858 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.Curated
The sequence AAD34641 differs from that shown. Reason: Frameshift at positions 321, 393, 407 and 459.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014315437T → A.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568331 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112227 mRNA. Translation: AAD22448.1.
U49188 mRNA. Translation: AAB48858.1. Frameshift.
AF153979 mRNA. Translation: AAD34641.1. Frameshift.
AK300618 mRNA. Translation: BAG62311.1.
Z97053 Genomic DNA. Translation: CAB09783.1.
BC006088 mRNA. Translation: AAH06088.1.
CCDSiCCDS13333.1. [Q13530-1]
RefSeqiNP_006802.1. NM_006811.3. [Q13530-1]
NP_945179.1. NM_198941.2. [Q13530-1]
XP_016883090.1. XM_017027601.1. [Q13530-2]
UniGeneiHs.272168.
Hs.696712.
Hs.744982.

Genome annotation databases

EnsembliENST00000255175; ENSP00000255175; ENSG00000132824. [Q13530-1]
ENST00000342374; ENSP00000340243; ENSG00000132824. [Q13530-1]
GeneIDi10955.
KEGGihsa:10955.
UCSCiuc002xme.4. human. [Q13530-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112227 mRNA. Translation: AAD22448.1.
U49188 mRNA. Translation: AAB48858.1. Frameshift.
AF153979 mRNA. Translation: AAD34641.1. Frameshift.
AK300618 mRNA. Translation: BAG62311.1.
Z97053 Genomic DNA. Translation: CAB09783.1.
BC006088 mRNA. Translation: AAH06088.1.
CCDSiCCDS13333.1. [Q13530-1]
RefSeqiNP_006802.1. NM_006811.3. [Q13530-1]
NP_945179.1. NM_198941.2. [Q13530-1]
XP_016883090.1. XM_017027601.1. [Q13530-2]
UniGeneiHs.272168.
Hs.696712.
Hs.744982.

3D structure databases

ProteinModelPortaliQ13530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116155. 12 interactors.
IntActiQ13530. 3 interactors.
STRINGi9606.ENSP00000255175.

Protein family/group databases

TCDBi9.A.29.3.4. the lantibiotic immunity protein/serine connector (lip/sip) family.

PTM databases

iPTMnetiQ13530.
PhosphoSitePlusiQ13530.
SwissPalmiQ13530.

Polymorphism and mutation databases

BioMutaiSERINC3.
DMDMi25453293.

Proteomic databases

MaxQBiQ13530.
PaxDbiQ13530.
PeptideAtlasiQ13530.
PRIDEiQ13530.

Protocols and materials databases

DNASUi10955.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255175; ENSP00000255175; ENSG00000132824. [Q13530-1]
ENST00000342374; ENSP00000340243; ENSG00000132824. [Q13530-1]
GeneIDi10955.
KEGGihsa:10955.
UCSCiuc002xme.4. human. [Q13530-1]

Organism-specific databases

CTDi10955.
DisGeNETi10955.
GeneCardsiSERINC3.
HGNCiHGNC:11699. SERINC3.
HPAiHPA043993.
HPA048116.
MIMi607165. gene.
neXtProtiNX_Q13530.
OpenTargetsiENSG00000132824.
PharmGKBiPA36418.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2592. Eukaryota.
ENOG410XP7K. LUCA.
GeneTreeiENSGT00550000074522.
HOGENOMiHOG000165463.
HOVERGENiHBG025699.
InParanoidiQ13530.
OMAiEPERNCN.
OrthoDBiEOG091G07WS.
PhylomeDBiQ13530.
TreeFamiTF312881.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132824-MONOMER.
ReactomeiR-HSA-977347. Serine biosynthesis.

Miscellaneous databases

ChiTaRSiSERINC3. human.
GeneWikiiSERINC3.
GenomeRNAii10955.
PROiQ13530.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132824.
CleanExiHS_SERINC3.
ExpressionAtlasiQ13530. baseline and differential.
GenevisibleiQ13530. HS.

Family and domain databases

InterProiIPR029557. Serinc3.
IPR005016. TDE1/TMS.
[Graphical view]
PANTHERiPTHR10383. PTHR10383. 1 hit.
PTHR10383:SF27. PTHR10383:SF27. 1 hit.
PfamiPF03348. Serinc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERC3_HUMAN
AccessioniPrimary (citable) accession number: Q13530
Secondary accession number(s): B4DUE9, O43717, Q9BR33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.