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Protein

Protein phosphatase 1 regulatory subunit 1A

Gene

PPP1R1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

GO - Molecular functioni

  • protein serine/threonine phosphatase inhibitor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135447-MONOMER.
SIGNORiQ13522.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1A
Alternative name(s):
Protein phosphatase inhibitor 1
Short name:
I-1
Short name:
IPP-1
Gene namesi
Name:PPP1R1A
Synonyms:IPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9286. PPP1R1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi35T → A: No activity. 1 Publication1
Mutagenesisi35T → D: 1000-fold reduction in activity, inhibits equally PP1 and PP2A. 1 Publication1

Organism-specific databases

DisGeNETi5502.
PharmGKBiPA33636.

Polymorphism and mutation databases

BioMutaiPPP1R1A.
DMDMi296452864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714771 – 171Protein phosphatase 1 regulatory subunit 1AAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei35Phosphothreonine; by PKA1 Publication1
Modified residuei43PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei47PhosphoserineBy similarity1
Modified residuei67PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of Thr-35 is required for activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13522.
PaxDbiQ13522.
PeptideAtlasiQ13522.
PRIDEiQ13522.

PTM databases

iPTMnetiQ13522.
PhosphoSitePlusiQ13522.

Expressioni

Gene expression databases

BgeeiENSG00000135447.
CleanExiHS_PPP1R1A.
ExpressionAtlasiQ13522. baseline and differential.
GenevisibleiQ13522. HS.

Organism-specific databases

HPAiCAB007811.
HPA041542.

Interactioni

Subunit structurei

Interacts with PPP1R15A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1R15AO758074EBI-1568511,EBI-714746

Protein-protein interaction databases

BioGridi111496. 14 interactors.
IntActiQ13522. 2 interactors.
STRINGi9606.ENSP00000257905.

Chemistry databases

BindingDBiQ13522.

Structurei

3D structure databases

ProteinModelPortaliQ13522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 12Essential for activity4
Regioni42 – 54Essential for activityCuratedAdd BLAST13
Regioni143 – 171Interaction with PPP1R15A1 PublicationAdd BLAST29

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J0ZP. Eukaryota.
ENOG41125ZM. LUCA.
HOGENOMiHOG000115665.
HOVERGENiHBG096069.
InParanoidiQ13522.
KOiK08050.
OrthoDBiEOG091G1A3V.
PhylomeDBiQ13522.
TreeFamiTF332576.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI
60 70 80 90 100
DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE
110 120 130 140 150
PEGAAESTET QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE
160 170
PSTKEPSTHI PPLDSKGANS V
Length:171
Mass (Da):19,011
Last modified:May 18, 2010 - v2
Checksum:i6F61FF08E4305729
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8R → Q in AAH22470 (PubMed:15489334).Curated1
Sequence conflicti43S → G in AAL48321 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053898109E → G.4 PublicationsCorresponds to variant rs1249958dbSNPEnsembl.1
Natural variantiVAR_053899147G → D.Corresponds to variant rs34376731dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48707 mRNA. Translation: AAB02402.1.
AY063766 mRNA. Translation: AAL48321.1.
CR457003 mRNA. Translation: CAG33284.1.
BC022470 mRNA. Translation: AAH22470.1.
CCDSiCCDS44912.1.
RefSeqiNP_006732.3. NM_006741.3.
UniGeneiHs.505662.

Genome annotation databases

EnsembliENST00000257905; ENSP00000257905; ENSG00000135447.
GeneIDi5502.
KEGGihsa:5502.
UCSCiuc001sgg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48707 mRNA. Translation: AAB02402.1.
AY063766 mRNA. Translation: AAL48321.1.
CR457003 mRNA. Translation: CAG33284.1.
BC022470 mRNA. Translation: AAH22470.1.
CCDSiCCDS44912.1.
RefSeqiNP_006732.3. NM_006741.3.
UniGeneiHs.505662.

3D structure databases

ProteinModelPortaliQ13522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111496. 14 interactors.
IntActiQ13522. 2 interactors.
STRINGi9606.ENSP00000257905.

Chemistry databases

BindingDBiQ13522.

PTM databases

iPTMnetiQ13522.
PhosphoSitePlusiQ13522.

Polymorphism and mutation databases

BioMutaiPPP1R1A.
DMDMi296452864.

Proteomic databases

EPDiQ13522.
PaxDbiQ13522.
PeptideAtlasiQ13522.
PRIDEiQ13522.

Protocols and materials databases

DNASUi5502.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257905; ENSP00000257905; ENSG00000135447.
GeneIDi5502.
KEGGihsa:5502.
UCSCiuc001sgg.3. human.

Organism-specific databases

CTDi5502.
DisGeNETi5502.
GeneCardsiPPP1R1A.
HGNCiHGNC:9286. PPP1R1A.
HPAiCAB007811.
HPA041542.
MIMi613246. gene.
neXtProtiNX_Q13522.
PharmGKBiPA33636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0ZP. Eukaryota.
ENOG41125ZM. LUCA.
HOGENOMiHOG000115665.
HOVERGENiHBG096069.
InParanoidiQ13522.
KOiK08050.
OrthoDBiEOG091G1A3V.
PhylomeDBiQ13522.
TreeFamiTF332576.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135447-MONOMER.
SIGNORiQ13522.

Miscellaneous databases

GenomeRNAii5502.
PROiQ13522.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135447.
CleanExiHS_PPP1R1A.
ExpressionAtlasiQ13522. baseline and differential.
GenevisibleiQ13522. HS.

Family and domain databases

InterProiIPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR1A_HUMAN
AccessioniPrimary (citable) accession number: Q13522
Secondary accession number(s): Q6IB01, Q8TBJ2, Q8WWV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.