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Protein

Prepronociceptin

Gene

PNOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity).By similarity

GO - Molecular functioni

  1. neuropeptide hormone activity Source: ProtInc

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. sensory perception Source: ProtInc
  3. signal transduction Source: ProtInc
  4. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter, Opioid peptide

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prepronociceptin
Cleaved into the following 3 chains:
Alternative name(s):
Orphanin FQ
PPNOC
Gene namesi
Name:PNOC
Synonyms:OFQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:9163. PNOC.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33485.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 9576PRO_0000008325Add
BLAST
Peptidei98 – 12730Neuropeptide 1CuratedPRO_0000008326Add
BLAST
Peptidei130 – 14617NociceptinPRO_0000008327Add
BLAST
Peptidei149 – 16517Neuropeptide 2CuratedPRO_0000008328Add
BLAST
Propeptidei169 – 1768PRO_0000008329

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MaxQBiQ13519.
PaxDbiQ13519.
PRIDEiQ13519.

PTM databases

PhosphoSiteiQ13519.

Expressioni

Tissue specificityi

Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.1 Publication

Gene expression databases

BgeeiQ13519.
CleanExiHS_PNOC.
ExpressionAtlasiQ13519. baseline and differential.
GenevestigatoriQ13519.

Organism-specific databases

HPAiHPA044507.

Interactioni

Protein-protein interaction databases

BioGridi111381. 1 interaction.
IntActiQ13519. 1 interaction.
STRINGi9606.ENSP00000301908.

Structurei

3D structure databases

ProteinModelPortaliQ13519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40726.
GeneTreeiENSGT00510000049153.
HOGENOMiHOG000082421.
HOVERGENiHBG008227.
InParanoidiQ13519.
OMAiFNLEVCI.
PhylomeDBiQ13519.
TreeFamiTF332620.

Family and domain databases

InterProiIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVLLCDLLL LSLFSSVFSS CQRDCLTCQE KLHPALDSFD LEVCILECEE
60 70 80 90 100
KVFPSPLWTP CTKVMARSSW QLSPAAPEHV AAALYQPRAS EMQHLRRMPR
110 120 130 140 150
VRSLFQEQEE PEPGMEEAGE MEQKQLQKRF GGFTGARKSA RKLANQKRFS
160 170
EFMRQYLVLS MQSSQRRRTL HQNGNV
Length:176
Mass (Da):20,295
Last modified:November 1, 1997 - v1
Checksum:i8FC8DB4BB094CE6A
GO
Isoform 2 (identifier: Q13519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Note: No experimental confirmation available.

Show »
Length:112
Mass (Da):13,047
Checksum:i633AAB7223669BD8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6464Missing in isoform 2. 1 PublicationVSP_055146Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97370 mRNA. Translation: CAA66040.1.
X97367, X97368 Genomic DNA. Translation: CAA66039.1.
U48263 mRNA. Translation: AAC50651.1.
AY335948 mRNA. Translation: AAP94601.1.
AK301456 mRNA. Translation: BAH13485.1.
BT019334 mRNA. Translation: AAV38141.1.
CR541940 mRNA. Translation: CAG46738.1.
CR541965 mRNA. Translation: CAG46763.1.
AC021678 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63526.1.
CH471080 Genomic DNA. Translation: EAW63527.1.
BC034758 mRNA. Translation: AAH34758.1.
CCDSiCCDS6066.1. [Q13519-1]
CCDS64862.1. [Q13519-2]
PIRiJC6152.
RefSeqiNP_001271173.1. NM_001284244.1. [Q13519-2]
NP_006219.1. NM_006228.4. [Q13519-1]
UniGeneiHs.88218.

Genome annotation databases

EnsembliENST00000301908; ENSP00000301908; ENSG00000168081. [Q13519-1]
ENST00000522209; ENSP00000430145; ENSG00000168081. [Q13519-2]
GeneIDi5368.
KEGGihsa:5368.
UCSCiuc003xgp.3. human. [Q13519-1]

Polymorphism databases

DMDMi2494348.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97370 mRNA. Translation: CAA66040.1.
X97367, X97368 Genomic DNA. Translation: CAA66039.1.
U48263 mRNA. Translation: AAC50651.1.
AY335948 mRNA. Translation: AAP94601.1.
AK301456 mRNA. Translation: BAH13485.1.
BT019334 mRNA. Translation: AAV38141.1.
CR541940 mRNA. Translation: CAG46738.1.
CR541965 mRNA. Translation: CAG46763.1.
AC021678 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63526.1.
CH471080 Genomic DNA. Translation: EAW63527.1.
BC034758 mRNA. Translation: AAH34758.1.
CCDSiCCDS6066.1. [Q13519-1]
CCDS64862.1. [Q13519-2]
PIRiJC6152.
RefSeqiNP_001271173.1. NM_001284244.1. [Q13519-2]
NP_006219.1. NM_006228.4. [Q13519-1]
UniGeneiHs.88218.

3D structure databases

ProteinModelPortaliQ13519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111381. 1 interaction.
IntActiQ13519. 1 interaction.
STRINGi9606.ENSP00000301908.

PTM databases

PhosphoSiteiQ13519.

Polymorphism databases

DMDMi2494348.

Proteomic databases

MaxQBiQ13519.
PaxDbiQ13519.
PRIDEiQ13519.

Protocols and materials databases

DNASUi5368.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301908; ENSP00000301908; ENSG00000168081. [Q13519-1]
ENST00000522209; ENSP00000430145; ENSG00000168081. [Q13519-2]
GeneIDi5368.
KEGGihsa:5368.
UCSCiuc003xgp.3. human. [Q13519-1]

Organism-specific databases

CTDi5368.
GeneCardsiGC08P028174.
HGNCiHGNC:9163. PNOC.
HPAiHPA044507.
MIMi601459. gene.
neXtProtiNX_Q13519.
PharmGKBiPA33485.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40726.
GeneTreeiENSGT00510000049153.
HOGENOMiHOG000082421.
HOVERGENiHBG008227.
InParanoidiQ13519.
OMAiFNLEVCI.
PhylomeDBiQ13519.
TreeFamiTF332620.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiPNOC. human.
GenomeRNAii5368.
NextBioi20808.
PROiQ13519.
SOURCEiSearch...

Gene expression databases

BgeeiQ13519.
CleanExiHS_PNOC.
ExpressionAtlasiQ13519. baseline and differential.
GenevestigatoriQ13519.

Family and domain databases

InterProiIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene."
    Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G., Meunier J.-C., Parmentier M.
    Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Human neutrophils as a source of nociceptin: a novel link between pain and inflammation."
    Fiset M.E., Gilbert C., Poubelle P.E., Pouliot M.
    Biochemistry 42:10498-10505(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Synovium.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  9. Cited for: STRUCTURE BY NMR OF NOCICEPTIN.

Entry informationi

Entry nameiPNOC_HUMAN
AccessioniPrimary (citable) accession number: Q13519
Secondary accession number(s): B7Z749, Q6FH16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.