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Q13519 (PNOC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prepronociceptin

Cleaved into the following 3 chains:

  1. Neuropeptide 1
  2. Nociceptin
    Alternative name(s):
    Orphanin FQ
    PPNOC
  3. Neuropeptide 2
Gene names
Name:PNOC
Synonyms:OFQ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development By similarity.

Subcellular location

Secreted.

Tissue specificity

Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. Ref.3

Post-translational modification

Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 9576
PRO_0000008325
Peptide98 – 12730Neuropeptide 1 Probable
PRO_0000008326
Peptide130 – 14617Nociceptin
PRO_0000008327
Peptide149 – 16517Neuropeptide 2 Probable
PRO_0000008328
Propeptide169 – 1768
PRO_0000008329

Sequences

Sequence LengthMass (Da)Tools
Q13519 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 8FC8DB4BB094CE6A

FASTA17620,295
        10         20         30         40         50         60 
MKVLLCDLLL LSLFSSVFSS CQRDCLTCQE KLHPALDSFD LEVCILECEE KVFPSPLWTP 

        70         80         90        100        110        120 
CTKVMARSSW QLSPAAPEHV AAALYQPRAS EMQHLRRMPR VRSLFQEQEE PEPGMEEAGE 

       130        140        150        160        170 
MEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMRQYLVLS MQSSQRRRTL HQNGNV 

« Hide

References

« Hide 'large scale' references
[1]"Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene."
Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G., Meunier J.-C., Parmentier M.
Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Primary structure and tissue distribution of the orphanin FQ precursor."
Nothacker H.-P., Reinscheid R.K., Mansour A., Henningsen R.A., Ardati A., Monsma F.J. Jr., Watson S.J., Civelli O.
Proc. Natl. Acad. Sci. U.S.A. 93:8677-8682(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Human neutrophils as a source of nociceptin: a novel link between pain and inflammation."
Fiset M.E., Gilbert C., Poubelle P.E., Pouliot M.
Biochemistry 42:10498-10505(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[8]"Solution conformation of nociceptin."
Salvadori S., Picone D., Tancredi T., Guerrini R., Spadaccini R., Lazarus L.H., Regoli D., Temussi P.A.
Biochem. Biophys. Res. Commun. 233:640-643(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF NOCICEPTIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97370 mRNA. Translation: CAA66040.1.
X97367, X97368 Genomic DNA. Translation: CAA66039.1.
U48263 mRNA. Translation: AAC50651.1.
AY335948 mRNA. Translation: AAP94601.1.
BT019334 mRNA. Translation: AAV38141.1.
CR541940 mRNA. Translation: CAG46738.1.
CR541965 mRNA. Translation: CAG46763.1.
CH471080 Genomic DNA. Translation: EAW63526.1.
CH471080 Genomic DNA. Translation: EAW63527.1.
BC034758 mRNA. Translation: AAH34758.1.
PIRJC6152.
RefSeqNP_006219.1. NM_006228.4.
UniGeneHs.88218.

3D structure databases

ProteinModelPortalQ13519.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111381. 1 interaction.
IntActQ13519. 1 interaction.
STRING9606.ENSP00000301908.

PTM databases

PhosphoSiteQ13519.

Polymorphism databases

DMDM2494348.

Proteomic databases

PaxDbQ13519.
PRIDEQ13519.

Protocols and materials databases

DNASU5368.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301908; ENSP00000301908; ENSG00000168081.
GeneID5368.
KEGGhsa:5368.
UCSCuc003xgp.3. human.

Organism-specific databases

CTD5368.
GeneCardsGC08P028174.
HGNCHGNC:9163. PNOC.
HPAHPA044507.
MIM601459. gene.
neXtProtNX_Q13519.
PharmGKBPA33485.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40726.
HOGENOMHOG000082421.
HOVERGENHBG008227.
InParanoidQ13519.
OMAHLKRMPR.
PhylomeDBQ13519.
TreeFamTF332620.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ13519.
BgeeQ13519.
CleanExHS_PNOC.
GenevestigatorQ13519.

Family and domain databases

InterProIPR002367. Nociceptin.
IPR006024. Opioid_neupept.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01031. ORPHNNPRCRSR.
PROSITEPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi5368.
NextBio20808.
PROQ13519.
SOURCESearch...

Entry information

Entry namePNOC_HUMAN
AccessionPrimary (citable) accession number: Q13519
Secondary accession number(s): Q6FH16
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM