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Q13519

- PNOC_HUMAN

UniProt

Q13519 - PNOC_HUMAN

Protein

Prepronociceptin

Gene

PNOC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development By similarity.By similarity

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW
    2. sensory perception Source: ProtInc
    3. signal transduction Source: ProtInc
    4. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide, Neurotransmitter, Opioid peptide

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prepronociceptin
    Cleaved into the following 3 chains:
    Alternative name(s):
    Orphanin FQ
    PPNOC
    Gene namesi
    Name:PNOC
    Synonyms:OFQ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:9163. PNOC.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33485.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 9576PRO_0000008325Add
    BLAST
    Peptidei98 – 12730Neuropeptide 1CuratedPRO_0000008326Add
    BLAST
    Peptidei130 – 14617NociceptinPRO_0000008327Add
    BLAST
    Peptidei149 – 16517Neuropeptide 2CuratedPRO_0000008328Add
    BLAST
    Propeptidei169 – 1768PRO_0000008329

    Post-translational modificationi

    Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.
    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    MaxQBiQ13519.
    PaxDbiQ13519.
    PRIDEiQ13519.

    PTM databases

    PhosphoSiteiQ13519.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.1 Publication

    Gene expression databases

    ArrayExpressiQ13519.
    BgeeiQ13519.
    CleanExiHS_PNOC.
    GenevestigatoriQ13519.

    Organism-specific databases

    HPAiHPA044507.

    Interactioni

    Protein-protein interaction databases

    BioGridi111381. 1 interaction.
    IntActiQ13519. 1 interaction.
    STRINGi9606.ENSP00000301908.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40726.
    HOGENOMiHOG000082421.
    HOVERGENiHBG008227.
    InParanoidiQ13519.
    OMAiHLKRMPR.
    PhylomeDBiQ13519.
    TreeFamiTF332620.

    Family and domain databases

    InterProiIPR002367. Nociceptin.
    IPR006024. Opioid_neupept.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01031. ORPHNNPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13519-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVLLCDLLL LSLFSSVFSS CQRDCLTCQE KLHPALDSFD LEVCILECEE    50
    KVFPSPLWTP CTKVMARSSW QLSPAAPEHV AAALYQPRAS EMQHLRRMPR 100
    VRSLFQEQEE PEPGMEEAGE MEQKQLQKRF GGFTGARKSA RKLANQKRFS 150
    EFMRQYLVLS MQSSQRRRTL HQNGNV 176
    Length:176
    Mass (Da):20,295
    Last modified:November 1, 1997 - v1
    Checksum:i8FC8DB4BB094CE6A
    GO
    Isoform 2 (identifier: Q13519-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-64: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:112
    Mass (Da):13,047
    Checksum:i633AAB7223669BD8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6464Missing in isoform 2. 1 PublicationVSP_055146Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97370 mRNA. Translation: CAA66040.1.
    X97367, X97368 Genomic DNA. Translation: CAA66039.1.
    U48263 mRNA. Translation: AAC50651.1.
    AY335948 mRNA. Translation: AAP94601.1.
    AK301456 mRNA. Translation: BAH13485.1.
    BT019334 mRNA. Translation: AAV38141.1.
    CR541940 mRNA. Translation: CAG46738.1.
    CR541965 mRNA. Translation: CAG46763.1.
    AC021678 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63526.1.
    CH471080 Genomic DNA. Translation: EAW63527.1.
    BC034758 mRNA. Translation: AAH34758.1.
    CCDSiCCDS6066.1. [Q13519-1]
    CCDS64862.1. [Q13519-2]
    PIRiJC6152.
    RefSeqiNP_001271173.1. NM_001284244.1.
    NP_006219.1. NM_006228.4.
    UniGeneiHs.88218.

    Genome annotation databases

    EnsembliENST00000301908; ENSP00000301908; ENSG00000168081. [Q13519-1]
    ENST00000522209; ENSP00000430145; ENSG00000168081. [Q13519-2]
    GeneIDi5368.
    KEGGihsa:5368.
    UCSCiuc003xgp.3. human. [Q13519-1]

    Polymorphism databases

    DMDMi2494348.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X97370 mRNA. Translation: CAA66040.1 .
    X97367 , X97368 Genomic DNA. Translation: CAA66039.1 .
    U48263 mRNA. Translation: AAC50651.1 .
    AY335948 mRNA. Translation: AAP94601.1 .
    AK301456 mRNA. Translation: BAH13485.1 .
    BT019334 mRNA. Translation: AAV38141.1 .
    CR541940 mRNA. Translation: CAG46738.1 .
    CR541965 mRNA. Translation: CAG46763.1 .
    AC021678 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63526.1 .
    CH471080 Genomic DNA. Translation: EAW63527.1 .
    BC034758 mRNA. Translation: AAH34758.1 .
    CCDSi CCDS6066.1. [Q13519-1 ]
    CCDS64862.1. [Q13519-2 ]
    PIRi JC6152.
    RefSeqi NP_001271173.1. NM_001284244.1.
    NP_006219.1. NM_006228.4.
    UniGenei Hs.88218.

    3D structure databases

    ProteinModelPortali Q13519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111381. 1 interaction.
    IntActi Q13519. 1 interaction.
    STRINGi 9606.ENSP00000301908.

    PTM databases

    PhosphoSitei Q13519.

    Polymorphism databases

    DMDMi 2494348.

    Proteomic databases

    MaxQBi Q13519.
    PaxDbi Q13519.
    PRIDEi Q13519.

    Protocols and materials databases

    DNASUi 5368.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301908 ; ENSP00000301908 ; ENSG00000168081 . [Q13519-1 ]
    ENST00000522209 ; ENSP00000430145 ; ENSG00000168081 . [Q13519-2 ]
    GeneIDi 5368.
    KEGGi hsa:5368.
    UCSCi uc003xgp.3. human. [Q13519-1 ]

    Organism-specific databases

    CTDi 5368.
    GeneCardsi GC08P028174.
    HGNCi HGNC:9163. PNOC.
    HPAi HPA044507.
    MIMi 601459. gene.
    neXtProti NX_Q13519.
    PharmGKBi PA33485.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40726.
    HOGENOMi HOG000082421.
    HOVERGENi HBG008227.
    InParanoidi Q13519.
    OMAi HLKRMPR.
    PhylomeDBi Q13519.
    TreeFami TF332620.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 5368.
    NextBioi 20808.
    PROi Q13519.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13519.
    Bgeei Q13519.
    CleanExi HS_PNOC.
    Genevestigatori Q13519.

    Family and domain databases

    InterProi IPR002367. Nociceptin.
    IPR006024. Opioid_neupept.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01031. ORPHNNPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene."
      Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G., Meunier J.-C., Parmentier M.
      Proc. Natl. Acad. Sci. U.S.A. 93:8666-8670(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Human neutrophils as a source of nociceptin: a novel link between pain and inflammation."
      Fiset M.E., Gilbert C., Poubelle P.E., Pouliot M.
      Biochemistry 42:10498-10505(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Synovium.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    9. Cited for: STRUCTURE BY NMR OF NOCICEPTIN.

    Entry informationi

    Entry nameiPNOC_HUMAN
    AccessioniPrimary (citable) accession number: Q13519
    Secondary accession number(s): B7Z749, Q6FH16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3