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Q13516

- OLIG2_HUMAN

UniProt

Q13516 - OLIG2_HUMAN

Protein

Oligodendrocyte transcription factor 2

Gene

OLIG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (13 Aug 2002)
      Previous versions | rss
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    Functioni

    Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. myelination Source: Ensembl
    2. negative regulation of neuron differentiation Source: Ensembl
    3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. neuron fate commitment Source: Ensembl
    5. positive regulation of oligodendrocyte differentiation Source: Ensembl
    6. spinal cord motor neuron differentiation Source: Ensembl
    7. spinal cord oligodendrocyte cell fate specification Source: Ensembl
    8. thalamus development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oligodendrocyte transcription factor 2
    Short name:
    Oligo2
    Alternative name(s):
    Class B basic helix-loop-helix protein 1
    Short name:
    bHLHb1
    Class E basic helix-loop-helix protein 19
    Short name:
    bHLHe19
    Protein kinase C-binding protein 2
    Protein kinase C-binding protein RACK17
    Gene namesi
    Name:OLIG2
    Synonyms:BHLHB1, BHLHE19, PRKCBP2, RACK17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:9398. OLIG2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Cytoplasm By similarity
    Note: The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA31919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Oligodendrocyte transcription factor 2PRO_0000127414Add
    BLAST

    Proteomic databases

    PaxDbiQ13516.
    PRIDEiQ13516.

    PTM databases

    PhosphoSiteiQ13516.

    Expressioni

    Tissue specificityi

    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.2 Publications

    Inductioni

    By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain By similarity.By similarity

    Gene expression databases

    ArrayExpressiQ13516.
    BgeeiQ13516.
    CleanExiHS_OLIG2.
    GenevestigatoriQ13516.

    Organism-specific databases

    HPAiCAB019381.
    HPA003254.

    Interactioni

    Subunit structurei

    Interacts with NKX2-2.By similarity

    Protein-protein interaction databases

    BioGridi115510. 2 interactions.
    IntActiQ13516. 1 interaction.
    STRINGi9606.ENSP00000331040.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13516.
    SMRiQ13516. Positions 110-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini108 – 16255bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi77 – 8812Poly-SerAdd
    BLAST
    Compositional biasi206 – 2127Poly-Ala
    Compositional biasi225 – 23713Poly-AlaAdd
    BLAST
    Compositional biasi266 – 2705Poly-Ala
    Compositional biasi273 – 2808Poly-Gly

    Domaini

    The bHLH is essential for interaction with NKX2-2.By similarity

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG313428.
    HOGENOMiHOG000015765.
    HOVERGENiHBG053370.
    InParanoidiQ13516.
    KOiK09085.
    OMAiKKSVHGF.
    OrthoDBiEOG7GQXWR.
    PhylomeDBiQ13516.
    TreeFamiTF322733.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13516-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE    50
    LSAELRGAMG SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ 100
    MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA 150
    TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPA 200
    ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLPS 250
    VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV 300
    PPPHHHVSAM GAGSLPRLTS DAK 323
    Length:323
    Mass (Da):32,385
    Last modified:August 13, 2002 - v2
    Checksum:i0EC9223961062509
    GO

    Sequence cautioni

    The sequence AAC72247.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAF61215.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671G → V in AAH36245. (PubMed:14702039)Curated
    Sequence conflicti150 – 1501A → T in AAH47511. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48250 mRNA. Translation: AAC72247.1. Different initiation.
    AF221520 mRNA. Translation: AAF61215.1. Different initiation.
    AK091462 mRNA. Translation: BAG52365.1.
    BC034681 mRNA. Translation: AAH34681.1.
    BC036245 mRNA. Translation: AAH36245.1.
    BC047511 mRNA. Translation: AAH47511.1.
    CCDSiCCDS13620.1.
    PIRiG02409.
    RefSeqiNP_005797.1. NM_005806.3.
    XP_005260965.1. XM_005260908.1.
    UniGeneiHs.176977.
    Hs.732068.

    Genome annotation databases

    EnsembliENST00000333337; ENSP00000331040; ENSG00000205927.
    ENST00000382357; ENSP00000371794; ENSG00000205927.
    GeneIDi10215.
    KEGGihsa:10215.
    UCSCiuc002yqx.2. human.

    Polymorphism databases

    DMDMi22261817.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48250 mRNA. Translation: AAC72247.1 . Different initiation.
    AF221520 mRNA. Translation: AAF61215.1 . Different initiation.
    AK091462 mRNA. Translation: BAG52365.1 .
    BC034681 mRNA. Translation: AAH34681.1 .
    BC036245 mRNA. Translation: AAH36245.1 .
    BC047511 mRNA. Translation: AAH47511.1 .
    CCDSi CCDS13620.1.
    PIRi G02409.
    RefSeqi NP_005797.1. NM_005806.3.
    XP_005260965.1. XM_005260908.1.
    UniGenei Hs.176977.
    Hs.732068.

    3D structure databases

    ProteinModelPortali Q13516.
    SMRi Q13516. Positions 110-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115510. 2 interactions.
    IntActi Q13516. 1 interaction.
    STRINGi 9606.ENSP00000331040.

    PTM databases

    PhosphoSitei Q13516.

    Polymorphism databases

    DMDMi 22261817.

    Proteomic databases

    PaxDbi Q13516.
    PRIDEi Q13516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333337 ; ENSP00000331040 ; ENSG00000205927 .
    ENST00000382357 ; ENSP00000371794 ; ENSG00000205927 .
    GeneIDi 10215.
    KEGGi hsa:10215.
    UCSCi uc002yqx.2. human.

    Organism-specific databases

    CTDi 10215.
    GeneCardsi GC21P034398.
    H-InvDB HIX0016071.
    HGNCi HGNC:9398. OLIG2.
    HPAi CAB019381.
    HPA003254.
    MIMi 606386. gene.
    neXtProti NX_Q13516.
    PharmGKBi PA31919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313428.
    HOGENOMi HOG000015765.
    HOVERGENi HBG053370.
    InParanoidi Q13516.
    KOi K09085.
    OMAi KKSVHGF.
    OrthoDBi EOG7GQXWR.
    PhylomeDBi Q13516.
    TreeFami TF322733.

    Miscellaneous databases

    GeneWikii OLIG2.
    GenomeRNAii 10215.
    NextBioi 38678.
    PROi Q13516.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13516.
    Bgeei Q13516.
    CleanExi HS_OLIG2.
    Genevestigatori Q13516.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein kinase C-binding protein."
      Kuroda S., Tokunaga C., Kiyohara Y., Konishi H., Kikkawa U.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    2. "The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene."
      Wang J., Jani-Sait S.N., Escalon E.A., Carroll A.J., de Jong P.J., Kirsch I.R., Aplan P.D.
      Proc. Natl. Acad. Sci. U.S.A. 97:3497-3502(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Cited for: TISSUE SPECIFICITY.
    6. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiOLIG2_HUMAN
    AccessioniPrimary (citable) accession number: Q13516
    Secondary accession number(s): B3KRF3
    , Q05BP9, Q49AL3, Q86X04, Q9NZ14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 13, 2002
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3