Q13516 (OLIG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 116.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Oligodendrocyte transcription factor 2 Short name=Oligo2 Alternative name(s): Class B basic helix-loop-helix protein 1 Short name=bHLHb1 Class E basic helix-loop-helix protein 19 Short name=bHLHe19 Protein kinase C-binding protein 2 Protein kinase C-binding protein RACK17 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 323 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development By similarity. |
| Subunit structure | Interacts with NKX2-2 By similarity. |
| Subcellular location | Nucleus By similarity. Cytoplasm By similarity. Note: The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 By similarity. |
| Tissue specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. Ref.5 Ref.6 |
| Induction | By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain By similarity. |
| Domain | The bHLH is essential for interaction with NKX2-2 By similarity. |
| Involvement in disease | A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. |
| Sequence similarities | Contains 1 bHLH (basic helix-loop-helix) domain. |
| Sequence caution | The sequence AAC72247.1 differs from that shown. Reason: Erroneous initiation. The sequence AAF61215.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 323 | 323 | Oligodendrocyte transcription factor 2 | PRO_0000127414 | |||||
Regions | |||||||||
| Domain | 108 – 162 | 55 | bHLH | ||||||
| Compositional bias | 77 – 88 | 12 | Poly-Ser | ||||||
| Compositional bias | 206 – 212 | 7 | Poly-Ala | ||||||
| Compositional bias | 225 – 237 | 13 | Poly-Ala | ||||||
| Compositional bias | 266 – 270 | 5 | Poly-Ala | ||||||
| Compositional bias | 273 – 280 | 8 | Poly-Gly | ||||||
Experimental info | |||||||||
| Sequence conflict | 150 | 1 | A → T in AAH47511. Ref.4 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Protein kinase C-binding protein." Kuroda S., Tokunaga C., Kiyohara Y., Konishi H., Kikkawa U. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus. |
| [2] | "The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene." Wang J., Jani-Sait S.N., Escalon E.A., Carroll A.J., de Jong P.J., Kirsch I.R., Aplan P.D. Proc. Natl. Acad. Sci. U.S.A. 97:3497-3502(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "OLIG2 as a specific marker of oligodendroglial tumour cells." Marie Y., Sanson M., Mokhtari K., Leuraud P., Kujas M., Delattre J.-Y., Poirier J., Zalc B., Hoang-Xuan K. Lancet 358:298-300(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [6] | "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors." Lu Q.R., Park J.K., Noll E., Chan J.A., Alberta J.A., Yuk D.-I., Alzamora M.G., Louis D.N., Stiles C.D., Rowitch D.H., Black P.M. Proc. Natl. Acad. Sci. U.S.A. 98:10851-10856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U48250 mRNA. Translation: AAC72247.1. Different initiation. AF221520 mRNA. Translation: AAF61215.1. Different initiation. AK091462 mRNA. Translation: BAG52365.1. BC047511 mRNA. Translation: AAH47511.1. |
| IPI | IPI00013699. |
| PIR | G02409. |
| RefSeq | NP_005797.1. NM_005806.3. |
| UniGene | Hs.176977. Hs.732068. |
3D structure databases | |
| ProteinModelPortal | Q13516. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q13516. 1 interaction. |
| STRING | 9606.ENSP00000331040. |
PTM databases | |
| PhosphoSite | Q13516. |
Polymorphism databases | |
| DMDM | 22261817. |
Proteomic databases | |
| PaxDb | Q13516. |
| PRIDE | Q13516. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000333337; ENSP00000331040; ENSG00000205927. ENST00000382357; ENSP00000371794; ENSG00000205927. |
| GeneID | 10215. |
| KEGG | hsa:10215. |
| UCSC | uc002yqx.2. human. |
Organism-specific databases | |
| CTD | 10215. |
| GeneCards | GC21P034398. |
| H-InvDB | HIX0016071. |
| HGNC | HGNC:9398. OLIG2. |
| HPA | CAB019381. HPA003254. |
| MIM | 606386. gene. |
| neXtProt | NX_Q13516. |
| PharmGKB | PA31919. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG313428. |
| HOGENOM | HOG000015765. |
| HOVERGEN | HBG053370. |
| InParanoid | Q13516. |
| KO | K09085. |
| OMA | SFQHWGG. |
| OrthoDB | EOG4RJG2Q. |
| PhylomeDB | Q13516. |
Gene expression databases | |
| ArrayExpress | Q13516. |
| Bgee | Q13516. |
| CleanEx | HS_OLIG2. |
| Genevestigator | Q13516. |
| GermOnline | ENSG00000205927. Homo sapiens. |
Family and domain databases | |
| Gene3D | 4.10.280.10. 1 hit. |
| InterPro | IPR011598. bHLH_dom. [Graphical view] |
| Pfam | PF00010. HLH. 1 hit. [Graphical view] |
| SMART | SM00353. HLH. 1 hit. [Graphical view] |
| SUPFAM | SSF47459. HLH_basic. 1 hit. |
| PROSITE | PS50888. BHLH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 10215. |
| NextBio | 38678. |
| SOURCE | Search... |
Entry information
| Entry name | OLIG2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13516 Secondary accession number(s): B3KRF3, Q86X04, Q9NZ14 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 21 Human chromosome 21: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
