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Q13516

- OLIG2_HUMAN

UniProt

Q13516 - OLIG2_HUMAN

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Protein

Oligodendrocyte transcription factor 2

Gene

OLIG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. myelination Source: Ensembl
  2. negative regulation of neuron differentiation Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. neuron fate commitment Source: Ensembl
  5. positive regulation of oligodendrocyte differentiation Source: Ensembl
  6. spinal cord motor neuron differentiation Source: Ensembl
  7. spinal cord oligodendrocyte cell fate specification Source: Ensembl
  8. thalamus development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oligodendrocyte transcription factor 2
Short name:
Oligo2
Alternative name(s):
Class B basic helix-loop-helix protein 1
Short name:
bHLHb1
Class E basic helix-loop-helix protein 19
Short name:
bHLHe19
Protein kinase C-binding protein 2
Protein kinase C-binding protein RACK17
Gene namesi
Name:OLIG2
Synonyms:BHLHB1, BHLHE19, PRKCBP2, RACK17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:9398. OLIG2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Cytoplasm By similarity
Note: The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA31919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Oligodendrocyte transcription factor 2PRO_0000127414Add
BLAST

Proteomic databases

PaxDbiQ13516.
PRIDEiQ13516.

PTM databases

PhosphoSiteiQ13516.

Expressioni

Tissue specificityi

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.2 Publications

Inductioni

By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).By similarity

Gene expression databases

BgeeiQ13516.
CleanExiHS_OLIG2.
ExpressionAtlasiQ13516. baseline and differential.
GenevestigatoriQ13516.

Organism-specific databases

HPAiCAB019381.
HPA003254.

Interactioni

Subunit structurei

Interacts with NKX2-2.By similarity

Protein-protein interaction databases

BioGridi115510. 2 interactions.
IntActiQ13516. 1 interaction.
STRINGi9606.ENSP00000331040.

Structurei

3D structure databases

ProteinModelPortaliQ13516.
SMRiQ13516. Positions 110-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 16255bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 8812Poly-SerAdd
BLAST
Compositional biasi206 – 2127Poly-Ala
Compositional biasi225 – 23713Poly-AlaAdd
BLAST
Compositional biasi266 – 2705Poly-Ala
Compositional biasi273 – 2808Poly-Gly

Domaini

The bHLH is essential for interaction with NKX2-2.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG313428.
GeneTreeiENSGT00530000063239.
HOGENOMiHOG000015765.
HOVERGENiHBG053370.
InParanoidiQ13516.
KOiK09085.
OMAiKKSVHGF.
OrthoDBiEOG7GQXWR.
PhylomeDBiQ13516.
TreeFamiTF322733.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13516-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE
60 70 80 90 100
LSAELRGAMG SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ
110 120 130 140 150
MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA
160 170 180 190 200
TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPA
210 220 230 240 250
ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLPS
260 270 280 290 300
VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV
310 320
PPPHHHVSAM GAGSLPRLTS DAK
Length:323
Mass (Da):32,385
Last modified:August 13, 2002 - v2
Checksum:i0EC9223961062509
GO

Sequence cautioni

The sequence AAC72247.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAF61215.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671G → V in AAH36245. (PubMed:14702039)Curated
Sequence conflicti150 – 1501A → T in AAH47511. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48250 mRNA. Translation: AAC72247.1. Different initiation.
AF221520 mRNA. Translation: AAF61215.1. Different initiation.
AK091462 mRNA. Translation: BAG52365.1.
BC034681 mRNA. Translation: AAH34681.1.
BC036245 mRNA. Translation: AAH36245.1.
BC047511 mRNA. Translation: AAH47511.1.
CCDSiCCDS13620.1.
PIRiG02409.
RefSeqiNP_005797.1. NM_005806.3.
XP_005260965.1. XM_005260908.1.
UniGeneiHs.176977.
Hs.732068.

Genome annotation databases

EnsembliENST00000333337; ENSP00000331040; ENSG00000205927.
ENST00000382357; ENSP00000371794; ENSG00000205927.
GeneIDi10215.
KEGGihsa:10215.
UCSCiuc002yqx.2. human.

Polymorphism databases

DMDMi22261817.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48250 mRNA. Translation: AAC72247.1 . Different initiation.
AF221520 mRNA. Translation: AAF61215.1 . Different initiation.
AK091462 mRNA. Translation: BAG52365.1 .
BC034681 mRNA. Translation: AAH34681.1 .
BC036245 mRNA. Translation: AAH36245.1 .
BC047511 mRNA. Translation: AAH47511.1 .
CCDSi CCDS13620.1.
PIRi G02409.
RefSeqi NP_005797.1. NM_005806.3.
XP_005260965.1. XM_005260908.1.
UniGenei Hs.176977.
Hs.732068.

3D structure databases

ProteinModelPortali Q13516.
SMRi Q13516. Positions 110-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115510. 2 interactions.
IntActi Q13516. 1 interaction.
STRINGi 9606.ENSP00000331040.

PTM databases

PhosphoSitei Q13516.

Polymorphism databases

DMDMi 22261817.

Proteomic databases

PaxDbi Q13516.
PRIDEi Q13516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333337 ; ENSP00000331040 ; ENSG00000205927 .
ENST00000382357 ; ENSP00000371794 ; ENSG00000205927 .
GeneIDi 10215.
KEGGi hsa:10215.
UCSCi uc002yqx.2. human.

Organism-specific databases

CTDi 10215.
GeneCardsi GC21P034398.
H-InvDB HIX0016071.
HGNCi HGNC:9398. OLIG2.
HPAi CAB019381.
HPA003254.
MIMi 606386. gene.
neXtProti NX_Q13516.
PharmGKBi PA31919.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313428.
GeneTreei ENSGT00530000063239.
HOGENOMi HOG000015765.
HOVERGENi HBG053370.
InParanoidi Q13516.
KOi K09085.
OMAi KKSVHGF.
OrthoDBi EOG7GQXWR.
PhylomeDBi Q13516.
TreeFami TF322733.

Miscellaneous databases

GeneWikii OLIG2.
GenomeRNAii 10215.
NextBioi 38678.
PROi Q13516.
SOURCEi Search...

Gene expression databases

Bgeei Q13516.
CleanExi HS_OLIG2.
ExpressionAtlasi Q13516. baseline and differential.
Genevestigatori Q13516.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein kinase C-binding protein."
    Kuroda S., Tokunaga C., Kiyohara Y., Konishi H., Kikkawa U.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. "The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene."
    Wang J., Jani-Sait S.N., Escalon E.A., Carroll A.J., de Jong P.J., Kirsch I.R., Aplan P.D.
    Proc. Natl. Acad. Sci. U.S.A. 97:3497-3502(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: TISSUE SPECIFICITY.
  6. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiOLIG2_HUMAN
AccessioniPrimary (citable) accession number: Q13516
Secondary accession number(s): B3KRF3
, Q05BP9, Q49AL3, Q86X04, Q9NZ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 13, 2002
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3