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Q13516 (OLIG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oligodendrocyte transcription factor 2

Short name=Oligo2
Alternative name(s):
Class B basic helix-loop-helix protein 1
Short name=bHLHb1
Class E basic helix-loop-helix protein 19
Short name=bHLHe19
Protein kinase C-binding protein 2
Protein kinase C-binding protein RACK17
Gene names
Name:OLIG2
Synonyms:BHLHB1, BHLHE19, PRKCBP2, RACK17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development By similarity.

Subunit structure

Interacts with NKX2-2 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 By similarity.

Tissue specificity

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. Ref.5 Ref.6

Induction

By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain By similarity.

Domain

The bHLH is essential for interaction with NKX2-2 By similarity.

Involvement in disease

A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence caution

The sequence AAC72247.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAF61215.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityChromosomal rearrangement
   DiseaseProto-oncogene
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmyelination

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

neuron fate commitment

Inferred from electronic annotation. Source: Ensembl

positive regulation of oligodendrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

spinal cord motor neuron differentiation

Inferred from electronic annotation. Source: Ensembl

spinal cord oligodendrocyte cell fate specification

Inferred from electronic annotation. Source: Ensembl

thalamus development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Oligodendrocyte transcription factor 2
PRO_0000127414

Regions

Domain108 – 16255bHLH
Compositional bias77 – 8812Poly-Ser
Compositional bias206 – 2127Poly-Ala
Compositional bias225 – 23713Poly-Ala
Compositional bias266 – 2705Poly-Ala
Compositional bias273 – 2808Poly-Gly

Experimental info

Sequence conflict671G → V in AAH36245. Ref.3
Sequence conflict1501A → T in AAH47511. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q13516 [UniParc].

Last modified August 13, 2002. Version 2.
Checksum: 0EC9223961062509

FASTA32332,385
        10         20         30         40         50         60 
MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE LSAELRGAMG 

        70         80         90        100        110        120 
SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ MTEPELQQLR LKINSRERKR 

       130        140        150        160        170        180 
MHDLNIAMDG LREVMPYAHG PSVRKLSKIA TLLLARNYIL MLTNSLEEMK RLVSEIYGGH 

       190        200        210        220        230        240 
HAGFHPSACG GLAHSAPLPA ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS 

       250        260        270        280        290        300 
ASLPGSGLPS VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV 

       310        320 
PPPHHHVSAM GAGSLPRLTS DAK 

« Hide

References

« Hide 'large scale' references
[1]"Protein kinase C-binding protein."
Kuroda S., Tokunaga C., Kiyohara Y., Konishi H., Kikkawa U.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[2]"The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene."
Wang J., Jani-Sait S.N., Escalon E.A., Carroll A.J., de Jong P.J., Kirsch I.R., Aplan P.D.
Proc. Natl. Acad. Sci. U.S.A. 97:3497-3502(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"OLIG2 as a specific marker of oligodendroglial tumour cells."
Marie Y., Sanson M., Mokhtari K., Leuraud P., Kujas M., Delattre J.-Y., Poirier J., Zalc B., Hoang-Xuan K.
Lancet 358:298-300(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors."
Lu Q.R., Park J.K., Noll E., Chan J.A., Alberta J.A., Yuk D.-I., Alzamora M.G., Louis D.N., Stiles C.D., Rowitch D.H., Black P.M.
Proc. Natl. Acad. Sci. U.S.A. 98:10851-10856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U48250 mRNA. Translation: AAC72247.1. Different initiation.
AF221520 mRNA. Translation: AAF61215.1. Different initiation.
AK091462 mRNA. Translation: BAG52365.1.
BC034681 mRNA. Translation: AAH34681.1.
BC036245 mRNA. Translation: AAH36245.1.
BC047511 mRNA. Translation: AAH47511.1.
CCDSCCDS13620.1.
PIRG02409.
RefSeqNP_005797.1. NM_005806.3.
XP_005260965.1. XM_005260908.1.
UniGeneHs.176977.
Hs.732068.

3D structure databases

ProteinModelPortalQ13516.
SMRQ13516. Positions 110-166.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115510. 2 interactions.
IntActQ13516. 1 interaction.
STRING9606.ENSP00000331040.

PTM databases

PhosphoSiteQ13516.

Polymorphism databases

DMDM22261817.

Proteomic databases

PaxDbQ13516.
PRIDEQ13516.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333337; ENSP00000331040; ENSG00000205927.
ENST00000382357; ENSP00000371794; ENSG00000205927.
GeneID10215.
KEGGhsa:10215.
UCSCuc002yqx.2. human.

Organism-specific databases

CTD10215.
GeneCardsGC21P034398.
H-InvDBHIX0016071.
HGNCHGNC:9398. OLIG2.
HPACAB019381.
HPA003254.
MIM606386. gene.
neXtProtNX_Q13516.
PharmGKBPA31919.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313428.
HOGENOMHOG000015765.
HOVERGENHBG053370.
InParanoidQ13516.
KOK09085.
OMAKKSVHGF.
OrthoDBEOG7GQXWR.
PhylomeDBQ13516.
TreeFamTF322733.

Gene expression databases

ArrayExpressQ13516.
BgeeQ13516.
CleanExHS_OLIG2.
GenevestigatorQ13516.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOLIG2.
GenomeRNAi10215.
NextBio38678.
PROQ13516.
SOURCESearch...

Entry information

Entry nameOLIG2_HUMAN
AccessionPrimary (citable) accession number: Q13516
Secondary accession number(s): B3KRF3 expand/collapse secondary AC list , Q05BP9, Q49AL3, Q86X04, Q9NZ14
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 13, 2002
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM