Reviewed,
UniProtKB/Swiss-Prot Q13509 (TBB3_HUMAN)
Last modified
June 16, 2009.
Version 86.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tubulin beta-3 chain Alternative name(s): Tubulin beta-III Tubulin beta-4 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 450 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. |
| Subunit structure | Dimer of alpha and beta chains. |
| Domain | The highly acidic C-terminal region may bind cations such as calcium. |
| Sequence similarities | Belongs to the tubulin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Microtubule |
| Ligand | GTP-binding Nucleotide-binding |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | microtubule-based movement Inferred from electronic annotation. Source: InterPro protein polymerizationInferred from electronic annotation. Source: InterPro |
| Cellular component | microtubule Inferred from electronic annotation. Source: UniProtKB-KW protein complexInferred from electronic annotation. Source: InterPro |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activityInferred from electronic annotation. Source: InterPro structural molecule activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and sequencing of human betaIII-tubulin cDNA: induction of betaIII isotype in human prostate carcinoma cells by acute exposure to antimicrotubule agents." Ranganathan S., Dexter D.W., Benetatos C.A., Hudes G.R. Biochim. Biophys. Acta 1395:237-245(1998) [PubMed: 9473684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | Banerjee A. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary cancer. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [4] | Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 63-77; 104-121; 242-251; 163-174 AND 381-390, MASS SPECTROMETRY. Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U47634 mRNA. Translation: AAC52035.1. AF427491 mRNA. Translation: AAL28094.1. BC000748 mRNA. Translation: AAH00748.1. BC003021 mRNA. Translation: AAH03021.2. | |
| IPI | IPI00013683. |
| RefSeq | NP_006077.2. |
| UniGene | Hs.511743 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FFX based on UniProtKB P02554. |
| SMR | Q13509. Positions 2-427. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q13509. 4 interactions. |
PTM databases | |
| PhosphoSite | Q13509. |
2-D gel databases | |
| OGP | Q13509. |
Proteomic databases | |
| PRIDE | Q13509. |
Genome annotation databases | |
| Ensembl | ENSG00000198211. Homo sapiens. [Contig view] |
| GeneID | 10381. |
| KEGG | hsa:10381. |
Organism-specific databases | |
| GeneCards | GC16P088514. |
| HGNC | HGNC:20772. TUBB3. |
| HPA | CAB011512. |
| MIM | 602661. gene. |
| PharmGKB | PA134953867. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q13509. |
Gene expression databases | |
| ArrayExpress | Q13509. |
| Bgee | Q13509. |
| CleanEx | HS_TUBB3. HS_TUBB4. |
| GermOnline | ENSG00000198211. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013838. Beta-tubulin_BS. IPR002453. Beta_tubulin. IPR000217. Tubulin. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view] |
| Gene3D | G3DSA:3.30.1330.20. Tubulin/FtsZ_2-layer-sand-dom. 1 hit. G3DSA:3.40.50.1440. Tubulin_FtsZ. 1 hit. |
| PANTHER | PTHR11588:SF9. Beta_tubulin. 1 hit. PTHR11588. Tubulin. 1 hit. |
| Pfam | PF00091. Tubulin. 1 hit. PF03953. Tubulin_C. 1 hit. [Graphical view] |
| PRINTS | PR01163. BETATUBULIN. PR01161. TUBULIN. |
| PROSITE | PS00227. TUBULIN. 1 hit. PS00228. TUBULIN_B_AUTOREG. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 39327. |
| SOURCE | Search... |
Entry information
| Entry name | TBB3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13509 Secondary accession number(s): Q9BTZ0, Q9BW10 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


